FlyBase Allele Report: Dmel\Sxl[M12]

General Information

Symbol

Dmel\Sxl^M12

Species

D. melanogaster

Name

FlyBase ID

FBal0103945

Feature type

allele

Associated gene

Dmel\Sxl

Associated Insertion(s)

H{}Sxl^M12

Carried in Construct

Key Links

Allele class

gain of function allele

Mutagen

hobo activity

Nature of the Allele

Allele class

gain of function allele

(Cline et al., 1999)

Mutagen

hobo activity

(Cline et al., 1999)

Progenitor genotype

Associated Insertion(s)

H{}Sxl^M12

Cytology

Description

Contains a hobo insertion between bps 6572 and 6581.

(Cline et al., 1999)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable | male

(Cline et al., 1999)

visible | male

(Cline et al., 2010, Cline, 2001)

Phenotype Manifest In

abdomen

(Cline et al., 1999)

abdominal sternite 2 & abdominal sternite bristle | male

(Cline, 2001)

abdominal sternite 3 & abdominal sternite bristle | male

(Cline, 2001)

abdominal sternite 4 & abdominal sternite bristle | male

(Cline, 2001)

abdominal sternite 5 & abdominal sternite bristle | male

(Cline, 2001)

abdominal sternite 6 & abdominal sternite bristle | ectopic | male

(Cline, 2001)

abdominal tergite 5 | male

(Cline et al., 2010)

abdominal tergite 6 | male

(Cline et al., 2010)

adult abdomen | male

(Cline, 2001)

tergite | male

(Cline, 2001)

Detailed Description

Statement

Reference

92% of Sxl^M12/Y males have etching of one or more abdominal tergites 5 or 6.

(Cline et al., 2010)

Sxl^M12/Y males have abnormalities confined to the adult abdomen, where tergite etching and reduction of bristle number on sternites two to five (indicating dosage compensation defects), and growth of bristles on sternite 6 (indicating feminisation) are seen.

(Cline, 2001)

Sxl^M12/Y males have frequent abdominal etching. The addition of a Sxl⁺ allele in trans, (carried on Dp(1;Y)ct⁺y⁺) reduces viability in Sxl^M12 males, about one third of the expected number of males survive.

(Cline et al., 1999)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Sxl^M12, noi²/noi^D has male sterile phenotype, non-enhanceable by snf^+t5.5

(Cline et al., 1999)

Sxl^M12, noi²/noi^D has abnormal developmental rate | male phenotype, non-enhanceable by snf^+t5.5

(Cline et al., 1999)

Suppressed by

Statement

Reference

Sxl^M12 has visible | male phenotype, suppressible by ssx⁵⁵

(Cline et al., 2010)

Sxl^M12, snf^+t5.5 has lethal phenotype, suppressible by vir^2f

(Cline et al., 1999)

NOT suppressed by

Statement

Reference

Sxl^M12, noi²/noi^D has male sterile phenotype, non-suppressible by snf^+t5.5

(Cline et al., 1999)

Sxl^M12, noi²/noi^D has abnormal developmental rate | male phenotype, non-suppressible by snf^+t5.5

(Cline et al., 1999)

Sxl^M12, snf^+t5.5 has lethal | male phenotype, non-suppressible by snRNP-U1-70K⁶²

(Cline et al., 1999)

Sxl^M12, snf^+t5.5 has lethal | male phenotype, non-suppressible by noi²/noi^D

(Cline et al., 1999)

Sxl^M12, snf^+t5.5 has lethal phenotype, non-suppressible by snRNP-U1-70K⁶²

(Cline et al., 1999)

Sxl^M12, snf^+t5.5 has lethal phenotype, non-suppressible by noi²/noi^D

(Cline et al., 1999)

Sxl^M12 has male sterile phenotype, non-suppressible by noi²/noi^D

(Cline et al., 1999)

Sxl^M12 has abnormal developmental rate | male phenotype, non-suppressible by noi²/noi^D

(Cline et al., 1999)

Other

Statement

Reference

Sxl^M12, snf^+t5.5 has lethal phenotype

(Cline et al., 1999)

Sxl^M12, msl-2^Hsp83.PK has abnormal sex-determination phenotype

(Cline et al., 1999)

Sxl^M12, vir^+t10 has viable phenotype

(Cline et al., 1999)

Sxl^M12, snRNP-U1-70K::Hsap\SRSF1^Tag:FLAG has viable phenotype

(Cline et al., 1999)

Sxl^M12, noi^+t3.6 has viable phenotype

(Cline et al., 1999)

Phenotype Manifest In

Suppressed by

Statement

Reference

Sxl^M12 has abdominal tergite 5 | male phenotype, suppressible by ssx⁵⁵

(Cline et al., 2010)

Sxl^M12 has abdominal tergite 6 | male phenotype, suppressible by ssx⁵⁵

(Cline et al., 2010)

Sxl^M12 has abdomen phenotype, suppressible by msl-2^Hsp83.PK

(Cline et al., 1999)

NOT suppressed by

Statement

Reference

Sxl^M12 has phenotype, non-suppressible by bb^flex-2

(Cline, 2001)

Other

Statement

Reference

Sxl^M12, msl-2^Hsp83.PK has abdominal tergite 5 phenotype

(Cline et al., 1999)

Sxl^M12, msl-2^Hsp83.PK has abdominal tergite 6 phenotype

(Cline et al., 1999)

Sxl^M12, msl-2^Hsp83.PK has sex comb phenotype

(Cline et al., 1999)

Sxl^M12, msl-2^Hsp83.PK has prothoracic leg phenotype

(Cline et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Only 16% of ssx⁵⁵ Sxl^M12/Y males have etching of one or more abdominal tergites 5 or 6.

(Cline et al., 2010)

The defects seen in Sxl^M12/Y males are not suppressed by bb^flex-2, if there is any effect the abnormalities are slightly worse, not better.

(Cline, 2001)

Addition of msl-2^Hsp83.PK leads to partial suppression of the abdominal etching phenotype seen in Sxl^M12/Y males. For Sxl^M12/Y males with msl-2^Hsp83.PK, 72% of their fifth and sixth hemitergites are completely feminized. In contrast none of their forelegs are fully female and 77% are entirely male. The addition of a single copy of P{snf⁺,dhd⁺} to Sxl^M12/Y males leads to complete lethality. The addition of homozygous vir^2f suppresses the lethality seen in P{snf⁺,dhd⁺},Sxl^M12/Y males. The addition of homozygous snRNP70K⁶² does not suppress the snf^+t5.5 dose effects on Sxl^M12/Y male viability. The addition of noi²/noi^D does not suppress the snf^+t5.5 dose effects on Sxl^M12/Y male viability. The addition of P{snf⁺,dhd⁺} has no effect on the male sterility and developmental delay phenotypes seen in noi²/noi^D, Sxl^M12/Y males.

(Cline et al., 1999)

Xenogenetic Interactions

Statement

Reference

The addition of vir^+t10, snRNP70K::Hsap\SFRS1^T:Zzzz\FLAG, or noi^+t3.6 essentially have no deleterious effects on Sxl^M12/Y males.

(Cline et al., 1999)

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Sxl^M12

(Cline et al., 2010)

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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