FlyBase Gene Report: Dmel\csul

General Information

Symbol

Dmel\csul

Species

D. melanogaster

Name

capsuleen

Annotation Symbol

CG3730

Feature Type

protein_coding_gene

FlyBase ID

FBgn0015925

Gene Model Status

Current

Stock Availability

7 publicly available

Enzyme Name (EC)

type II protein arginine methyltransferase (2.1.1.320)

Gene Summary

capsuleen (csul) encodes a protein arginine methyltransferase that carries out symmetric dimethylation of arginine residues. It forms a complex with the product of vls, which is the substrate recognition subunit. Primary substrates for this complex include the spliceosomal Sm proteins. The products of csull and vls function in germline specification and are required for proper localization of the product of tud to the posterior pole of the oocyte. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

dart5, dPRMT5, PRMT5, JBP1

Key Links

Genomic Location

Cytogenetic map

53A3-53A3

Sequence location

2R:16,264,652..16,266,959 [+]

Recombination map

2-79

RefSeq locus

NT_033778 REGION:16264652..16266959

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (12 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (3 terms)

CV Term

Evidence

References

enables protein methyltransferase activity

inferred from mutant phenotype

(Anne et al., 2007)

enables protein-arginine N-methyltransferase activity

inferred from mutant phenotype

(Nishida et al., 2009, Gonsalvez et al., 2006)

enables protein-arginine omega-N symmetric methyltransferase activity

inferred from mutant phenotype

(Gonsalvez et al., 2008)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

enables histone arginine N-methyltransferase activity

inferred from biological aspect of ancestor with PANTHER:PTN000077429

(GO Reference Genome Project, 2011-)

enables protein-arginine N-methyltransferase activity

inferred from electronic annotation with InterPro:IPR025799

(InterPro Project Members, 2004-)

Biological Process (6 terms)

Terms Based on Experimental Evidence (5 terms)

CV Term

Evidence

References

involved_in intracellular mRNA localization

inferred from mutant phenotype

(Anne et al., 2007)

involved_in P granule organization

inferred from mutant phenotype

(Anne et al., 2007)

involved_in peptidyl-arginine methylation

inferred from mutant phenotype

(Gonsalvez et al., 2008)

involved_in pole plasm assembly

inferred from mutant phenotype

(Vrettos et al., 2021, Anne et al., 2007, Gonsalvez et al., 2006)

involved_in pole plasm protein localization

inferred from mutant phenotype

(Anne et al., 2007)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

involved_in P granule organization

traceable author statement

(Nishida et al., 2009)

involved_in regulation of DNA-templated transcription

inferred from biological aspect of ancestor with PANTHER:PTN000077429

(GO Reference Genome Project, 2011-)

Cellular Component (2 terms)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (2 terms)

CV Term

Evidence

References

is_active_in cytosol

inferred from biological aspect of ancestor with PANTHER:PTN000077429

(GO Reference Genome Project, 2011-)

is_active_in nucleus

inferred from biological aspect of ancestor with PANTHER:PTN000077429

(GO Reference Genome Project, 2011-)

Gene Group (FlyBase)

PROTEIN ARGININE N-METHYLTRANSFERASES

Protein Family (UniProt)

Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. (Q9U6Y9)

Protein Signatures (InterPro)

Catalytic Activity (EC/Rhea)

protein-arginine omega-N symmetric methyltransferase activity

L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) + N(omega),N(omega)'-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L- homocysteine (2.1.1.320)

RHEA 48108:

Summaries

Gene Snapshot

Gene Group (FlyBase)

PROTEIN ARGININE N-METHYLTRANSFERASES -: Protein arginine methyltransferases catalyze the addition of one or two methyl groups to arginine. (Adapted from FBrf0174380 and FBrf0193526).

Protein Function (UniProtKB)

Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA) (By similarity). Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins SmD1 and SmD3. Required for arginine symmetrical dimethylation of piwi family proteins, piwi, aub and AGO3, during germline development. Required during oogenesis for pole cell formation in the pathway controlled by oskar (osk) and for abdominal segments during early embryogenesis. Involved in nanos (nos) and germ cell mRNAs localization.

(UniProt, Q9U6Y9)

Summary (Interactive Fly)

protein arginine methyltransferase - together with its partner Valois Capsuléen is involved in protein localization in germ cells - required for the localization of specific components of the nuage and pole plasm, and in particular of Tudor

Interactive Fly

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\csul for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9U6Y9)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

Comments on Gene Model

Low-frequency RNA-Seq exon junction(s) not annotated.

Gene model reviewed during 5.50

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

csul-RA

FBtr0089871

NM_057836

2013

610

csul-RB

FBtr0089872

NM_166158

1998

605

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

csul-PA

FBpp0088810

69.7

610

6.17

FBpp0088811

69.2

605

6.37

NP_725552

AAF58030

Polypeptides with Identical Sequences

None of the polypeptides share 100% sequence identity.

