Gene Group: PSEUDOENZYMES

General Information

Name

PSEUDOENZYMES

Species

D. melanogaster

Symbol

PSENZ

FlyBase ID

FBgg0001798

Date last reviewed

2022-10-27

Number of members

256

Description

Pseudoenzymes are proteins that are evolutionary related to enzymes but lack relevant catalytic activity. Despite this, many pseudoenzymes are remarkably well conserved and have evolved essential catalytic-independent functions. They are found in almost all enzyme families and are distributed across the whole tree of life. The most abundant pseudoenzyme groups are pseudokinases, pseudophosphatases and pseudoproteases. (Adapted from PMID:31733177 and PMID:31618524.)

Notes on Group

Source Material

The PSEUDOENZYMES Gene Group has been compiled using the following publication(s): Werner et al., 2024, Shekhar et al., 2023, Sustar et al., 2023, Erven et al., 2022, Li et al., 2022, Meyer et al., 2021, Elías-Villalobos et al., 2019, Jiang, 2019.3.1, Laurinyecz et al., 2019, Mele and Johnson, 2019, Metwally et al., 2019, Naba et al., 2019.7.9, Cao and Jiang, 2018, Meyer et al., 2018.7.18, Zimmerman et al., 2017, Parkhitko et al., 2016, Pesch et al., 2016, Cenci et al., 2015, Hatzihristidis et al., 2015, Kollmar, 2015.9.15, Reynaud et al., 2015, Kurata, 2014, Sitnik et al., 2014, Sopko et al., 2014, Clague et al., 2013, Crosby et al., 2013.1.30, Lombard et al., 2013, Masoner et al., 2013, Okamoto et al., 2013, Petrova et al., 2013, Vogel et al., 2013, Adolphsen et al., 2012, Chen et al., 2012, Dorus et al., 2011, Du et al., 2011, Zhang et al., 2011, Cooper et al., 2010, Anamika et al., 2009, Belote and Zhong, 2009, Biswas et al., 2009, Michelle et al., 2009, Odronitz et al., 2009, Bland et al., 2008, Dixit et al., 2008, Zhu et al., 2008, Funkhouser and Aronson, 2007, Klose et al., 2006, Martinez Agosto and McCabe, 2006, Tian and Ten Hagen, 2006, Chihara et al., 2005, Landis and Tower, 2005, Friedrich et al., 2004, Zhu et al., 2004, Kocks et al., 2003, Mellroth et al., 2003, Ma et al., 2002, Manning et al., 2002, Tzolovsky et al., 2002, Urban et al., 2002, Zurovec et al., 2002, Berg et al., 2001, Halford and Stacker, 2001, Coates et al., 2000, Fenwick et al., 2000, Guichard et al., 2000, Sheffield et al., 2000, Wasserman et al., 2000, Yamashita et al., 2000, Persson et al., 1997, and Rawlings and Barrett, 1996- .

Key Gene Ontology (GO) terms

Molecular Function

Biological Process

Cellular Component

Related Gene Groups

Component group(s)

IMAGINAL DISC GROWTH FACTORS

NON-MOTOR MYOSINS

NON-PEPTIDASE HOMOLOGS

PSEUDO-CHITIN DEACETYLASES

PSEUDOKINASES

PSEUDOPHOSPHATASES

UBIQUITIN E2 ENZYME VARIANTS

UNCLASSIFIED PSEUDOENZYMES

Other related group(s)

ENZYMES

Members (256)

For all members:

GO ribbon stack

	molecular function	biological process	cellular component

ANGIOTENSIN-CONVERTING PSEUDOENZYMES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Ance-2

(Coates et al., 2000, Rawlings and Barrett, 1996-)

Ance-3

DS00180.5, BG:DS00180.5

(Coates et al., 2000, Rawlings and Barrett, 1996-)

Ance-4

(Coates et al., 2000, Rawlings and Barrett, 1996-)

Ance-5

(Coates et al., 2000, Rawlings and Barrett, 1996-)

