FB2024_03 , released June 25, 2024
Allele: Dmel\perT
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General Information
Symbol
Dmel\perT
Species
D. melanogaster
Name
FlyBase ID
FBal0051296
Feature type
allele
Associated gene
Dmel\per
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Konopka et al., 1994)
Progenitor genotype
Cytology
Description

Amino acid replacement: G593D.

(Hamblen et al., 1998)

Nucleotide substitution is numbered using the system of FBrf0047067. 3bp are deleted from the 3' UTR with respect to the sequence published in FBrf0049579. Two additional bases exist in the perT sequence, 800 bases upstream of the translation start site, in intron 1.

(Hamblen et al., 1998)

Nucleotide substitution: G4800A.

(Hamblen et al., 1998)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
X:2,690,208..2,690,208 [+]
Nucleotide change:

G2690208A

Reported nucleotide change:

G4800A

Amino acid change:

G593D | per-PA; G593D | per-PB

Reported amino acid change:

G593D

(Hamblen et al., 1998)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      perT mutants show increased responsiveness to initial cocaine 75μg exposure, and weak sensitization (as compared to wild-type) to a second exposure when tested for behavioural responses. These flies do not show sensitization to other cocaine doses.

      (Andretic et al., 1999)

      Very fast 16hr clock mutant.

      (Hamblen et al., 1998)

      Period-altering mutations. Homozygotes have a 16 hour period, heterozygotes with per+ have a 20 hour period and heterozygotes with per- have a shorter period than with per+. The rhythmic mutant can be entrained. At 25oC individuals exhibit marginal emergence rhythm but at 19oC periodicity is 17-18 hours. CkIIβAnd combined with perT exhibits a 1 hour lengthening of the adult periodicities, an additive effect. Combination with so mutation has no effect on rhythms.

      (Konopka et al., 1994)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Suppressor of
      Statement
      Reference

      perT is a suppressor | partially of abnormal circadian rhythm phenotype of Df(3R)tll-g/dcoar

      (Rothenfluh et al., 2000)

      perT is a suppressor | partially of abnormal circadian rhythm phenotype of dcoj3B9/dcoar

      (Rothenfluh et al., 2000)
      NOT Suppressor of
      Statement
      Reference

      perT/per[+] is a non-suppressor of abnormal circadian rhythm | partially phenotype of tim01

      (Rothenfluh et al., 2000)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The addition of perT to dcoj3B9/dcoar flies suppresses the arrhythmicity phenotype seen in these flies. the addition of perT/+ has nor effect on the arrhythmia phenotype seen in tim01 flies.

      (Rothenfluh et al., 2000)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Fails to complement

      perSLIH

      (Hamblen et al., 1998)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer

      Induced on: CG2650T.

      (Hamblen et al., 1998)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      Reported As
      Symbol Synonym
      E331
      (Konopka et al., 1994)
      perT
      (Singh et al., 2019)
      Name Synonyms
      line E331
      (Konopka et al., 1994)
      Secondary FlyBase IDs
        References (13)