FlyBase Allele Report: Dmel\Pc[4]

General Information

Symbol

Dmel\Pc⁴

Species

D. melanogaster

Name

FlyBase ID

FBal0013554

Feature type

allele

Associated gene

Dmel\Pc

Associated Insertion(s)

Carried in Construct

Also Known As

Pc^R1

Key Links

Allele class

loss of function allele

Mutagen

gamma ray

Nature of the Allele

Allele class

loss of function allele

(Cheng et al., 1994)

Mutagen

gamma ray

(Tiong and Russell, 1990)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

abdominal segment

(Milne et al., 1999)

anaphase | embryonic stage

(O'Dor et al., 2006)

leg

(Huang et al., 2002)

mesothoracic leg

(Gutierrez et al., 2003, Kehle et al., 1998, Brizuela and Kennison, 1997, Harding et al., 1995, Tiong and Russell, 1990)

mesothoracic leg & sex comb | ectopic

(Zorin et al., 1999)

mesothoracic leg & sex comb tooth | ectopic

(Ragab, 2006)

metathoracic leg

(Gutierrez et al., 2003, Kehle et al., 1998, Brizuela and Kennison, 1997, Harding et al., 1995, Tiong and Russell, 1990)

metathoracic leg & sex comb | ectopic

(Zorin et al., 1999)

metathoracic leg & sex comb tooth | ectopic

(Ragab, 2006)

sex comb

(Milne et al., 1999, Kehle et al., 1998)

sex comb (with Df(3R)ry27)

(Wang and Brock, 2003)

sex comb (with Df(3R)ry619)

(Wang and Brock, 2003)

sex comb | ectopic

(Gutierrez et al., 2003, Huang et al., 2002, Chang et al., 2001, Schulze et al., 2001, Zorin et al., 1999)

sex comb | increased number

(Brown and Kassis, 2010)

telophase | embryonic stage

(O'Dor et al., 2006)

wing

(Tiong and Russell, 1990)

Detailed Description

Statement

Reference

Pc⁴ embryos from hetrozygous mothers show segregation defects in anaphase and telophase as judged by the presence of chromatin bridges. Most of these chromatin bridges are probably resolved because large irregularly-shaped nuclei and polyploid nuclei are only seen at a low penetrance. Pc⁴ embryos also show a higher level of "nuclear fallout", a process that removes nuclei with abnormal mitoses, than wild-type embryos. Fallout nuclei tend to be observed in pairs or clusters and have a late telophase appearance. There is no evidence of metaphase defects in these embryos.

(O'Dor et al., 2006)

Pc⁴ males have ectopic sex combs on the second and third leg.

(Ragab, 2006)

93% of heterozygous males have sex comb teeth on the second and/or third leg. Expressivity of the phenotype is 14%.

(Gutierrez et al., 2003)

Pc⁴/+ heterozygotes exhibit a wild-type number of sex combs, with 2 legs exhibiting sex combs.

Pc⁴/Df(3R)ry27 mutant flies exhibit a higher than wild-type average number of legs with sex combs, with a statistically significant average of 2.7 legs with sex combs, compared to 2.1 in Pc⁴/+ heterozygotes.

Pc⁴/Df(3R)ry619 mutant flies exhibit a higher than wild-type average number of legs with sex combs, with a statistically significant average of 2.9 legs with sex combs, compared to 2.3 in Pc⁴/Tp(3;3)MRS heterozygotes.

(Wang and Brock, 2003)

Heterozygous males have ectopic sex combs on the second and third legs.

(Huang et al., 2002)

An average of about 1 ectopic sex comb teeth are seen per leg in Pc⁴ mutant animals.

(Chang et al., 2001)

Approximately 57% of heterozygous males have ectopic sex combs on the second and/or third legs, indicating a transformation towards first leg.

(Zorin et al., 1999)

The extra sex combs phenotype of Pc⁴ is dominantly enhanced by E(Pc)¹ and E(Pc)². The extra sex combs phenotype is also very weakly enhanced by E(Pc)^rv4, E(Pc)^rv9 and E(Pc)^rv10.

