FlyBase Allele Report: Dmel\DAAM[Ex1]

General Information

Symbol

Dmel\DAAM^Ex1

Species

D. melanogaster

Name

FlyBase ID

FBal0194068

Feature type

allele

Associated gene

Dmel\DAAM

Associated Insertion(s)

Carried in Construct

Also Known As

dDAAM^Ex1

Key Links

Allele class

hypomorphic allele - molecular evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - molecular evidence

(Gombos et al., 2015, Molnár et al., 2014)

Mutagen

P-element activity

(Matusek et al., 2006)

Progenitor genotype

P{EP}EP1542

(Matusek et al., 2006)

Cytology

Description

Imprecise excision of the P{EP}EP1542 element, resulting in deletion of most of the 3'UTR and a very small part of the C-terminal end of the coding region.

(Matusek et al., 2006)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Gombos et al., 2015)

abnormal neuroanatomy (with DAAM^Ex68)

(Matusek et al., 2008)

abnormal neuroanatomy | adult stage

(Dollar et al., 2016)

fertile

(Matusek et al., 2006)

flightless

(Molnár et al., 2014)

flightless, with DAAM^{RNAi.UAS.T129M}, Dcr-2^UAS.cDa, Scer\GAL4^Hk-UH3

(Molnár et al., 2014)

lethal (with DAAM^Ex36)

(Matusek et al., 2006)

lethal (with DAAM^Ex68)

(Matusek et al., 2006)

partially lethal - majority die

(Matusek et al., 2006)

viable

(Dollar et al., 2016, Gombos et al., 2015, Molnár et al., 2014)

viable (with DAAM^Ex65)

(Matusek et al., 2006)

viable (with DAAM^Ex184)

(Matusek et al., 2006)

viable (with DAAM^Ex202)

(Matusek et al., 2006)

viable (with DAAM^Ex249)

(Matusek et al., 2006)

Phenotype Manifest In

adult mushroom body alpha-lobe

(Gombos et al., 2015)

adult mushroom body alpha-lobe | adult stage

(Dollar et al., 2016)

adult mushroom body beta-lobe

(Gombos et al., 2015)

adult mushroom body beta-lobe | adult stage

(Dollar et al., 2016)

axon | adult stage

(Dollar et al., 2016)

connective (with DAAM^Ex68)

(Matusek et al., 2008)

embryo (with DAAM^Ex68)

(Matusek et al., 2008)

embryonic/larval tracheal section

(Matusek et al., 2006)

fascicle (with DAAM^Ex68)

(Matusek et al., 2008)

filopodium (with DAAM^Ex68)

(Gonçalves-Pimentel et al., 2011)

indirect flight muscle cell

(Molnár et al., 2014)

indirect flight muscle cell, with DAAM^{RNAi.UAS.T129M}, Dcr-2^UAS.cDa, Scer\GAL4^Hk-UH3

(Molnár et al., 2014)

lateral longitudinal fascicle (with DAAM^Ex68)

(Matusek et al., 2008)

M band, with DAAM^{RNAi.UAS.T129M}, Dcr-2^UAS.cDa, Scer\GAL4^Hk-UH3

(Molnár et al., 2014)

myofibril

(Molnár et al., 2014)

myofibril, with DAAM^{RNAi.UAS.T129M}, Dcr-2^UAS.cDa, Scer\GAL4^Hk-UH3

(Molnár et al., 2014)

neuropil (with DAAM^Ex68)

(Matusek et al., 2008)

sarcomere

(Molnár et al., 2014)

sarcomere, with DAAM^{RNAi.UAS.T129M}, Dcr-2^UAS.cDa, Scer\GAL4^Hk-UH3

(Molnár et al., 2014)

striated muscle myosin thick filament, with DAAM^{RNAi.UAS.T129M}, Dcr-2^UAS.cDa, Scer\GAL4^Hk-UH3

(Molnár et al., 2014)

striated muscle thin filament, with DAAM^{RNAi.UAS.T129M}, Dcr-2^UAS.cDa, Scer\GAL4^Hk-UH3

(Molnár et al., 2014)

Z disc, with DAAM^{RNAi.UAS.T129M}, Dcr-2^UAS.cDa, Scer\GAL4^Hk-UH3

(Molnár et al., 2014)

Detailed Description

Statement

Reference

DAAM^Ex1/Y males are viable and have moderate mushroom body axon growth and guidance defects.

