FlyBase Allele Report: Dmel\noi[D]

General Information

Symbol

Dmel\noi^D

Species

D. melanogaster

Name

FlyBase ID

FBal0088760

Feature type

allele

Associated gene

Dmel\noi

Associated Insertion(s)

Carried in Construct

Also Known As

Df(3R)noi-D

Key Links

Genomic Maps

JBrowse

Allele class

Mutagen

Delta2-3 transposase

Nature of the Allele

Allele class

Mutagen

Delta2-3 transposase

(Meyer et al., 1998)

Progenitor genotype

noi²

(Meyer et al., 1998)

noi¹

(Meyer et al., 1998)

Cytology

Description

Deletion of the entire P{lacW} insertion and entire noi genomic sequences, from 92 nucleotides upstream of the start codon to 117 nucleotides upstream of the stop codon.

(Meyer et al., 1998)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

deletion

3R:5,589,938..5,591,423 [-]

Comment:

A deletion from 92 nucleotides upstream of the start codon to 117 nucleotides upstream of the stop codon of noi.

(Meyer et al., 1998)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during embryonic stage | recessive

(Meyer et al., 1998)

some die during embryonic stage | recessive

(Meyer et al., 1998)

Phenotype Manifest In

Detailed Description

Statement

Reference

Homozygous embryonic development is completely normal but the embryos fail to hatch. noi^+t3.6 cannot rescue the homozygous lethality.

(Meyer et al., 1998)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT Enhanced by

Statement

Reference

Sxl^M12, noi²/noi^D has male sterile phenotype, non-enhanceable by snf^+t5.5

(Cline et al., 1999)

Sxl^M12, noi²/noi^D has abnormal developmental rate | male phenotype, non-enhanceable by snf^+t5.5

(Cline et al., 1999)

NOT suppressed by

Statement

Reference

Sxl^M12, noi²/noi^D has male sterile phenotype, non-suppressible by snf^+t5.5

(Cline et al., 1999)

Sxl^M12, noi²/noi^D has abnormal developmental rate | male phenotype, non-suppressible by snf^+t5.5

(Cline et al., 1999)

Enhancer of

Statement

Reference

noi²/noi^D is an enhancer of partially lethal - majority die | male phenotype of Sxl^Mf1, snf^+t5.5

(Cline et al., 1999)

NOT Suppressor of

Statement

Reference

noi²/noi^D is a non-suppressor of lethal | male phenotype of Sxl^M12, snf^+t5.5

(Cline et al., 1999)

noi²/noi^D is a non-suppressor of lethal phenotype of Sxl^M12, snf^+t5.5

(Cline et al., 1999)

noi²/noi^D is a non-suppressor of male sterile phenotype of Sxl^M12

(Cline et al., 1999)

noi²/noi^D is a non-suppressor of abnormal developmental rate | male phenotype of Sxl^M12

(Cline et al., 1999)

Other

Statement

Reference

Sxl^Mf1, noi²/noi^D, snf^+t5.5 has lethal | male phenotype

(Cline et al., 1999)

Phenotype Manifest In

Enhancer of

Statement

Reference

noi²/noi^D is an enhancer of sex comb phenotype of Sxl^Mf1, snf^+t5.5

(Cline et al., 1999)

Suppressor of

Statement

Reference

noi²/noi^D is a suppressor of sex comb phenotype of Sxl^Mf1, snf^+t5.5

(Cline et al., 1999)

Other

Statement

Reference

Sxl^Mf1, noi²/noi^D, snf^+t5.5 has sex comb phenotype

(Cline et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

The removal of noi function (by adding noi²/noi^D) leads to an almost complete suppression of the foreleg feminisation phenotype seen in Sxl^Mf1/Y flies with two copies of P{snf⁺,dhd⁺}. The addition of two copies of P{snf⁺,dhd⁺} to Sxl^Mf1/Y males that also carry noi²/noi^D, leads to feminisation of the foreleg and a reduction in viability. The addition of noi²/noi^D does not suppress the snf^+t5.5 dose effects on Sxl^M12/Y male viability. The addition of P{snf⁺,dhd⁺} has no effect on the male sterility and developmental delay phenotypes seen in noi²/noi^D, Sxl^M12/Y males.

(Cline et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Not rescued by

noi^D is not rescued by noi^+t3.6

(Meyer et al., 1998)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

"noi¹" was stated as tentative. "noi²" was stated as tentative. It is not known if the homozygous lethality is due to deletion of another essential gene or if the chromosome bears another lethal mutation elsewhere.

(Meyer et al., 1998)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Df(3R)noi-D

(Cline et al., 1999, Meyer et al., 1998)

noi^D

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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