FlyBase Allele Report: Dmel\Sb[sbd-201]

General Information

Symbol

Dmel\Sb^sbd-201

Species

D. melanogaster

Name

FlyBase ID

FBal0015157

Feature type

allele

Associated gene

Dmel\Sb

Associated Insertion(s)

Carried in Construct

Also Known As

sbd²⁰¹

Key Links

Genomic Maps

JBrowse

Allele class

antimorphic allele - genetic evidence

hypomorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

antimorphic allele - genetic evidence

(Hammonds and Fristrom, 2006)

hypomorphic allele - genetic evidence

(Gotwals and Fristrom, 1991)

Mutagen

ethyl methanesulfonate

(Gotwals and Fristrom, 1991)

Progenitor genotype

Cytology

Description

Amino acid replacement: R572H.

(Hammonds and Fristrom, 2006)

Nucleotide substitution: A2583G.

(Hammonds and Fristrom, 2006)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

point_mutation

3R:16,143,756..16,143,756 [+]

Nucleotide change:

A16143756G

Reported nucleotide change:

A2583G

Amino acid change:

H573R | Sb-PA; H573R | Sb-PB

Reported amino acid change:

H572R

(Hammonds and Fristrom, 2006)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

viable | reduced

(Bayer et al., 2003)

visible

(Hammonds and Fristrom, 2006, Bayer et al., 2003)

visible (with Sb^sbd-1)

(Bayer et al., 2003)

visible | recessive

(Gotwals and Fristrom, 1991)

Phenotype Manifest In

chaeta

(Hammonds and Fristrom, 2006)

leg

(Hammonds and Fristrom, 2006, Bayer et al., 2003)

leg (with Sb^sbd-1)

(Bayer et al., 2003)

Detailed Description

Statement

Reference

Sb^sbd-201 does not enhance the bristle phenotype of the Sb^sbd-2 allele.

Homozygotes have a malformed leg phenotype.

(Hammonds and Fristrom, 2006)

100% of Sb^sbd-201 homozygotes have a malformed leg phenotype. 10% of Sb^sbd-201/Sb^sbd-1 animals have a malformed leg phenotype. 1% of Sb^sbd-201/Sb^sbd-2 animals have a malformed leg phenotype.

(Bayer et al., 2003)

First difference from wild type evident at around 40 hours of pupal development, when the number of actin filament bundles becomes abruptly reduced, then disorganised at the tip accounting for the resulting frayed bristle ends.

(Appel et al., 1993)

Short tapered bristles and malformed appendages. zip interacts very weakly with Sb recessive mutations.

(Gotwals and Fristrom, 1991)

homozygous viable

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Sb^sbd-201, br^unspecified has visible phenotype

(Hammonds and Fristrom, 2006)

Sb^sbd-201, zip^unspecified has visible phenotype

(Hammonds and Fristrom, 2006)

E(zip)31-6^31-6, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

RhoGEF2⁰⁴²⁹¹, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

RhoGEF2^1.1, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

RhoGEF2^4.1, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

Rho1^E3.10, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

Rok², Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

Sb^sbd-1/Sb^sbd-201, zip^33-1 has visible phenotype

(Bayer et al., 2003)

Df(2R)Jp1/+, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

Df(2R)Jp8/+, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

E(zip)12-5[+]/E(zip)12-5^12-5, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

E(zip)18-5[+]/E(zip)18-5^18-5, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

E(zip)31-6^31-6/E(zip)31-6[+], Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

Rho1^12-6/Rho1[+], Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

Rho1^E3.10/Rho1[+], Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

RhoGEF2⁰⁴²⁹¹/RhoGEF2[+], Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

Rho1^E3.10, Sb^sbd-201/Sb^sbd-2 has visible phenotype

(Bayer et al., 2003)

RhoGEF2^1.1/RhoGEF2[+], Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

RhoGEF2^11-3/RhoGEF2[+], Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

RhoGEF2^4.1/RhoGEF2[+], Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

rok[+]/Rok¹, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

rok[+]/Rok², Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

Sb^sbd-1/Sb^sbd-201, zip^33-1/zip[+] has visible phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

Df(2R)Jp8/+, Sb^sbd-201/Sb^sbd-2 has visible phenotype

(Bayer et al., 2003)

Rho1^E3.10/Rho1[+], Sb^sbd-201/Sb^sbd-2 has visible phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], Sb^sbd-201/Sb^sbd-2 has visible phenotype

(Bayer et al., 2003)

