FB2024_03 , released June 25, 2024
Allele: Dmel\vir4
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General Information
Symbol
Dmel\vir4
Species
D. melanogaster
Name
FlyBase ID
FBal0050752
Feature type
allele
Associated gene
Dmel\vir
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Hilfiker et al., 1995)
Progenitor genotype
Cytology
Description

Amino acid replacement: Q1177term.

(Niessen et al., 2001)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
2R:23,362,602..23,362,602 [-]
Nucleotide change:

C23362602T

Amino acid change:

Q1177term | vir-PA

Reported amino acid change:

Q1177term

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change.

(Niessen et al., 2001)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      XX and XY homozygotes do not survive.

      (Niessen et al., 2001)

      Female germ cells homozygous for vir4 can complete oogenesis. Females carrying these homozygous germ line clones produce eggs but when mated to vir+ males no larvae hatch. This phenotype is rescued if the homozygous germ line clones are induced in females carrying vir+t10. Whole larval gonads of the genotype XY ; vir4/Df(2R)vir130 form sperm after they are transplanted into the abdomen of adult females.

      (Schutt et al., 1998)

      Male homozygotes and male transheterozygotes with other EMS induced vir mutations die during larval or pupal stage, very few male escapers are present. Transheterozygotes with virts transform XX animals into intersexes at 29oC. Sxl+/Sxl+;vir4/virts and Sxlf1/Sxl+;vir4/vir+ are viable but doubly heterozygous Sxlf1/Sxl+;vir4/virts females are lethal.

      (Hilfiker et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT suppressed by
      Statement
      Reference

      virunspecified/vir4 has lethal | female | larval stage phenotype, non-suppressible by SxlF1.hs

      (Hilfiker et al., 1995)

      virunspecified/vir4 has lethal | female | larval stage phenotype, non-suppressible by SxlM1

      (Hilfiker et al., 1995)

      virunspecified/vir4 has lethal | female | larval stage phenotype, non-suppressible by SxlM4

      (Hilfiker et al., 1995)

      vir4 has lethal | female | larval stage phenotype, non-suppressible by msl-1γ222

      (Hilfiker et al., 1995)

      vir4 has lethal | female | larval stage phenotype, non-suppressible by msl-2γ136

      (Hilfiker et al., 1995)

      vir4 has lethal | female | larval stage phenotype, non-suppressible by mle9

      (Hilfiker et al., 1995)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      The phenotype seen in females carrying homozygous germ line clones is not rescued if the germ line cells also carry SxlM1 or SxlM4.

      (Schutt et al., 1998)

      Female lethality cannot be rescued by msl-1γ222, msl-2γ136 or mle9 mutations. The presence of SxlM1, SxlM4 or SxlF1.hs failed to rescue female lethality in vir transheterozygotes.

      (Hilfiker et al., 1995)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Rescued by

      vir4 is rescued by vir+t10

      (Schutt et al., 1998)
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (1)
      Reported As
      Symbol Synonym
      vir4
      Name Synonyms
      Secondary FlyBase IDs
        References (3)