FB2024_03 , released June 25, 2024
Allele: Dmel\HDAC1313
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General Information
Symbol
Dmel\HDAC1313
Species
D. melanogaster
Name
FlyBase ID
FBal0104002
Feature type
allele
Associated gene
Dmel\HDAC1
Associated Insertion(s)
Carried in Construct
Key Links
Genomic Maps

Allele class

hypomorphic allele - genetic evidence

Mutagen
Nature of the Allele
Allele class

hypomorphic allele - genetic evidence

(Mottus et al., 2000)
Mutagen
ethyl methanesulfonate
(Mottus et al., 2000)
Progenitor genotype
Cytology
Description

The mutated residue R30 is perfectly conserved in homologs from S. cerevisiae to H. sapiens, in a region of the protein that is almost perfectly conserved, and that is thought to be required for deacetylase activity.

(Mottus et al., 2000)

Amino acid replacement: R30C.

(Mottus et al., 2000)
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
point_mutation
3L:4,627,470..4,627,470 [+]
Nucleotide change:

C4627470T

Amino acid change:

R32C | HDAC1-PA

Reported amino acid change:

R30C

Comment:

Site of nucleotide substitution in mutant inferred by FlyBase based on reported amino acid change. The mutation is reported at residue R30. The analagous amino acid in the reference sequence is R32.

(Mottus et al., 2000)
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Rpd3313/+ flies have the normal number of dorsocentral bristles.

      (Biryukova and Heitzler, 2008)

      One copy of Rpd3313 strongly suppresses position effect variegation (PEV) at the w locus caused by In(1)wm4.

      One copy of Rpd3313 weakly suppresses the telomeric position effect (TPE) in stocks carrying a variegating P{hsp26-pt-T}39C-5 insertion at the telomere of the left arm of chromosome two.

      (Doheny et al., 2008)

      Rpd3313/+ enhances the silencing of the w marker gene which is seen in the P{UAS-lacZ.Abd-B.24F6}GCD-6 insertion, such that the eye is less pigmented in the presence of Rpd3313/+.

      (Canudas et al., 2005)

      Strong suppressor of PEV in In(1)wm4. Raises the pigment levels of In(1)wm4 eyes from 5-15% of wild type levels to 60-90% of wild type levels. Lethality principally affects the third larval instar stage. Shows a dominant semi-lethal effect on males: viability 51% of expected.

      (Mottus et al., 2000)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Other
      Statement
      Reference

      Df(3R)sbd45/+, HDAC1313 has visible | dominant phenotype

      (Canudas et al., 2005)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      HDAC1313 is an enhancer of sex comb phenotype of Pc4

      (Chang et al., 2001)
      NOT Enhancer of
      Statement
      Reference

      Rpd3[+]/HDAC1313 is a non-enhancer of dorsocentral bristle | increased number phenotype of pnrD1

      (Biryukova and Heitzler, 2008)
      Other
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Flies heterozygous for Rpd3313 and pnrD1 do not show enhancement of the pnrD1/+ phenotype.

      (Biryukova and Heitzler, 2008)

      No Rpd3313 mutant males expressing GugdsRNA.1.Scer\UAS under the control of Scer\GAL4dpp.blk1 develop melanotic masses in their heads.

      (Wang et al., 2008)

      60% of Rpd3313/Df(3R)sbd45 transheterozygous males show transformation of A6 to A5, as judged by the presence of at least one bristle on the sixth sternite.

      (Canudas et al., 2005)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Partially complements

      HDAC115-1

      (Mottus et al., 2000)
      Fails to complement

      HDAC1303

      (Mottus et al., 2000)

      HDAC1328

      (Mottus et al., 2000)

      HDAC104556

      (Mottus et al., 2000)

      HDAC1326

      (Mottus et al., 2000)
      Comments

      Transheterozygotes of Rpd315-1 with Rpd3303, Rpd3313, Rpd3326 or Rpd3328 are viable and fertile, and show weak to moderate suppression of In(1)wm4 PEV.

      (Mottus et al., 2000)
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (4)
      Reported As
      Symbol Synonym
      HDAC1313
      (Biryukova and Heitzler, 2008, Mottus et al., 2000)
      HDAC313
      (Canudas et al., 2005)
      Hdac1313
      (Doheny et al., 2008, Chang et al., 2001)
      Rpd3313
      (Wang et al., 2008)
      Name Synonyms
      Secondary FlyBase IDs
        References (6)