FB2024_03 , released June 25, 2024
Allele: Dmel\per04
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General Information
Symbol
Dmel\per04
Species
D. melanogaster
Name
FlyBase ID
FBal0013652
Feature type
allele
Associated gene
Dmel\per
Associated Insertion(s)
Carried in Construct
Also Known As
pero4
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
N-methyl-N'-nitro-N-nitrosoguanidine
Progenitor genotype
Cytology
Description

Splice site mutation at the boundary of the third intron and the fourth exon. An AG has been changed to TG. 3bp are deleted from the 3' UTR with respect to the sequence published in FBrf0049579.

(Hamblen et al., 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:2,689,502..2,689,502 [+]
Nucleotide change:

A2689502T

Reported nucleotide change:

A?T

Comment:

mutation in splice acceptor site

(Hamblen et al., 1998)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      The time spent copulating is significantly increased in per04 mutant couples, compared to wild-type.

      (Beaver and Giebultowicz, 2004)

      Single per04 mutant females mated once to single per04 mutant males don't lay significantly less eggs than wild-type flies. However, the percentage of unfertilised eggs from this mating is significantly greater and the number of progeny significantly less than for wild-type flies. The numbers of sperm released to the seminal vesicles by per04 males over the 2 days following eclosion is significantly less than that seen in wild-type males.

      (Beaver et al., 2002)

      Arrhythmic clock mutant.

      (Hamblen et al., 1998)

      Flies are arrhythmic in constant darkness.

      (Hardin et al., 1992)

      per01 and per04 adults have very low melatonin and hydroxy indole O-methyl transferase levels. 5-HT, N-acetyl serotonin and N-acetyl transferase levels were in the normal range.

      (Callebert et al., 1991)

      Flies are not strictly arrhythmic, but appear to have fast cycles in their activity patterns (Hamblen-Coyle, J. Neurogenet 5: 229).

      (Kyriacou, 1990)

      Arrhythmic eclosion of flies.

      (Lorenz et al., 1989)

      multiple periods; short ultradian rhythms; hyperactive flies adults are antigenically null (Siwicki et al., 1988)

      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      perSLIH

      (Hamblen et al., 1998)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Konopka.

      Induced on: CG2650T.

      (Hamblen et al., 1998)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      per04
      pero4
      (Kyriacou, 1990, Lorenz et al., 1989)
      Name Synonyms
      Secondary FlyBase IDs
        References (14)