FlyBase Allele Report: Hsap\MAPT[GMR.Ex.PJ]

General Information

Symbol

Hsap\MAPT^GMR.Ex.PJ

Species

H. sapiens

Name

FlyBase ID

FBal0137485

Feature type

allele

Associated gene

Hsap\MAPT

Associated Insertion(s)

Carried in Construct

P{GMR-htau.Ex}

Also Known As

gl-tau, gl-Tau^WT

Key Links

Transgenic product class

cDNA

(Jackson et al., 2002)

wild_type

(Jackson et al., 2002)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Jackson et al., 2002)

wild_type

(Jackson et al., 2002)

Mutagen

in vitro construct

(Jackson et al., 2002)

Progenitor genotype

Carried in construct

P{GMR-htau.Ex}

Cytology

Description

Expression of a Hsap\MAPT cDNA is driven by the GMR regulatory sequences. The alpha tubulin 3' UTR provides stability to the message.

(Jackson et al., 2002)

Allele components

Component

Use(s)

Regulatory region(s)

GMR

engineered transcription regulatory region

Encoded product / tool

Hsap\MAPT

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of tauopathy

CEA

(Oliveira et al., 2023, Park et al., 2021, Chatterjee et al., 2019, Bakhoum et al., 2014, Ambegaokar and Jackson, 2010, Karsten et al., 2006, Jackson et al., 2002)

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

model of tauopathy

is ameliorated by Atg1^Δ3D

(Bakhoum et al., 2014)

is ameliorated by Rab5^S43N.UAS

(Bakhoum et al., 2014)

is ameliorated by Atg2^UAS.cUa

(Bakhoum et al., 2014)

is ameliorated by cathD^UAS.cUa

(Bakhoum et al., 2014)

is ameliorated by Rab7^{T22N.UASp.YFP}

(Bakhoum et al., 2014)

is ameliorated by S6k^UAS.cUa

(Bakhoum et al., 2014)

is ameliorated by Diap2^GMR.PH

(Jackson et al., 2002)

is ameliorated by arm¹

(Jackson et al., 2002)

is ameliorated by sgg¹

(Jackson et al., 2002)

is ameliorated by Diap1^GMR.PH

(Jackson et al., 2002)

is ameliorated by BacA\p35^GMR.PH

(Jackson et al., 2002)

is ameliorated by arm⁴

(Jackson et al., 2002)

is exacerbated by arm^{S10.UAS.Tag:MYC}

(Jackson et al., 2002)

is exacerbated by sgg^UAS.cSa

(Chatterjee et al., 2009, Jackson et al., 2002)

is exacerbated by pan^UAS.cWa

(Jackson et al., 2002)

is ameliorated by Psa^GMR.Ex.PK

(Karsten et al., 2006)

is ameliorated by eIF1A^c04533

(Karsten et al., 2006)

is exacerbated by Psa⁰⁶²²⁶

(Karsten et al., 2006)

is ameliorated by Vap33^Δ448

(Karsten et al., 2006)

is exacerbated by stg^C379S.UAS

(Oliveira et al., 2023)

is exacerbated by stg^JF03235

(Oliveira et al., 2023)

is ameliorated by stg^UAS.cNa

(Oliveira et al., 2023)

is ameliorated by chico^UAS.cCa

(Chatterjee et al., 2019)

is exacerbated by bw¹

(Ambegaokar and Jackson, 2010)

is exacerbated by w¹¹¹⁸

(Ambegaokar and Jackson, 2010)

is ameliorated by Alk^UAS.DN

(Park et al., 2021)

is exacerbated by Alk::Hsap\NPM1^UAS.act

(Park et al., 2021)

is exacerbated by Mekk1^EY02276

(Ambegaokar and Jackson, 2011)

is exacerbated by HnRNP-K^KG02524

(Ambegaokar and Jackson, 2011)

is exacerbated by CaMKI^EY07197

(Ambegaokar and Jackson, 2011)

is ameliorated by Dlic^G0190

(Ambegaokar and Jackson, 2011)

is exacerbated by cana^k07716

(Ambegaokar and Jackson, 2011)

is exacerbated by crp^EY07016

(Ambegaokar and Jackson, 2011)

is ameliorated by csul^EY10871

(Ambegaokar and Jackson, 2011)

is exacerbated by CycE^k05007

(Ambegaokar and Jackson, 2011)

is ameliorated by eRF3^EY12435

(Ambegaokar and Jackson, 2011)

is ameliorated by Fs(2)Ket^EY06666

(Ambegaokar and Jackson, 2011)

is exacerbated by His2Av⁰⁵¹⁴⁶

(Ambegaokar and Jackson, 2011)

is exacerbated by Klp61F⁰⁷⁰¹²

(Ambegaokar and Jackson, 2011)

is exacerbated by eRF1⁰⁰¹⁰³

(Ambegaokar and Jackson, 2011)

is exacerbated by Stip1^k14504

(Ambegaokar and Jackson, 2011)

is exacerbated by Hr39^EY04579

(Ambegaokar and Jackson, 2011)

is ameliorated by frc^L6750

(Ambegaokar and Jackson, 2011)

is ameliorated by Nrg^G0099

(Ambegaokar and Jackson, 2011)

is ameliorated by NC2α^EY18723

(Ambegaokar and Jackson, 2011)

is ameliorated by ksr^j5E2

(Ambegaokar and Jackson, 2011)

is ameliorated by Mi-2^L1243

(Ambegaokar and Jackson, 2011)

is ameliorated by mei-9^EY14578

(Ambegaokar and Jackson, 2011)

is exacerbated by RpS21^k16804a

(Ambegaokar and Jackson, 2011)

is exacerbated by RpLP0⁰¹⁵⁴⁴

(Ambegaokar and Jackson, 2011)