(Dollar et al., 2016)

DAAM^Ex1 mutant flies exhibit growth and axon guidance defects in the α and β lobes of the mushroom body. No changes in Kenyon cell number or dendritic organisation are detected.

(Gombos et al., 2015)

16.2 +/- 5.3% of DAAM^Ex1 adults are flightless.

Expression of DAAM^{dsRNA.Scer\UAS.T129M} under the control of Scer\GAL4^UH3 (in the presence of Dcr-2^Scer\UAS.cDa to enhance RNAi efficiency) in a DAAM^Ex1 background results in 98.9 +/- 1.1% of adults being flightless.

The indirect flight muscles of homozygous flies appear largely normal, but 25% of the myofibrils are thinner than normal and some sarcomeres are reduced in length. The elasticity (Young's modulus) of the mutant myofibrils is significantly lower than that of wild type.

Flies expressing DAAM^{dsRNA.Scer\UAS.T129M} under the control of Scer\GAL4^UH3 (in the presence of Dcr-2^Scer\UAS.cDa in a DAAM^Ex1 background show gross alterations in indirect flight muscle morphology. The myofibrils are thinner than normal, irregularly shaped and have frayed edges. Shortened sarcomeres are seen. There is a reduction in F-actin staining without a significant change in the amount of G-actin. M-lines are absent and strong Z-disc defects are seen. Thick filaments rarely run parallel to each other, the average number of thick filaments per sarcomere is strongly reduced and filament packing is much looser than normal. The organisation of thin filaments is very different from wild type. These defects are already seen at 48 hours after puparium formation at 29[o]C. The elasticity (Young's modulus) of the mutant myofibrils is significantly lower than that of wild type.

(Molnár et al., 2014)

Cultured primary neurons derived from DAAM^Ex1/DAAM^Ex68 embryos show a significant reduction in the number of filopodia compared to control neurons. In live analyses, the mutant neurons show modestly increased protrusion rates and strongly increased retraction rates of filopodia.

(Gonçalves-Pimentel et al., 2011)

DAAM^Ex1 flies show 17% viability compared to wild-type flies.

DAAM^Ex1/DAAM^Ex249 adults show no defects in the eye or wing.

Trachea dissected out from third instar DAAM^Ex1 mutant larvae display a moderate tracheal cuticle phenotype.

(Matusek et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

DAAM^Ex1 has abnormal neuroanatomy | adult stage phenotype, enhanceable by Frl[+]/Frl^Ex83

(Dollar et al., 2016)

DAAM^Ex1 has abnormal neuroanatomy | adult stage phenotype, enhanceable by Frl[+]/Frl^Ex88

(Dollar et al., 2016)

DAAM^Ex1 has abnormal neuroanatomy | adult stage phenotype, enhanceable by Frl[+]/Frl^ExK62

(Dollar et al., 2016)

DAAM^Ex1 has abnormal neuroanatomy | adult stage phenotype, enhanceable by Frl^HMS00445/Scer\GAL4^ey-OK107

(Dollar et al., 2016)

DAAM^Ex1 has abnormal neuroanatomy phenotype, enhanceable by stan[+]/stan^frz3

(Gombos et al., 2015)

DAAM^Ex1 has abnormal neuroanatomy phenotype, enhanceable by Vang^stbm-6/Vang[+]

(Gombos et al., 2015)

DAAM^Ex1 has abnormal neuroanatomy phenotype, enhanceable by pk[+]/pk³⁰

(Gombos et al., 2015)

DAAM^Ex1 has abnormal neuroanatomy phenotype, enhanceable by fz²⁰

(Gombos et al., 2015)

DAAM^Ex1 has abnormal neuroanatomy phenotype, enhanceable by dsh¹/dsh[+]

(Gombos et al., 2015)

DAAM^Ex1 has abnormal neuroanatomy phenotype, enhanceable by Wnt5⁴⁰⁰/Wnt5[+]

(Gombos et al., 2015)

DAAM^Ex1 has abnormal neuroanatomy phenotype, enhanceable by Rac1^J11/Rac1[+]

(Gombos et al., 2015)

DAAM^Ex1 has partially lethal - majority die phenotype, enhanceable by Rho1^72F

(Matusek et al., 2006)

DAAM^Ex1 has partially lethal - majority die phenotype, enhanceable by Src42A^E1

(Matusek et al., 2006)

DAAM^Ex1 has partially lethal - majority die phenotype, enhanceable by Btk^k05610

(Matusek et al., 2006)

