FlyBase Allele Report: Dmel\SmD3[EP2176]

General Information

Symbol

Dmel\SmD3^EP2176

Species

D. melanogaster

Name

FlyBase ID

FBal0141412

Feature type

allele

Associated gene

Dmel\SmD3

Associated Insertion(s)

P{EP}SmD3^EP2176

Carried in Construct

Also Known As

EP(2)2176

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Schenkel et al., 2002, Gene Disruption Project members, 2001-, FlyBase, 1996-)

Progenitor genotype

Associated Insertion(s)

P{EP}SmD3^EP2176

Cytology

Description

The P{EP}SmD3^EP2176 insertion maps within both SmD3 and Oda (nested genes).

(FlyBase, 1996-)

Allele components

Component

Use(s)

Inserted element

P{EP}

misexpression element

Regulatory region(s)

UAS

binary expression system - regulatory region

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

2R:12,168,693..12,168,693 [+]

(Cziko et al., 2009, Maybeck and Röper, 2009, Schenkel et al., 2002, Gene Disruption Project members, 2001-, FlyBase, 1996-)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die before end of larval stage (with SmD3^k09037)

(Schenkel et al., 2002)

lethal - all die before end of larval stage (with SmD3^k09540)

(Schenkel et al., 2002)

lethal - all die before end of larval stage (with SmD3^k11803)

(Schenkel et al., 2002)

lethal - all die before end of larval stage (with SmD3^k13107)

(Schenkel et al., 2002)

lethal - all die before end of larval stage (with SmD3^k15401)

(Schenkel et al., 2002)

lethal - all die before end of larval stage (with SmD3^lex47)

(Schenkel et al., 2002)

lethal - all die before end of larval stage (with SmD3^ΔLR51)

(Schenkel et al., 2002)

lethal - all die before end of larval stage | recessive

(Schenkel et al., 2002)

some die during larval stage (with SmD3^k09037)

(Schenkel et al., 2002)

some die during larval stage (with SmD3^k09540)

(Schenkel et al., 2002)

some die during larval stage (with SmD3^k11803)

(Schenkel et al., 2002)

some die during larval stage (with SmD3^k13107)

(Schenkel et al., 2002)

some die during larval stage (with SmD3^k15401)

(Schenkel et al., 2002)

some die during larval stage (with SmD3^lex47)

(Schenkel et al., 2002)

some die during larval stage (with SmD3^ΔLR51)

(Schenkel et al., 2002)

some die during larval stage | recessive

(Schenkel et al., 2002)

Phenotype Manifest In

embryonic/larval salivary gland, with Scer\GAL4^fkh.PH

(Maybeck and Röper, 2009)

Detailed Description

Statement

Reference

Over-expression of SmD3^EP2176 does not reduce dendrite branching or alter dendritic morphology in larval class IV sensory neurons (induced under the control of Scer\GAL4^Act.PU). Total dendrite length is not significantly reduced in these neurons.

The rough eye phenotype observed in Fmr1^sev.PW flies is suppressed in a SmD3^EP2176/+ background.

(Cziko et al., 2009)

Expression via Scer\GAL4^fkh.PH results in a strongly penetrant positioning ('hook') phenotype in the embryonic salivary gland.

(Maybeck and Röper, 2009)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

Suppressor of

Statement

Reference

SmD3[+]/SmD3^EP2176 is a suppressor of eye phenotype of Fmr1^sev.PW

(Cziko et al., 2009)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

SmD3^ΔLR51

(Schenkel et al., 2002)

SmD3^lex47

(Schenkel et al., 2002)

SmD3^k09037

(Schenkel et al., 2002)

SmD3^k09540

(Schenkel et al., 2002)

SmD3^k11803

(Schenkel et al., 2002)

SmD3^k13107

(Schenkel et al., 2002)

SmD3^k15401

(Schenkel et al., 2002)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Complements: Oda^EP2104.

(Schenkel et al., 2002)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

SmD3^EP2176

guf^EP2176

Name Synonyms

Secondary FlyBase IDs

FBal0130222

References (5)

Report Sections

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