(Sinclair et al., 1998)

Heterozygous adults have sex comb teeth on the second and third legs. The penetrance of this phenotype is 100% and the expressivity is 25%.

(Brizuela and Kennison, 1997)

Mutation has no effect on the hh^Mrt wing phenotype.

(Felsenfeld and Kennison, 1995)

Partial transformation of T2 and T3 legs toward T1.

(Harding et al., 1995)

Embryonic lethal or semi-lethal when heterozygous with ph-d². Unhatched larvae carry segmentation defects or polarity defects.

(McKeon et al., 1994)

Heterozygous adults show transformations of 3rd and 2nd leg to 1st leg, wing to haltere, and ventral wing margin to dorsal wing margin.

(Tiong and Russell, 1990)

Haplo-abnormal phenotype is suppressed by a duplication carrying Pc.

(Kennison and Russell, 1987)

partial transformations of second and third legs into first legs in Pc/+ heterozygotes

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Pc⁴ has visible | dominant phenotype, enhanceable by psq[+]/psq⁰¹¹⁵

(Huang et al., 2002)

Pc⁴ has visible | dominant phenotype, enhanceable by psq[+]/psq⁰²⁴⁰³

(Huang et al., 2002)

Pc⁴ has visible | dominant phenotype, enhanceable by psq⁸¹⁰⁹/psq[+]

(Huang et al., 2002)

Pc⁴ has visible | dominant phenotype, enhanceable by psq^Δ18/psq[+]

(Huang et al., 2002)

Pc⁴ has visible | dominant phenotype, enhanceable by psq[+]/psq^F112

(Huang et al., 2002)

Pc⁴ has visible | dominant phenotype, enhanceable by psq[+]/psq^E34

(Huang et al., 2002)

Pc⁴ has visible | dominant phenotype, enhanceable by psq^E39/psq[+]

(Huang et al., 2002)

Pc⁴ has visible | dominant | homeotic phenotype, enhanceable by Mi-2^K1/Mi-2[+]

(Kehle et al., 1998)

Pc⁴ has visible | dominant | homeotic phenotype, enhanceable by Mi-2¹/Mi-2[+]

(Kehle et al., 1998)

Pc⁴ has visible | dominant | homeotic phenotype, enhanceable by Mi-2[+]/Mi-2^j3D4

(Kehle et al., 1998)

Pc⁴ has visible | dominant | homeotic phenotype, enhanceable by Mi-2⁴/Mi-2[+]

(Kehle et al., 1998)

Pc⁴ has visible | dominant | homeotic phenotype, enhanceable by Mi-2⁵/Mi-2[+]

(Kehle et al., 1998)

Pc⁴ has visible | dominant | homeotic phenotype, enhanceable by Mi-2[+]/Mi-2⁶

(Kehle et al., 1998)

Pc⁴ has visible | dominant | homeotic phenotype, enhanceable by Mi-2⁷/Mi-2[+]

(Kehle et al., 1998)

Pc⁴ has visible | dominant | homeotic phenotype, enhanceable by Mi-2⁸/Mi-2[+]

(Kehle et al., 1998)

Pc⁴ has visible | dominant | homeotic phenotype, enhanceable by Mi-2⁹/Mi-2[+]

(Kehle et al., 1998)

Pc⁴ has visible | dominant | homeotic phenotype, enhanceable by Pcl¹⁰/Pcl[+]

(Kehle et al., 1998)

Pc⁴ has visible | dominant phenotype, enhanceable by E(Pc)¹

(Sinclair et al., 1998)

Pc⁴ has visible | dominant phenotype, enhanceable by E(Pc)²

(Sinclair et al., 1998)

Pc⁴ has visible | dominant phenotype, enhanceable by E(Pc)^rv4

(Sinclair et al., 1998)

Pc⁴ has visible | dominant phenotype, enhanceable by E(Pc)^rv9

(Sinclair et al., 1998)

Pc⁴ has visible | dominant phenotype, enhanceable by E(Pc)^rv10

(Sinclair et al., 1998)