NOT Enhanced by

Statement

Reference

DAAM^Ex1 has abnormal neuroanatomy phenotype, non-enhanceable by fz[+]/fz³⁰

(Gombos et al., 2015)

DAAM^Ex1 has abnormal neuroanatomy phenotype, non-enhanceable by Rho1^72F/Rho1[+]

(Gombos et al., 2015)

DAAM^Ex1 has abnormal neuroanatomy phenotype, non-enhanceable by Cdc42[+]/Cdc42³

(Gombos et al., 2015)

Suppressed by

Statement

Reference

DAAM^Ex1 has flightless phenotype, suppressible by tmod[+]/tmod⁰⁰⁸⁴⁸

(Molnár et al., 2014)

DAAM^Ex1/DAAM^Ex68 has abnormal neuroanatomy phenotype, suppressible | partially by Scer\GAL4^elav-C155/Mmus\Daam1^UAS.EGFP

(Matusek et al., 2008)

Enhancer of

Statement

Reference

DAAM[+]/DAAM^Ex1 is an enhancer of abnormal neuroanatomy phenotype of dsh¹

(Gombos et al., 2015)

Suppressor of

Statement

Reference

DAAM^Ex1 is a suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^ey-OK107, Vang^UAS.mGFP6

(Gombos et al., 2015)

DAAM^Ex1 is a suppressor of abnormal neuroanatomy phenotype of Scer\GAL4^ey-OK107, Wnt5^UAS.cFa

(Gombos et al., 2015)

Phenotype Manifest In

Enhanced by

Statement

Reference

DAAM^Ex1 has axon | adult stage phenotype, enhanceable by Frl[+]/Frl^Ex83

(Dollar et al., 2016)

DAAM^Ex1 has adult mushroom body alpha-lobe | adult stage phenotype, enhanceable by Frl[+]/Frl^Ex83

(Dollar et al., 2016)

DAAM^Ex1 has adult mushroom body beta-lobe | adult stage phenotype, enhanceable by Frl[+]/Frl^Ex83

(Dollar et al., 2016)

DAAM^Ex1 has axon | adult stage phenotype, enhanceable by Frl[+]/Frl^Ex88

(Dollar et al., 2016)

DAAM^Ex1 has adult mushroom body alpha-lobe | adult stage phenotype, enhanceable by Frl[+]/Frl^Ex88

(Dollar et al., 2016)

DAAM^Ex1 has adult mushroom body beta-lobe | adult stage phenotype, enhanceable by Frl[+]/Frl^Ex88

(Dollar et al., 2016)

DAAM^Ex1 has axon | adult stage phenotype, enhanceable by Frl[+]/Frl^ExK62

(Dollar et al., 2016)

DAAM^Ex1 has adult mushroom body alpha-lobe | adult stage phenotype, enhanceable by Frl[+]/Frl^ExK62

(Dollar et al., 2016)

DAAM^Ex1 has adult mushroom body beta-lobe | adult stage phenotype, enhanceable by Frl[+]/Frl^ExK62

(Dollar et al., 2016)

DAAM^Ex1 has axon | adult stage phenotype, enhanceable by Frl^HMS00445/Scer\GAL4^ey-OK107

(Dollar et al., 2016)

DAAM^Ex1 has adult mushroom body beta-lobe | adult stage phenotype, enhanceable by Frl^HMS00445/Scer\GAL4^ey-OK107

(Dollar et al., 2016)

DAAM^Ex1 has adult mushroom body alpha-lobe phenotype, enhanceable by Vang^stbm-6/Vang[+]

(Gombos et al., 2015)

DAAM^Ex1 has adult mushroom body beta-lobe phenotype, enhanceable by Vang^stbm-6/Vang[+]

(Gombos et al., 2015)

DAAM^Ex1 has adult mushroom body alpha-lobe phenotype, enhanceable by pk[+]/pk³⁰

(Gombos et al., 2015)

DAAM^Ex1 has adult mushroom body beta-lobe phenotype, enhanceable by pk[+]/pk³⁰

(Gombos et al., 2015)

DAAM^Ex1 has adult mushroom body alpha-lobe phenotype, enhanceable by fz²⁰

(Gombos et al., 2015)

DAAM^Ex1 has adult mushroom body beta-lobe phenotype, enhanceable by fz²⁰

(Gombos et al., 2015)

DAAM^Ex1 has adult mushroom body alpha-lobe phenotype, enhanceable by dsh¹/dsh[+]

(Gombos et al., 2015)

