FlyBase Allele Report: Dmel\Rok[1]

General Information

Symbol

Dmel\Rok¹

Species

D. melanogaster

Name

FlyBase ID

FBal0122919

Feature type

allele

Associated gene

Dmel\Rok

Associated Insertion(s)

Carried in Construct

Also Known As

Drok¹

Key Links

Allele class

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

Mutagen

ethyl methanesulfonate

(Winter et al., 2001)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal planar polarity

(Simões et al., 2010)

female sterile | germline clone

(Verdier et al., 2006)

lethal | recessive

(Winter et al., 2001)

Phenotype Manifest In

dorsal appendage | germline clone

(Verdier et al., 2006)

egg | germline clone

(Verdier et al., 2006)

filamentous actin & nurse cell | germ-line clone

(Verdier et al., 2006)

filamentous actin & oocyte | germ-line clone

(Verdier et al., 2006)

plasma membrane & oocyte | germ-line clone

(Verdier et al., 2006)

Detailed Description

Statement

Reference

baz and arm planar polarity is strongly defective in rok¹ mutants.

(Simões et al., 2010)

Females carrying rok² germline clones (GLCs) produce eggs that are small in 58% of cases and exhibit fused dorsal appendages in 100% of cases. Oocytes within these clones exhibit actin clumps in the ooplasm (75% penetrance) and an altered plasma membrane (62% penetrance). Additionally, the F-actin network is perturbed in nurse cells in 72% of rok¹ GLCs.

(Verdier et al., 2006)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

rok[+]/Rok¹ is an enhancer of visible | dominant phenotype of Sb⁷⁰

(Chen et al., 2004)

rok[+]/Rok¹ is an enhancer of visible | dominant phenotype of Sb^63b

(Chen et al., 2004)

NOT Enhancer of

Statement

Reference

rok[+]/Rok¹ is a non-enhancer of visible phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

Suppressor of

Statement

Reference

Rok[+]/Rok¹ is a suppressor | partially of decreased size | adult stage phenotype of Scer\GAL4^A9, Shrm^A.UAS

(Hildebrand et al., 2021)

Rok[+]/Rok¹ is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^A9, Shrm^A.UAS

(Hildebrand et al., 2021)

Rok¹ is a suppressor of visible phenotype of H^UAS.cMa, Scer\GAL4^GMR.PF

(Müller et al., 2005)

rok[+]/Rok¹ is a suppressor of visible phenotype of LIMK1^UAS.cCa, Scer\GAL4^en-e16E

(Chen et al., 2004)

Rok¹ is a suppressor of abnormal cell polarity phenotype of pk^pk.sev

(Jenny et al., 2003)

Rok¹ is a suppressor of lethal | recessive | larval stage phenotype of Moe^G0323

(Speck et al., 2003)

NOT Suppressor of

Statement

Reference

rok[+]/Rok¹ is a non-suppressor of visible phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

Other

Statement

Reference

Rok¹, sqh^EE.EGFP has abnormal cell migration phenotype

(Vasquez et al., 2014)

rok[+]/Rok¹, zip^Ebr has visible phenotype

(Bayer et al., 2003)

rok[+]/Rok¹, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], Rok¹ has visible | dominant phenotype

(Bayer et al., 2003)

Rho1^E3.10, rok[+]/Rok¹ has visible phenotype

(Bayer et al., 2003)

Rok¹, Sb[+]/Sb⁷⁰ has visible | dominant phenotype

(Bayer et al., 2003)

Rok¹, Sb[+]/Sb⁷⁰ has visible phenotype

(Bayer et al., 2003)

Rok¹, zip[+]/zip^Ebr has visible | dominant phenotype

(Bayer et al., 2003)

Df(3R)sbd105/+, Rok¹ has visible | dominant phenotype

(Bayer et al., 2003)

Rho1^12-6/Rho1[+], Rok¹ has visible phenotype

(Bayer et al., 2003)

Rho1^J3.8, rok[+]/Rok¹ has visible phenotype

(Bayer et al., 2003)

Rok¹, Sb^63b/Sb[+] has visible phenotype

(Bayer et al., 2003)

Rok¹, Sb^sbd-1/Sb^sbd-201 has visible phenotype

(Bayer et al., 2003)

Rho1^E3.10/Rho1[+], Rok¹ has visible | dominant phenotype

(Bayer et al., 2003)

Rho1^12-6, rok[+]/Rok¹ has visible | dominant phenotype

(Bayer et al., 2003)

Rho1^E3.10/Rho1[+], Rok¹ has partially lethal phenotype

(Bayer et al., 2003)

rok[+]/Rok¹, Sb^63b has visible | dominant phenotype

(Bayer et al., 2003)

rok[+]/Rok¹, Sb⁷⁰ has visible | dominant phenotype

(Bayer et al., 2003)

rok[+]/Rok¹, Sb⁷⁰ has visible phenotype

(Bayer et al., 2003)

Phenotype Manifest In

Enhancer of

Statement

Reference

Rok[+]/Rok¹ is an enhancer of wing hair | increased number phenotype of Scer\GAL4^en.PU, cmb^{UAS.RA.Tag:FLAG}

(Fagan et al., 2014)

rok[+]/Rok¹ is an enhancer of leg phenotype of Sb⁷⁰

(Chen et al., 2004)

rok[+]/Rok¹ is an enhancer of leg phenotype of Sb^63b

(Chen et al., 2004)

NOT Enhancer of

Statement

Reference

rok[+]/Rok¹ is a non-enhancer of wing hair phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

