FlyBase Allele Report: Dmel\Asx[13]

General Information

Symbol

Dmel\Asx¹³

Species

D. melanogaster

Name

FlyBase ID

FBal0029004

Feature type

allele

Associated gene

Dmel\Asx

Associated Insertion(s)

Carried in Construct

Key Links

Allele class

gain of function allele

Mutagen

gamma ray

Nature of the Allele

Allele class

gain of function allele

(Sinclair et al., 1992)

Mutagen

gamma ray

(Sinclair et al., 1992)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

enhancer of variegation | dominant, with Dp(1;Y)Bar^SCV

(Sinclair et al., 1998)

enhancer of variegation | dominant, with In(1)w^m4

(Sinclair et al., 1998)

enhancer of variegation | dominant, with T(2;3)Sb^V

(Sinclair et al., 1998)

lethal | recessive

(Milne et al., 1999)

visible | homeotic

(Sinclair et al., 1992)

Phenotype Manifest In

abdominal segment 4

(Sinclair et al., 1992)

thoracic segment

(Sinclair et al., 1992)

Detailed Description

Statement

Reference

Dominantly enhances position effect variegation (PEV) at the w locus caused by In(1)w^m4, PEV at the B locus caused by Dp(1;Y)B^SCV and PEV at the Sb locus caused by T(2;3)Sb^V.

(Sinclair et al., 1998)

More severe Asx phenotype than Asx^- deletion and also a more severe transformation of thoracic segments towards abdominal segments. Segmentation defects are also present: missing segments, midline denticles missing and hemisegments. Hemizygous embryos have weak head and thoracic defects and weak abdominal homeotic transformations. Heterozygous adults have a mild transformation of A4 to A5 in males.

(Sinclair et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Asx[+]/Asx¹³ is an enhancer of visible | dominant | homeotic phenotype of brm[+]/brm², trx^E2

(Gildea et al., 2000)

Other

Statement

Reference

Asx¹³, ash1²² has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Asx[+]/Asx¹³, brm² has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Asx[+]/Asx¹³, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Asx¹³, brm² has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Asx¹³, trx^B11 has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Asx[+]/Asx¹³, ash1²² has visible | dominant | homeotic phenotype

(Gildea et al., 2000)

Phenotype Manifest In

Enhancer of

Statement

Reference

Asx[+]/Asx¹³ is an enhancer of adult metathoracic segment phenotype of brm[+]/brm², trx^E2

(Gildea et al., 2000)

Asx¹³ is an enhancer of sex comb phenotype of Pc⁴

(Milne et al., 1999)

Other

Statement

Reference

Asx¹³, ash1²² has adult metathoracic segment phenotype

(Gildea et al., 2000)

Asx[+]/Asx¹³, brm² has adult metathoracic segment phenotype

(Gildea et al., 2000)

Asx[+]/Asx¹³, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Asx¹³, brm² has adult metathoracic segment phenotype

(Gildea et al., 2000)

Asx¹³, trx^B11 has adult metathoracic segment phenotype

(Gildea et al., 2000)

Asx[+]/Asx¹³, ash1²² has adult metathoracic segment phenotype

(Gildea et al., 2000)

Asx¹³, sxc³ has haltere phenotype

(Milne et al., 1999)

Asx¹³, sxc³ has abdominal segment 4 phenotype

(Milne et al., 1999)

Additional Comments

Genetic Interactions

Statement

Reference

Enhances the trx-G homeotic transformations of Df(3R)red1. Strongly enhances the extra sex comb phenotype of Pc⁴. Double heterozygotes with sxc³ show reduced viability and survivors show transformations typical of Pc-G mutants including transformation of A4 to A5. Most also show haltere to wing transformations typical of trx-G mutants.

(Milne et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Asx¹³

Name Synonyms

Secondary FlyBase IDs

References (5)

Report Sections

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