is exacerbated by par-1^k06323

(Ambegaokar and Jackson, 2011)

is ameliorated by SdhB^EY12081

(Ambegaokar and Jackson, 2011)

is ameliorated by Past1^EY01852

(Ambegaokar and Jackson, 2011)

is ameliorated by Vha14-1^EY12998

(Ambegaokar and Jackson, 2011)

is exacerbated by Tango5^G0145b

(Ambegaokar and Jackson, 2011)

is ameliorated by sgg^G0335

(Ambegaokar and Jackson, 2011)

is exacerbated by sm^EY07191

(Ambegaokar and Jackson, 2011)

is ameliorated by smid^j6B8

(Ambegaokar and Jackson, 2011)

is ameliorated by l(3)L6332^L6332

(Ambegaokar and Jackson, 2011)

is ameliorated by CycT^j11B2

(Ambegaokar and Jackson, 2011)

is ameliorated by l(3)j6A6^j6A6

(Ambegaokar and Jackson, 2011)

is ameliorated by l(3)L0499^L0499

(Ambegaokar and Jackson, 2011)

is exacerbated by Tis11^EY09433

(Ambegaokar and Jackson, 2011)

is exacerbated by unc-45⁰³⁶⁹²

(Ambegaokar and Jackson, 2011)

is ameliorated by milt^EY14443

(Ambegaokar and Jackson, 2011)

is ameliorated by unc-45^EY03034

(Ambegaokar and Jackson, 2011)

is ameliorated by POLDIP2^EY08866

(Kim et al., 2015)

is exacerbated by dco^{K38R.UAS.Tag:MYC}

(Means et al., 2015)

is ameliorated by Hsap\AK1^UAS.cPa

(Park et al., 2012)

is exacerbated by spin^Δ2b

(Dermaut et al., 2005)

is exacerbated by par-1^UAS.cSa

(Chatterjee et al., 2009)

ameliorates Parkinson's disease

modeled by Hsap\SNCA^UAS.cTa

(Roy and Jackson, 2014)

model of Parkinson's disease

is ameliorated by Hsap\SNCA^UAS.cTa

(Roy and Jackson, 2014)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

autophagosome | adult stage

(Bakhoum et al., 2014)

autophagosome | third instar larval stage

(Bakhoum et al., 2014)

eye

(Park et al., 2021, Chatterjee et al., 2019, Kim et al., 2015, Means et al., 2015, Roy and Jackson, 2014, Chatterjee et al., 2009, Karsten et al., 2006, Jackson et al., 2002)

eye, with Scer\GAL4^GMR.PU

(Park et al., 2012)

eye | adult stage

(Bakhoum et al., 2014)

eye | anterior

(Jackson et al., 2002)

eye disc | third instar larval stage

(Bakhoum et al., 2014)

eye photoreceptor cell

(Chatterjee et al., 2019)

interommatidial bristle

(Park et al., 2021, Chatterjee et al., 2019, Chatterjee et al., 2009, Jackson et al., 2002)

interommatidial bristle | ectopic

(Jackson et al., 2002)

medulla

(Jackson et al., 2002)

microtubule

(Roy and Jackson, 2014)

ommatidium

(Park et al., 2021, Chatterjee et al., 2019, Chatterjee et al., 2009, Jackson et al., 2002)

photoreceptor

(Jackson et al., 2002)

retina

(Park et al., 2021, Roy and Jackson, 2014)

retina | adult stage

(Bakhoum et al., 2014)

rhabdomere

(Chatterjee et al., 2009)

Detailed Description

Statement

Reference

Hsap\MAPT^GMR.Ex.PJ flies exhibit a rough eye phenotype, with mild disorganization and thinning of the retina, disordered ommatidia and bristle abnormalities.

(Park et al., 2021)

Expression of Hsap\MAPT^GMR.Ex.PJ leads to severe eye defects: small size, rough eye particularly at the anterior, fused and disorganized ommatidia with loss of eye photoreceptor neurons, and missing interommaditidial bristles.

(Chatterjee et al., 2019)

Eyes of Hsap\MAPT^GMR.Ex.PJ flies have a rough surface.

(Kim et al., 2015)

Expression of Hsap\MAPT^GMR.Ex.PJ leads to rough eye phenotype and formation of giant autophagic bodies in the adult retina along with accumulation of autophagic intermediates both in the third instar eye discs and adult retinas.

(Bakhoum et al., 2014)

Expression of Hsap\MAPT^GMR.Ex.PJ results in rough, reduced eyes, with the posterior area of the eye remaining more normal.

Microtubule shafts appear disorganised in the retinas of flies expressing Hsap\MAPT^GMR.Ex.PJ.

(Roy and Jackson, 2014)

The eyes of flies expressing Hsap\MAPT^GMR.Ex.PJ under the control of Scer\GAL4^GMR.PU show moderate toxicity compared to controls, characterized by the loss of photoreceptor neurons, leading to a rough eye phenotype in adults.

(Park et al., 2012)

Hsap\MAPT^GMR.Ex.PJ adult eyes display a reduced, rough-eye phenotype, with fused and disordered ommatidia with missing and irregular bristles. Retinal sections show marked ommatidial disorganization and cell loss.

(Chatterjee et al., 2009)

Flies carrying one copy of Hsap\MAPT^GMR.Ex.PJ have a mild rough eye phenotype, with mild loss and disorganisation of photoreceptor neurons.

(Karsten et al., 2006)

Flies that express one copy of Hsap\MAPT^GMR.Ex.PJ display no obvious rough eye phenotype.

