FlyBase Allele Report: Dmel\Fmr1[sev.PW]

General Information

Symbol

Dmel\Fmr1^sev.PW

Species

D. melanogaster

Name

sevenless promoter construct of Wan

FlyBase ID

FBal0120820

Feature type

allele

Associated gene

Dmel\Fmr1

Associated Insertion(s)

Carried in Construct

P{sev-Fmr1.W}

Key Links

Transgenic product class

wild_type

(Wan et al., 2000)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

wild_type

(Wan et al., 2000)

Mutagen

in vitro construct

(Wan et al., 2000)

Progenitor genotype

Carried in construct

P{sev-Fmr1.W}

Cytology

Description

sev enhancer sequences drive expression of the Fmr1 open reading frame.

(Wan et al., 2000)

Allele components

Component

Use(s)

Regulatory region(s)

sev

Encoded product / tool

Fmr1

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of fragile X syndrome

CEA

(Yao et al., 2011)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of fragile X syndrome

is ameliorated by spas^5.75

(Yao et al., 2011)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Xu et al., 2013)

visible | dominant

(Zarnescu et al., 2005)

Phenotype Manifest In

eye

(Xu et al., 2013, Cziko et al., 2009, Zarnescu et al., 2005, Wan et al., 2000)

ommatidium

(Xu et al., 2013, Zarnescu et al., 2005, Wan et al., 2000)

retina

(Zarnescu et al., 2005)

Detailed Description

Statement

Reference

Expression of Fmr1^sev.PW causes a rough eye phenotype with increased necrosis of ommatidia.

(Xu et al., 2013)

Flies expressing Fmr1^sev.PW display a rough-eye phenotype.

(Cziko et al., 2009)

Fmr1^sev.PW mutants exhibit a rough eye phenotype.

(Estes et al., 2008)

Fmr1^sev.PW/+ flies have a rough eye phenotype and retinal disorganisation.

(Zarnescu et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Fmr1^sev.PW has visible phenotype, enhanceable by Top3β²⁶

(Xu et al., 2013)

Fmr1^sev.PW has visible | dominant phenotype, enhanceable by par-6[+]/par-6^Δ226

(Zarnescu et al., 2005)

Fmr1^sev.PW has visible | dominant phenotype, enhanceable by baz⁴/baz[+]

(Zarnescu et al., 2005)

Suppressed by

Statement

Reference

Fmr1^sev.PW has visible phenotype, suppressible by Tdrd3^EY06846

(Xu et al., 2013)

Fmr1^sev.PW has visible | dominant phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a6

(Zarnescu et al., 2005)

Fmr1^sev.PW has visible | dominant phenotype, suppressible | partially by l(2)gl^a7/l(2)gl[+]

(Zarnescu et al., 2005)

Fmr1^sev.PW has visible | dominant phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a8

(Zarnescu et al., 2005)

Fmr1^sev.PW has visible | dominant phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a9

(Zarnescu et al., 2005)

Fmr1^sev.PW has visible | dominant phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a10

(Zarnescu et al., 2005)

Fmr1^sev.PW has visible | dominant phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a11

(Zarnescu et al., 2005)

Fmr1^sev.PW has visible | dominant phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a12

(Zarnescu et al., 2005)

Fmr1^sev.PW has visible | dominant phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a13

(Zarnescu et al., 2005)

Fmr1^sev.PW has visible | dominant phenotype, suppressible | partially by l(2)gl^a14/l(2)gl[+]

(Zarnescu et al., 2005)

Fmr1^sev.PW has visible | dominant phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a15

(Zarnescu et al., 2005)

Fmr1^sev.PW has visible | dominant phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a16

(Zarnescu et al., 2005)

Fmr1^sev.PW has visible | dominant phenotype, suppressible | partially by l(2)gl^a17/l(2)gl[+]

(Zarnescu et al., 2005)

Fmr1^sev.PW has visible | dominant phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a18

(Zarnescu et al., 2005)