Additional Polypeptide Data and Comments

Reported size (kDa)

Comments

External Data

Subunit Structure (UniProtKB)

Interacts with vls.

(UniProt, Q9U6Y9)

Crossreferences

InterPro - A database of protein families, domains and functional sites

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9U6Y9

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\csul using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

csul_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.34

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 9 -- 10

head mesoderm

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

head mesoderm

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic/larval midgut

(Fisher et al., 2012)

northern blot

Stage

Tissue/Position (including subcellular localization)

Reference

oogenesis & adult stage | female

ovary

(Boulanger et al., 2004)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\csul in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\csul

View exonic expression by tissue for Dmel\csul

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0015925

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36809/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0015925

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015925

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0015925

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3730

Flygut - An atlas of the Drosophila adult midgut

FBgn0015925

Images

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 6 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 18 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of csul

Transgenic constructs containing regulatory region of csul

Aberrations (Deficiencies and Duplications) ( 1 )

Inferred from experimentation ( 1 )

Gene disrupted in

Df(2R)Exel6063

(Ryder, 2004.4.26)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^VP16.otu

viable

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

csul^GD10685

viable, with Scer\GAL4^Mef2.PR

csul^GD10685

viable, with Scer\GAL4^pnr-MD237

csul^GD10685

viable, with Scer\GAL4^tin.CΔ4

csul^GD10685

Sterility

Allele

female sterile | recessive

csul^P

fertile

csul^EY10871

grandchildless

male sterile

csul^e00797

Other Phenotypes

Allele

decreased fecundity

csul^e00797

Phenotype manifest in

Allele

embryonic abdominal segment

csul^P

embryonic abdominal segment | maternal effect

csul^P

primordial germ cell

primordial germ cell | maternal effect

csul^P

spermatid

csul^e00797

spermatid cyst

csul^e00797

spermatozoon

csul^e00797

testis

csul^e00797

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (9)

Hsap\PRMT5

14 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (4)

Rnor\Prmt5

14 of 14

Yes

Rnor\Prmt2

1 of 14

Rnor\Prmt3

1 of 14

Rnor\Prmt6

1 of 14

Mus musculus (laboratory mouse) (4)

Mmus\Prmt5

13 of 14

Yes

Mmus\Prmt2

1 of 14

Mmus\Prmt3

1 of 14

Mmus\Prmt6

1 of 14

Xenopus tropicalis (Western clawed frog) (7)

Xtro\prmt5

8 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Danio rerio (Zebrafish) (4)

Drer\prmt5

14 of 14

Yes

Drer\carm1l

1 of 14

Drer\prmt3

1 of 14

Drer\prmt6

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (4)

Cele\prmt-5

13 of 14

Yes

Cele\prmt-1

1 of 14

Cele\prmt-7

1 of 14

Cele\prmt-9

1 of 14

Anopheles gambiae (African malaria mosquito) (7)

Agam\AgaP_AGAP009048

12 of 12

Yes

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (9)

Atha\SKB1

13 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (2)

Scer\HSL7

12 of 13

Yes

Scer\HMT1

1 of 13

Schizosaccharomyces pombe (Fission yeast) (1)

Spom\skb1

11 of 12

Yes

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:csul. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (9)

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 2 )

Allele

Disease

Interaction

References

csul^EY10871

ameliorates tauopathy

modeled by Hsap\MAPT^GMR.Ex.PJ

(Ambegaokar and Jackson, 2011)

csul^UAS.Tag:MYC

ameliorates amyotrophic lateral sclerosis type 6

modeled by Hsap\FUS^UAS.cIa

(Lo Piccolo et al., 2019)

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

PRMT5; protein arginine methyltransferase 5

14 of 14

604045

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

csul - aub

anti tag coimmunoprecipitation, anti tag western blot

(Huang et al., 2021)

csul - vls

two hybrid, pull down, western blot, anti tag coimmunoprecipitation

(Anne and Mechler, 2005)

Summary of Genetic Interactions

esyN Network Diagram

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

esyN Network Key:

Suppression

Enhancement

Other Interaction Browsers

View in FlyBase Interactions Browser View in MIST tool (external link)

Please look at the allele data for full details of the genetic interactions

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

osk

suppressible

csul

(Anne et al., 2007)

External Data

Subunit Structure (UniProtKB)

Interacts with vls.

(UniProt, Q9U6Y9 )

Linkouts

BioGRID - A database of protein and genetic interactions.

62528

DroID - A comprehensive database of gene and protein interactions.

