FlyBase Allele Report: Dmel\Sb[sbd-2]

General Information

Symbol

Dmel\Sb^sbd-2

Species

D. melanogaster

Name

FlyBase ID

FBal0015152

Feature type

allele

Associated gene

Dmel\Sb

Associated Insertion(s)

Carried in Construct

Also Known As

sbd²

Key Links

Allele class

hypomorphic allele - genetic evidence

Mutagen

spontaneous

Nature of the Allele

Allele class

hypomorphic allele - genetic evidence

(Hammonds and Fristrom, 2006)

Mutagen

spontaneous

Progenitor genotype

Cytology

Description

The intron between exons 6 and 7 also contains a 7bp tandem repeat (that is also present in Sb^Spi).

(Hammonds and Fristrom, 2006)

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

visible

(Dickinson and Thatcher, 1997)

Phenotype Manifest In

ventral denticle belt

(Dickinson and Thatcher, 1997)

Detailed Description

Statement

Reference

Sb^sbd-201 does not enhance the bristle phenotype of the Sb^sbd-2 allele.

(Hammonds and Fristrom, 2006)

1% of Sb^sbd-201/Sb^sbd-2 animals have a malformed leg phenotype.

(Bayer et al., 2003)

Heterozygotes have denticles that are smaller, thinner and more variable in size and shape than those in wild type. Hairs appear normal.

(Dickinson and Thatcher, 1997)

Sb^sbd-1, Sb^sbd-2 and Sb^sbd-207 have much milder phenotypes than other 'sbd' alleles. They are viable and not malformed as homozygotes.

(Appel, 1995)

Sb¹/Sb^sbd-2 are more extreme than Sb¹/+. Sb^sbd-2, Sb¹ behaves as a recessive 'sbd' allele but is homozygous lethal; rare escapers more extreme and easy to recognize.

(Davis, 1971)

homozygous viable Most bristles about three-fourths normal length although some (i.e., posterior postalars) are shorter. Less extreme than Sb^sbd-1. Sb^sbd-2/Sb¹ has shorter bristles than homozygous Sb^sbd-2 or Sb¹/+. Sb^sbd-2 Sb¹/+ + has wild-type bristles (Lewis, 1951). RK1.

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Other

Statement

Reference

Rho1^E3.10, Sb^sbd-201/Sb^sbd-2 has visible phenotype

(Bayer et al., 2003)

Rho1^J3.8, Sb^sbd-201/Sb^sbd-2 has visible phenotype

(Bayer et al., 2003)

Df(2R)Jp8/+, Sb^sbd-201/Sb^sbd-2 has visible phenotype

(Bayer et al., 2003)

Rho1^E3.10/Rho1[+], Sb^sbd-201/Sb^sbd-2 has visible phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], Sb^sbd-201/Sb^sbd-2 has visible phenotype

(Bayer et al., 2003)

Phenotype Manifest In

NOT suppressed by

Statement

Reference

Sb^sbd-2 has phenotype, non-suppressible by su(Hw)²

(Lindsley and Grell, 1968)

Other

Statement

Reference

Rho1^E3.10, Sb^sbd-201/Sb^sbd-2 has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8, Sb^sbd-201/Sb^sbd-2 has leg phenotype

(Bayer et al., 2003)

Df(2R)Jp8/+, Sb^sbd-201/Sb^sbd-2 has leg phenotype

(Bayer et al., 2003)

Rho1^E3.10/Rho1[+], Sb^sbd-201/Sb^sbd-2 has leg phenotype

(Bayer et al., 2003)

Rho1^J3.8/Rho1[+], Sb^sbd-201/Sb^sbd-2 has leg phenotype

(Bayer et al., 2003)

Additional Comments

Genetic Interactions

Statement

Reference

Sb^sbd-201/Sb^sbd-2 shows a moderate interaction (25-49% of double mutants have at least one malformed leg) with the following mutations: Rho1^J3.8/+ and Rho1^E3.10/+. Sb^sbd-201/Sb^sbd-2 shows a weak interaction (5-24% of double mutants have at least one malformed leg) with the following mutations: Df(2R)Jp8/+.

(Bayer et al., 2003)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

Sb^sbd-2 is rescued by Sb^hs.PB

(Hammonds and Fristrom, 2006)

Not rescued by

Sb^sbd-2 is not rescued by Sb^S737A.hs

(Hammonds and Fristrom, 2006)

Comments

Images (0)

Mutant

Wild-type

Stocks (62)

Bloomington

589

Sb^sbd-2

4507

Df(3L)iro-2, Sb^sbd-2/TM3, Sb¹

3457

Sb^sbd-2 Ubx^bx-3 Ubx^pbx-1/TM1

2251

Tp(3;2)Antp^Ctx, Antp^Ctx Sb^sbd-2/TM1

983

v^71P; red¹ su(Hw)² Sb^sbd-2/TM1

3485

Df(3R)red-P52, Sb^sbd-2 Ubx^bx-3 Ubx^pbx-1/TM1

Kyoto

107769

Df(3L)iro-2, Sb^sbd-2/TM3, Sb¹

103294

Df(3L)iro-2, Sb^sbd-2 / TM3, Sb¹

106155

v^71P; red¹ su(Hw)² Sb^sbd-2/TM1

106317

ru¹ hry¹ hid¹ Sb^sbd-2 Tb¹

107061

Df(3R)red-P52, Sb^sbd-2 Ubx^bx-3 Ubx^pbx-1/TM1

107428

Df(3L)W10, ru¹ hry¹ Sb^sbd-2/TM6B, Tb¹

More stocks available...

Notes on Origin

Discoverer

Harnly, Dec. 1927.

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Sb^r2

Sb^sbd-2

sbd²

(Hammonds and Fristrom, 2006, Bayer et al., 2003, Lewis, 1998, Dickinson and Thatcher, 1997, Appel, 1995, Nelson and Szauter, 1992, Hannah-Alava, 1991)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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