FlyBase Allele Report: Dmel\Frl[Ex88]

General Information

Symbol

Dmel\Frl^Ex88

Species

D. melanogaster

Name

FlyBase ID

FBal0318779

Feature type

allele

Associated gene

Dmel\Frl

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Dollar et al., 2016)

Progenitor genotype

P{XP}Frl^d06832

(Dollar et al., 2016)

Caused by aberration

Df(3L)Frl^Ex88

Cytology

Description

Remobilizaton of the isogenized P{XP}Frl^d06832 progenitor (after recombining away a second site lethal). The resulting deletion retains some scrambled P-element sequences at the original 5' P end in intron 1 of Frl, but deletes the Frl start codon. The upstream breakpoint is in Neurl4 and deletes a total of 16 kb.

(Dollar et al., 2016)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy | adult stage | somatic clone

(Dollar et al., 2016)

abnormal planar polarity | adult stage | somatic clone - Minute background

(Dollar et al., 2016)

lethal

(Dollar et al., 2016)

Phenotype Manifest In

axon | adult stage | somatic clone

(Dollar et al., 2016)

eye | somatic clone - Minute background

(Dollar et al., 2016)

ommatidium | somatic clone - Minute background

(Dollar et al., 2016)

Detailed Description

Statement

Reference

Frl^Ex88/Frl^Ex88 clones (in a Minute background) have weak ommatidial rotation defects (planar cell polarity-like defects) in the adult eye. Around 17% of Frl^Ex88/Frl^Ex88 mutant mushroom body clones show premature axon growth arrest (but not bifurcation/guidance defects).

(Dollar et al., 2016)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Frl[+]/Frl^Ex88 is an enhancer of abnormal neuroanatomy | adult stage phenotype of Cdc42²

(Dollar et al., 2016)

Frl[+]/Frl^Ex88 is an enhancer of abnormal neuroanatomy | adult stage phenotype of DAAM^Ex1

(Dollar et al., 2016)

Frl[+]/Frl^Ex88 is an enhancer of abnormal neuroanatomy | adult stage phenotype of DAAM^Ex4

(Dollar et al., 2016)

NOT Enhancer of

Statement

Reference

Frl[+]/Frl^Ex88 is a non-enhancer of abnormal planar polarity | adult stage phenotype of Rac1^V12.UAS, Scer\GAL4^hs.2sev

(Dollar et al., 2016)

Frl[+]/Frl^Ex88 is a non-enhancer of decreased cell number | adult stage phenotype of Rac1^V12.UAS, Scer\GAL4^hs.2sev

(Dollar et al., 2016)

Frl[+]/Frl^Ex88 is a non-enhancer of abnormal neuroanatomy | adult stage phenotype of dsh¹

(Dollar et al., 2016)

Suppressor of

Statement

Reference

Frl[+]/Frl^Ex88 is a suppressor | partially of decreased cell number | adult stage phenotype of Cdc42^UAS.cWa, Scer\GAL4^sev.EP

(Dollar et al., 2016)

Phenotype Manifest In

Enhancer of

Statement

Reference

Frl[+]/Frl^Ex88 is an enhancer of axon | adult stage phenotype of Cdc42²

(Dollar et al., 2016)

Frl[+]/Frl^Ex88 is an enhancer of axon | adult stage phenotype of DAAM^Ex1

(Dollar et al., 2016)

Frl[+]/Frl^Ex88 is an enhancer of adult mushroom body alpha-lobe | adult stage phenotype of DAAM^Ex1

(Dollar et al., 2016)

Frl[+]/Frl^Ex88 is an enhancer of adult mushroom body beta-lobe | adult stage phenotype of DAAM^Ex1

(Dollar et al., 2016)

Frl[+]/Frl^Ex88 is an enhancer of axon | adult stage phenotype of DAAM^Ex4

(Dollar et al., 2016)

Frl[+]/Frl^Ex88 is an enhancer of adult mushroom body alpha-lobe | adult stage phenotype of DAAM^Ex4

(Dollar et al., 2016)

Frl[+]/Frl^Ex88 is an enhancer of adult mushroom body beta-lobe | adult stage phenotype of DAAM^Ex4

(Dollar et al., 2016)

Frl[+]/Frl^Ex88 is an enhancer of adult mushroom body beta-lobe | adult stage phenotype of Cdc42²

(Dollar et al., 2016)

Frl[+]/Frl^Ex88 is an enhancer of adult mushroom body alpha-lobe | adult stage phenotype of Cdc42²

(Dollar et al., 2016)

NOT Enhancer of

Statement

Reference

Frl[+]/Frl^Ex88 is a non-enhancer of adult mushroom body beta-lobe | adult stage phenotype of dsh¹

(Dollar et al., 2016)

Frl[+]/Frl^Ex88 is a non-enhancer of adult mushroom body alpha-lobe | adult stage phenotype of dsh¹

(Dollar et al., 2016)

Frl[+]/Frl^Ex88 is a non-enhancer of eye photoreceptor cell phenotype of Rac1^V12.UAS, Scer\GAL4^hs.2sev

(Dollar et al., 2016)

Frl[+]/Frl^Ex88 is a non-enhancer of ommatidium phenotype of Rac1^V12.UAS, Scer\GAL4^hs.2sev

(Dollar et al., 2016)

Frl[+]/Frl^Ex88 is a non-enhancer of axon | adult stage phenotype of dsh¹

(Dollar et al., 2016)

Suppressor of

Statement

Reference

Frl[+]/Frl^Ex88 is a suppressor | partially of eye photoreceptor cell phenotype of Cdc42^UAS.cWa, Scer\GAL4^sev.EP

(Dollar et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

R-cell loss in flies with Cdc42^Scer\UAS.cWa driven by Scer\GAL4^sev.EP is partially (but significantly) suppressible in the presence of Frl^Ex88/+.

Presence of Frl^Ex88/+ does not enhance eye phenotypes in flies with Rac1^V12.Scer\UAS driven by Scer\GAL4^hs.2sev.

Presence of Frl^Ex88/+ enhances axon growth phenotypes seen in the mushroom body of DAAM^Ex4/Y or Cdc42²/Y (but not dsh¹/Y) males.

(Dollar et al., 2016)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Frl^Ex88 is rescued by Frl^{+tFlyFOS-023275}

(Dollar et al., 2016)

Comments

Frl^{+tFlyFOS-023275} rescues ommatidial rotation defects in Frl^Ex88/Frl^Ex88 somatic clones (in a Minute background), and rescues lethality of homozygous mutants.

(Dollar et al., 2016)

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Frl^Ex88

frl^Ex88

(Dollar et al., 2016)

Name Synonyms

Secondary FlyBase IDs

References (1)

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