C1 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG6337

(Kocks et al., 2003, Rawlings and Barrett, 1996-)

CG6357

(Kocks et al., 2003)

CG13423

(Rawlings and Barrett, 1996-)

Swim

Secreted Wg-interacting molecule

(Kocks et al., 2003, Rawlings and Barrett, 1996-)

C19 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

echinus

EG:EG0002.3

(FlyBase, 2017-, Clague et al., 2013, Rawlings and Barrett, 1996-)

PAN2

Poly(A)-binding protein-dependent poly(A) ribonuclease 2

(FlyBase, 2017-, Clague et al., 2013, Rawlings and Barrett, 1996-)

Usp39

Ubiquitin specific protease 39

(FlyBase, 2017-, Clague et al., 2013, Rawlings and Barrett, 1996-)

C26 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

rudimentary

Su(b), CAD, fs(1)M34

(Rawlings and Barrett, 1996-)

C48 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG1503

(Rawlings and Barrett, 1996-)

C110 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Hil

Hillarin

(Rawlings and Barrett, 1996-)

CALPAIN NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CalpC

Calpain C

(Metwally et al., 2019, Friedrich et al., 2004, Rawlings and Barrett, 1996-)

IMAGINAL DISC GROWTH FACTORS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Idgf1

Imaginal disc growth factor 1

BG:DS02780.5, IDGF, DmIDGF1

(Sustar et al., 2023, Zimmerman et al., 2017, Pesch et al., 2016, Lombard et al., 2013, Zhang et al., 2011, Zhu et al., 2008, Funkhouser and Aronson, 2007, Zhu et al., 2004)

Idgf2

Imaginal disc growth factor 2

IDGF, DmIDGF2, BG:DS02780.4

(Sustar et al., 2023, Zimmerman et al., 2017, Pesch et al., 2016, Lombard et al., 2013, Zhang et al., 2011, Zhu et al., 2008, Funkhouser and Aronson, 2007, Zhu et al., 2004)

Idgf3

Imaginal disc growth factor 3

DmIDGF3, lincRNA.163, BG:DS02780.2, IDGF

(Sustar et al., 2023, Zimmerman et al., 2017, Pesch et al., 2016, Lombard et al., 2013, Zhang et al., 2011, Zhu et al., 2008, Funkhouser and Aronson, 2007, Zhu et al., 2004)

Idgf4

Imaginal disc growth factor 4

DmIDGF4, IDGF

(Sustar et al., 2023, Zimmerman et al., 2017, Pesch et al., 2016, Lombard et al., 2013, Zhang et al., 2011, Zhu et al., 2008, Funkhouser and Aronson, 2007, Zhu et al., 2004)

Idgf5

Imaginal disc growth factor 5

DmIDGF5, IDGF-5

(Sustar et al., 2023, Zimmerman et al., 2017, Pesch et al., 2016, Lombard et al., 2013, Zhang et al., 2011, Zhu et al., 2008, Funkhouser and Aronson, 2007, Zhu et al., 2004)

Idgf6

Imaginal disc growth factor 6

DS47, Chit, Chitinase-like, DmDS47

(Sustar et al., 2023, Zimmerman et al., 2017, Pesch et al., 2016, Lombard et al., 2013, Zhang et al., 2011, Zhu et al., 2008, Funkhouser and Aronson, 2007, Zhu et al., 2004)

M1 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG2111

(Li et al., 2022, Rawlings and Barrett, 1996-)

CG4467

(Li et al., 2022, Rawlings and Barrett, 1996-)

CG6071

(Li et al., 2022, Rawlings and Barrett, 1996-)

CG9806

(Li et al., 2022, Rawlings and Barrett, 1996-)

CG40470

(Li et al., 2022, Rawlings and Barrett, 1996-)

Taf2

TBP-associated factor 2

dTAF_II150, TAF_II150, Taf150, TFIID, TAFII150

(Rawlings and Barrett, 1996-)

