Contains a 207-bp genomic deletion that removes the last 62 codons of Arpc1.
Reported as a 207bp genomic deletion that removes the last 62 codons of Arpc1 . Exact boundaries not reported.
lethal (with Arpc1Q25sd)
lethal (with Arpc1Q25st)
lethal (with Arpc1R337st)
lethal (with Arpc1W82st)
lethal (with Arpc1W108R)
Arpc11 has filopodium phenotype, enhanceable by DAAMEx1/DAAMEx68
Arpc11 is an enhancer of filopodium phenotype of DAAMEx1/DAAMEx68
Arpc11, ena23/ena[+] has filopodium phenotype
Sop2[+]/Arpc11, DAAMEx68 has filopodium phenotype
Cultured primary neurons derived from DAAMEx1/DAAMEx68 Sop21 embryos show a very strong reduction in the number of filopodia (to 5% of the wild type average) compared to control neurons.
Only 20% of cultured primary neurons derived from DAAMEx1/DAAMEx68 Sop21/Sop2Q25sd embryos have neurites.
Cultured primary neurons derived from DAAMEx68/+ Sop21/+ and Sop21/+ ena23/+ double heterozygous embryos show a significant reduction in the number of filopodia compared to control neurons.
Cultured primary neurons derived from Sop21/+ chic221/+ double heterozygous embryos have a normal number of filopodia.
O'Donnell.