FB2024_03 , released June 25, 2024
Allele: Dmel\sls1
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General Information
Symbol
Dmel\sls1
Species
D. melanogaster
Name
FlyBase ID
FBal0015717
Feature type
allele
Associated gene
Dmel\sls
Associated Insertion(s)
Carried in Construct
Key Links
Allele class
Mutagen
Nature of the Allele
Allele class
Mutagen
ethyl methanesulfonate
(Lindsley and Zimm, 1992, Kennison and Tamkun, 1988)
Progenitor genotype
Cytology
Description
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      exacerbates  myopathy
      modeled by cherJF02077
      (González-Morales et al., 2017)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      sls1 heterozygous adults have an apparently normal morphology and are able to fly.

      (González-Morales et al., 2017)

      The lethality caused by sevS11.T:Hsap\MYC in combination with Ras85DV12.sev is not suppressed by sls1.

      (Maixner et al., 1998)

      Mutation changes the level of w expression in ph-plac+3 flies; eye colour is lighter.

      (Fauvarque et al., 1995)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Enhancer of
      Statement
      Reference

      sls1/sls[+] is an enhancer of partially lethal - majority live phenotype of Scer\GAL4Mef2.PU, cherJF02077

      (González-Morales et al., 2017)
      NOT Suppressor of
      Statement
      Reference

      sls1 is a non-suppressor of lethal phenotype of Ras85DV12.sev, sevS11.Tag:MYC

      (Maixner et al., 1998)
      Phenotype Manifest In
      Enhancer of
      Statement
      Reference

      sls1/sls[+] is an enhancer of myofibril | adult stage phenotype of Scer\GAL4Mef2.PU, cherJF02077

      (González-Morales et al., 2017)

      sls1/sls[+] is an enhancer of sarcomere | adult stage phenotype of Scer\GAL4Mef2.PU, cherJF02077

      (González-Morales et al., 2017)
      Suppressor of
      Statement
      Reference

      sls1/sls[+] is a suppressor of adult mesothoracic segment | ectopic phenotype of E(z)Trm

      (Bajusz et al., 2001)

      sls1/sls[+] is a suppressor of adult metathoracic segment phenotype of E(z)Trm

      (Bajusz et al., 2001)

      sls1/sls[+] is a suppressor of adult prothoracic segment phenotype of E(z)Trm

      (Bajusz et al., 2001)

      sls1 is a suppressor of phenotype of Pc4

      (Kennison and Tamkun, 1988)
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Heterozygosity for sls1 enhances the semi-lethality and the myofibril shredding defects (even leading to the loss of the sarcomere structure) resulting from the expression of cherJF02077 under the control of Scer\GAL4Mef2.PU.

      (González-Morales et al., 2017)

      Dominant suppressor of the extra-sex-combs phenotype of heterozygous Pc alleles. Also suppresses the dominant extra-sex-combs phenotype of Pcl alleles.

      (Lindsley and Zimm, 1992)

      Suppresses the extra sex comb phenotype of Pc4, Ts(YLt;2Lt)L124. Causes between 50% and 100% suppression of the Pc4/+ extra sex combs phenotype.

      (Kennison and Tamkun, 1988)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (2)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (3)
      References (21)