FlyBase Allele Report: Dmel\csul[P]

General Information

Symbol

Dmel\csul^P

Species

D. melanogaster

Name

FlyBase ID

FBal0045478

Feature type

allele

Associated gene

Dmel\csul

Associated Insertion(s)

P{white-un4}csul^P

Carried in Construct

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

P-element activity

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Marhold et al., 2003)

Mutagen

P-element activity

(Anne, 1996.4.28)

Progenitor genotype

Associated Insertion(s)

P{white-un4}csul^P

Cytology

Description

Insertion within the transcription unit, 51bp downstream of the 5' end and 7 nucleotides downstream of the putative translation initiation site.

(Anne et al., 2007)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

female sterile | recessive

(Anne et al., 1996)

grandchildless

(Anne et al., 2007)

Phenotype Manifest In

embryonic abdominal segment

(Marhold et al., 2003)

embryonic abdominal segment | maternal effect

(Anne et al., 2007)

primordial germ cell

(Marhold et al., 2003)

primordial germ cell | maternal effect

(Anne et al., 2007)

Detailed Description

Statement

Reference

Homozygous females produce embryos that have defects in abdominal patterning and lack pole cells. Animals that hatch from these embryos are fully agametic.

The severity of the abdominal defects of embryos derived from homozygous females is variable, ranging in from the presence of only one or two abdominal segments to a fully normal abdomen.

(Anne et al., 2007)

The csul^P mutation produces a "grandchildless knirps-like" phenotype characterised by a failure in pole cell formation and variable deletions in the abdominal segments of the embryo.

(Marhold et al., 2003)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Phenotype Manifest In

NOT suppressed by

Statement

Reference

csul^P has primordial germ cell phenotype, non-suppressible by osk^bcd.UTR

(Anne et al., 2007)

Suppressor of

Statement

Reference

csul^P is a suppressor of embryo | anterior phenotype of osk^bcd.UTR

(Anne et al., 2007)

Additional Comments

Genetic Interactions

Statement

Reference

csul^P suppresses the bicaudal phenotype of osk^bcd.UTR embryos. The embryos produced have cuticle with a normal polarity, but the head is malformed. Pole cells are not formed in these double mutant embryos.

(Anne et al., 2007)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Reversion of the P-element insertion demonstrates it to be responsible for female sterility.

(Anne et al., 1996)

Excision of the insertion can revert the mutant phenotype.

(Anne et al., 2007)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

csul^P

(Anne et al., 2007)

Name Synonyms

Secondary FlyBase IDs

References (4)

Report Sections

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