Suppressed by

Statement

Reference

Pc⁴ has visible | dominant phenotype, suppressible by tna¹

(Gutierrez et al., 2003)

Pc⁴ has visible phenotype, suppressible by l(3)80Fj^2-30

(Schulze et al., 2001)

Pc⁴ has visible phenotype, suppressible by vtd¹⁰

(Schulze et al., 2001)

Pc⁴ has visible phenotype, suppressible by vtd³

(Schulze et al., 2001)

Pc⁴ has visible phenotype, suppressible by vtd⁴

(Schulze et al., 2001)

Pc⁴ has visible phenotype, suppressible by vtd⁷

(Schulze et al., 2001)

Pc⁴ has visible phenotype, suppressible by vtd⁸

(Schulze et al., 2001)

Pc⁴ has visible phenotype, suppressible by vtd⁹

(Schulze et al., 2001)

Pc⁴ has visible phenotype, suppressible by vtd²

(Schulze et al., 2001)

Pc⁴ has visible | dominant | homeotic phenotype, suppressible by lawc^p1

(Zorin et al., 1999)

Pc⁴ has visible | dominant | adult stage phenotype, suppressible by mor⁴

(Brizuela and Kennison, 1997)

Pc⁴ has visible | dominant | homeotic phenotype, suppressible by mor¹

(Brizuela and Kennison, 1997)

Pc⁴ has visible | dominant | adult stage phenotype, suppressible by mor¹

(Brizuela and Kennison, 1997)

Pc⁴ has visible | dominant | homeotic phenotype, suppressible by mor²

(Brizuela and Kennison, 1997)

Pc⁴ has visible | dominant | adult stage phenotype, suppressible by mor²

(Brizuela and Kennison, 1997)

Pc⁴ has visible | dominant | homeotic phenotype, suppressible by mor⁴

(Brizuela and Kennison, 1997)

NOT suppressed by

Statement

Reference

Pc⁴ has visible phenotype, non-suppressible by vtd¹¹

(Schulze et al., 2001)

Pc⁴ has visible phenotype, non-suppressible by vtd¹²

(Schulze et al., 2001)

Suppressor of

Statement

Reference

Pc[+]/Pc⁴ is a suppressor | partially of visible | adult stage phenotype of eya^cs/eya¹

(Tian et al., 2019)

Pc[+]/Pc⁴ is a suppressor | partially of abnormal size | adult stage phenotype of eya^cs/eya¹

(Tian et al., 2019)

NOT Suppressor of

Statement

Reference

Pc⁴ is a non-suppressor of lethal phenotype of Ras85D^V12.sev, sev^S11.Tag:MYC

(Maixner et al., 1998)

Phenotype Manifest In

Enhanced by

Statement

Reference

Pc⁴ has sex comb phenotype, enhanceable by Hsc70-4¹⁹⁵/Hsc70-4[+]

(Wang and Brock, 2003)

Pc⁴ has leg phenotype, enhanceable by psq[+]/psq⁰¹¹⁵

(Huang et al., 2002)

Pc⁴ has sex comb | ectopic phenotype, enhanceable by psq[+]/psq⁰¹¹⁵

(Huang et al., 2002)

Pc⁴ has leg phenotype, enhanceable by psq[+]/psq⁰²⁴⁰³

(Huang et al., 2002)

Pc⁴ has sex comb | ectopic phenotype, enhanceable by psq[+]/psq⁰²⁴⁰³

(Huang et al., 2002)

Pc⁴ has leg phenotype, enhanceable by psq⁸¹⁰⁹/psq[+]

(Huang et al., 2002)

Pc⁴ has sex comb | ectopic phenotype, enhanceable by psq⁸¹⁰⁹/psq[+]

(Huang et al., 2002)

Pc⁴ has leg phenotype, enhanceable by psq^Δ18/psq[+]

(Huang et al., 2002)

Pc⁴ has sex comb | ectopic phenotype, enhanceable by psq^Δ18/psq[+]

(Huang et al., 2002)