Rho1^J3.8, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

Rok¹, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

Rho1^12-6, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

E(zip)12-5^12-5, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

E(zip)18-5^18-5, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

Rho1^J3.8, Sb^sbd-201/Sb^sbd-2 has visible phenotype

(Bayer et al., 2003)

Phenotype Manifest In

Other

Statement

Reference

Sb^sbd-201, br^unspecified has leg phenotype

(Hammonds and Fristrom, 2006)

Sb^sbd-201, zip^unspecified has leg phenotype

(Hammonds and Fristrom, 2006)

E(zip)31-6^31-6, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

RhoGEF2⁰⁴²⁹¹, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

RhoGEF2^1.1, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

RhoGEF2^4.1, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

Rok², Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

Sb^sbd-1/Sb^sbd-201, zip^33-1 has leg phenotype

(Bayer et al., 2003)

Df(2R)Jp1/+, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

Df(2R)Jp8/+, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

E(zip)12-5[+]/E(zip)12-5^12-5, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

Rho1^E3.10, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

E(zip)18-5[+]/E(zip)18-5^18-5, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

E(zip)31-6^31-6/E(zip)31-6[+], Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

Rho1^12-6/Rho1[+], Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

Rho1^E3.10/Rho1[+], Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

RhoGEF2⁰⁴²⁹¹/RhoGEF2[+], Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

RhoGEF2^1.1/RhoGEF2[+], Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

RhoGEF2^11-3/RhoGEF2[+], Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

RhoGEF2^4.1/RhoGEF2[+], Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

rok[+]/Rok¹, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

rok[+]/Rok², Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

Rho1^E3.10, Sb^sbd-201/Sb^sbd-2 has leg phenotype

(Bayer et al., 2003)

Sb^sbd-1/Sb^sbd-201, zip^33-1/zip[+] has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

Df(2R)Jp8/+, Sb^sbd-201/Sb^sbd-2 has leg phenotype

(Bayer et al., 2003)

Rho1^E3.10/Rho1[+], Sb^sbd-201/Sb^sbd-2 has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], Sb^sbd-201/Sb^sbd-2 has leg phenotype

(Bayer et al., 2003)

Rok¹, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

Rho1^12-6, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

E(zip)12-5^12-5, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

E(zip)18-5^18-5, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8, Sb^sbd-201/Sb^sbd-2 has leg phenotype

(Bayer et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Sb^sbd-201 interacts with br^unspecified or zip^unspecified to produce flies with severely malformed legs.

(Hammonds and Fristrom, 2006)

Pkn⁰⁶⁷³⁶ shows a weak dominant enhancement of leg malformation in Sb^sbd-201/Sb^sbd-1 flies. Pkn³ shows a weak dominant enhancement of leg malformation in Sb^sbd-201/Sb^sbd-1 flies. Sb^sbd-201/Sb^sbd-1 shows a strong interaction (at least 50% of double mutants have at least one malformed leg) with the following mutations: Rho1^J3.8/+, Rho1^E3.10/+, Df(2R)Jp8/+, Df(2R)Jp1/+, Rho1^12-6/+. Sb^sbd-201/Sb^sbd-1 shows a moderate interaction (25-49% of double mutants have at least one malformed leg) with the following mutations: E(zip)18-5^18-5/+, E(zip)31-6^31-6/+, zip^33-1/+, RhoGEF2^11-3/+. Sb^sbd-201/Sb^sbd-1 shows a weak interaction (5-24% of double mutants have at least one malformed leg) with the following mutations: RhoGEF2^1.1/+, RhoGEF2^4.1/+, RhoGEF2⁰⁴²⁹¹/+, rok¹/+, rok²/+ and E(zip)12-5^12-5/+.

(Bayer et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Sb^sbd-201 is rescued by Sb^hs.PB

(Bayer et al., 2003)

Partially rescued by

Df(3R)sbd105/Sb^sbd-201 is partially rescued by Sb^hs.PB

(Hammonds and Fristrom, 2006)

Sb^sbd-201 is partially rescued by Sb^hs.PB

(Hammonds and Fristrom, 2006)

Not rescued by

Df(3R)sbd105/Sb^sbd-201 is not rescued by Sb^S737A.hs

(Hammonds and Fristrom, 2006)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Sb^sbd-201

Sb^sbd-20l

sbd²⁰¹

(Hammonds and Fristrom, 2006, Bayer et al., 2003, Appel, 1995, Appel et al., 1993, Gotwals and Fristrom, 1991)

sbd^20l

sbd[201]

(Ruggiero et al., 2006)

Name Synonyms

Secondary FlyBase IDs

References (7)

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