FlyBase Allele Report: Dmel\Mi-2[j3D4]

FB2024_03 , released June 25, 2024

FB2024_03 , released June 25, 2024

Allele: Dmel\Mi-2^j3D4

General Information

Symbol

Dmel\Mi-2^j3D4

Species

D. melanogaster

Name

FlyBase ID

FBal0028380

Feature type

allele

Associated gene

Associated Insertion(s)

P{lacW}Mi-2^j3D4

Carried in Construct

Also Known As

l(3)j3D4

Key Links

Genomic Maps

Allele class

Mutagen

P-element activity

Nature of the Allele

Allele class

Mutagen

P-element activity

(Khattak et al., 2002, Spradling et al., 1999, Kehle et al., 1998, FlyBase, 1996-, BDGP Project Members, 1994-1999)

Progenitor genotype

Associated Insertion(s)

P{lacW}Mi-2^j3D4

Cytology

Description

P{lacW} insertion in an intron of Mi-2. This intron also contains the nested gene Su(Tpl), so the P{lacW} insertion is also within an intron of Su(Tpl).

(Khattak et al., 2002)

Allele components

Component

Use(s)

Inserted element

Encoded product / tool

reporter enzyme

Tagged with

nuclear protein localization tag

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

transposable_element_insertion_site

3L:19,907,252..19,907,252 [+]

(Cooper et al., 2010, Khattak et al., 2002, Spradling et al., 1999, Kehle et al., 1998, FlyBase, 1996-, BDGP Project Members, 1994-1999)

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

exacerbates multiple endocrine neoplasia type 2B

modeled by Ret^MEN2B.GMR

(Read et al., 2005)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal neuroanatomy

(Parrish et al., 2006)

lethal | recessive

(Spradling et al., 1999)

Phenotype Manifest In

(Parrish et al., 2006)

egg | germline clone

(Kehle et al., 1998)

Detailed Description

Statement

Reference

Mi-2^j3D4 mutants show only minor defects in late embryonic stages, but show an obvious reduction in arborization of class I da neurons by 72 hours after egg laying.

(Parrish et al., 2006)

Homozygous female germline clones only rarely produce eggs, which are abnormal.

(Kehle et al., 1998)

External Data

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Mi-2[+]/Mi-2^j3D4 is an enhancer of visible phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Mi-2[+]/Mi-2^j3D4 is an enhancer of visible phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^ptc-559.1

(Ji et al., 2012)

Mi-2^j3D4 is an enhancer of visible phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

Mi-2[+]/Mi-2^j3D4 is an enhancer of visible | dominant | homeotic phenotype of Pc⁴

(Kehle et al., 1998)

NOT Enhancer of

Statement

Reference

Mi-2[+]/Mi-2^j3D4 is a non-enhancer of visible phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Suppressor of

Statement

Reference

Mi-2[+]/Mi-2^j3D4 is a suppressor | partially of visible phenotype of E2f1^UAS.cNa, Scer\GAL4^Act88F.PD

(Ji et al., 2012)

NOT Suppressor of

Statement

Reference

Mi-2[+]/Mi-2^j3D4 is a non-suppressor of visible phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Phenotype Manifest In

Enhancer of

Statement

Reference

Mi-2[+]/Mi-2^j3D4 is an enhancer of eye phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Mi-2[+]/Mi-2^j3D4 is an enhancer of 1st posterior cell phenotype of E2f1^RNAi.UAS.cJa, Scer\GAL4^ptc-559.1

(Ji et al., 2012)

Mi-2^j3D4 is an enhancer of eye phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

Mi-2[+]/Mi-2^j3D4 is an enhancer of mesothoracic leg phenotype of Pc⁴

(Kehle et al., 1998)

Mi-2[+]/Mi-2^j3D4 is an enhancer of metathoracic leg phenotype of Pc⁴

(Kehle et al., 1998)

Mi-2[+]/Mi-2^j3D4 is an enhancer of sex comb | ectopic phenotype of Pc⁴

(Kehle et al., 1998)

NOT Enhancer of

Statement

Reference

Mi-2[+]/Mi-2^j3D4 is a non-enhancer of eye phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Suppressor of

Statement

Reference

Mi-2[+]/Mi-2^j3D4 is a suppressor | partially of wing phenotype of E2f1^UAS.cNa, Scer\GAL4^Act88F.PD

(Ji et al., 2012)

NOT Suppressor of

Statement

Reference

Mi-2[+]/Mi-2^j3D4 is a non-suppressor of eye phenotype of Dp^UAS.cDa, E2f1^UAS.cNa, Scer\GAL4^GMR.PU

(Ji et al., 2012)

Additional Comments

Genetic Interactions

Statement

Reference

The formation of extra sex combs on the second and third legs in Pc⁴/+ flies is dominantly enhanced by Mi-2^j3D4.

(Kehle et al., 1998)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Fails to complement

Mi-2^unspecified

(Cooper et al., 2010)

(Read et al., 2005)

(Read et al., 2005)

(Read et al., 2005)

(Khattak et al., 2002)

(Khattak et al., 2002)

(Khattak et al., 2002)

Mi-2⁰¹⁰⁵⁸

(BDGP Project Members, 1994-1999)

Comments

The Mi-2^j3D4/Mi-2^BL7 combination produces escapers.

(Khattak et al., 2002)

Images (0)

Mutant

Wild-type

Stocks (1)

12106

y¹ w^*; P{lacW}Mi-2^j3D4 Su(Tpl)^j3D4/TM3, Sb¹ Ser¹

Notes on Origin

Discoverer

L. and Y. Jan.

Comments

Comments

Complements: l(3)L1243^L1243.

(BDGP Project Members, 1994-1999)

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (6)

Reported As

Symbol Synonym

Mi-2^j3D4

(Ji et al., 2012, Parrish et al., 2006)

Mi-2^j3d4

(Merzetti et al., 2013)

Pha^j3D4

(Bloomington Drosophila Stock Center, 1999.2.23, BDGP Project Members, 1994-1999)

dMi-2³

(Kehle et al., 1998)

l(3)j3D4

(Spradling et al., 1999, Kehle et al., 1998, Kennison, 1995.6.21)

l(3)j3D4^j3D4

Name Synonyms

Secondary FlyBase IDs

References (14)

Report Sections