FlyBase Allele Report: Dmel\Sxl[M4]

General Information

Symbol

Dmel\Sxl^M4

Species

D. melanogaster

Name

FlyBase ID

FBal0016710

Feature type

allele

Associated gene

Dmel\Sxl

Associated Insertion(s)

hopper{}Sxl^M4

Carried in Construct

Also Known As

Sxl^M#4

Key Links

Genomic Maps

JBrowse

Allele class

gain of function allele

Mutagen

spontaneous

Nature of the Allele

Allele class

gain of function allele

(Maine et al., 1985)

Mutagen

spontaneous

(Bernstein et al., 1995, Lindsley and Zimm, 1992, Maine et al., 1985)

Progenitor genotype

Associated Insertion(s)

hopper{}Sxl^M4

Cytology

Description

Insertion of a 1.4kb hopper element into the male specific exon 3 of Sxl. The insertion splits the exon into 135bp and 60bp segments. The direction of transcription of the hopper element with respect to Sxl is unknown.

(Bernstein et al., 1995)

2 kb insert near male-specific exon 3.

(Lindsley and Zimm, 1992)

Insert stated as cause: undefined Insertion of 1.7kb DNA into Sxl, approximately 8-9kb distal to the site of P-element insertion in Sxl^fPb.

(Maine et al., 1985)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

X:7,088,633..7,088,637

(Bernstein et al., 1995, Bernstein, 1994.6.30, Lindsley and Zimm, 1992)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

X80025

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | dominant | male

(Maine et al., 1985)

lethal | male

(Cline, 2001, Bhattacharya et al., 1999, Hilfiker et al., 1995)

lethal | male limited

(Kappes et al., 2011)

Phenotype Manifest In

Detailed Description

Statement

Reference

The Sxl^M alleles differ in their ability to bypass the X:A signal. Sxl^M4 is more effective than Sxl^M3, is more effective than Sxl^M1, at suppressing female-specific zygotic lethality of sisA and sc^sisB mutations.

(Bernstein et al., 1995)

Sxl^M4/X ; tra^unspecified/tra^unspecified larvae have gonads that are indistinguishable from XX ; tra^unspecified/tra^unspecified larvae. Sxl^M4/X ; tra^unspecified/tra^unspecified adult pseudomales often have degenerating cells in the testes. Germ cells in these flies can be either oogenic or spermatogenic (a single animal contains only oogenic or spermatogenic testes, not both).

(Steinmann-Zwicky, 1994)

XY germ cells carrying Sxl^M4 are spermatogenic in female host gonads.

(Steinmann-Zwicky, 1993)

Female sterility can be suppressed by Sxl^M4. Hemizygous male lethality is not suppressed by snf¹.

(Salz, 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

NOT suppressed by

Statement

Reference

Sxl^M4 has lethal | male phenotype, non-suppressible by bb^flex-2

(Cline, 2001)

Suppressor of

Statement

Reference

Sxl^M4/Sxl^M4 is a suppressor of lethal | female | heat sensitive phenotype of Df(1)sc19/sc^sisB-3

(Wrischnik et al., 2003)

Sxl^M4/Sxl^M4 is a suppressor of partially lethal - majority die | female phenotype of Df(1)sc19/sc^M6

(Wrischnik et al., 2003)

Sxl^M4/Sxl^M4 is a suppressor of partially lethal - majority die | female | heat sensitive phenotype of Df(1)sc19/sc^sisB-2

(Wrischnik et al., 2003)

Sxl^M4 is a suppressor of lethal | female phenotype of sisA¹/Df(1)N71

(Walker et al., 2000)

Sxl^M4 is a suppressor of lethal | female phenotype of sisA²/sisA¹

(Walker et al., 2000)

Sxl^M4 is a suppressor of lethal | female | larval stage phenotype of vir^unspecified/vir^2f

(Hilfiker et al., 1995)

NOT Suppressor of

Statement

Reference

Sxl^M4 is a non-suppressor of lethal | recessive | female phenotype of sisA²

(Walker et al., 2000)

