FlyBase Aberration Report: Dmel\Df(2R)Jp8

General Information

Symbol

Df(2R)Jp8

Species

D. melanogaster

Name

FlyBase ID

FBab0001974

Feature type

chromosomal_deletion

Computed Breakpoints include

52F5-52F9;53A1

Features within 52E1--53C1 (Estimated cytology)

Genomic Maps

JBrowse

Sequence coordinates

2R:16,059,113..16,100,060 (Df(2R)Jp8:bk1)

(Cook et al., 2010.2.12)

2R:16,324,513..16,336,565 (Df(2R)Jp8:bk2)

(Cook et al., 2010.2.12)

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Dp(1;2)51b

(Saxton et al., 1991)

Mutagen

Class of aberration (relative to wild type)

chromosomal_deletion

(Cook et al., 2010.2.12, FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Harbecke and Lengyel, 1995, Kania et al., 1995, Pauli et al., 1995)

Breakpoints

52F5-52F9;52F10-53A1

(Harbecke and Lengyel, 1995, Kania et al., 1995, Pauli et al., 1995)

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

bk1 << l(2)52Fe << Rho1 << bk2 << veg

Genetic mapping information

Comments

Comments on Cytology

The left Df(2R)Jp8 breakpoint lies within CG8405 or CG8414 or in the region between them, and lies in the range 2R:11946618..11987565 (R5) (predicted cytology: 52E1-52E4).

(Cook et al., 2010.2.12)

The right Df(2R)Jp8 breakpoint lies within CG4282 or Vha44 or in the region between them, and lies in the range 2R:12212018..12224070 (R5) (predicted cytology: 53B5-53C1).

(Cook et al., 2010.2.12)

Breakpoints reported for Df(2R)Jp8 (52F5--9;53A1) are under question as Df(2R)Jp8 appears to delete Rho1 (52E5).

(Prokopenko et al., 1999)

Ref: Saxton et al., 1991, Cell 64: 1093--1102

(Kania et al., 1995)

Limits of break 1 from polytene analysis (FBrf0080145) Left limit of break 2 from inclusion of Khc (FBrf0102325) Right limit of break 2 from polytene analysis (FBrf0080145)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

cato

(Goulding et al., 2000)

Khc

(Liu et al., 1999, Halsell and Kiehart, 1998)

l(2)52Fb

(Halsell and Kiehart, 1998)

l(2)52Fc

(Halsell and Kiehart, 1998)

l(2)52Fd

(Halsell and Kiehart, 1998)

l(2)52Fe

(Halsell and Kiehart, 1998)

(Liu et al., 1999)

(Liu et al., 1999)

(Liu et al., 1999)

(Liu et al., 1999)

(Liu et al., 1999)

(Liu et al., 1999)

(Liu et al., 1999)

(Liu et al., 1999)

(Liu et al., 1999)

(Liu et al., 1999)

(Liu et al., 1999)

(Liu et al., 1999)

(Liu et al., 1999)

(Liu et al., 1999)

(Liu et al., 1999)

(Liu et al., 1999)

(Bayer et al., 2003, Ward et al., 2003, Halsell et al., 2000, Prokopenko et al., 1999, Halsell and Kiehart, 1998, BDGP Project Members, 1994-1999)

Shark

(Liu et al., 1999)

sotv

(Han et al., 2004, Takei et al., 2004)

spin

(Dermaut et al., 2005, Liu et al., 1999, BDGP Project Members, 1994-1999)

Partially deleted / disrupted

Molecular Data

Completely deleted

CG30100

(Marygold et al., 2007)

Shark

(Fernandez et al., 2000)

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

tef

(Tomkiel et al., 2001)

veg

(Kania et al., 1995)

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location

Related Comments

Phenotypic Data

In combination with other aberrations

Fails to complement Df(2R)BSC309.

(Christensen and Cook, 2007.5.8)

Inferred to overlap with: Df(2R)BSC309.

(Christensen and Cook, 2007.5.8)

NOT in combination with other aberrations

Heterozygosity for Df(2R)Jp8 results in 0.7% X chromosome nondisjunction and 1.4% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females.

(Harris et al., 2003)

Df(2R)Jp7/Df(2R)Jp8 embryos retain a grossly normal number of sense organs. However, neuronal disruption is observed, most noticeable in the chordotonal organs. The dendrites of chordotonal organs are consistently malformed, appearing longer and often thicker than their wild-type equivalents. The dendrite tips occasionally appear enlarged around a non-staining "hole" at the point where the dendrite enters the scolopale. The scolopale itself is disorganised, and the arrangement of the neurons are also disorganised with their characteristic dendritic orientations often awry. The single exception to the observation that this combination of deficiencies is a duplication of v'ch1 chordotonal neurons.

(Goulding et al., 2000)

Strong second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1 : malformed phenotype penetrance >75%.

(Halsell and Kiehart, 1998)

Shows no maternal enhancement of dpp^hr4.

(Nicholls and Gelbart, 1998)

Midgut development of mutant embryos is wild type.

(Bilder and Scott, 1995)

Homozygous embryos have smaller heads than normal.

(Harbecke and Lengyel, 1995)

Heterozygosity for this deletion suppresses the mutant ovarian phenotype of ovo^D2.

(Pauli et al., 1995)

Stocks (2)

Bloomington

3520

w^a N^fa-g; Df(2R)Jp8, w⁺/CyO

Kyoto

107079

w^a N^fa-g; Df(2R)Jp8, w⁺/CyO

Notes on Origin

Discoverer

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms and Secondary IDs (4)

Reported As

Symbol Synonym

Df(2R) JP8

(Duncan et al., 2013)

Df(2R)^Jp8

(Muraoka et al., 2018)

Df(2R)JP8

(Schindelholz et al., 2001, Lei and Warrior, 2000, Pauli et al., 1995)

Df(2R)Jp8

(Tan et al., 2020, Lee et al., 2018, Clough et al., 2014, Cook et al., 2010.2.12, Christensen and Cook, 2007.5.8, Crest et al., 2007, Dermaut et al., 2005)

Name Synonyms

Secondary FlyBase IDs

References (46)

Report Sections

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