M3 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG11771

(Rawlings and Barrett, 1996-)

M12 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

mmd

mind-meld

CT26192

(Rawlings and Barrett, 1996-)

M14 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG8945

(Rawlings and Barrett, 1996-)

CG42264

(Rawlings and Barrett, 1996-)

M16 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

UQCR-C2

Ubiquinol-cytochrome c reductase core protein 2

dUQCRC2, BEST:GH10978

(Rawlings and Barrett, 1996-)

M19 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG5282

(Rawlings and Barrett, 1996-)

M24 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG6225

(Rawlings and Barrett, 1996-)

CG10576

(Rawlings and Barrett, 1996-)

CG32454

(Rawlings and Barrett, 1996-)

dre4

Spt16, dSPT16, l(3)dre4, l(3)62Bg

(Rawlings and Barrett, 1996-)

M48 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG7573

(Adolphsen et al., 2012, Rawlings and Barrett, 1996-)

M67 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CSN6

COP9 signalosome subunit 6

Dch6

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

Prp8

pre-mRNA processing factor 8

(FlyBase, 2017-)

Rpn8

Regulatory particle non-ATPase 8

Mov34, p39B, l(2)k08003

(FlyBase, 2017-, Rawlings and Barrett, 1996-)

NEPRILYSIN-LIKE METALLOENDOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

frma

fra mauro

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Rawlings and Barrett, 1996-)

goe

gone early

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Bland et al., 2008, Rawlings and Barrett, 1996-)

Nepl3

Neprilysin-like 3

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Rawlings and Barrett, 1996-)

Nepl4

Neprilysin-like 4

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Rawlings and Barrett, 1996-)

Nepl5

Neprilysin-like 5

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Rawlings and Barrett, 1996-)

Nepl6

Neprilysin-like 6

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Rawlings and Barrett, 1996-)

Nepl7

Neprilysin-like 7

(Meyer et al., 2021, Meyer et al., 2018.7.18, Bland et al., 2008, Rawlings and Barrett, 1996-)

Nepl8

Neprilysin-like 8

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Rawlings and Barrett, 1996-)

Nepl9

Neprilysin-like 9

(Meyer et al., 2021, Meyer et al., 2018.7.18, Rawlings and Barrett, 1996-)

Nepl10

Neprilysin-like 10

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Rawlings and Barrett, 1996-)

Nepl11

Neprilysin-like 11

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Rawlings and Barrett, 1996-)

Nepl12

Neprilysin-like 12

(Meyer et al., 2021, Meyer et al., 2018.7.18, Bland et al., 2008, Rawlings and Barrett, 1996-)

Nepl13

Neprilysin-like 13

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Bland et al., 2008, Rawlings and Barrett, 1996-)

Nepl14

Neprilysin-like 14

(Meyer et al., 2021, Meyer et al., 2018.7.18, Rawlings and Barrett, 1996-)

Nepl15

Neprilysin-like 15

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Bland et al., 2008, Rawlings and Barrett, 1996-)

Nepl16

Neprilysin-like 16

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Rawlings and Barrett, 1996-)

Nepl17

Neprilysin-like 17

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Bland et al., 2008, Rawlings and Barrett, 1996-)

Nepl18

Neprilysin-like 18

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Bland et al., 2008, Rawlings and Barrett, 1996-)

Nepl19

Neprilysin-like 19

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Rawlings and Barrett, 1996-)

Nepl20

Neprilysin-like 20

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Bland et al., 2008, Rawlings and Barrett, 1996-)

Nepl21

Neprilysin-like 21

(Meyer et al., 2021, Meyer et al., 2018.7.18, Sitnik et al., 2014, Bland et al., 2008, Rawlings and Barrett, 1996-)

NON-MOTOR MYOSINS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

dachs

d, Myo29D

(Kollmar, 2015.9.15, Odronitz et al., 2009, Tzolovsky et al., 2002, Berg et al., 2001, Yamashita et al., 2000)