Sxl^M4 is a non-suppressor of lethal | female | larval stage phenotype of vir^unspecified/vir³

(Hilfiker et al., 1995)

Sxl^M4 is a non-suppressor of lethal | female | larval stage phenotype of vir^unspecified/vir⁴

(Hilfiker et al., 1995)

Sxl^M4 is a non-suppressor of lethal | female | larval stage phenotype of vir^unspecified/vir⁵

(Hilfiker et al., 1995)

Sxl^M4 is a non-suppressor of lethal | female | larval stage phenotype of vir^unspecified/vir⁶

(Hilfiker et al., 1995)

Sxl^M4 is a non-suppressor of lethal | female | larval stage phenotype of vir^unspecified/vir⁷

(Hilfiker et al., 1995)

Sxl^M4 is a non-suppressor of lethal | female | larval stage phenotype of vir^unspecified/vir^ts

(Hilfiker et al., 1995)

Other

Statement

Reference

sisA¹/Df(1)N71, Sxl^M4 has viable phenotype

(Walker et al., 2000)

Sxl^M4, vir⁶ has viable | female phenotype

(Schutt et al., 1998)

Phenotype Manifest In

NOT Suppressor of

Statement

Reference

Sxl^M4 is a non-suppressor of ovary phenotype of ovo^D1rv22

(Oliver and Pauli, 1998)

Sxl^M4 is a non-suppressor of ovary phenotype of ovo^D1rv23

(Oliver and Pauli, 1998)

Additional Comments

Genetic Interactions

Statement

Reference

Sxl^M4, dm^P0/dm^P0 females are fully viable. While a Sxl^M4/+ background rescues the female-specific lethality of dm^P0, it does not rescue the dm^P0 bristle or female sterility phenotypes. No Sxl^M4, dm^P0/dm^P0 males are recovered from the cross.

(Kappes et al., 2011)

Viable Sxl^M4 bb^flex-2 double mutant males have not been recovered.

(Cline, 2001)

87% of Sxl^M4 ; hh^ts2/hh^AC ovarioles contain multi-chambered cysts.

(Vied and Horabin, 2001)

FlyBase curator comment: subsequent publication (FBrf0134557) calls into question the validity of the genetic interaction between bb^flex-2 and Sxl^M alleles (Sxl^M1 and Sxl^M4) stated in FBrf0111803. The suppression of the male lethality by bb^flex-2 is slightly temperature dependent with fewer males surviving at 29^oC than at 25^oC. The resulting males are viable and fertile with no evidence of transformation.

(Bhattacharya et al., 1999)

Ovaries of ovo^D1rv23/ovo^D1rv22 females contain germline chambers in less than 20% of cases. The phenotype is not affected if the females are also carrying Sxl^M4.

(Oliver and Pauli, 1998)

The daughters of females with homozygous vir⁶ germ line clones are rescued if the daughters carry Sxl^M4; Sxl^M4/+ ; vir⁶/+ animals develop as normal females. Sxl^M4/+ ; vir⁶/vir^2f animals derived from females carrying homozygous vir⁶ germ line clones mated to vir^2f/+ males survive, but are sexually transformed. Does not rescue the lethality of embryos derived from females with homozygous vir³ or vir⁴ germ line clones mated to vir⁺ males.

(Schutt et al., 1998)

The presence of Sxl^M4 failed to rescue female lethality in vir transheterozygotes. vir^2f/vir^- males are lethal in the presence of Sxl^M4.

(Hilfiker et al., 1995)

Suppresses the dominant female lethality of Sxl^f1 and Sxl^fP7B0 in embryos derived from snf^e8H mothers.

(Albrecht and Salz, 1993)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Comments

Can partially suppress sexual transformation of germ cells in otu mutant ovaries.

(Pauli et al., 1993)

External Crossreferences and Linkouts ( 1 )

Crossreferences

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

X80025

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Sxl^M#4

(Bhadra et al., 2000, Maine et al., 1985)

Sxl^M4

(Kappes et al., 2011, González et al., 2008)

Name Synonyms

Secondary FlyBase IDs

References (21)

Report Sections

Open Close