FlyBase Allele Report: Dmel\fz[20]

General Information

Symbol

Dmel\fz²⁰

Species

D. melanogaster

Name

FlyBase ID

FBal0004936

Feature type

allele

Associated gene

Dmel\fz

Associated Insertion(s)

Carried in Construct

Also Known As

fz^N21

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Adler et al., 1990)

Progenitor genotype

Cytology

Polytene chromosomes normal.

Description

Mutation is in the first cytoplasmic loop of the fz protein.

(Jones et al., 1996)

Amino acid replacement: P278S.

(Jones et al., 1996)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3L:14,311,900..14,311,900 [+]

Nucleotide change:

C14311900T

Reported nucleotide change:

C?T

Amino acid change:

P278S | fz-PA; P278S | fz-PC

Reported amino acid change:

P278S

Comment:

P278 is in the first cytoplasmic loop of the fz protein.

(Jones et al., 1996)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal cell polarity (with fz¹⁹)

(Strutt et al., 2006, Strutt and Strutt, 2003)

abnormal planar polarity (with fz¹⁹)

(Rawls et al., 2007)

abnormal planar polarity | somatic clone (with fz¹⁹)

(Strutt et al., 2002)

visible

(Strutt et al., 2012)

Phenotype Manifest In

eye photoreceptor cell | somatic clone (with fz¹⁹)

(Strutt et al., 2002)

leg

(Strutt et al., 2012)

leg joint | ectopic

(Strutt et al., 2012)

ommatidium (with fz¹⁹)

(Fetting et al., 2009, Rawls et al., 2007, Strutt et al., 2006, Strutt and Strutt, 2003)

ommatidium | somatic clone (with fz¹⁹)

(Strutt et al., 2002)

wing

(Jones et al., 1996)

Detailed Description

Statement

Reference

Mutant adults have an average of 1.6 +/- 0.5 extra tarsal joints in the leg compared to wild type.

(Strutt et al., 2012)

Some fz¹⁹/fz²⁰ ommatidia over- or under-rotate; the variance (s.d.) in degree of rotation is greater than in wild type in adult eyes.

(Fetting et al., 2009)

fz²⁰/fz¹⁹ flies show defects in ommatidial polarity.

(Rawls et al., 2007)

In the eyes of fz¹⁹/fz²⁰ transheterozygotes, 10% of ommatidia are mispolarized.

(Strutt et al., 2006)

fz¹⁹/fz²⁰ animals exhibit a weak eye phenotype - 9% of ommatidia show polarity defects.

(Strutt and Strutt, 2003)

84.8% of ommatidia in fz¹⁹/fz²⁰ mutant somatic clones in the eye are normal. 6.3% have rotated ommatidia, 6.1% have chirality defects, 2.5% are achiral (0.3% unscorable).

(Strutt et al., 2002)

Autonomous phenotype in wing clones.

(Jones et al., 1996)

eye texture normal A neomorphic allele causing severe disruption of trichome orientation in the costal wing cell, a region little affected by most alleles; phenotype of homozygote more severe than that of hemizygote. Also unlike other alleles, homozygous clones of fz¹³ cells in the wing do not affect orientation of trichomes in surrounding normal cells. A third notable feature of fz¹³ is that it is without effect on eye texture. moderate thoracic bristle phenotype moderate wing-hair disorientation

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

fz²⁰/fz¹⁹ has abnormal planar polarity phenotype, enhanceable by bdg¹⁶⁴/bdg¹⁶⁴

(Rawls et al., 2007)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by dsh¹/dsh[+]

(Strutt et al., 2006)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by dco[+]/dco^5B2.6

(Strutt et al., 2006)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by dco^j3B9/dco[+]

(Strutt et al., 2006)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by dco²/dco[+]

(Strutt et al., 2006)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by dco[+]/dco³

(Strutt et al., 2006)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by Ras85D^2F4

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by sty^Δ5

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by sty²²⁶

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by sty^F7

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by sty^X3F7

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by sty^X3J3

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by aos^Δ7

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by dsh¹

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by aos^5F4

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by aos^A254Δ15

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, enhanceable by aos^rlt

(Strutt and Strutt, 2003)