Mhcl

Myosin heavy chain-like

PDZ-myosin

(Kollmar, 2015.9.15, Odronitz et al., 2009, Tzolovsky et al., 2002, Berg et al., 2001, Yamashita et al., 2000)

PROTEASOME ALPHA SUBUNITS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Prosα1

Proteasome α1 subunit

α1, Prosalpha6, Proteasome alpha6 subunit, Proteasome α6 subunit, alpha1

(Belote and Zhong, 2009, Ma et al., 2002, Rawlings and Barrett, 1996-)

Prosα1R

Proteasome α1 subunit-related

(Crosby et al., 2013.1.30)

Prosα2

Proteasome α2 subunit

Pros25, α2, PROS Dm25, Su(DTS)-1, Proteasome 25kD subunit

(Belote and Zhong, 2009, Ma et al., 2002, Rawlings and Barrett, 1996-)

Prosα3

Proteasome α3 subunit

Pros29, α3, Proteasome 29kD subunit

(Belote and Zhong, 2009, Ma et al., 2002, Rawlings and Barrett, 1996-)

Prosα3T

Proteasome α3 subunit, Testis-specific

(Belote and Zhong, 2009, Ma et al., 2002)

Prosα4

Proteasome α4 subunit

Pros28.1, α4, Proteasome 28kD subunit 1, PROS-Dm28.1, α4_dm

(Belote and Zhong, 2009, Ma et al., 2002, Rawlings and Barrett, 1996-)

Prosα4T1

Proteasome α4 subunit, Testis-specific 1

Pros28.1A, α4t1_dm

(Belote and Zhong, 2009, Ma et al., 2002)

Prosα4T2

Proteasome α4 subunit, Testis-specific 2

Pros28.1B, α4t2_dm

(Belote and Zhong, 2009, Ma et al., 2002)

Prosα5

Proteasome α5 subunit

ProsMA5, α5, PSMA5, alpha5

(Belote and Zhong, 2009, Ma et al., 2002)

Prosα6

Proteasome α6 subunit

Pros35, α6, anon-SAGE:Wang-116, PROS-35, Proteasome 35kD subunit

(Belote and Zhong, 2009, Ma et al., 2002)

Prosα6T

Proteasome α6 subunit, Testis-specific

(Belote and Zhong, 2009, Ma et al., 2002, Rawlings and Barrett, 1996-)

Prosα7

Proteasome α7 subunit

α7, CPα7, alpha7

(Belote and Zhong, 2009, Ma et al., 2002)

PROTEASOME NON-CATALYTIC BETA SUBUNITS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Prosβ3

Proteasome β3 subunit

β3

(Belote and Zhong, 2009, Ma et al., 2002, Rawlings and Barrett, 1996-)

Prosβ4

Proteasome β4 subunit

β4

(Belote and Zhong, 2009, Ma et al., 2002, Rawlings and Barrett, 1996-)

Prosβ4R1

Proteasome β4 subunit-related 1

(Belote and Zhong, 2009, Ma et al., 2002)

Prosβ4R2

Proteasome β4 subunit-related 2

(Belote and Zhong, 2009, Ma et al., 2002)

Prosβ6

Proteasome β6 subunit

Pros26, DTS5, l(3)73Ai, β6, DTS-5

(Belote and Zhong, 2009, Ma et al., 2002, Rawlings and Barrett, 1996-)

Prosβ7

Proteasome β7 subunit

Prosβ4, β7

(Belote and Zhong, 2009, Ma et al., 2002)

PSEUDO-CHITIN DEACETYLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Cda4

Chitin deacetylase-like 4

(Naba et al., 2019.7.9, Dixit et al., 2008)

verm

vermiform

N63, LCBP1, hlm, helmsman, l(3)76BDx

(Naba et al., 2019.7.9, Dixit et al., 2008)

PSEUDO-GLYCEROL KINASE

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG1271

(Martinez Agosto and McCabe, 2006)

CG8298

(Martinez Agosto and McCabe, 2006)

mri

mrityu

(Martinez Agosto and McCabe, 2006)

PSEUDOPHOSPHATASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG5026

(Hatzihristidis et al., 2015)

CG14411

(Hatzihristidis et al., 2015)

IA-2

IA-2 protein tyrosine phosphatase

ia2

(Hatzihristidis et al., 2015)

mop

myopic

(Hatzihristidis et al., 2015, Chen et al., 2012)

Pez

(Chen et al., 2012)

Ptp36E

Protein tyrosine phosphatase 36E

DPTP36E

(Hatzihristidis et al., 2015, Chen et al., 2012)

Sbf

SET domain binding factor

Sbf1

(Hatzihristidis et al., 2015)

RECEPTOR GUANYLATE CYCLASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG3216

(Werner et al., 2024, Sopko et al., 2014, Vogel et al., 2013, Anamika et al., 2009, Biswas et al., 2009, Manning et al., 2002)

CG10738

(Werner et al., 2024, Sopko et al., 2014, Vogel et al., 2013, Anamika et al., 2009, Biswas et al., 2009, Manning et al., 2002)

CG31183

(Werner et al., 2024, Sopko et al., 2014, Vogel et al., 2013, Anamika et al., 2009, Biswas et al., 2009, Manning et al., 2002)

CG33958

(Biswas et al., 2009)

CG42637

(Vogel et al., 2013, Cooper et al., 2010)

Gucy2d

Guanylate cyclase 2d

(Werner et al., 2024, Sopko et al., 2014, Vogel et al., 2013, Biswas et al., 2009, Manning et al., 2002)

Gyc32E

Guanylyl cyclase at 32E

GC, Guanyl cyclase at 32E

(Werner et al., 2024, Vogel et al., 2013, Anamika et al., 2009, Biswas et al., 2009, Manning et al., 2002)

Gyc76C

Guanylyl cyclase at 76C

l(3)76BDl, DrGC-1, drgc, gimli

(Werner et al., 2024, Vogel et al., 2013, Cooper et al., 2010, Biswas et al., 2009, Manning et al., 2002)

nompB

no mechanoreceptor potential B

IFT88, osm-5

(Werner et al., 2024)

RECEPTOR RELATED TO TYROSINE KINASE

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

dnt

doughnut on 2

doughnut

(Mele and Johnson, 2019, Petrova et al., 2013, Halford and Stacker, 2001)

drl

derailed

lio, linotte

(Mele and Johnson, 2019, Reynaud et al., 2015, Petrova et al., 2013, Halford and Stacker, 2001)

Drl-2

Derailed 2

dnl, doughnut-like

(Mele and Johnson, 2019, Reynaud et al., 2015, Petrova et al., 2013)

RHOMBOID PSEUDOPROTEASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

rho-5

rhomboid-5

iRhom

(Urban et al., 2002, Guichard et al., 2000, Wasserman et al., 2000)

S1A NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

aqrs

aquarius

(Cao and Jiang, 2018)

CG1632

SPH198

(Cao and Jiang, 2018)

CG3088

SPH188

(Cao and Jiang, 2018)

CG3117

(Cao and Jiang, 2018)

CG3505

(Cao and Jiang, 2018)

CG4259

SPH173

(Cao and Jiang, 2018)

CG4271

SPH164

(Cao and Jiang, 2018)

CG4477

(Cao and Jiang, 2018)

CG4650

SPH197

(Cao and Jiang, 2018)

CG4653

SPH179

(Cao and Jiang, 2018)

CG4793

BG:DS07486.3

(Cao and Jiang, 2018)

CG4998

(Cao and Jiang, 2018)

CG6067

(Cao and Jiang, 2018)

CG8586

(Cao and Jiang, 2018)

CG8738

(Cao and Jiang, 2018)

CG9377

(Cao and Jiang, 2018)

CG9672

SPH161

(Cao and Jiang, 2018)

CG9673

SPH81

(Cao and Jiang, 2018)

