Recessive lethal in XX females. Lethal to males in the absence of a Y chromosome.
Viable SxlM1 bbflex-2 and SxlM4 bbflex-2 double mutant males have not been recovered. The temperature sensitive lethality of snf1 SxlM1 males is still seen if they are also mutant for bbflex-2; triple mutant males are recovered at 18oC, but not at 25oC. The defects seen in SxlM12/Y males are not suppressed by bbflex-2, if there is any effect the abnormalities are slightly worse, not better. bbflex-2 is male lethal over the Df(YS)bb chromosome, which is Ybb-.
bbflex-2 suppresses the male lethality of SxlM1 and SxlM4. The suppression is slightly temperature dependent with fewer males surviving at 29oC than at 25oC. The resulting males are viable and fertile with no evidence of transformation. FlyBase curator comment: subsequent publication (FBrf0134557) calls into question the validity of the genetic interaction between bbflex-2 and SxlM alleles (SxlM1 and SxlM4) stated in FBrf0111803.