Pc⁴ has leg phenotype, enhanceable by psq[+]/psq^F112

(Huang et al., 2002)

Pc⁴ has sex comb | ectopic phenotype, enhanceable by psq[+]/psq^F112

(Huang et al., 2002)

Pc⁴ has leg phenotype, enhanceable by psq[+]/psq^E34

(Huang et al., 2002)

Pc⁴ has sex comb | ectopic phenotype, enhanceable by psq[+]/psq^E34

(Huang et al., 2002)

Pc⁴ has leg phenotype, enhanceable by psq^E39/psq[+]

(Huang et al., 2002)

Pc⁴ has sex comb | ectopic phenotype, enhanceable by psq^E39/psq[+]

(Huang et al., 2002)

Pc⁴ has sex comb phenotype, enhanceable by Df(3L)10^H

(Chang et al., 2001)

Pc⁴ has sex comb phenotype, enhanceable by HDAC1⁰⁴⁵⁵⁶

(Chang et al., 2001)

Pc⁴ has sex comb phenotype, enhanceable by HDAC1³⁰³

(Chang et al., 2001)

Pc⁴ has sex comb phenotype, enhanceable by HDAC1³¹³

(Chang et al., 2001)

Pc⁴ has sex comb phenotype, enhanceable by HDAC1^def8

(Chang et al., 2001)

Pc⁴ has sex comb phenotype, enhanceable by Asx³

(Milne et al., 1999)

Pc⁴ has sex comb phenotype, enhanceable by Asx⁸

(Milne et al., 1999)

Pc⁴ has sex comb phenotype, enhanceable by Asx⁹

(Milne et al., 1999)

Pc⁴ has abdominal segment phenotype, enhanceable by Asx^P1

(Milne et al., 1999)

Pc⁴ has sex comb phenotype, enhanceable by Asx^P1

(Milne et al., 1999)

Pc⁴ has phenotype, enhanceable by Df(2R)trix/+

(Milne et al., 1999)

Pc⁴ has sex comb phenotype, enhanceable by Asx¹³

(Milne et al., 1999)

Pc⁴ has sex comb phenotype, enhanceable by Asx¹

(Milne et al., 1999)

Pc⁴ has abdominal segment phenotype, enhanceable by Asx³

(Milne et al., 1999)

Pc⁴ has mesothoracic leg phenotype, enhanceable by Mi-2^K1/Mi-2[+]

(Kehle et al., 1998)

Pc⁴ has metathoracic leg phenotype, enhanceable by Mi-2^K1/Mi-2[+]

(Kehle et al., 1998)

Pc⁴ has sex comb | ectopic phenotype, enhanceable by Mi-2^K1/Mi-2[+]

(Kehle et al., 1998)

Pc⁴ has mesothoracic leg phenotype, enhanceable by Mi-2¹/Mi-2[+]

(Kehle et al., 1998)

Pc⁴ has metathoracic leg phenotype, enhanceable by Mi-2¹/Mi-2[+]

(Kehle et al., 1998)

Pc⁴ has sex comb | ectopic phenotype, enhanceable by Mi-2¹/Mi-2[+]

(Kehle et al., 1998)

Pc⁴ has mesothoracic leg phenotype, enhanceable by Mi-2[+]/Mi-2^j3D4

(Kehle et al., 1998)

Pc⁴ has metathoracic leg phenotype, enhanceable by Mi-2[+]/Mi-2^j3D4

(Kehle et al., 1998)

Pc⁴ has sex comb | ectopic phenotype, enhanceable by Mi-2[+]/Mi-2^j3D4

(Kehle et al., 1998)

Pc⁴ has mesothoracic leg phenotype, enhanceable by Mi-2⁴/Mi-2[+]

(Kehle et al., 1998)

Pc⁴ has metathoracic leg phenotype, enhanceable by Mi-2⁴/Mi-2[+]

(Kehle et al., 1998)

Pc⁴ has sex comb | ectopic phenotype, enhanceable by Mi-2⁴/Mi-2[+]

(Kehle et al., 1998)