Suppressor of

Statement

Reference

Rok[+]/Rok¹ is a suppressor | partially of wing phenotype of Scer\GAL4^A9, Shrm^A.UAS

(Hildebrand et al., 2021)

Rok¹ is a suppressor of eye phenotype of H^UAS.cMa, Scer\GAL4^GMR.PF

(Müller et al., 2005)

rok[+]/Rok¹ is a suppressor of wing phenotype of LIMK1^UAS.cCa, Scer\GAL4^en-e16E

(Chen et al., 2004)

Rok¹ is a suppressor of ommatidium phenotype of pk^pk.sev

(Jenny et al., 2003)

NOT Suppressor of

Statement

Reference

rok[+]/Rok¹ is a non-suppressor of wing hair phenotype of Scer\GAL4^en-e16E, kermit^GS2053

(Djiane and Mlodzik, 2010)

Other

Statement

Reference

Rok¹, sqh^EE.EGFP has embryo | gastrula stage phenotype

(Vasquez et al., 2014)

Rho1^E3.10, Rok¹ has wing phenotype

(Bayer et al., 2003)

Rho1^E3.10, Rok¹ has leg phenotype

(Bayer et al., 2003)

rok[+]/Rok¹, Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

Rok¹, Sb⁷⁰ has wing phenotype

(Bayer et al., 2003)

Rok¹, zip^Ebr has wing phenotype

(Bayer et al., 2003)

Rok¹, zip^Ebr has leg phenotype

(Bayer et al., 2003)

rok[+]/Rok¹, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

Rok¹, Sb^63b has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], Rok¹ has leg phenotype

(Bayer et al., 2003)

Rok¹, Sb[+]/Sb⁷⁰ has wing phenotype

(Bayer et al., 2003)

Rok¹, zip[+]/zip^Ebr has wing phenotype

(Bayer et al., 2003)

Rok¹, zip[+]/zip^Ebr has leg phenotype

(Bayer et al., 2003)

Df(3R)sbd105/+, Rok¹ has leg phenotype

(Bayer et al., 2003)

Rok¹, Sb^63b/Sb[+] has wing phenotype

(Bayer et al., 2003)

Rok¹, Sb^sbd-1/Sb^sbd-201 has leg phenotype

(Bayer et al., 2003)

Rho1^12-6, Rok¹ has leg phenotype

(Bayer et al., 2003)

Rok¹, Sb⁷⁰ has leg phenotype

(Bayer et al., 2003)

Rho1^E3.10/Rho1[+], Rok¹ has wing phenotype

(Bayer et al., 2003)

Rho1^E3.10/Rho1[+], Rok¹ has leg phenotype

(Bayer et al., 2003)

Rho1^12-6, rok[+]/Rok¹ has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8, Rok¹ has leg phenotype

(Bayer et al., 2003)

rok[+]/Rok¹, Sb^63b has leg phenotype

(Bayer et al., 2003)

Rok¹, Sb^63b has wing phenotype

(Bayer et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygosity significantly enhances the multiple hair cell phenotype of Scer\GAL4^en.PU cmb^Scer\UAS.RA wings.

(Fagan et al., 2014)

Embryos expressing sqh^{EE.T:Avic\GFP-EGFP} in a Rok¹ mutant background fail to undergo mesoderm invagination.

(Vasquez et al., 2014)

rok¹/+ suppresses the mutant wing phenotype caused by expression of LIMK1^Scer\UAS.cCa under the control of Scer\GAL4^en-e16E (the % of wings with normal morphology at 18^oC is increased from 9% to 64%). The frequency of the malformed leg phenotype seen in Sb^63b/+ heterozygotes (8%) is increased if the flies are also heterozygous for rok¹ (24%). The frequency of the malformed leg phenotype seen in Sb⁷⁰/+ heterozygotes (7%) is increased if the flies are also heterozygous for rok¹ (94%).

(Chen et al., 2004)

rok¹ shows a strong interaction (at least 50% of double heterozygotes have at least one malformed leg) with the following mutations: Sb⁷⁰. rok¹ shows a weak interaction (5-24% of double heterozygotes have at least one malformed leg) with the following mutations: Sb^63b, Df(3R)sbd105 and Rho1^12-6. rok¹ shows a strong interaction (at least 50% of double heterozygotes have at least one malformed wing) with the following mutations: Rho1^E3.10 and zip^Ebr. rok¹ shows a moderate interaction (25-49% of double heterozygotes have at least one malformed wing) with the following mutations: Sb⁷⁰. rok¹ shows a weak interaction (5-24% of double heterozygotes have at least one malformed wing) with the following mutations: Sb^63b. Sb^sbd-201/Sb^sbd-1 shows a weak interaction (5-24% of double mutants have at least one malformed leg) with the following mutations: rok¹/+.

(Bayer et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Rok²

(Winter et al., 2001)

Rescued by

Rok¹ is rescued by Rok^αTub84B.PW

(Winter et al., 2001)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

6665

w^* Rok¹/FM7i, P{ActGFP}JMR3

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (5)

Reported As

Symbol Synonym

Drok¹

(Marchetti et al., 2014, Simões et al., 2010, Todi et al., 2008, Verdier et al., 2006, Chen et al., 2004, Speck et al., 2003, Winter et al., 2001)

ROK[1]

(Qin et al., 2017)

Rok¹

(Hildebrand et al., 2021, Simões et al., 2014)

drok¹

(Bayer et al., 2003, Jenny et al., 2003)

rok¹

(Fagan et al., 2014, Vasquez et al., 2014, Djiane and Mlodzik, 2010, Popodi et al., 2010-)

Name Synonyms

Secondary FlyBase IDs

References (18)

Report Sections

Open Close