(Dermaut et al., 2005)

Mutants exhibit an abnormal eye phenotype on eclosion. They are reduced in size and display a rough phenotype in anterior regions, while posterior aspects appear normal. Ommatidia are fused and disordered, with missing, irregular, and occasional supernumerary mechanosensory bristles. Flies with two copies of the P{GMR-htau.Ex} insert have severely reduced eyes. In third instar larval eye discs expressing two copies of P{GMR-htau.Ex}, early cell loss, and irregularities in differentiating neurons are apparent. Loss of photoreceptor neurons and disorganisation of the normal ommatidial architecture is also observed. Vacuolisation is also seen in the medulla.

(Jackson et al., 2002)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Hsap\MAPT^GMR.Ex.PJ has visible | adult stage phenotype, enhanceable by Alk::Hsap\NPM1^UAS.act/Scer\GAL4^GMR.PU

(Park et al., 2021)

Hsap\MAPT^GMR.Ex.PJ has decreased size | adult stage phenotype, enhanceable by Alk::Hsap\NPM1^UAS.act/Scer\GAL4^GMR.PU

(Park et al., 2021)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by Scer\GAL4^GMR.PS/Hsap\SNCA^UAS.cTa

(Roy and Jackson, 2014)

Hsap\MAPT^GMR.Ex.PJ, Scer\GAL4^GMR.PU has visible | adult stage phenotype, enhanceable by Hsap\AK1^UAS.cPa, Scer\GAL4^GMR.PU

(Park et al., 2012)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by Tis11^EY09107/Tis11[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by Tis11^EY09107/Scer\GAL4^GMR.PS

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by unc-45⁰³⁶⁹²/unc-45[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by Tango5[+]/Tango5^BG02353

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by Hop[+]/Stip1^k14504

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by Hop[+]/Stip1^EP418

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by Hop[+]/Stip1^k00616

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by HnRNP-K[+]/HnRNP-K^KG02524

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by HnRNP-K^G13574/HnRNP-K[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by CaMKI^EY07197/CaMKI[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by Scer\GAL4^GMR.PS/CaMKI^EY07197

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by cana^k07716/cana[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by cana^DG06604/cana[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by crp^EY07016/Scer\GAL4^GMR.PS

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by Scer\GAL4^GMR.PS/crp^EY14841

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by csul[+]/csul^unspecified

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by CycE[+]/CycE^k05007

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by CycE[+]/CycE⁰⁵²⁰⁶

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by eRF1⁰⁰¹⁰³/eRF1[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by eRF1^KY7/eRF1[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by eRF1^U3/eRF1[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by His2Av[+]/His2Av⁰⁵¹⁴⁶

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by His2Av[+]/His2Av⁸¹⁰

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by Scer\GAL4^GMR.PS/Hr39^EY04579

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by Klp61F[+]/Klp61F⁰⁷⁰¹²

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by Klp61F[+]/Klp61F⁰⁶³⁴⁵

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by Scer\GAL4^GMR.PS/Mekk1^EY02276

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by Scer\GAL4^GMR.PS/Mekk1^EY11461

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by RpS21[+]/RpS21^k16804a

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by RpS21[+]/RpS21⁰³⁵⁷⁵

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by par-1^k06323/par-1[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by RpLP0⁰¹⁵⁴⁴/RpLP0[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by RpLP0^DP00460/RpLP0[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by sm^EY07191/Scer\GAL4^GMR.PS

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by Tango5[+]/Tango5^G0145b

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by Tis11[+]/Tis11^EY09433

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by Scer\GAL4^GMR.PS/Tis11^EY09433

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has abnormal size phenotype, enhanceable by Scer\GAL4^GMR.PS/par-1^UAS.cSa

(Chatterjee et al., 2009)

Hsap\MAPT^GMR.Ex.PJ has abnormal planar polarity phenotype, enhanceable by Scer\GAL4^GMR.PS/par-1^UAS.cSa

(Chatterjee et al., 2009)

Hsap\MAPT^GMR.Ex.PJ has abnormal size phenotype, enhanceable by sgg^UAS.cSa/Scer\GAL4^GMR.PS

(Chatterjee et al., 2009)

Hsap\MAPT^GMR.Ex.PJ has abnormal planar polarity phenotype, enhanceable by sgg^UAS.cSa/Scer\GAL4^GMR.PS

(Chatterjee et al., 2009)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by Psa⁰⁶²²⁶

(Karsten et al., 2006)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by arm^{S10.UAS.Tag:MYC}/Scer\GAL4^hs.2sev

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by sgg^UAS.cSa/Scer\GAL4^elav-C155

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, enhanceable by Scer\GAL4^sev.EP/pan^UAS.cWa

(Jackson et al., 2002)

NOT Enhanced by

Statement

Reference

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, non-enhanceable by corolla^d01774/Scer\GAL4^GMR.PU

(Ermanoska et al., 2014)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, non-enhanceable by CG15599^EY06842/Scer\GAL4^GMR.PU

(Ermanoska et al., 2014)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, non-enhanceable by rig[+]/rig⁰⁵⁰⁵⁶

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, non-enhanceable by U2af38[+]/U2af38⁰⁶⁷⁵¹

(Ambegaokar and Jackson, 2011)

Suppressed by

Statement

Reference

Hsap\MAPT^GMR.Ex.PJ has visible | adult stage phenotype, suppressible by Alk^UAS.DN/Scer\GAL4^GMR.PU

(Park et al., 2021)

Hsap\MAPT^GMR.Ex.PJ has decreased size | adult stage phenotype, suppressible by Alk^UAS.DN/Scer\GAL4^GMR.PU

(Park et al., 2021)

Hsap\MAPT^GMR.Ex.PJ has visible | adult stage phenotype, suppressible by chico^UAS.cCa/Scer\GAL4^GMR.PU

(Chatterjee et al., 2019)

Hsap\MAPT^GMR.Ex.PJ has abnormal size | adult stage phenotype, suppressible by chico^UAS.cCa/Scer\GAL4^GMR.PU

(Chatterjee et al., 2019)