CG9897

SPH195

(Cao and Jiang, 2018)

CG9997

(Cao and Jiang, 2018)

CG13318

(Cao and Jiang, 2018)

CG13527

SPH182

(Cao and Jiang, 2018)

CG14088

SPH199

(Cao and Jiang, 2018)

CG14990

SPH97

(Cao and Jiang, 2018)

CG15046

(Jiang, 2019.3.1)

CG15873

SPH184

(Cao and Jiang, 2018)

CG17242

SPH187, anon-SAGE:Wang-110

(Cao and Jiang, 2018)

CG17572

(Cao and Jiang, 2018)

CG18223

SPH200

(Cao and Jiang, 2018)

CG18420

BG:DS06874.6, SPH111

(Cao and Jiang, 2018)

CG18477

BG:DS07108.1

(Cao and Jiang, 2018)

CG18478

BG:DS07108.5, DS07108.5, SPH157

(Cao and Jiang, 2018)

CG18557

(Cao and Jiang, 2018)

CG18563

(Cao and Jiang, 2018)

CG30323

SPH206

(Cao and Jiang, 2018)

CG31199

(Cao and Jiang, 2018)

CG31200

(Cao and Jiang, 2018)

CG31205

(Cao and Jiang, 2018)

CG31266

(Cao and Jiang, 2018)

CG31267

(Cao and Jiang, 2018)

CG31326

SPH144

(Cao and Jiang, 2018)

CG31780

(Cao and Jiang, 2018)

CG31827

(Cao and Jiang, 2018)

CG32833

(Cao and Jiang, 2018)

CG32834

(Cao and Jiang, 2018)

CG33127

(Cao and Jiang, 2018)

CG33225

(Cao and Jiang, 2018)

CG33460

(Cao and Jiang, 2018)

CG33465

(Cao and Jiang, 2018)

CG34129

(Cao and Jiang, 2018)

CG34130

(Cao and Jiang, 2018)

CG34171

(Cao and Jiang, 2018)

CG34295

(Cao and Jiang, 2018)

CG34436

(Cao and Jiang, 2018)

CG34437

(Cao and Jiang, 2018)

CG42694

(Cao and Jiang, 2018)

CG43124

(Cao and Jiang, 2018)

CG43125

(Cao and Jiang, 2018)

intr

intrepid

SPH202

(Cao and Jiang, 2018)

κTry

SPH109

(Cao and Jiang, 2018)

mas

masquerade

(Cao and Jiang, 2018)

scaf

scarface

(Cao and Jiang, 2018)

Sph35

Serine protease homolog 35

cSPH35

(Cao and Jiang, 2018)

SPH93

Serine protease homolog 93

(Cao and Jiang, 2018)

Sph242

Serine protease homolog 242

cSPH242

(Cao and Jiang, 2018)

sphe

spheroide

SPH114

(Cao and Jiang, 2018)

sphinx1

SPH194

(Cao and Jiang, 2018)

sphinx2

SPH194

(Cao and Jiang, 2018)

S9 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Ace

Acetylcholine esterase

AChE, acetylcholinesterase, DmAChE

(Rawlings and Barrett, 1996-)

α-Est1

α-Esterase-1

αE1, A, Est1, DmαE1, fragment A

(Rawlings and Barrett, 1996-)

α-Est3

α-Esterase-3

αE3, DmαE3, α-Ests

(Rawlings and Barrett, 1996-)

α-Est5

α-Esterase-5

αE5, DmαE5, Est-C

(Rawlings and Barrett, 1996-)

α-Est8

α-Esterase-8

αE8, Est8, DmαE8

(Rawlings and Barrett, 1996-)

α-Est9

α-Esterase-9

αE9, DmαE9, Dm_3R:18691

(Rawlings and Barrett, 1996-)

CG4382

(Rawlings and Barrett, 1996-)

CG5397

(Rawlings and Barrett, 1996-)

CG12869

(Rawlings and Barrett, 1996-)

