FlyBase Allele Report: Dmel\Sb[sbd-1]

General Information

Symbol

Dmel\Sb^sbd-1

Species

D. melanogaster

Name

FlyBase ID

FBal0015151

Feature type

allele

Associated gene

Dmel\Sb

Associated Insertion(s)

Carried in Construct

Also Known As

sbd¹

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Gotwals and Fristrom, 1991)

Mutagen

spontaneous

(Gotwals and Fristrom, 1991)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | recessive

(Spillmann and Nothiger, 1978)

visible (with Sb^sbd-201)

(Bayer et al., 2003)

visible | recessive

(Gotwals and Fristrom, 1991)

Phenotype Manifest In

leg (with Sb^sbd-201)

(Bayer et al., 2003)

Detailed Description

Statement

Reference

10% of Sb^sbd-201/Sb^sbd-1 animals have a malformed leg phenotype.

(Bayer et al., 2003)

Sb^sbd-1, Sb^sbd-2 and Sb^sbd-207 have much milder phenotypes than other 'sbd' alleles. They are viable and not malformed as homozygotes.

(Appel, 1995)

Short tapered bristles and malformed appendages. zip interacts very weakly with Sb recessive mutations.

(Gotwals and Fristrom, 1991)

Bristles short but usually slightly longer than in Sb¹/+. One or both wings often shortened and crumpled at base. Tibia and femur often shortened, thickened, and bowed. sbd genotypes interact synergistically with br genotypes to exaggerate reductions in wing length and short gnarled legs (Beaton et al., FBrf0048216). Viability somewhat low. RK2. homozygous viable

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

E(zip)31-6^31-6, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

RhoGEF2^4.1, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

Df(2R)Jp8/+, Sb^sbd-1 has visible | dominant phenotype

(Bayer et al., 2003)

Rok², Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

Sb^sbd-1/Sb^sbd-201, zip^33-1 has visible phenotype

(Bayer et al., 2003)

Df(2R)Jp1/+, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

Rho1^E3.10, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

Df(2R)Jp8/+, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

E(zip)12-5[+]/E(zip)12-5^12-5, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

E(zip)18-5[+]/E(zip)18-5^18-5, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

E(zip)31-6^31-6/E(zip)31-6[+], Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

Rho1^12-6/Rho1[+], Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

Rho1^E3.10/Rho1[+], Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

RhoGEF2⁰⁴²⁹¹/RhoGEF2[+], Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

RhoGEF2^1.1/RhoGEF2[+], Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

RhoGEF2^11-3/RhoGEF2[+], Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

RhoGEF2^4.1/RhoGEF2[+], Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

Rho1^J3.8, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

rok[+]/Rok¹, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

rok[+]/Rok², Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

Sb^sbd-1/Sb^sbd-201, zip^33-1/zip[+] has visible phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

Rok¹, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

Rho1^12-6, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

E(zip)12-5^12-5, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

E(zip)18-5^18-5, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

RhoGEF2⁰⁴²⁹¹, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

RhoGEF2^1.1, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

Phenotype Manifest In

Other

Statement

Reference

E(zip)31-6^31-6, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

RhoGEF2^4.1, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

Df(2R)Jp8/+, Sb^sbd-1 has leg phenotype

(Bayer et al., 2003)

Rok², Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

Sb^sbd-1/Sb^sbd-201, zip^33-1 has leg phenotype

(Bayer et al., 2003)

Df(2R)Jp1/+, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

Df(2R)Jp8/+, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

E(zip)12-5[+]/E(zip)12-5^12-5, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

E(zip)18-5[+]/E(zip)18-5^18-5, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

E(zip)31-6^31-6/E(zip)31-6[+], Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

Rho1^12-6/Rho1[+], Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

Rho1^E3.10, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

Rho1^E3.10/Rho1[+], Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

RhoGEF2⁰⁴²⁹¹/RhoGEF2[+], Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

RhoGEF2^1.1/RhoGEF2[+], Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

RhoGEF2^11-3/RhoGEF2[+], Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

RhoGEF2^4.1/RhoGEF2[+], Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

rok[+]/Rok¹, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

rok[+]/Rok², Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

Sb^sbd-1/Sb^sbd-201, zip^33-1/zip[+] has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

Rok¹, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

RhoGEF2^11-3, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

Rho1^12-6, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

E(zip)12-5^12-5, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

E(zip)18-5^18-5, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

RhoGEF2⁰⁴²⁹¹, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

RhoGEF2^1.1, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Sb^sbd-1 shows a weak interaction (5-24% of double heterozygotes have at least one malformed leg) with the following mutations: Df(2R)Jp8. Sb^sbd-201/Sb^sbd-2 shows a moderate interaction (25-49% of double mutants have at least one malformed leg) with the following mutations: Rho1^J3.8/+ and Rho1^E3.10/+. Sb^sbd-201/Sb^sbd-2 shows a weak interaction (5-24% of double mutants have at least one malformed leg) with the following mutations: Df(2R)Jp8/+. Pkn⁰⁶⁷³⁶ shows a weak dominant enhancement of leg malformation in Sb^sbd-201/Sb^sbd-1 flies. Pkn³ shows a weak dominant enhancement of leg malformation in Sb^sbd-201/Sb^sbd-1 flies. Sb^sbd-201/Sb^sbd-1 shows a strong interaction (at least 50% of double mutants have at least one malformed leg) with the following mutations: Rho1^J3.8/+, Rho1^E3.10/+, Df(2R)Jp8/+, Df(2R)Jp1/+, Rho1^12-6/+. Sb^sbd-201/Sb^sbd-1 shows a moderate interaction (25-49% of double mutants have at least one malformed leg) with the following mutations: E(zip)18-5^18-5/+, E(zip)31-6^31-6/+, zip^33-1/+, RhoGEF2^11-3/+. Sb^sbd-201/Sb^sbd-1 shows a weak interaction (5-24% of double mutants have at least one malformed leg) with the following mutations: RhoGEF2^1.1/+, RhoGEF2^4.1/+, RhoGEF2⁰⁴²⁹¹/+, rok¹/+, rok²/+ and E(zip)12-5^12-5/+.