Fmr1^sev.PW has visible | dominant phenotype, suppressible | partially by l(2)gl^a19/l(2)gl[+]

(Zarnescu et al., 2005)

Fmr1^sev.PW has visible | dominant phenotype, suppressible | partially by l(2)gl³³⁴/l(2)gl[+]

(Zarnescu et al., 2005)

Fmr1^sev.PW has visible | dominant phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a1

(Zarnescu et al., 2005)

Fmr1^sev.PW has visible | dominant phenotype, suppressible | partially by l(2)gl^a2/l(2)gl[+]

(Zarnescu et al., 2005)

Fmr1^sev.PW has visible | dominant phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a3

(Zarnescu et al., 2005)

Fmr1^sev.PW has visible | dominant phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a4

(Zarnescu et al., 2005)

Fmr1^sev.PW has visible | dominant phenotype, suppressible | partially by l(2)gl^a5/l(2)gl[+]

(Zarnescu et al., 2005)

Fmr1^sev.PW has increased cell death phenotype, suppressible by Diap1^GMR.PH

(Wan et al., 2000)

Phenotype Manifest In

Enhanced by

Statement

Reference

Fmr1^sev.PW has eye phenotype, enhanceable by Top3β²⁶

(Xu et al., 2013)

Fmr1^sev.PW has ommatidium phenotype, enhanceable by Top3β²⁶

(Xu et al., 2013)

Fmr1^sev.PW has eye phenotype, enhanceable by par-6[+]/par-6^Δ226

(Zarnescu et al., 2005)

Fmr1^sev.PW has ommatidium phenotype, enhanceable by baz⁴/baz[+]

(Zarnescu et al., 2005)

Suppressed by

Statement

Reference

Fmr1^sev.PW has eye phenotype, suppressible by Tdrd3^EY06846

(Xu et al., 2013)

Fmr1^sev.PW has ommatidium phenotype, suppressible by Tdrd3^EY06846

(Xu et al., 2013)

Fmr1^sev.PW has eye phenotype, suppressible by orb2[+]/orb2^c06090

(Cziko et al., 2009)

Fmr1^sev.PW has eye phenotype, suppressible by orb2[+]/orb2^f01556

(Cziko et al., 2009)

Fmr1^sev.PW has eye phenotype, suppressible by Rm62[+]/Rm62^EY10915

(Cziko et al., 2009)

Fmr1^sev.PW has eye phenotype, suppressible by Rm62[+]/Rm62^d02918

(Cziko et al., 2009)

Fmr1^sev.PW has eye phenotype, suppressible by Oda[+]/Oda^EP2104

(Cziko et al., 2009)

Fmr1^sev.PW has eye phenotype, suppressible by orb2^Δ2/orb2[+]

(Cziko et al., 2009)

Fmr1^sev.PW has eye phenotype, suppressible by dco[+]/dco^S139602

(Cziko et al., 2009)

Fmr1^sev.PW has eye phenotype, suppressible by dco[+]/dco^S053813

(Cziko et al., 2009)

Fmr1^sev.PW has eye phenotype, suppressible by orb2[+]/orb2^BG02373

(Cziko et al., 2009)

Fmr1^sev.PW has eye phenotype, suppressible by pAbp[+]/pAbp^k10109

(Cziko et al., 2009)

Fmr1^sev.PW has eye phenotype, suppressible by pAbp[+]/pAbp^EP310

(Cziko et al., 2009)

Fmr1^sev.PW has eye phenotype, suppressible by Rm62[+]/Rm62⁰¹⁰⁸⁶

(Cziko et al., 2009)

Fmr1^sev.PW has eye phenotype, suppressible by Rm62[+]/Rm62^EY06795

(Cziko et al., 2009)

Fmr1^sev.PW has eye phenotype, suppressible by SmD3[+]/SmD3^EP2176

(Cziko et al., 2009)

Fmr1^sev.PW has eye phenotype, suppressible by SmD3[+]/SmD3^k09029

(Cziko et al., 2009)