Hsap\MAPT^GMR.Ex.PJ has decreased cell number | adult stage phenotype, suppressible by chico^UAS.cCa/Scer\GAL4^GMR.PU

(Chatterjee et al., 2019)

Hsap\MAPT^GMR.Ex.PJ has visible | adult stage phenotype, suppressible by Atg2^UAS.cUa/Scer\GAL4^GMR.PU

(Bakhoum et al., 2014)

Hsap\MAPT^GMR.Ex.PJ has visible | adult stage phenotype, suppressible by S6k^UAS.cUa/Scer\GAL4^GMR.PU

(Bakhoum et al., 2014)

Hsap\MAPT^GMR.Ex.PJ has visible | adult stage phenotype, suppressible by cathD^UAS.cUa/Scer\GAL4^GMR.PU

(Bakhoum et al., 2014)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by l(3)L6332[+]/l(3)L6332^L6332

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by milt[+]/milt^EY14443

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by Scer\GAL4^GMR.PS/milt^EY14443

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by Scer\GAL4^GMR.PS/csul^EY10871

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by Dlic^G0190/Dlic[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by Dlic^G0065/Dlic[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by Elf[+]/eRF3^EY12435

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by Scer\GAL4^GMR.PS/eRF3^EY12435

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by eRF3^k06909

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by frc^L6750/frc[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by frc[+]/frc⁰⁰⁰⁷³

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by Fs(2)Ket^EY06666/Fs(2)Ket[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by Scer\GAL4^GMR.PS/Fs(2)Ket^EY06666

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by ksr^j5E2/ksr[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by ksr^EY01688/ksr[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by Mi-2^L1243/Mi-2[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by Scer\GAL4^GMR.PS/mei-9^EY14578

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by NC2α^EY18723/NC2alpha[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by Scer\GAL4^GMR.PS/NC2α^EY18723

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by Nrg[+]/Nrg^G0099

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by Nrg^G0413/Nrg[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by Scer\GAL4^GMR.PS/Past1^EY01852

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by Scer\GAL4^GMR.PS/SdhB^EY12081

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by Scer\GAL4^GMR.PS/SdhB^c00364

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by sgg^G0335/sgg[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by sgg[+]/sgg¹

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by sgg^M1-1/sgg[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by sgg^EP1576/sgg[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by smid[+]/smid^j6B8

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by Scer\GAL4^GMR.PS/unc-45^EY03034

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by Vha14-1[+]/Vha14-1^EY12998

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by Scer\GAL4^GMR.PS/Vha14-1^EY12998

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by Scer\GAL4^GMR.PS/Vha14-1^c01762

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by CycT^j11B2/l(3)j11B2[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by l(3)j6A6[+]/l(3)j6A6^j6A6

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by l(3)L0499^L0499/l(3)L0499[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by Vap33^Δ448/Vap-33-1[+]

(Karsten et al., 2006)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by eIF1A^c04533/eIF-1A[+]

(Karsten et al., 2006)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by Psa^GMR.Ex.PK

(Karsten et al., 2006)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by BacA\p35^GMR.PH

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by Diap2^GMR.PH

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by arm¹

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by arm⁴

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by pan²

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, suppressible by sgg¹

(Jackson et al., 2002)

NOT suppressed by

Statement

Reference

Hsap\MAPT^GMR.Ex.PJ has visible phenotype, non-suppressible by milt[+]/milt^EY20737

(Ambegaokar and Jackson, 2011)

Enhancer of

Statement

Reference

Hsap\MAPT^GMR.Ex.PJ is an enhancer of visible phenotype of Scer\GAL4^sev.EP, pan^UAS.cWa

(Jackson et al., 2002)

Other

Statement

Reference

Hsap\MAPT^GMR.Ex.PJ, Scer\GAL4^GMR.PU, dco^{K38R.UAS.Tag:MYC} has abnormal size phenotype

(Means et al., 2015)

Atg6[+]/Atg6⁰⁰⁰⁹⁶, Hsap\MAPT^GMR.Ex.PJ has visible phenotype

(Ambegaokar and Jackson, 2011)

Phenotype Manifest In

Enhanced by

Statement

Reference

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by Alk::Hsap\NPM1^UAS.act/Scer\GAL4^GMR.PU

(Park et al., 2021)

Hsap\MAPT^GMR.Ex.PJ has retina phenotype, enhanceable by Alk::Hsap\NPM1^UAS.act/Scer\GAL4^GMR.PU

(Park et al., 2021)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by chico^RNAi.UAS.cUa/Scer\GAL4^GMR.PU

(Chatterjee et al., 2019)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by dco^{K38R.UAS.Tag:MYC}/Scer\GAL4^GMR.PU

(Means et al., 2015)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by Scer\GAL4^GMR.PS/Hsap\SNCA^UAS.cTa

(Roy and Jackson, 2014)

Hsap\MAPT^GMR.Ex.PJ has retina phenotype, enhanceable by Scer\GAL4^GMR.PS/Hsap\SNCA^UAS.cTa

(Roy and Jackson, 2014)

Hsap\MAPT^GMR.Ex.PJ has microtubule phenotype, enhanceable by Scer\GAL4^GMR.PS/Hsap\SNCA^UAS.cTa

(Roy and Jackson, 2014)

Hsap\MAPT^GMR.Ex.PJ, Scer\GAL4^GMR.PU has eye phenotype, enhanceable by Hsap\AK1^UAS.cPa, Scer\GAL4^GMR.PU

(Park et al., 2012)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by Tis11^EY09107/Scer\GAL4^GMR.PS

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by unc-45⁰³⁶⁹²/unc-45[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by Tango5[+]/Tango5^BG02353

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by Hop[+]/Stip1^k14504

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by Hop[+]/Stip1^EP418

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by Hop[+]/Stip1^k00616

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by HnRNP-K[+]/HnRNP-K^KG02524