Pc⁴ has mesothoracic leg phenotype, enhanceable by Mi-2⁵/Mi-2[+]

(Kehle et al., 1998)

Pc⁴ has metathoracic leg phenotype, enhanceable by Mi-2⁵/Mi-2[+]

(Kehle et al., 1998)

Pc⁴ has sex comb | ectopic phenotype, enhanceable by Mi-2⁵/Mi-2[+]

(Kehle et al., 1998)

Pc⁴ has mesothoracic leg phenotype, enhanceable by Mi-2[+]/Mi-2⁶

(Kehle et al., 1998)

Pc⁴ has metathoracic leg phenotype, enhanceable by Mi-2[+]/Mi-2⁶

(Kehle et al., 1998)

Pc⁴ has sex comb | ectopic phenotype, enhanceable by Mi-2[+]/Mi-2⁶

(Kehle et al., 1998)

Pc⁴ has mesothoracic leg phenotype, enhanceable by Mi-2⁷/Mi-2[+]

(Kehle et al., 1998)

Pc⁴ has metathoracic leg phenotype, enhanceable by Mi-2⁷/Mi-2[+]

(Kehle et al., 1998)

Pc⁴ has sex comb | ectopic phenotype, enhanceable by Mi-2⁷/Mi-2[+]

(Kehle et al., 1998)

Pc⁴ has mesothoracic leg phenotype, enhanceable by Mi-2⁸/Mi-2[+]

(Kehle et al., 1998)

Pc⁴ has metathoracic leg phenotype, enhanceable by Mi-2⁸/Mi-2[+]

(Kehle et al., 1998)

Pc⁴ has sex comb | ectopic phenotype, enhanceable by Mi-2⁸/Mi-2[+]

(Kehle et al., 1998)

Pc⁴ has mesothoracic leg phenotype, enhanceable by Mi-2⁹/Mi-2[+]

(Kehle et al., 1998)

Pc⁴ has metathoracic leg phenotype, enhanceable by Mi-2⁹/Mi-2[+]

(Kehle et al., 1998)

Pc⁴ has sex comb | ectopic phenotype, enhanceable by Mi-2⁹/Mi-2[+]

(Kehle et al., 1998)

Pc⁴ has mesothoracic leg phenotype, enhanceable by Pcl¹⁰/Pcl[+]

(Kehle et al., 1998)

Pc⁴ has metathoracic leg phenotype, enhanceable by Pcl¹⁰/Pcl[+]

(Kehle et al., 1998)

Pc⁴ has sex comb | ectopic phenotype, enhanceable by Pcl¹⁰/Pcl[+]

(Kehle et al., 1998)

Pc⁴ has leg phenotype, enhanceable by E(Pc)¹

(Sinclair et al., 1998)

Pc⁴ has leg phenotype, enhanceable by E(Pc)²

(Sinclair et al., 1998)

Pc⁴ has leg phenotype, enhanceable by E(Pc)^rv4

(Sinclair et al., 1998)

Pc⁴ has leg phenotype, enhanceable by E(Pc)^rv9

(Sinclair et al., 1998)

Pc⁴ has leg phenotype, enhanceable by E(Pc)^rv10

(Sinclair et al., 1998)

Pc⁴ has sex comb | ectopic phenotype, enhanceable by E(Pc)[+]/E(Pc)¹

(Sinclair et al., 1998)

Pc⁴ has sex comb | ectopic phenotype, enhanceable by E(Pc)[+]/E(Pc)²

(Sinclair et al., 1998)

Pc⁴ has sex comb | ectopic phenotype, enhanceable by E(Pc)[+]/E(Pc)^rv4

(Sinclair et al., 1998)

Pc⁴ has sex comb | ectopic phenotype, enhanceable by E(Pc)[+]/E(Pc)^rv9

(Sinclair et al., 1998)

Pc⁴ has sex comb | ectopic phenotype, enhanceable by E(Pc)^rv10/E(Pc)[+]

(Sinclair et al., 1998)

Pc⁴ has phenotype, enhanceable by Pcl¹⁸

(Kennison and Tamkun, 1988)

