FlyBase Allele Report: Dmel\RhoGEF2[11-3]

General Information

Symbol

Dmel\RhoGEF2^11-3

Species

D. melanogaster

Name

FlyBase ID

FBal0155962

Feature type

allele

Associated gene

Dmel\RhoGEF2

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Bayer et al., 2003)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Bayer et al., 2003)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Rho1^J3.8, RhoGEF2^11-3/RhoGEF2[+] has visible phenotype

(Bayer et al., 2003)

RhoGEF2^11-3/RhoGEF2[+], Sb^63b has visible | dominant phenotype

(Bayer et al., 2003)

RhoGEF2^11-3/RhoGEF2[+], Sb^63b has visible phenotype

(Bayer et al., 2003)

RhoGEF2^11-3/RhoGEF2[+], Sb⁷⁰ has visible | dominant phenotype

(Bayer et al., 2003)

RhoGEF2^11-3/RhoGEF2[+], Sb⁷⁰ has visible phenotype

(Bayer et al., 2003)

RhoGEF2^11-3/RhoGEF2[+], zip^Ebr has visible phenotype

(Bayer et al., 2003)

RhoGEF2^11-3/RhoGEF2[+], Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

Df(2R)Jp8/+, RhoGEF2^11-3 has visible | dominant phenotype

(Bayer et al., 2003)

Df(2R)Jp8/+, RhoGEF2^11-3 has partially lethal phenotype

(Bayer et al., 2003)

Rho1^E3.10/Rho1[+], RhoGEF2^11-3 has visible | dominant phenotype

(Bayer et al., 2003)

Rho1^E3.10/Rho1[+], RhoGEF2^11-3 has partially lethal phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], RhoGEF2^11-3 has visible | dominant phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], RhoGEF2^11-3 has partially lethal phenotype

(Bayer et al., 2003)

E(zip)12-5[+]/E(zip)12-5^12-5, RhoGEF2^11-3 has visible | dominant phenotype

(Bayer et al., 2003)

E(zip)12-5[+]/E(zip)12-5^12-5, RhoGEF2^11-3 has visible phenotype

(Bayer et al., 2003)

E(zip)18-5[+]/E(zip)18-5^18-5, RhoGEF2^11-3 has visible | dominant phenotype

(Bayer et al., 2003)

Rho1^12-6/Rho1[+], RhoGEF2^11-3 has visible | dominant phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, Sb^63b/Sb[+] has visible | dominant phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, Sb^63b/Sb[+] has visible phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, Sb[+]/Sb⁷⁰ has visible | dominant phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, Sb[+]/Sb⁷⁰ has visible phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, zip[+]/zip^Ebr has visible | dominant phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

Rho1^E3.10, RhoGEF2^11-3/RhoGEF2[+] has visible phenotype

(Bayer et al., 2003)

Rho1^12-6, RhoGEF2^11-3/RhoGEF2[+] has visible phenotype

(Bayer et al., 2003)

E(zip)12-5^12-5, RhoGEF2^11-3/RhoGEF2[+] has visible | dominant phenotype

(Bayer et al., 2003)

E(zip)12-5^12-5, RhoGEF2^11-3/RhoGEF2[+] has visible phenotype

(Bayer et al., 2003)

E(zip)18-5^18-5, RhoGEF2^11-3/RhoGEF2[+] has visible phenotype

(Bayer et al., 2003)

E(br)444^Ebr444, RhoGEF2^11-3/RhoGEF2[+] has visible | dominant phenotype

(Ward et al., 2003)

E(br)65^Ebr65, RhoGEF2^11-3/RhoGEF2[+] has visible | dominant phenotype

(Ward et al., 2003)

E(br)444[+]/E(br)444^Ebr444, RhoGEF2^11-3 has visible phenotype

(Ward et al., 2003)

E(br)65^Ebr65/E(br)65[+], RhoGEF2^11-3 has visible phenotype

(Ward et al., 2003)

Rho1^Ebr233/Rho1[+], RhoGEF2^11-3 has visible phenotype

(Ward et al., 2003)

Rho1[+]/Rho1^Ebr246, RhoGEF2^11-3 has visible phenotype

(Ward et al., 2003)

Rho1^Ebr233, RhoGEF2^11-3/RhoGEF2[+] has visible | dominant phenotype

(Ward et al., 2003)

Rho1^Ebr246, RhoGEF2^11-3/RhoGEF2[+] has visible | dominant phenotype

(Ward et al., 2003)

Phenotype Manifest In

Other

Statement

Reference

Rho1^J3.8, RhoGEF2^11-3 has wing phenotype

(Bayer et al., 2003)

Rho1^J3.8, RhoGEF2^11-3 has leg phenotype

(Bayer et al., 2003)

RhoGEF2^11-3/RhoGEF2[+], Sb^63b has leg phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, Sb^63b has wing phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, Sb^63b has leg phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, Sb⁷⁰ has wing phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

RhoGEF2^11-3/RhoGEF2[+], Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, zip^Ebr has wing phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, zip^Ebr has leg phenotype

(Bayer et al., 2003)

RhoGEF2^11-3/RhoGEF2[+], Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

Df(2R)Jp8/+, RhoGEF2^11-3 has leg phenotype

(Bayer et al., 2003)