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by HnRNP-K^G13574/HnRNP-K[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by CaMKI^EY07197/CaMKI[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by Scer\GAL4^GMR.PS/CaMKI^EY07197

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by cana^k07716/cana[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by cana^DG06604/cana[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by crp^EY07016/Scer\GAL4^GMR.PS

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by Scer\GAL4^GMR.PS/crp^EY14841

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by csul[+]/csul^unspecified

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by CycE[+]/CycE^k05007

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by CycE[+]/CycE⁰⁵²⁰⁶

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by eRF1⁰⁰¹⁰³/eRF1[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by eRF1^KY7/eRF1[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by eRF1^U3/eRF1[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by His2Av[+]/His2Av⁰⁵¹⁴⁶

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by His2Av[+]/His2Av⁸¹⁰

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by Scer\GAL4^GMR.PS/Hr39^EY04579

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by Klp61F[+]/Klp61F⁰⁷⁰¹²

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by Klp61F[+]/Klp61F⁰⁶³⁴⁵

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by Scer\GAL4^GMR.PS/Mekk1^EY02276

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by Scer\GAL4^GMR.PS/Mekk1^EY11461

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by RpS21[+]/RpS21^k16804a

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by RpS21[+]/RpS21⁰³⁵⁷⁵

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by par-1^k06323/par-1[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by RpLP0⁰¹⁵⁴⁴/RpLP0[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by RpLP0^DP00460/RpLP0[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by sm^EY07191/Scer\GAL4^GMR.PS

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by Tango5[+]/Tango5^G0145b

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by Tis11[+]/Tis11^EY09433

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by Scer\GAL4^GMR.PS/Tis11^EY09433

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by Tis11^EY09107/Tis11[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has ommatidium phenotype, enhanceable by Scer\GAL4^GMR.PS/par-1^UAS.cSa

(Chatterjee et al., 2009)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by Scer\GAL4^GMR.PS/par-1^UAS.cSa

(Chatterjee et al., 2009)

Hsap\MAPT^GMR.Ex.PJ has interommatidial bristle phenotype, enhanceable by Scer\GAL4^GMR.PS/par-1^UAS.cSa

(Chatterjee et al., 2009)

Hsap\MAPT^GMR.Ex.PJ has rhabdomere phenotype, enhanceable by Scer\GAL4^GMR.PS/par-1^UAS.cSa

(Chatterjee et al., 2009)

Hsap\MAPT^GMR.Ex.PJ has ommatidium phenotype, enhanceable by sgg^UAS.cSa/Scer\GAL4^GMR.PS

(Chatterjee et al., 2009)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by sgg^UAS.cSa/Scer\GAL4^GMR.PS

(Chatterjee et al., 2009)

Hsap\MAPT^GMR.Ex.PJ has interommatidial bristle phenotype, enhanceable by sgg^UAS.cSa/Scer\GAL4^GMR.PS

(Chatterjee et al., 2009)

Hsap\MAPT^GMR.Ex.PJ has rhabdomere phenotype, enhanceable by sgg^UAS.cSa/Scer\GAL4^GMR.PS

(Chatterjee et al., 2009)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by Psa⁰⁶²²⁶

(Karsten et al., 2006)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by sgg^UAS.cSa/Scer\GAL4^elav-C155

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ has ommatidium phenotype, enhanceable by sgg^UAS.cSa/Scer\GAL4^elav-C155

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, enhanceable by arm^{S10.UAS.Tag:MYC}/Scer\GAL4^hs.2sev

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ has interommatidial bristle phenotype, enhanceable by arm^{S10.UAS.Tag:MYC}/Scer\GAL4^hs.2sev

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ has ommatidium phenotype, enhanceable by arm^{S10.UAS.Tag:MYC}/Scer\GAL4^hs.2sev

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ has eye | anterior phenotype, enhanceable by Scer\GAL4^sev.EP/pan^UAS.cWa

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ has interommatidial bristle phenotype, enhanceable by Scer\GAL4^sev.EP/pan^UAS.cWa

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ has ommatidium phenotype, enhanceable by Scer\GAL4^sev.EP/pan^UAS.cWa

(Jackson et al., 2002)

NOT Enhanced by

Statement

Reference

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, non-enhanceable by corolla^d01774/Scer\GAL4^GMR.PU

(Ermanoska et al., 2014)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, non-enhanceable by CG15599^EY06842/Scer\GAL4^GMR.PU

(Ermanoska et al., 2014)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, non-enhanceable by rig[+]/rig⁰⁵⁰⁵⁶

(Ambegaokar and Jackson, 2011)

Suppressed by

Statement

Reference

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by Alk^UAS.DN/Scer\GAL4^GMR.PU

(Park et al., 2021)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by chico^UAS.cCa/Scer\GAL4^GMR.PU

(Chatterjee et al., 2019)

Hsap\MAPT^GMR.Ex.PJ has interommatidial bristle phenotype, suppressible by chico^UAS.cCa/Scer\GAL4^GMR.PU

(Chatterjee et al., 2019)

Hsap\MAPT^GMR.Ex.PJ has ommatidium phenotype, suppressible by chico^UAS.cCa/Scer\GAL4^GMR.PU

(Chatterjee et al., 2019)

Hsap\MAPT^GMR.Ex.PJ has eye photoreceptor cell phenotype, suppressible by chico^UAS.cCa/Scer\GAL4^GMR.PU

(Chatterjee et al., 2019)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by POLDIP2^EY08866

(Kim et al., 2015)

Hsap\MAPT^GMR.Ex.PJ has retina | adult stage phenotype, suppressible by Atg1[+]/Atg1^Δ3D

(Bakhoum et al., 2014)

Hsap\MAPT^GMR.Ex.PJ has autophagosome | adult stage phenotype, suppressible by Atg1[+]/Atg1^Δ3D