CG45002

(FlyBase, 2017-, Chihara et al., 2005, Rawlings and Barrett, 1996-)

Est-6

Esterase 6

Est6, Est-D, Est

(Rawlings and Barrett, 1996-)

Gli

Gliotactin

l(2)35Dg, l(2)br45, BG:DS09217.3

(Rawlings and Barrett, 1996-)

Glt

Glutactin

(Rawlings and Barrett, 1996-)

Jhedup

Juvenile hormone esterase duplication

(Rawlings and Barrett, 1996-)

Nlg2

Neuroligin 2

neuroligin, dnlg2, dnl2

(Rawlings and Barrett, 1996-)

Nrt

Neurotactin

dab, BP106, disabled, Neur

(Rawlings and Barrett, 1996-)

S33 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG2059

(Rawlings and Barrett, 1996-)

CG2082

BcDNA:GH02439

(Rawlings and Barrett, 1996-)

CG14717

anon-SAGE:Wang-126

(Rawlings and Barrett, 1996-)

Jheh1

Juvenile hormone epoxide hydrolase 1

Jheh, JH, EH, epoxide hydrolase

(Rawlings and Barrett, 1996-)

Jheh2

Juvenile hormone epoxide hydrolase 2

epoxide hydrolase, EH

(Rawlings and Barrett, 1996-)

Jheh3

Juvenile hormone epoxide hydrolase 3

EH, epoxide hydrolase

(Rawlings and Barrett, 1996-)

S60 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Tsf1

Transferrin 1

Transferrin, lincRNA.S9601

(Rawlings and Barrett, 1996-)

Tsf2

Transferrin 2

Melanotransferrin, MTf

(Rawlings and Barrett, 1996-)

Tsf3

Transferrin 3

(Rawlings and Barrett, 1996-)

S81 NON-PEPTIDASE HOMOLOGS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG6421

EG:EG0003.8

(Rawlings and Barrett, 1996-)

CG6426

n(2)k04810

(Rawlings and Barrett, 1996-)

CG6429

(Rawlings and Barrett, 1996-)

SCYL PSEUDOKINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

bma

black match

(Manning et al., 2002)

CG1344

BcDNA:LD22679

(Sopko et al., 2014, Anamika et al., 2009, Manning et al., 2002)

CG1951

(Sopko et al., 2014, Anamika et al., 2009, Manning et al., 2002)

yata

(Sopko et al., 2014, Anamika et al., 2009, Manning et al., 2002)

SPERM LEUCYL AMINOPEPTIDASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

loopin-1

(Laurinyecz et al., 2019, Dorus et al., 2011)

S-Lap1

Sperm-Leucylaminopeptidase 1

(Laurinyecz et al., 2019, Dorus et al., 2011)

S-Lap2

Sperm-Leucylaminopeptidase 2

(Laurinyecz et al., 2019, Dorus et al., 2011)

S-Lap3

Sperm-Leucylaminopeptidase 3

lincRNA.S4635

(Laurinyecz et al., 2019, Dorus et al., 2011)

S-Lap4

Sperm-Leucylaminopeptidase 4

(Laurinyecz et al., 2019, Dorus et al., 2011)

S-Lap5

Sperm-Leucylaminopeptidase 5

(Laurinyecz et al., 2019, Dorus et al., 2011)

S-Lap7

Sperm-Leucylaminopeptidase 7

(Laurinyecz et al., 2019, Dorus et al., 2011)

S-Lap8

Sperm-Leucylaminopeptidase 8

(Laurinyecz et al., 2019, Dorus et al., 2011)

UBIQUITIN E2 ENZYME VARIANTS

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

CG16894

(Cenci et al., 2015, Du et al., 2011, Michelle et al., 2009)

morgue

modifier of rpr and grim, ubiquitously expressed

BcDNA:GH02435

(Du et al., 2011, Michelle et al., 2009)

peo

pendolino

cbx

(Cenci et al., 2015, Du et al., 2011, Michelle et al., 2009)