Fmr1^sev.PW has eye phenotype, suppressible by dco^j3B9/dco[+]

(Cziko et al., 2009)

Fmr1^sev.PW has eye phenotype, suppressible by dco[+]/dco³

(Cziko et al., 2009)

Fmr1^sev.PW has eye phenotype, suppressible by dco^S146009b/dco[+]

(Cziko et al., 2009)

Fmr1^sev.PW has eye phenotype, suppressible by orb2^d01793/orb2[+]

(Cziko et al., 2009)

Fmr1^sev.PW has eye phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a1

(Zarnescu et al., 2005)

Fmr1^sev.PW has ommatidium phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a1

(Zarnescu et al., 2005)

Fmr1^sev.PW has retina phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a1

(Zarnescu et al., 2005)

Fmr1^sev.PW has eye phenotype, suppressible | partially by l(2)gl^a2/l(2)gl[+]

(Zarnescu et al., 2005)

Fmr1^sev.PW has ommatidium phenotype, suppressible | partially by l(2)gl^a2/l(2)gl[+]

(Zarnescu et al., 2005)

Fmr1^sev.PW has retina phenotype, suppressible | partially by l(2)gl^a2/l(2)gl[+]

(Zarnescu et al., 2005)

Fmr1^sev.PW has eye phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a3

(Zarnescu et al., 2005)

Fmr1^sev.PW has ommatidium phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a3

(Zarnescu et al., 2005)

Fmr1^sev.PW has retina phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a3

(Zarnescu et al., 2005)

Fmr1^sev.PW has eye phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a4

(Zarnescu et al., 2005)

Fmr1^sev.PW has ommatidium phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a4

(Zarnescu et al., 2005)

Fmr1^sev.PW has retina phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a4

(Zarnescu et al., 2005)

Fmr1^sev.PW has eye phenotype, suppressible | partially by l(2)gl^a5/l(2)gl[+]

(Zarnescu et al., 2005)

Fmr1^sev.PW has ommatidium phenotype, suppressible | partially by l(2)gl^a5/l(2)gl[+]

(Zarnescu et al., 2005)

Fmr1^sev.PW has retina phenotype, suppressible | partially by l(2)gl^a5/l(2)gl[+]

(Zarnescu et al., 2005)

Fmr1^sev.PW has eye phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a6

(Zarnescu et al., 2005)

Fmr1^sev.PW has ommatidium phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a6

(Zarnescu et al., 2005)

Fmr1^sev.PW has retina phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a6

(Zarnescu et al., 2005)

Fmr1^sev.PW has eye phenotype, suppressible | partially by l(2)gl^a7/l(2)gl[+]

(Zarnescu et al., 2005)

Fmr1^sev.PW has ommatidium phenotype, suppressible | partially by l(2)gl^a7/l(2)gl[+]

(Zarnescu et al., 2005)

Fmr1^sev.PW has retina phenotype, suppressible | partially by l(2)gl^a7/l(2)gl[+]

(Zarnescu et al., 2005)

Fmr1^sev.PW has eye phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a8

(Zarnescu et al., 2005)

Fmr1^sev.PW has ommatidium phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a8

(Zarnescu et al., 2005)

Fmr1^sev.PW has retina phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a8

(Zarnescu et al., 2005)

Fmr1^sev.PW has eye phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a9

(Zarnescu et al., 2005)

Fmr1^sev.PW has ommatidium phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a9

(Zarnescu et al., 2005)

Fmr1^sev.PW has retina phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a9

(Zarnescu et al., 2005)

Fmr1^sev.PW has eye phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a10

(Zarnescu et al., 2005)

Fmr1^sev.PW has ommatidium phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a10

(Zarnescu et al., 2005)

Fmr1^sev.PW has retina phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a10

(Zarnescu et al., 2005)

Fmr1^sev.PW has eye phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a11

(Zarnescu et al., 2005)