Rho1^E3.10/Rho1[+], RhoGEF2^11-3 has wing phenotype

(Bayer et al., 2003)

Rho1^E3.10/Rho1[+], RhoGEF2^11-3 has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], RhoGEF2^11-3 has wing phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], RhoGEF2^11-3 has leg phenotype

(Bayer et al., 2003)

Rho1^E3.10, RhoGEF2^11-3 has wing phenotype

(Bayer et al., 2003)

E(zip)12-5[+]/E(zip)12-5^12-5, RhoGEF2^11-3 has leg phenotype

(Bayer et al., 2003)

E(zip)18-5[+]/E(zip)18-5^18-5, RhoGEF2^11-3 has leg phenotype

(Bayer et al., 2003)

Rho1^12-6/Rho1[+], RhoGEF2^11-3 has leg phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, Sb^63b/Sb[+] has wing phenotype

(Bayer et al., 2003)

Rho1^E3.10, RhoGEF2^11-3 has leg phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, Sb^63b/Sb[+] has leg phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, Sb[+]/Sb⁷⁰ has wing phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, Sb[+]/Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, zip[+]/zip^Ebr has wing phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, zip[+]/zip^Ebr has leg phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

E(zip)12-5^12-5, RhoGEF2^11-3 has leg phenotype

(Bayer et al., 2003)

Rho1^12-6, RhoGEF2^11-3 has leg phenotype

(Bayer et al., 2003)

E(zip)12-5^12-5, RhoGEF2^11-3/RhoGEF2[+] has leg phenotype

(Bayer et al., 2003)

E(zip)18-5^18-5, RhoGEF2^11-3 has leg phenotype

(Bayer et al., 2003)

E(br)444^Ebr444, RhoGEF2^11-3/RhoGEF2[+] has leg phenotype

(Ward et al., 2003)

Rho1^Ebr246, RhoGEF2^11-3/RhoGEF2[+] has leg phenotype

(Ward et al., 2003)

E(br)65^Ebr65, RhoGEF2^11-3/RhoGEF2[+] has leg phenotype

(Ward et al., 2003)

E(br)444^Ebr444, RhoGEF2^11-3 has leg phenotype

(Ward et al., 2003)

E(br)65^Ebr65, RhoGEF2^11-3 has leg phenotype

(Ward et al., 2003)

Rho1^Ebr233, RhoGEF2^11-3 has leg phenotype

(Ward et al., 2003)

Rho1^Ebr246, RhoGEF2^11-3 has leg phenotype

(Ward et al., 2003)

Rho1^Ebr233, RhoGEF2^11-3/RhoGEF2[+] has leg phenotype

(Ward et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

RhoGEF2^11-3 shows a strong interaction (at least 50% of double heterozygotes have at least one malformed leg) with the following mutations: zip^Ebr, Rho1^J3.8, Df(2R)Jp8, Rho1^12-6 and Rho1^E3.10. RhoGEF2^11-3 shows a moderate interaction (25-49% of double heterozygotes have at least one malformed leg) with the following mutations: Sb^63b, Sb⁷⁰ and E(zip)12-5^12-5. RhoGEF2^11-3 shows a weak interaction (5-24% of double heterozygotes have at least one malformed leg) with the following mutations: E(zip)18-5^18-5. br¹ fails to show a significant genetic interaction (assayed in terms of a malformed leg phenotype) with RhoGEF2^11-3. RhoGEF2^11-3 shows a strong interaction (at least 50% of double heterozygotes have at least one malformed wing) with the following mutations: Rho1^E3.10, Rho1^J3.8, zip^Ebr and Sb^63b. RhoGEF2^11-3 shows a moderate interaction (25-49% of double heterozygotes have at least one malformed wing) with the following mutations: Sb⁷⁰. Sb^sbd-201/Sb^sbd-1 shows a moderate interaction (25-49% of double mutants have at least one malformed leg) with the following mutations: RhoGEF2^11-3/+.

(Bayer et al., 2003)

The fraction of flies showing a malformed leg phenotype in at least one leg, for RhoGEF2^11-3 in double heterozygous combination with one of the following alleles is - Sb^Ebr20 : 3%, Sb^Ebr48 : 3%, Sb^Ebr228 : 2%, Sb^Ebr448 : 4%, Sb^Ebr536 : 2%, Sb^Ebr623 : 0%, Rho1^Ebr233 : 62%, Rho1^Ebr246 : 63%, bs^Ebr292 : 0%, E(br)24^Ebr24 : 5%, E(br)65^Ebr65 : 28%, E(br)155^Ebr155 : 1%, E(br)165^Ebr165 : 1%, E(br)333^Ebr333 : 3%, E(br)72^Ebr72 : 3%, E(br)121^Ebr121 : 0%, E(br)160^Ebr160 : 4%, E(br)187^Ebr187 : 1%, E(br)420^Ebr420 : 6% and E(br)444^Ebr444 : 44%.

(Ward et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

RhoGEF2^1.1

(Bayer et al., 2003)

RhoGEF2^4.1

(Bayer et al., 2003)

RhoGEF2⁰⁴²⁹¹

(Bayer et al., 2003)

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

DRhoGEF2^11-3

(Bayer et al., 2003)

GEF2^11-3

(Bayer et al., 2003)

RhoGEF2^11-3

Name Synonyms

Secondary FlyBase IDs

References (2)

Report Sections

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