(Bakhoum et al., 2014)

Hsap\MAPT^GMR.Ex.PJ has retina | adult stage phenotype, suppressible by Rab5^S43N.UAS/Scer\GAL4^GMR.PU

(Bakhoum et al., 2014)

Hsap\MAPT^GMR.Ex.PJ has autophagosome | adult stage phenotype, suppressible by Rab5^S43N.UAS/Scer\GAL4^GMR.PU

(Bakhoum et al., 2014)

Hsap\MAPT^GMR.Ex.PJ has retina | adult stage phenotype, suppressible by Rab7^{T22N.UASp.YFP}/Scer\GAL4^GMR.PU

(Bakhoum et al., 2014)

Hsap\MAPT^GMR.Ex.PJ has autophagosome | adult stage phenotype, suppressible by Rab7^{T22N.UASp.YFP}/Scer\GAL4^GMR.PU

(Bakhoum et al., 2014)

Hsap\MAPT^GMR.Ex.PJ has eye | adult stage phenotype, suppressible by Atg2^UAS.cUa/Scer\GAL4^GMR.PU

(Bakhoum et al., 2014)

Hsap\MAPT^GMR.Ex.PJ has eye | adult stage phenotype, suppressible by S6k^UAS.cUa/Scer\GAL4^GMR.PU

(Bakhoum et al., 2014)

Hsap\MAPT^GMR.Ex.PJ has eye | adult stage phenotype, suppressible by cathD^UAS.cUa/Scer\GAL4^GMR.PU

(Bakhoum et al., 2014)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by Scer\GAL4^GMR.PS/csul^EY10871

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by Dlic^G0190/Dlic[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by Dlic^G0065/Dlic[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by Elf[+]/eRF3^EY12435

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by Scer\GAL4^GMR.PS/eRF3^EY12435

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by eRF3^k06909

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by frc^L6750/frc[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by frc[+]/frc⁰⁰⁰⁷³

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by Fs(2)Ket^EY06666/Fs(2)Ket[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by Scer\GAL4^GMR.PS/Fs(2)Ket^EY06666

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by ksr^j5E2/ksr[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by ksr^EY01688/ksr[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by Mi-2^L1243/Mi-2[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by Scer\GAL4^GMR.PS/mei-9^EY14578

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by NC2α^EY18723/NC2alpha[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by Scer\GAL4^GMR.PS/NC2α^EY18723

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by Nrg[+]/Nrg^G0099

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by Nrg^G0413/Nrg[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by Scer\GAL4^GMR.PS/Past1^EY01852

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by Scer\GAL4^GMR.PS/SdhB^EY12081

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by Scer\GAL4^GMR.PS/SdhB^c00364

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by sgg^G0335/sgg[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by sgg[+]/sgg¹

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by sgg^M1-1/sgg[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by sgg^EP1576/sgg[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by smid[+]/smid^j6B8

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by Scer\GAL4^GMR.PS/unc-45^EY03034

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by Vha14-1[+]/Vha14-1^EY12998

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by Scer\GAL4^GMR.PS/Vha14-1^EY12998

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by Scer\GAL4^GMR.PS/Vha14-1^c01762

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by CycT^j11B2/l(3)j11B2[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by l(3)j6A6[+]/l(3)j6A6^j6A6

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by l(3)L0499^L0499/l(3)L0499[+]

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by l(3)L6332[+]/l(3)L6332^L6332

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by milt[+]/milt^EY14443

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by Scer\GAL4^GMR.PS/milt^EY14443

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by Vap33^Δ448/Vap-33-1[+]

(Karsten et al., 2006)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by eIF1A^c04533/eIF-1A[+]

(Karsten et al., 2006)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by Psa^GMR.Ex.PK

(Karsten et al., 2006)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by arm¹

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by arm⁴

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by sgg¹

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by pan²

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ has ommatidium phenotype, suppressible by arm¹

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ has ommatidium phenotype, suppressible by arm⁴

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ has ommatidium phenotype, suppressible by sgg¹

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ has ommatidium phenotype, suppressible by pan²

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ has eye | anterior phenotype, suppressible by arm¹

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ has eye | anterior phenotype, suppressible by arm⁴

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ has eye | anterior phenotype, suppressible by sgg¹

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ has eye | anterior phenotype, suppressible by pan²

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by BacA\p35^GMR.PH

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, suppressible by Diap2^GMR.PH

(Jackson et al., 2002)

NOT suppressed by

Statement

Reference

Hsap\MAPT^GMR.Ex.PJ has retina | adult stage phenotype, non-suppressible by Rab14^{S49N.UASp.YFP}/Scer\GAL4^GMR.PU

(Bakhoum et al., 2014)

Hsap\MAPT^GMR.Ex.PJ has autophagosome | adult stage phenotype, non-suppressible by Rab14^{S49N.UASp.YFP}/Scer\GAL4^GMR.PU

(Bakhoum et al., 2014)

Hsap\MAPT^GMR.Ex.PJ has eye phenotype, non-suppressible by milt[+]/milt^EY20737

(Ambegaokar and Jackson, 2011)

Enhancer of

Statement

Reference

Hsap\MAPT^GMR.Ex.PJ is an enhancer of ommatidium phenotype of Scer\GAL4^hs.2sev, arm^{S10.UAS.Tag:MYC}

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ is an enhancer of eye phenotype of Scer\GAL4^hs.2sev, arm^{S10.UAS.Tag:MYC}

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ is an enhancer of interommatidial bristle phenotype of Scer\GAL4^sev.EP, pan^UAS.cWa

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ is an enhancer of interommatidial bristle phenotype of Scer\GAL4^hs.2sev, arm^{S10.UAS.Tag:MYC}

(Jackson et al., 2002)