TSG101

Tumor susceptibility gene 101

ept, erupted, vps23, dTsg101, ESCRT-I

(Du et al., 2011)

Uev1A

Ubiquitin-conjugating enzyme variant 1A

dUev1A

(Du et al., 2011, Michelle et al., 2009)

UNCLASSIFIED PSEUDOENZYMES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

Adgf-E

Adenosine deaminase-related growth factor E

(Zurovec et al., 2002)

AhcyL1

Adenosylhomocysteinase like 1

(Parkhitko et al., 2016)

AhcyL2

Adenosylhomocysteinase like 2

Ahcy89E, AHCY, pH200

(Parkhitko et al., 2016)

CG4669

(Erven et al., 2022)

CG7304

(Tian and Ten Hagen, 2006)

CG7579

(Tian and Ten Hagen, 2006)

CG14402

(Erven et al., 2022)

CG14535

KIF26

(FlyBase, 2017-)

CG32436

(Erven et al., 2022)

CG32462

(Erven et al., 2022)

Hsdl2

Hydroxysteroid dehydrogenase like 2

(FlyBase, 2017-)

Jarid2

Jumonji, AT rich interactive domain 2

l(3)j2B8, dJmj

(Klose et al., 2006)

κB-Ras

(Fenwick et al., 2000)

ms(3)76Cc

male sterile (3) 76Cc

(Erven et al., 2022)

Paf-AHα

Platelet-activating factor acetylhydrolase alpha

(Sheffield et al., 2000)

PGRP-LA

Peptidoglycan recognition protein LA

(Kurata, 2014, Mellroth et al., 2003)

PGRP-LC

Peptidoglycan recognition protein LC

PGRP-LCx, PGRP-LCa, ird7

(Kurata, 2014, Mellroth et al., 2003)

PGRP-LD

Peptidoglycan recognition protein LD

(Kurata, 2014, Mellroth et al., 2003)

PGRP-LE

Peptidoglycan recognition protein LE

PGRP

(Kurata, 2014, Mellroth et al., 2003)

PGRP-LF

Peptidoglycan recognition protein LF

(Kurata, 2014, Mellroth et al., 2003)

PGRP-SA

Peptidoglycan recognition protein SA

seml, semmelweis

(Kurata, 2014, Mellroth et al., 2003)

PGRP-SD

Peptidoglycan recognition protein SD

Peptidoglycan-recognition protein-SD precursor

(Kurata, 2014, Mellroth et al., 2003)

Sodq

Sodesque

(Landis and Tower, 2005)

UNCLASSIFIED PSEUDOKINASES

Gene Symbol

Gene Name

Also Known As

Source Material for Membership

aln

allnighter

(Shekhar et al., 2023)

CG4041

(Anamika et al., 2009)

CG8726

(Anamika et al., 2009)

Ilk

Integrin linked kinase

l(3)78Ca

(Anamika et al., 2009)

Madm

MLF1-adaptor molecule

lincRNA.S6031

(Anamika et al., 2009)

Nipped-A

Tra1, TRRAP, dTra1, l(2)41Ah, 41Ah

(Elías-Villalobos et al., 2019)

Obsc

Obscurin

Unc-89, BEST:HL01080, obs

(Anamika et al., 2009)

PAN3

Poly(A) specific ribonuclease subunit PAN3

polyA-nuclease related

(Anamika et al., 2009)

Sdr

Secreted decoy of InR

(Okamoto et al., 2013)

Sps1

Selenophosphate synthetase 1

SelD, ptuf, patufet, selenide,water dikinase

(Persson et al., 1997)

Stlk

Ste20-like kinase

(Anamika et al., 2009)

trbl

tribbles

trb

(Masoner et al., 2013)

Wsck

(Anamika et al., 2009)

External Data

Equivalent Group(s)

Other resource(s)

Synonyms and Secondary IDs

Synonym(s)

PSENZ

PSEUDOENZYMES

Secondary FlyBase ID(s)

References (72)

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