NOT Enhanced by

Statement

Reference

Pc⁴ has sex comb | increased number phenotype, non-enhanceable by Spps¹/Spps¹

(Brown and Kassis, 2010)

Pc⁴ has mesothoracic leg phenotype, non-enhanceable by Deaf1^S10B

(Veraksa et al., 2002)

Pc⁴ has sex comb | ectopic phenotype, non-enhanceable by Deaf1^S10B

(Veraksa et al., 2002)

Pc⁴ has mesothoracic leg phenotype, non-enhanceable by Deaf1^k3

(Veraksa et al., 2002)

Pc⁴ has sex comb | ectopic phenotype, non-enhanceable by Deaf1^k3

(Veraksa et al., 2002)

Suppressed by

Statement

Reference

Pc⁴ has sex comb phenotype, suppressible by vtd⁴

(Strübbe et al., 2011)

Pc⁴ has sex comb phenotype, suppressible by vtd^ex3

(Strübbe et al., 2011)

Pc⁴ has phenotype, suppressible by Nipped-B²⁹/Nipped-B[+]

(Hallson et al., 2008)

Pc⁴ has mesothoracic leg phenotype, suppressible by tna¹

(Gutierrez et al., 2003)

Pc⁴ has metathoracic leg phenotype, suppressible by tna¹

(Gutierrez et al., 2003)

Pc⁴ has sex comb | ectopic phenotype, suppressible by tna¹

(Gutierrez et al., 2003)

Pc⁴ has sex comb phenotype, suppressible by HDAC1³²⁶

(Chang et al., 2001)

Pc⁴ has sex comb | ectopic phenotype, suppressible by l(3)80Fj^2-30

(Schulze et al., 2001)

Pc⁴ has sex comb | ectopic phenotype, suppressible by vtd¹⁰

(Schulze et al., 2001)

Pc⁴ has sex comb | ectopic phenotype, suppressible by vtd²

(Schulze et al., 2001)

Pc⁴ has sex comb | ectopic phenotype, suppressible by vtd³

(Schulze et al., 2001)

Pc⁴ has sex comb | ectopic phenotype, suppressible by vtd⁴

(Schulze et al., 2001)

Pc⁴ has sex comb | ectopic phenotype, suppressible by vtd⁷

(Schulze et al., 2001)

Pc⁴ has sex comb | ectopic phenotype, suppressible by vtd⁸

(Schulze et al., 2001)

Pc⁴ has sex comb | ectopic phenotype, suppressible by vtd⁹

(Schulze et al., 2001)

Pc⁴ has prothoracic leg phenotype, suppressible by lawc^p1

(Zorin et al., 1999)

Pc⁴ has mesothoracic leg phenotype, suppressible by lawc^p1

(Zorin et al., 1999)

Pc⁴ has mesothoracic leg phenotype, suppressible by mor¹

(Brizuela and Kennison, 1997)

Pc⁴ has metathoracic leg phenotype, suppressible by mor¹

(Brizuela and Kennison, 1997)

Pc⁴ has sex comb phenotype, suppressible by mor¹

(Brizuela and Kennison, 1997)

Pc⁴ has mesothoracic leg phenotype, suppressible by mor²

(Brizuela and Kennison, 1997)

Pc⁴ has metathoracic leg phenotype, suppressible by mor²

(Brizuela and Kennison, 1997)

Pc⁴ has sex comb phenotype, suppressible by mor²

(Brizuela and Kennison, 1997)

Pc⁴ has mesothoracic leg phenotype, suppressible by mor⁴

(Brizuela and Kennison, 1997)

Pc⁴ has metathoracic leg phenotype, suppressible by mor⁴

(Brizuela and Kennison, 1997)

Pc⁴ has sex comb phenotype, suppressible by mor⁴

(Brizuela and Kennison, 1997)

