FB2024_03 , released June 25, 2024
Allele: Dmel\orb2c06090
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General Information
Symbol
Dmel\orb2c06090
Species
D. melanogaster
Name
FlyBase ID
FBal0178570
Feature type
allele
Associated gene
Dmel\orb2
Associated Insertion(s)
PBac{PB}orb2c06090
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - molecular evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - molecular evidence

(Xu et al., 2012)
Mutagen
piggyBac activity
(Gene Disruption Project members and Exelixis, 2005)
Progenitor genotype
Associated Insertion(s)
PBac{PB}orb2c06090
Cytology
Description

The PBac{PB}orb2c06090 insertion maps within both orb2 and CG43783 (the genes share some exons at the 5' end, including some coding sequence).

(FlyBase, 1996-)
Allele components
Component
Use(s)
Also carries
FRT
Mutations Mapped to the Genome
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Fertility of homozygous males is substantially impaired. Fertile orb2c06090/Df(3L)ED4416 males are occasionally recovered.

      (Xu et al., 2012)

      orb2c06090 mutants exhibit a reduction in lifespan.

      25% of orb2c06090 embryos show RP2 neuron specification defects. In approximately 70% of cases the RP2 neurons are duplicated and two Eve-positive cell are seen per hemisegment. However, hemisegments are also seen that lack Eve-positive cells. Abnormalities in asymmetric division are also observed in the P2 to EPC and P15 to DA1 lineages.

      The orb2c06090 mutant takes longer than wild type to return to a standing position following vortexing and fewer flies climb the vial following knockdown. Recovery from heat shock also occurs more slowly than in controls.

      (Hafer et al., 2011)

      The rough eye phenotype observed in Fmr1sev.PW flies is suppressed in a orb2c06090/+ background.

      (Cziko et al., 2009)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Suppressor of
      Statement
      Reference

      orb2[+]/orb2c06090 is a suppressor of eye phenotype of Fmr1sev.PW

      (Cziko et al., 2009)
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      Comments
      Comments

      Precise excision of the transposon rescues the lethality seen in orb2c06090.

      (Hafer et al., 2011)

      Excision of the insertion reverts the male sterility phenotype.

      (Xu et al., 2012)
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      6090
      (Xu et al., 2012)
      orb2c06090
      (Cziko et al., 2009)
      Name Synonyms
      Secondary FlyBase IDs
        References (5)