SxlM12, snf+t5.5 has lethal | male phenotype, non-suppressible by snRNP-U1-70K62
SxlM12, snf+t5.5 has lethal phenotype, non-suppressible by snRNP-U1-70K62
snf+t5.5 is an enhancer of partially lethal - majority die | male phenotype of SxlMf1
snf+t5.5 is an enhancer of lethal | male phenotype of Tp(1;3)sn13a1/Sxlf7,M1
snf+t5.5 is a non-suppressor of male sterile phenotype of SxlM12, noi2/noiD
Dp(1;1)jnR1-A, snf+t5.5 has wild-type | male phenotype
Sxlf7,M1, Tp(1;3)sn13a1, snf+t5.5 has lethal | male phenotype
SxlMf1, snf+t5.5 has sex comb phenotype, enhanceable by snRNP-U1-70K62/snRNP-U1-70K62
snf+t5.5 is an enhancer of macrochaeta phenotype of SxlMf1
snf+t5.5 is an enhancer of imaginal disc phenotype of SxlMf1
If up to four copies of P{snf+,dhd+} are added to Sxlf7,M1/Y, males are fully viable. If up to four copies of P{snf+,dhd+}
are added to flies with Dp(1;1)jnR1-A ( which contains a duplication
of Sxl+), males are fully viable. If up to 10 copies of P{snf+,dhd+}
are added to wild-type flies males are fully viable and somatically
wild-type.
However, the combination of Sxlf7,M1/Y, Tp(1;3)sn13a1 ( which
contains a duplication of Sxl+) and one copy of snf+ in the
transgene P{snf+,dhd+}, leads to 75% of males dying, and two
extra copies leads to complete lethality.
The addition of up to three copies of P{snf+,dhd+} to Sxlf1/Y;SxlF1.hs,
tra1 partially feminised males does not enhance the feminisation
or lethality phenotypes seen in these flies.
The addition of one copy of P{snf+,dhd+} to SxlMf1/Y males
reduces the viability of males to about 50% of the expected number.
The addition of two copies reduces the survival rate to about 3%.
The survivors exhibit a wide range of imaginal discs defects, including
thin or missing bristles, as well as small and rough eyes. Also feminizing
effects are also seen in the sex combs, the majority of flies show
some loss of sex combs, and only 1% had wild-type male sex combs.
Intersexuality is predominantly of the "mosaic" type in which individual
cells are either male or female rather than intermediate.
The addition of noi+t3.6 to SxlMf1/Y males with two copies
of P{snf+,dhd+} has no significant effect on the foreleg feminisation
phenotype seen in those flies.
There is a slight increase in the foreleg feminisation phenotype seen
in SxlMf1/Y males carrying two copies of P{snf+,dhd+}, when
you compare the addition of homozygous snRNP70K62, to heterozygous
The removal of noi function (by adding noi2/noiD) leads to
an almost complete suppression of the foreleg feminisation phenotype
seen in SxlMf1/Y flies with two copies of P{snf+,dhd+}.
The addition of two copies of P{snf+,dhd+} to SxlMf1/Y males
that also carry noi2/noiD, leads to feminisation of the foreleg
and a reduction in viability.
SxlMf1/Y males with a single extra copy of P{snf+,dhd+},
are considerably more masculine after the addition of Df(1)J210 (which
causes snfJ210).
The addition of P{snf+,dhd+} to snf1, SxlM6/Y males,
completely removes the suppression of the SxlM6 lethality phenotype
seen when snf1 is added alone.
The addition of homozygous snRNP70K62 does not suppress the snf+t5.5
dose effects on SxlM12/Y male viability. Extra copies of P{snf+,dhd+}
do not suppress the homozygous snRNP70K62 phenotype.
The addition of noi2/noiD does not suppress the snf+t5.5
dose effects on SxlM12/Y male viability.
The addition of P{snf+,dhd+} has no effect on the male sterility
and developmental delay phenotypes seen in noi2/noiD, SxlM12/Y
males.