Pc⁴ has phenotype, suppressible by Dll¹²

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by Scr^E1

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by Scr^E2

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by Scr^E3

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by Scr^E4

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by Su(Pc)37D¹

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by Vha55¹⁵

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by Vha55¹⁶

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by brm²

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by brm³

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by brm⁴

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by brm⁵

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by brm⁶

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by btl^dev1

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by btl^dev2

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by kis¹

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by kis²

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by kis³

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by kis⁴

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by kis⁵

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by kis⁶

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by kis⁷

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by kis⁸

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by kis⁹

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by kto¹

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by mor³

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by mor⁴

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by mor⁵

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by mor⁶

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by osa¹

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by osa²

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by osa³

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by osa⁴

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by skd¹

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by skd²

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by sls¹

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by trx^B14

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by trx^E10

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by trx^E11

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by trx^E13

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by trx^E1

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by trx^E2

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by trx^E4

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by trx^E5

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by trx^E6

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by trx^E7

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by trx^E8

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by trx^E9

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by urd¹

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by Nsf2^urd-2

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by vtd¹

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by vtd²

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by vtd³

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by vtd⁴

(Kennison and Tamkun, 1988)

Pc⁴ has phenotype, suppressible by vtd⁵

(Kennison and Tamkun, 1988)

NOT suppressed by

Statement

Reference

Pc⁴ has mesothoracic leg & sex comb tooth | ectopic phenotype, non-suppressible by Df(2R)ED3921

(Ragab, 2006)

Pc⁴ has metathoracic leg & sex comb tooth | ectopic phenotype, non-suppressible by Df(2R)ED3921

(Ragab, 2006)

Pc⁴ has mesothoracic leg phenotype, non-suppressible by Deaf1^S10B

(Veraksa et al., 2002)

Pc⁴ has mesothoracic leg phenotype, non-suppressible by Deaf1^k3

(Veraksa et al., 2002)

Pc⁴ has sex comb | ectopic phenotype, non-suppressible by Deaf1^S10B

(Veraksa et al., 2002)

Pc⁴ has sex comb | ectopic phenotype, non-suppressible by Deaf1^k3

(Veraksa et al., 2002)

Pc⁴ has sex comb | ectopic phenotype, non-suppressible by vtd¹¹

(Schulze et al., 2001)

Pc⁴ has sex comb | ectopic phenotype, non-suppressible by vtd¹²

(Schulze et al., 2001)

Pc⁴ has phenotype, non-suppressible by lawc⁺¹⁰

(Zorin et al., 1999)

Enhancer of

Statement

Reference

Pc⁴ is an enhancer of wing vein L3 phenotype of rho^ve-1

(Marenda et al., 2004)

NOT Enhancer of

Statement

Reference

Pc⁴ is a non-enhancer of sex comb phenotype of Scr²

(Southworth and Kennison, 2002)

Suppressor of

Statement

Reference

Pc[+]/Pc⁴ is a suppressor | partially of eye phenotype of eya^cs/eya¹

(Tian et al., 2019)

Pc⁴ is a suppressor of eye phenotype of CycE^JP

(Brumby et al., 2002)

NOT Suppressor of

Statement

Reference

Pc⁴ is a non-suppressor of sex comb phenotype of Scr²

(Southworth and Kennison, 2002)

Other

Statement

Reference

Pc⁴, Snr1^E1 has wing phenotype

(Marenda et al., 2004)

Pc⁴, Snr1^E1 has wing vein L5 phenotype

(Marenda et al., 2004)

Pc⁴, Snr1^E1 has wing vein L3 phenotype

(Marenda et al., 2004)

Pc⁴, Snr1^E1 has wing vein L4 phenotype

(Marenda et al., 2004)

Pc⁴, brm² has wing vein L3 phenotype

(Marenda et al., 2004)

Df(2R)trix, Pc⁴ has adult prothoracic segment phenotype

(Milne et al., 1999)

Pc[+]/Pc⁴, Pcl¹⁸ has sex comb phenotype

(Kennison and Tamkun, 1988)

Pc[+]/Pc⁴, Scm^K1 has sex comb phenotype

(Kennison and Tamkun, 1988)

Additional Comments

Genetic Interactions

Statement

Reference

Df(2R)ED3921 fails to suppress the ectopic sex comb phenotype of Pc⁴ mutants.