NOT Enhanced by

Statement

Reference

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, non-enhanceable by Rho1^k07903

(Strutt and Strutt, 2003)

NOT suppressed by

Statement

Reference

fz²⁰/fz¹⁹ has abnormal cell polarity phenotype, non-suppressible by Rho1^72R

(Strutt and Strutt, 2003)

Enhancer of

Statement

Reference

fz²⁰ is an enhancer of abnormal neuroanatomy phenotype of DAAM^Ex1

(Gombos et al., 2015)

Phenotype Manifest In

Enhanced by

Statement

Reference

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by ed[+]/ed^1X5

(Fetting et al., 2009)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by bdg¹⁶⁴/bdg¹⁶⁴

(Rawls et al., 2007)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by dsh¹/dsh[+]

(Strutt et al., 2006)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by dco[+]/dco^5B2.6

(Strutt et al., 2006)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by dco^j3B9/dco[+]

(Strutt et al., 2006)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by dco²/dco[+]

(Strutt et al., 2006)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by dco[+]/dco³

(Strutt et al., 2006)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by Ras85D^2F4

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by sty^Δ5

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by sty²²⁶

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by sty^F7

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by sty^X3F7

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by sty^X3J3

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by dsh¹

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by aos^Δ7

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by aos^5F4

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by aos^A254Δ15

(Strutt and Strutt, 2003)

fz²⁰/fz¹⁹ has ommatidium phenotype, enhanceable by aos^rlt

(Strutt and Strutt, 2003)

NOT Enhanced by

Statement

Reference

fz²⁰/fz¹⁹ has ommatidium phenotype, non-enhanceable by Rho1^k07903

(Strutt and Strutt, 2003)

NOT suppressed by

Statement

Reference

fz²⁰/fz¹⁹ has ommatidium phenotype, non-suppressible by Rho1^72R

(Strutt and Strutt, 2003)

Enhancer of

Statement

Reference

fz²⁰ is an enhancer of adult mushroom body alpha-lobe phenotype of DAAM^Ex1

(Gombos et al., 2015)

fz²⁰ is an enhancer of adult mushroom body beta-lobe phenotype of DAAM^Ex1

(Gombos et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Homozygous fz²⁰ enhances the axonal projection defects seen in the α and β lobes of DAAM^Ex1 mutant mushroom bodies.

(Gombos et al., 2015)

fz²⁰ fz2^C1 double homozygous clones in the wing do not result in loss of wing margin bristles in the mutant tissue.

(Strutt et al., 2012)

ed^1X5 dominantly enhances the phenotype of mis-rotation of ommatidia that is seen in fz¹⁹/fz²⁰ animals, without affecting the chirality phenotype.

(Fetting et al., 2009)

Homozygosity for bdg¹⁶⁴ enhances the ommatidial polarity defects caused by fz²⁰/fz¹⁹.

(Rawls et al., 2007)

The addition of dsh¹/+ strongly enhances the eye cell polarity phenotype seen in fz¹⁹/fz²⁰ animals. The addition of argos^5F4/+ , argos^Δ7/+, argos^A254Δ15/+, or argos^rlt/+ , enhances the eye cell polarity phenotype seen in fz¹⁹/fz²⁰ animals. The addition of sty^F7/+, sty^X3J3/+, sty^X3F7/+, sty^Δ5/+, or sty²²⁶/+ , enhances the eye cell polarity phenotype seen in fz¹⁹/fz²⁰ animals. The addition of Ras85D^2F4/+ enhances the eye cell polarity phenotype seen in fz¹⁹/fz²⁰ animals. The addition of Rho1^k07903 or Rho1^72R has no effect on the eye cell polarity phenotype seen in fz¹⁹/fz²⁰ animals.

(Strutt and Strutt, 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Adler.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

fz²⁰

(Gombos et al., 2015, Strutt et al., 2006)

fz^N21

(Strutt et al., 2012, Fetting et al., 2009, Rawls et al., 2007, Jones et al., 1996, Wong and Adler, 1993, Adler, 1992, Adler et al., 1990)

Name Synonyms

Secondary FlyBase IDs

References (14)

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