DAAM^Ex1 has adult mushroom body beta-lobe phenotype, enhanceable by dsh¹/dsh[+]

(Gombos et al., 2015)

DAAM^Ex1 has adult mushroom body alpha-lobe phenotype, enhanceable by Wnt5⁴⁰⁰/Wnt5[+]

(Gombos et al., 2015)

DAAM^Ex1 has adult mushroom body beta-lobe phenotype, enhanceable by Wnt5⁴⁰⁰/Wnt5[+]

(Gombos et al., 2015)

DAAM^Ex1 has adult mushroom body alpha-lobe phenotype, enhanceable by Rac1^J11/Rac1[+]

(Gombos et al., 2015)

DAAM^Ex1 has adult mushroom body beta-lobe phenotype, enhanceable by Rac1^J11/Rac1[+]

(Gombos et al., 2015)

DAAM^Ex1 has adult mushroom body alpha-lobe phenotype, enhanceable by stan^frz3

(Gombos et al., 2015)

DAAM^Ex1 has indirect flight muscle cell phenotype, enhanceable by Act88F⁶/Act88F[+]

(Molnár et al., 2014)

DAAM^Ex1 has indirect flight muscle cell phenotype, enhanceable by Tm2³/Tm2[+]

(Molnár et al., 2014)

DAAM^Ex1/DAAM^Ex68 has filopodium phenotype, enhanceable by Arpc1¹

(Gonçalves-Pimentel et al., 2011)

DAAM^Ex1 has embryonic/larval tracheal section phenotype, enhanceable by Rho1^72F

(Matusek et al., 2006)

DAAM^Ex1 has embryonic/larval tracheal section phenotype, enhanceable by Src42A^E1

(Matusek et al., 2006)

DAAM^Ex1 has embryonic/larval tracheal section phenotype, enhanceable by Btk^k05610

(Matusek et al., 2006)

NOT Enhanced by

Statement

Reference

DAAM^Ex1 has adult mushroom body alpha-lobe | adult stage phenotype, non-enhanceable by Frl^HMS00445/Scer\GAL4^ey-OK107

(Dollar et al., 2016)

DAAM^Ex1 has adult mushroom body beta-lobe phenotype, non-enhanceable by stan[+]/stan^frz3

(Gombos et al., 2015)

DAAM^Ex1 has adult mushroom body alpha-lobe phenotype, non-enhanceable by fz[+]/fz³⁰

(Gombos et al., 2015)

DAAM^Ex1 has adult mushroom body beta-lobe phenotype, non-enhanceable by fz[+]/fz³⁰

(Gombos et al., 2015)

DAAM^Ex1 has adult mushroom body alpha-lobe phenotype, non-enhanceable by Rho1^72F/Rho1[+]

(Gombos et al., 2015)

DAAM^Ex1 has adult mushroom body beta-lobe phenotype, non-enhanceable by Rho1^72F/Rho1[+]

(Gombos et al., 2015)

DAAM^Ex1 has adult mushroom body alpha-lobe phenotype, non-enhanceable by Cdc42[+]/Cdc42³

(Gombos et al., 2015)

DAAM^Ex1 has adult mushroom body beta-lobe phenotype, non-enhanceable by Cdc42[+]/Cdc42³

(Gombos et al., 2015)

DAAM^Ex1 has indirect flight muscle cell phenotype, non-enhanceable by sals^f07849/sals[+]

(Molnár et al., 2014)

DAAM^Ex1 has indirect flight muscle cell phenotype, non-enhanceable by Tm1[+]/Tm1⁰²²⁹⁹

(Molnár et al., 2014)

DAAM^Ex1 has indirect flight muscle cell phenotype, non-enhanceable by Act5C[+]/Act5C^G0025

(Molnár et al., 2014)

Suppressed by

Statement

Reference

DAAM^Ex1/DAAM^Ex68 has connective phenotype, suppressible | partially by Scer\GAL4^elav-C155/Mmus\Daam1^UAS.EGFP

(Matusek et al., 2008)

NOT suppressed by

Statement

Reference

DAAM^Ex1 has indirect flight muscle cell phenotype, non-suppressible by Tm1[+]/Tm1⁰²²⁹⁹

(Molnár et al., 2014)

DAAM^Ex1 has indirect flight muscle cell phenotype, non-suppressible by Act5C[+]/Act5C^G0025

(Molnár et al., 2014)

DAAM^Ex1 has indirect flight muscle cell phenotype, non-suppressible by sals^f07849/sals[+]