Fmr1^sev.PW has ommatidium phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a11

(Zarnescu et al., 2005)

Fmr1^sev.PW has retina phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a11

(Zarnescu et al., 2005)

Fmr1^sev.PW has eye phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a12

(Zarnescu et al., 2005)

Fmr1^sev.PW has ommatidium phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a12

(Zarnescu et al., 2005)

Fmr1^sev.PW has retina phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a12

(Zarnescu et al., 2005)

Fmr1^sev.PW has eye phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a13

(Zarnescu et al., 2005)

Fmr1^sev.PW has ommatidium phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a13

(Zarnescu et al., 2005)

Fmr1^sev.PW has retina phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a13

(Zarnescu et al., 2005)

Fmr1^sev.PW has eye phenotype, suppressible | partially by l(2)gl^a14/l(2)gl[+]

(Zarnescu et al., 2005)

Fmr1^sev.PW has ommatidium phenotype, suppressible | partially by l(2)gl^a14/l(2)gl[+]

(Zarnescu et al., 2005)

Fmr1^sev.PW has retina phenotype, suppressible | partially by l(2)gl^a14/l(2)gl[+]

(Zarnescu et al., 2005)

Fmr1^sev.PW has eye phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a15

(Zarnescu et al., 2005)

Fmr1^sev.PW has ommatidium phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a15

(Zarnescu et al., 2005)

Fmr1^sev.PW has retina phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a15

(Zarnescu et al., 2005)

Fmr1^sev.PW has eye phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a16

(Zarnescu et al., 2005)

Fmr1^sev.PW has ommatidium phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a16

(Zarnescu et al., 2005)

Fmr1^sev.PW has retina phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a16

(Zarnescu et al., 2005)

Fmr1^sev.PW has eye phenotype, suppressible | partially by l(2)gl^a17/l(2)gl[+]

(Zarnescu et al., 2005)

Fmr1^sev.PW has ommatidium phenotype, suppressible | partially by l(2)gl^a17/l(2)gl[+]

(Zarnescu et al., 2005)

Fmr1^sev.PW has retina phenotype, suppressible | partially by l(2)gl^a17/l(2)gl[+]

(Zarnescu et al., 2005)

Fmr1^sev.PW has eye phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a18

(Zarnescu et al., 2005)

Fmr1^sev.PW has ommatidium phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a18

(Zarnescu et al., 2005)

Fmr1^sev.PW has retina phenotype, suppressible | partially by l(2)gl[+]/l(2)gl^a18

(Zarnescu et al., 2005)

Fmr1^sev.PW has eye phenotype, suppressible | partially by l(2)gl^a19/l(2)gl[+]

(Zarnescu et al., 2005)

Fmr1^sev.PW has ommatidium phenotype, suppressible | partially by l(2)gl^a19/l(2)gl[+]

(Zarnescu et al., 2005)

Fmr1^sev.PW has retina phenotype, suppressible | partially by l(2)gl^a19/l(2)gl[+]

(Zarnescu et al., 2005)

Fmr1^sev.PW has eye phenotype, suppressible | partially by l(2)gl³³⁴/l(2)gl[+]

(Zarnescu et al., 2005)

Fmr1^sev.PW has ommatidium phenotype, suppressible | partially by l(2)gl³³⁴/l(2)gl[+]

(Zarnescu et al., 2005)

Fmr1^sev.PW has retina phenotype, suppressible | partially by l(2)gl³³⁴/l(2)gl[+]

(Zarnescu et al., 2005)

Fmr1^sev.PW has eye phenotype, suppressible | partially by aPKC^k06403/aPKC[+]

(Zarnescu et al., 2005)

Fmr1^sev.PW has ommatidium phenotype, suppressible | partially by aPKC^k06403/aPKC[+]

(Zarnescu et al., 2005)

Fmr1^sev.PW has eye phenotype, suppressible by Diap1^GMR.PH

(Wan et al., 2000)