Other

Statement

Reference

Atg6[+]/Atg6⁰⁰⁰⁹⁶, Hsap\MAPT^GMR.Ex.PJ has eye phenotype

(Ambegaokar and Jackson, 2011)

Hsap\MAPT^GMR.Ex.PJ, spin^Δ2b has eye phenotype

(Dermaut et al., 2005)

Hsap\MAPT^GMR.Ex.PJ, Scer\GAL4^elav-C155, sgg^UAS.cSa has lamina phenotype

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ, Scer\GAL4^elav-C155, sgg^UAS.cSa has retina phenotype

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ, Scer\GAL4^elav-C155, sgg^UAS.cSa has medulla phenotype

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ, Scer\GAL4^sev.EP, pan^UAS.cWa has ommatidium phenotype

(Jackson et al., 2002)

Hsap\MAPT^GMR.Ex.PJ, Scer\GAL4^sev.EP, pan^UAS.cWa has eye | anterior phenotype

(Jackson et al., 2002)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

The rough eye induced by Hsap\MAPT^GMR.Ex.PJ is enhanced by the expression of Alk::Hsap\NPM1^UAS.act under the control of Scer\GAL4^GMR.PU, with marked neuronal loss.

(Park et al., 2021)

When Scer\GAL4^GMR.PU>dco^{K38R.Scer\UAS.T:Hsap\MYC} is expressed along with Hsap\MAPT^GMR.Ex.PJ, there is significantly increased disruption in the eye. The enhanced disruption of the eye is manifested by the appearance of melanized patches in the eye and a decreased average surface area of the eye.

(Means et al., 2015)

The formation of giant autophagic bodies in the retina of adult flies expressing Hsap\MAPT^GMR.Ex.PJ is partially suppressed by combination with a single copy of Atg1^Δ3D or by Scer\GAL4^GMR.PU-driven co-expression of either Rab5^{S43N.Scer\UAS} or Rab7^{T22N.Scer\UAS.P\T.T:Avic\GFP-YFP} but not Rab14^{S49N.Scer\UAS.P\T.T:Avic\GFP-YFP}.

The rough eye phenotype characteristic for Hsap\MAPT^GMR.Ex.PJ-expressing adult flies is strongly suppressed by co-expression of any of the following: Atg2^Scer\UAS.cUa, S6k^Scer\UAS.cUa or cathD^Scer\UAS.cUa under the control of Scer\GAL4^GMR.PU.

(Bakhoum et al., 2014)

Expression of CG8316^d01774 under the control of Scer\GAL4^GMR.PU does not enhance the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

Expression of CG15599^EY06842 under the control of Scer\GAL4^GMR.PU does not enhance the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

(Ermanoska et al., 2014)

Expression of Hsap\SNCA^Scer\UAS.cTa under the control of Scer\GAL4^GMR.PS enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ, with the phenotype extending farther posteriorly. Eyes of animals co-expressing Hsap\SNCA^Scer\UAS.cTa are more flattened than those expressing Hsap\MAPT^GMR.Ex.PJ alone.

Flies co-expressing Hsap\SNCA^Scer\UAS.cTa and Hsap\MAPT^GMR.Ex.PJ under the control of Scer\GAL4^GMR.PS show highly disorganised actin bundles.

Expression of Hsap\SNCA^Scer\UAS.cTa enhances the extent of the microtubule shaft disorganisation seen in the retinas of flies expressing Hsap\MAPT^GMR.Ex.PJ.

(Roy and Jackson, 2014)

Expression of Hsap\AK1^Scer\UAS.cPa enhances the rough eye phenotype seen when Hsap\MAPT^GMR.Ex.PJ is expressed under the control of Scer\GAL4^GMR.PU.

(Park et al., 2012)

One copy of Atg6⁰⁰⁰⁹⁶ produces a necrotic plaque phenotype in the eyes of flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of HnRNP-K^KG02524 enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ. Necrotic plaques are often seen.

One copy of HnRNP-K^G13574 enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ. Necrotic plaques are often seen.

One copy of CaMKI^EY07197 under the control of Scer\GAL4^GMR.PS enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ. The same phenotype is seen when CaMKI^EY07197 is expressed under the control of Scer\GAL4^GMR.PU.

One copy of cana^k07716 enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of cana^DG06604 enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

Expression of crp^EY07016 under the control of Scer\GAL4^GMR.PS enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

Expression of crp^EY14841 under the control of Scer\GAL4^GMR.PS enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

Expression of csul^EY10871 under the control of Scer\GAL4^GMR.PS suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of CycE^k05007 enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of CycE⁰⁵²⁰⁶ enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of Dlic^G0190 suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of Dlic^G0065 suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of Elf^EY12435 under the control of Scer\GAL4^GMR.PS suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ. The same phenotype is seen when Elf^EY12435 is expressed under the control of Scer\GAL4^GMR.PU.

One copy of Elf^k06909 under the control of Scer\GAL4^GMR.PS suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of eRF1⁰⁰¹⁰³ enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ. Necrotic plaques are also seen.

One copy of eRF1^KY7 enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ. Necrotic plaques are also seen.

One copy of eRF1^U3 enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ. Necrotic plaques are also seen.

One copy of frc^L6750 suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of frc⁰⁰⁰⁷³ suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of Fs(2)Ket^EY06666 under the control of Scer\GAL4^GMR.PS suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ. The same phenotype is seen when Fs(2)Ket^EY06666 is expressed under the control of Scer\GAL4^GMR.PU.

One copy of His2Av⁰⁵¹⁴⁶ enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ. Necrotic plaques are also seen.

One copy of His2Av⁸¹⁰ enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ. Necrotic plaques are also seen.