(Ragab, 2006)

Pc⁴/Snr1^E1 animals have incomplete L3, L4 and L5 wing veins (9%, 42% and 37% respectively) and moderate curling and disruption of the wing along the posterior wing margin. Pc⁴/brm² animals have an incomplete L3 wing vein (15%).

(Marenda et al., 2004)

Pc⁴/Hsc70-4¹⁹⁵ mutant flies exhibit a higher than wild-type average number of legs with sex combs, with a statistically significant average of 2.4 legs with sex combs, compared to 2.0 in wild-type.

(Wang and Brock, 2003)

Mutant weakly suppresses the CycE^JP rough eye phenotype.

(Brumby et al., 2002)

The ectopic sex comb phenotype seen on the second and third legs of Pc⁴/+ males is dominantly enhanced by psq⁰¹¹⁵, psq⁰²⁴⁰³, psq⁸¹⁰⁹, psq^Δ18, psq^F112, psq^E34 or psq^E39.

(Huang et al., 2002)

The average number of sex comb teeth per first leg Scr²/+ males is not affected if they are also carrying Pc⁴. The average number of sex comb teeth per first leg Df(3R)Scr/+ males is not affected if they are also carrying Pc⁴.

(Southworth and Kennison, 2002)

Deaf1^k3 or Deaf1^S10B do not change the number of ectopic sex combs in the T2 legs of Pc⁴ males.

(Veraksa et al., 2002)

The addition of Df(3L)10^H, Rpd3⁰⁴⁵⁵⁶, Rpd3³⁰³, Rpd3³¹³ or Rpd3^def8 to Pc⁴ animals more than doubles the average number of ectopic sex comb teeth seen per leg. The addition of Rpd3³²⁶ to Pc⁴ animals partially suppresses the ectopic sex comb teeth phenotype.

(Chang et al., 2001)

Asx^P1 strongly enhances the extra sex combs phenotype and abdominal homeotic transformations associated with Pc⁴. Pc⁴/+, Df(2R)trix/+ show a darkly pigmented outgrowth from the first thoracic segment, corresponding to a strong posterior transformation of the prothorax to mesothorax.

(Milne et al., 1999)

The leg transformation phenotype of Pc⁴/+ males is largely suppressed by lawc^p1.

(Zorin et al., 1999)

The formation of extra sex combs on the second and third legs in Pc⁴/+ flies is dominantly enhanced by Mi-2^K1, Mi-2¹, Mi-2^j3D4, Mi-2⁴, Mi-2⁵, Mi-2⁶, Mi-2⁷, Mi-2⁸, Mi-2⁹ or Pcl¹⁰. The formation of extra sex combs on the second and third legs in Pc⁴/+ flies is not enhanced by Trl⁶², Trl³ or Trl^s2325.

(Kehle et al., 1998)

The lethality caused by sev^{S11.T:Hsap\MYC} in combination with Ras85D^V12.sev is not suppressed by Pc⁴.

(Maixner et al., 1998)

The penetrance and expressivity of the Pc⁴/+ transformation phenotype is dominantly suppressed by mor¹, mor² or mor⁴.

(Brizuela and Kennison, 1997)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

Russell.

Comments

The penetrance for the Scr derepression phenotype in Pc⁴ heterozygotes is 100%.

(Tamkun et al., 1992)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (2)

Reported As

Symbol Synonym

Pc⁴

(Pherson et al., 2019, Tian et al., 2019, Akishina et al., 2017, Schaaf et al., 2013, Strübbe et al., 2011, Brown and Kassis, 2010, Fujioka et al., 2008, Hallson et al., 2008, O'Dor et al., 2006, Wang and Brock, 2003, Huang et al., 2002)

Pc^R1

(Fuse et al., 1999, Tiong and Russell, 1990, Kennison and Tamkun, 1988, Kennison and Russell, 1987, Riley et al., 1987)

Name Synonyms

Secondary FlyBase IDs

References (42)

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