Fmr1^sev.PW has ommatidium phenotype, suppressible by Diap1^GMR.PH

(Wan et al., 2000)

NOT suppressed by

Statement

Reference

Fmr1^sev.PW has eye phenotype, non-suppressible by dco[+]/dco^s139602-REV

(Cziko et al., 2009)

Fmr1^sev.PW has eye phenotype, non-suppressible by SmD3[+]/SmD3^EP2176-REV

(Cziko et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

A Top3β²⁶ mutant background enhances the rough eye phenotype seen in flies expressing Fmr1^sev.PW. Flies show a threefold increase in necrosis and a more disorganised photoreceptor cluster in each ommatidium when compared to expression of Fmr1^sev.PW in a wild type background.

A Tdrd3^EY06846 mutant background suppresses the rough eye phenotype seen in flies expressing Fmr1^sev.PW. Flies show an almost complete absence of necrotic ommatidia and a better organised photoreceptor cluster when compared to expression of Fmr1^sev.PW in a wild type background.

(Xu et al., 2013)

The rough eye phenotype observed in Fmr1^sev.PW flies is suppressed in a dco^S139602/+ background, but not suppressed in a dco^s139602-REV/+ background.

The rough eye phenotype observed in Fmr1^sev.PW flies is suppressed in a dco^S053813/+ background.

The rough eye phenotype observed in Fmr1^sev.PW flies is suppressed in a orb2^BG02373/+ background.

The rough eye phenotype observed in Fmr1^sev.PW flies is suppressed in a pAbp^k10109/+ background.

The rough eye phenotype observed in Fmr1^sev.PW flies is suppressed in a pAbp^EP310/+ background.

The rough eye phenotype observed in Fmr1^sev.PW flies is suppressed in a Rm62⁰¹⁰⁸⁶/+ background.

The rough eye phenotype observed in Fmr1^sev.PW flies is suppressed in a Rm62^EY06795/+ background.

The rough eye phenotype observed in Fmr1^sev.PW flies is suppressed in a SmD3^EP2176/+ background, but not suppressed in a SmD3^EP2176-REV/+ background.

The rough eye phenotype observed in Fmr1^sev.PW flies is suppressed in a SmD3^k09029/+ background.

The rough eye phenotype observed in Fmr1^sev.PW flies is suppressed in a dco^j3B9/+ background.

The rough eye phenotype observed in Fmr1^sev.PW flies is suppressed in a dco³/+ background.

The rough eye phenotype observed in Fmr1^sev.PW flies is suppressed in a dco^S146009b/+ background.

The rough eye phenotype observed in Fmr1^sev.PW flies is suppressed in a orb2^d01793/+ background.

The rough eye phenotype observed in Fmr1^sev.PW flies is suppressed in a orb2^c06090/+ background.

The rough eye phenotype observed in Fmr1^sev.PW flies is suppressed in a orb2^f01556/+ background.

The rough eye phenotype observed in Fmr1^sev.PW flies is suppressed in a Rm62^EY10915/+ background.

The rough eye phenotype observed in Fmr1^sev.PW flies is suppressed in a Rm62^d02918/+ background.

The rough eye phenotype observed in Fmr1^sev.PW flies is suppressed in a Oda^EP2104/+ background.

The rough eye phenotype observed in Fmr1^sev.PW flies is suppressed in a orb2^Δ2/+ background.

(Cziko et al., 2009)

A CG9293^EY13364 or CG9293^f03884 heterozygous background partially suppresses the rough eye phenotype seen in Fmr1^sev.PW mutants.

A chic²²¹, chic⁰¹³²⁰ or chic¹¹ heterozygous background partially suppresses the rough eye phenotype seen in Fmr1^sev.PW mutants.

(Estes et al., 2008)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Fmr1^sev.PW

sev:dFmr1

(Estes et al., 2008)

Name Synonyms

sevenless promoter construct of Wan

(Wan et al., 2000)

Secondary FlyBase IDs

References (6)

Report Sections

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