One copy of Hop^k14504 enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of Hop^EP418 enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

Expression of Hr39^EY04579 under the control of Scer\GAL4^GMR.PS enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of Klp61F⁰⁷⁰¹² enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of Klp61F⁰⁶³⁴⁵ enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of ksr^j5E2 suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of ksr^EY01688 suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of Mi-2^L1243 suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

Expression of mei-9^EY14578 under the control of Scer\GAL4^GMR.PS suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

Expression of Mekk1^EY02276 under the control of Scer\GAL4^GMR.PS enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

Expression of Mekk1^EY11461 under the control of Scer\GAL4^GMR.PS enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of NC2α^EY18723 under the control of Scer\GAL4^GMR.PS suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ. The same phenotype is seen when NC2α^EY18723 is expressed under the control of Scer\GAL4^GMR.PU.

One copy of Nrg^G0099 suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of Nrg^G0413 suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of RpS21^k16804a enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of RpS21⁰³⁵⁷⁵ enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of par-1^k06323 enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

Expression of Past1^EY01852 under the control of Scer\GAL4^GMR.PS suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of RpLP0⁰¹⁵⁴⁴ enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of RpLP0^DP00460 enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

Expression of SdhB^EY12081 under the control of Scer\GAL4^GMR.PS suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

Expression of SdhB^c00364 under the control of Scer\GAL4^GMR.PS suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of sgg^G0335 suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of sgg¹ suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of sgg^M1-1 suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of sgg^EP1576 suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

Expression of sm^EY07191 under the control of Scer\GAL4^GMR.PS enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of smid^j6B8 suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of Tango5^G0145b enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ. Necrotic plaques are also seen.

One copy of Tis11^EY09433 under the control of Scer\GAL4^GMR.PS enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ. The same phenotype is seen when Tis11^EY09433 is expressed under the control of Scer\GAL4^GMR.PU.

One copy of Tis11^EY09107 under the control of Scer\GAL4^GMR.PS enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of unc-45⁰³⁶⁹² enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

Expression of unc-45^EY03034 under the control of Scer\GAL4^GMR.PS suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of Vha14-1^EY12998 under the control of Scer\GAL4^GMR.PS suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ. The same phenotype is seen when Vha14-1^EY12998 is expressed under the control of Scer\GAL4^GMR.PU.

Expression of Vha14-1^c01762 under the control of Scer\GAL4^GMR.PS suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of l(3)j11B2^j11B2 suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of l(3)j6A6^j6A6 suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of l(3)L0499^L0499 suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of l(3)L6332^L6332 suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of milt^EY14443 under the control of Scer\GAL4^GMR.PS suppresses the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ. The same phenotype is seen when milt^EY14443 is expressed under the control of Scer\GAL4^GMR.PU.

One copy of U2af38⁰⁶⁷⁵¹ under the control of Scer\GAL4^GMR.PS does not enhance the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of Hop^k00616 enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of Tango5^BG02353 enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of rig⁰⁵⁰⁵⁶ under the control of Scer\GAL4^GMR.PS does not enhance the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of milt^EY20737 under the control of Scer\GAL4^GMR.PS does not suppress the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

One copy of csul^unspecified enhances the rough eye phenotype seen in flies expressing Hsap\MAPT^GMR.Ex.PJ.

(Ambegaokar and Jackson, 2011)

The eye and retinal phenotypes seen in Hsap\MAPT^GMR.Ex.PJ animals are enhanced by Scer\GAL4^GMR.PS-mediated co-expression of par-1^Scer\UAS.cSa or sgg^Scer\UAS.cSa.

(Chatterjee et al., 2009)

The rough eye phenotype caused by Hsap\MAPT^GMR.Ex.PJ is suppressed by Vap-33-1^Δ448/+ or eIF-1A^c04533/+.

The rough eye phenotype caused by Hsap\MAPT^GMR.Ex.PJ is enhanced by Psa⁰⁶²²⁶/+.

The rough eye phenotype caused by Hsap\MAPT^GMR.Ex.PJ is suppressed by co-expression of Psa^GMR.Ex.PK.

(Karsten et al., 2006)

Flies that express Hsap\MAPT^GMR.Ex.PJ in spin^Δ2b/+ mosaic eyes show a mild rough eye phenotype while flies that express Hsap\MAPT^GMR.Ex.PJ in spin^Δ2b homozygous mosaic eyes show a severe rough eye phenotype.

(Dermaut et al., 2005)

When sgg¹ is added to Hsap\MAPT^GMR.Ex.PJ, the eye phenotype is ameliorated. This is seen when one copy of the P{GMR-htau.Ex} insertion is added, but is very marked when 2 copies are present. When sgg^Scer\UAS.cSa (when driven by Scer\GAL4^elav-C155) is added to Hsap\MAPT^GMR.Ex.PJ, the eye phenotype is enhanced. The eye is markedly reduced and there is an almost complete loss of normal ommatidia and a loss of the majority of bristles. Abundant discrete flam-shaped and fibrillar aggregates and vacuolisation are observed throughout the retina and underlying lamina and medulla. The addition of arm¹ or arm⁴ suppresses the eye phenotype seen in Hsap\MAPT^GMR.Ex.PJ animals almost to wild-type, except for the anterior margin. Hsap\MAPT^GMR.Ex.PJ and arm^{S10.Scer\UAS.T:Hsap\MYC} (driven by Scer\GAL4^hs.2sev) enhance each other leading to markedly reduced eye, with a complete loss of ommatidial borders and bristles. The addition of pan² suppresses the eye phenotype seen in Hsap\MAPT^GMR.Ex.PJ subtly. Hsap\MAPT^GMR.Ex.PJ and pan^Scer\UAS.cWa (driven by Scer\GAL4^hs.2sev) enhance each other leading to more roughened anterior part of the eye, with fusion, pitting, and collapse of ommatidia along with irregularity of bristles. The addition of BacA\p35^GMR.PH, Iap2^GMR.PH or th^GMR.PH suppresses the eye phenotype in Hsap\MAPT^GMR.Ex.PJ animals.