FBgn0015925

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

RMTs methylate histone arginines

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

2-79

Cytogenetic map

53A3-53A3

Sequence location

2R:16,264,652..16,266,959 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

53A3-53A3

Limits computationally determined from genome sequence between P{lacW}Lis-1^k11702&P{EP}CG8443^EP969 and P{lacW}l(2)k07824^k07824&P{lacW}veg^k03402

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

52F-52F

(Anne, 1997.11.7, Anne et al., 1996)

Experimentally Determined Recombination Data

Location

2-79

(FlyBase, 2016)

2-81.9

(Comeron et al., 2012)

(Anne et al., 1996)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (7)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

43200

y¹ v¹; P{TRiP.GL01544}attP40

85115

w¹¹¹⁸; PBac{RB}csul^e00797/CyO

20227

y¹ w^67c23; P{EPgy2}csul^EY10871

56978

y¹ sc^* v¹ sev²¹; P{TRiP.HMC04418}attP40

NIG-Fly

2RG-1176

y² VhaAC39-1^cho-1 v¹; P{U6-csul.NIG.sgRNA}attP40/CyO

VDRC

v108850

P{KK100685}VIE-260B

v34290

w¹¹¹⁸; P{GD10685}v34290

Genomic Clones (13)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (52)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0015925

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0015925

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

New stable cell line derived from S2-unspecified : Stable S2 cell lines were generated containing inducible csul, icln, Gar1. All are tagged with the affinity tag pMTagIt.
(Kroiss et al., 2009)

Other Comments

Mutant animals can survive for two generations in the complete absence of csul function.

(Gonsalvez et al., 2006)

Relationship to Other Genes

Source for database merge of

Source for merge of: csul JBP1

(FlyBase, 1996-)

Additional comments

Source for merge of csul JBP1 was sequence comparison ( date:000202 ).

(FlyBase, 1996-)

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (16)

Reported As

Symbol Synonym

ART5

(Jantrapirom et al., 2021)

Art5

(Garcia et al., 2024)

CG3730

(National Institute of Genetics Fly Stocks, 2022-, Kumar et al., 2016, Ni et al., 2010.12.1, Keleman et al., 2009.8.5)

Csul

(Huang et al., 2021, Gistelinck et al., 2012, Kirino et al., 2010)

DART5

(Layalle et al., 2021, Lo Piccolo et al., 2019, Wang et al., 2015, Nishida et al., 2009, Boulanger et al., 2004)

Dart5

(Kibanov et al., 2012, Kirino et al., 2010)

JBP1

(Pollack, 1999.7.12, Pollack et al., 1999)

PRMT5

(Meister, 2013, Wang and Li, 2012, Kroiss et al., 2009)

csul

(Vrettos et al., 2021, Gulati et al., 2020, Saint-Leandre et al., 2020, Dufourt et al., 2017, Lee et al., 2016, Japanese National Institute of Genetics, 2012.5.21, Ambegaokar and Jackson, 2011, Liu et al., 2011, Anne, 2010, Cunha et al., 2010, Kirino et al., 2010, Kirino et al., 2009, Nishida et al., 2009, Anne and Mechler, 2008, Anne et al., 2007)

dPRMT5

(Liu et al., 2011, Kirino et al., 2010, Kirino et al., 2010, Kroiss et al., 2009)

dart5

(McCambridge et al., 2020, Sato et al., 2015, Liu et al., 2011, Gonsalvez et al., 2010, Kirino et al., 2009, Gonsalvez et al., 2008, Liu and Gall, 2007, Gonsalvez et al., 2006)

dprmt5

(Nishida et al., 2009)

Name Synonyms

Capsuleen

(Kibanov et al., 2012, Anne, 2010, Nishida et al., 2009, Anne et al., 2007, Gonsalvez et al., 2006)

Drosophila arginine methyltransferase 5

(Boulanger et al., 2004)

capsuleen

(Specchia et al., 2017, Handler et al., 2013, Gonsalvez et al., 2010, Olivieri et al., 2010, Anne, 1997.11.7, Anne et al., 1996)

capsuleenn

(Kirino et al., 2009)

Secondary FlyBase IDs

FBgn0028723

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 50 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

36809

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9U6Y9

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9U6Y9

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9U6Y9

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0015925

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

36809/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0015925

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0015925

FlyMine - An integrated database for Drosophila genomics

FBgn0015925

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG3730

MARRVEL_MODEL - MARRVEL (model organism gene)

36809

Linkouts

BioGRID - A database of protein and genetic interactions.

62528

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0015925

DroID - A comprehensive database of gene and protein interactions.

FBgn0015925

DRSC - Results frm RNAi screens

FBgn0015925

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

csul_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0015925

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0015925

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG3730

Flygut - An atlas of the Drosophila adult midgut

FBgn0015925

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0015925

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC003689

Interactive Fly - A cyberspace guide to Drosophila development and metazoan evolution

Interactive Fly

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

RMTs methylate histone arginines

References (84)

The following external sites may use different assemblies or annotations than FlyBase.

-0.34

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