(Molnár et al., 2014)

Enhancer of

Statement

Reference

DAAM[+]/DAAM^Ex1 is an enhancer of adult mushroom body alpha-lobe phenotype of dsh¹

(Gombos et al., 2015)

DAAM[+]/DAAM^Ex1 is an enhancer of adult mushroom body beta-lobe phenotype of dsh¹

(Gombos et al., 2015)

DAAM^Ex1/DAAM^Ex1 is an enhancer of indirect flight muscle cell phenotype of Act88F⁶

(Molnár et al., 2014)

DAAM^Ex1/DAAM^Ex68 is an enhancer of filopodium phenotype of Arpc1¹

(Gonçalves-Pimentel et al., 2011)

Suppressor of

Statement

Reference

DAAM^Ex1 is a suppressor of adult mushroom body beta-lobe phenotype of Scer\GAL4^ey-OK107, Wnt5^UAS.cFa

(Gombos et al., 2015)

DAAM^Ex1 is a suppressor of mushroom body medial lobe phenotype of Scer\GAL4^ey-OK107, Wnt5^UAS.cFa

(Gombos et al., 2015)

DAAM^Ex1 is a suppressor of adult mushroom body beta-lobe phenotype of Scer\GAL4^ey-OK107, Vang^UAS.mGFP6

(Gombos et al., 2015)

DAAM^Ex1 is a suppressor of mushroom body medial lobe phenotype of Scer\GAL4^ey-OK107, Vang^UAS.mGFP6

(Gombos et al., 2015)

DAAM^Ex1 is a suppressor of sarcomere phenotype of Scer\GAL4^Hk-UH3, tmod^NIG.1539R

(Molnár et al., 2014)

DAAM^Ex1 is a suppressor of indirect flight muscle cell phenotype of Scer\GAL4^Hk-UH3, tmod^NIG.1539R

(Molnár et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Presence of Frl^Ex83/+, Frl^Ex88/+ or Frl^ExK62/+ enhances axon growth phenotypes seen in the mushroom body of DAAM^Ex1/Y males. Expression of Frl^HMS00445 driven by Scer\GAL4^ey-OK107 enhances axon growth phenotypes seen in the mushroom body (β but not α lobe) of DAAM^Ex1/Y males.

(Dollar et al., 2016)

One copy of stan^frz3 strongly enhances the axonal projection defects seen in the αlobes of DAAM^Ex1 mutant mushroom bodies. The β lobe defects are not significantly enhanced.

One copy of Vang^stbm-6 enhances the axonal projection defects seen in the αlobes of DAAM^Ex1 mutant mushroom bodies. The β lobe defects are also enhanced but not as strongly.

One copy of pk³⁰ enhances the axonal projection defects seen in the αlobes of DAAM^Ex1 mutant mushroom bodies. The β lobe defects are also enhanced but not as strongly.

One copy of fz³⁰ does not enhance the axonal projection defects seen in the α and β lobes of DAAM^Ex1 mutant mushroom bodies.

Homozygous fz²⁰ enhances the axonal projection defects seen in the α and β lobes of DAAM^Ex1 mutant mushroom bodies.

One copy of dsh¹ enhances the axonal projection defects seen in the α and β lobes of DAAM^Ex1 mutant mushroom bodies in females. Very few, if any, defects are seen in dsh¹ DAAM^Ex1 double heterozygotes. DAAM^Ex1 enhances the axon projection phenotypes seen in dsh¹/Y males alone. Many of these double hemizygous males exhibit an early growth termination phenotype not seen in either mutant alone.

One copy of Wnt5⁴⁰⁰ enhances the defects seen in the axonal projection defects seen in the α and β lobes of DAAM^Ex1 mutant mushroom bodies.

One copy of Rac1^J11 enhances the axonal growth defects seen in the α and β lobes of DAAM^Ex1 mutant mushroom bodies.

One copy of Rho1^72F does not enhance the axonal growth defects seen in the α and β lobes of DAAM^Ex1 mutant mushroom bodies.

One copy of Cdc42³ does not enhance the axonal growth defects seen in the α and β lobes of DAAM^Ex1 mutant mushroom bodies.

Hemizygous DAAM^Ex1 suppresses the β lobe axon overextension and medial lobe fusion phenotype seen when Vang^{Scer\UAS.T:Avic\GFP-m6} is expressed in male flies under the control of Scer\GAL4^ey-OK107.

Hemizygous DAAM^Ex1 suppresses the β lobe axon overextension and medial lobe fusion phenotype seen when Wnt5^Scer\UAS.cFa is expressed in male flies under the control of Scer\GAL4^ey-OK107.

(Gombos et al., 2015)

The mild indirect muscle phenotype seen in DAAM^Ex1 mutants is strongly enhanced by Act88F⁶/+. The double mutants have a network of very thin myofibrils which often appear branched and the regular Z-disc and sarcomere organisation is completely abolished.

The mild indirect muscle phenotype seen in DAAM^Ex1 mutants is enhanced by Tm2³/+. The myofibrils are disorganised, with variable width, unequal sarcomere and thin filament length and mini-sarcomeres are common.

The mild indirect muscle phenotype seen in DAAM^Ex1 mutants is not altered by Tm1⁰²²⁹⁹/+, sals^f07849 or by Act5C^G0025/+.

The weak flightless phenotype of DAAM^Ex1 mutants is completely suppressed by tmod⁰⁰⁸⁴⁸/+.

(Molnár et al., 2014)

Cultured primary neurons derived from DAAM^Ex1/DAAM^Ex68 Sop2¹ embryos show a very strong reduction in the number of filopodia (to 5% of the wild type average) compared to control neurons.

Only 20% of cultured primary neurons derived from DAAM^Ex1/DAAM^Ex68 Sop2¹/Sop2^Q25sd embryos have neurites.

(Gonçalves-Pimentel et al., 2011)

The tracheal cuticle phenotype of DAAM^Ex1 larvae is enhanced by Rho1^72F, Src42A^E1 and Btk29A^k05610. These alleles also decrease the viability of the semilethal DAAM^Ex1 larvae.

(Matusek et al., 2006)

Xenogenetic Interactions

Statement

Reference

Expression of Mmus\Daam1^{Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^elav-C155 rescues central nervous system axon defects in 70% of DAAM^Ex68/DAAM^Ex1 embryos derived from homozygous DAAM^Ex1 females.

(Matusek et al., 2008)

Complementation and Rescue Data

Complements

DAAM^Ex202

(Matusek et al., 2006)

DAAM^Ex65

(Matusek et al., 2006)

DAAM^Ex184

(Matusek et al., 2006)

DAAM^Ex249

(Matusek et al., 2006)

Fails to complement

DAAM^Ex68

(Matusek et al., 2006)

DAAM^Ex36

(Matusek et al., 2006)

Rescued by

DAAM^Ex1 is rescued by DAAM^UASp.cMa/Scer\GAL4^elav.PU

(Gombos et al., 2015)

DAAM^Ex1 is rescued by DAAM^UASp.cMa/Scer\GAL4^Hk-UH3

(Molnár et al., 2014)

DAAM^Ex1/DAAM^Ex68 is rescued by Scer\GAL4^elav-C155/DAAM^UASp.cMa

(Matusek et al., 2008)

DAAM^Ex1/DAAM^Ex68 is rescued by DAAM^UASp.cMa/Scer\GAL4^Act5C.PI

(Matusek et al., 2008)

DAAM^Ex1 is rescued by DAAM^UASp.cMa/Scer\GAL4^Act.PU

(Matusek et al., 2006)

DAAM^Ex1 is rescued by DAAM^UASp.cMa/Scer\GAL4^Tub.PU

(Matusek et al., 2006)

Comments

Expression of DAAM^{Scer\UAS.P\T.cMa} under the control of Scer\GAL4^elav.PU rescues the α and β lobe mushroom body defects seen in DAAM^Ex1 mutant flies.

(Gombos et al., 2015)

Expression of DAAM^{Scer\UAS.P\T.cMa} under the control of Scer\GAL4^UH3 rescues the flightless phenotype seen in some DAAM^Ex1 adults.

(Molnár et al., 2014)

The CNS defects revealed in DAAM^Ex68/DAAM^Ex1 mutants are fully rescued when DAAM^{Scer\UAS.P\T.cMa} is expressed under the control of the pan-neuronal Scer\GAL4^elav-C155 or the ubiquitous Scer\GAL4^Act5C.PI driver.

(Matusek et al., 2008)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

DAAM^Ex1

(Dollar et al., 2016, Gonçalves-Pimentel et al., 2011, Matusek et al., 2008, Matusek et al., 2006)

dDAAM^Ex1

(Gombos et al., 2015, Molnár et al., 2014)

Name Synonyms

Secondary FlyBase IDs

References (6)

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