FlyBase Gene Report: Dmel\CSN6

General Information

Symbol

Dmel\CSN6

Species

D. melanogaster

Name

COP9 signalosome subunit 6

Annotation Symbol

CG6932

Feature Type

protein_coding_gene

FlyBase ID

FBgn0028837

Gene Model Status

Current

Stock Availability

9 publicly available

Gene Summary

COP9 signalosome subunit 6 (CSN6) encodes the subunit 6 of the COP9 signalosome (CSN). The CSN plays a central role in the regulation of E3-cullin RING ubiquitin ligases. [Date last reviewed: 2019-03-07] (FlyBase Gene Snapshot)

All Summaries

Gene Snapshot
Alliance
Auto summary
Gene Group
UniProtKB
Interactive Fly

Also Known As

Dch6

Key Links

Genomic Location

Cytogenetic map

94B5-94B5

Sequence location

3R:22,580,773..22,582,033 [+]

Recombination map

3-75

RefSeq locus

NT_033777 REGION:22580773..22582033

Sequence

Get Decorated FASTA

Genomic Maps

JBrowse

Other Genome Views

The following external sites may use different assemblies or annotations than FlyBase.

Function

Gene Ontology (GO) Annotations (10 terms)

Molecular Function (4 terms)

Terms Based on Experimental Evidence (1 term)

CV Term

Evidence

References

NOT enables zinc ion binding

inferred from direct assay

(Zhang et al., 2012)

Terms Based on Predictions or Assertions (3 terms)

CV Term

Evidence

References

NOT enables metal-dependent deubiquitinase activity

inferred from sequence or structural similarity with UniProtKB:Q7L5N1

(Gene Ontology Curators, 2002-)

NOT enables metallopeptidase activity

inferred from key residues

(Zhang et al., 2012)

NOT enables peptidase activity

inferred from sequence or structural similarity with UniProtKB:Q7L5N1

(Gene Ontology Curators, 2002-)

inferred from key residues with MEROPS:M67.972

(GO curators, 2012-)

inferred from key residues

(Zhang et al., 2012)

Biological Process (5 terms)

Terms Based on Experimental Evidence (4 terms)

CV Term

Evidence

References

involved_in female germ-line stem cell population maintenance

inferred from mutant phenotype

(Pan et al., 2014)

involved_in germ cell development

inferred from mutant phenotype

(Qian et al., 2015)

involved_in male germ-line cyst encapsulation

inferred from mutant phenotype

(Qian et al., 2015)

involved_in protein stabilization

inferred from mutant phenotype

(Ullah et al., 2007)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

involved_in protein deneddylation

inferred from electronic annotation with InterPro:IPR033859

(InterPro Project Members, 2004-)

inferred from sequence or structural similarity with HGNC:21749

(Gene Ontology Curators, 2002-)

Cellular Component (1 term)

Terms Based on Experimental Evidence (0 terms)

Terms Based on Predictions or Assertions (1 term)

CV Term

Evidence

References

part_of COP9 signalosome

inferred from electronic annotation with InterPro:IPR033859

(InterPro Project Members, 2004-)

inferred from biological aspect of ancestor with PANTHER:PTN000057105

(GO Reference Genome Project, 2011-)

inferred from sequence or structural similarity with MGI:MGI:1349439

(Freilich et al., 1999)

Gene Group (FlyBase)

COP9 SIGNALOSOME

M67 NON-PEPTIDASE HOMOLOGS

COP9 SIGNALOSOME COMPLEX - TESTIS-SPECIFIC VARIANT

Protein Family (UniProt)

Belongs to the peptidase M67A family. CSN6 subfamily. (Q9VCY3)

Protein Signatures (InterPro)

Summaries

Gene Snapshot

Gene Group (FlyBase)

COP9 SIGNALOSOME -: The COP9 signalosome is an eight-subunit complex that is structurally and evolutionarily related to the 19S lid of the 26S proteasome. The COP9 signalosome plays a central role in the regulation of the E3-cullin RING ubiquitin ligases, deNEDDylating the cullin subunit via the isopeptidase activity of the CNS5 subunit. (Adapted from FBrf0225508 and FBrf0225509).
M67 NON-PEPTIDASE HOMOLOGS -: M67 non-peptidase homologs are similar in amino acid sequence to JAMM deubiquitinases (M67 metallopeptidases) but lack one or more of the expected catalytic residues or zinc-binding sites. They may act as scaffold proteins or as ubiquitin-binding modules within complexes. (Adapted from FBrf0239469 and PMID:17559875.)
COP9 SIGNALOSOME COMPLEX - TESTIS-SPECIFIC VARIANT -: The COP9 signalosome is an eight-subunit complex that is structurally and evolutionarily related to the 19S lid of the 26S proteasome. The COP9 signalosome plays a central role in the regulation of the E3-cullin RING ubiquitin ligases, deNEDDylating the cullin subunit via the isopeptidase activity of the CNS5 subunit. (Adapted from FBrf0225508 and FBrf0225509).

Protein Function (UniProtKB)

Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of the SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF. The CSN complex plays an essential role in oogenesis and embryogenesis and is required for proper photoreceptor R cell differentiation and promote lamina glial cell migration or axon targeting. It also promotes Ubl-dependent degradation of cyclin E (CycE) during early oogenesis.

(UniProt, Q9VCY3)

Gene Model and Products

Number of Transcripts

Number of Unique Polypeptides

Please see the JBrowse view of Dmel\CSN6 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)

Isoform displayed:

Pfam protein domains

InterPro name

classification

start

end

Protein Domains (via SMART)

Isoform displayed:

SMART protein domains

InterPro name

classification

start

end

Structure

Protein 3D structure (Predicted by AlphaFold) (AlphaFold entry Q9VCY3)

If you don't see a structure in the viewer, refresh your browser.

Model Confidence:

Very high (pLDDT > 90)
Confident (90 > pLDDT > 70)
Low (70 > pLDDT > 50)
Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures

Crossreferences

PDB - An information portal to biological macromolecular structures

4E0Q

Comments on Gene Model

Gene model reviewed during 5.47

Gene model reviewed during 5.52

Sequence Ontology: Class of Gene

nuclear_gene

protein_coding_gene

Transcript Data

Annotated Transcripts

Name

FlyBase ID

RefSeq ID

Length (nt)

Assoc. CDS (aa)

CSN6-RA

FBtr0084265

NM_079727

1203

341

Additional Transcript Data and Comments

Reported size (kB)

Comments

External Data

Crossreferences

Polypeptide Data

Annotated Polypeptides

Name

FlyBase ID

Predicted MW (kDa)

Length (aa)

Theoretical pI

UniProt

RefSeq ID

GenBank

CSN6-PA

FBpp0083658

38.3

341

5.62

Q9VCY3

NP_524451

AAF56022

Polypeptides with Identical Sequences

There is only one protein coding transcript and one polypeptide associated with this gene

Additional Polypeptide Data and Comments

Reported size (kDa)

332 (aa)

(Freilich et al., 1999)

Comments

External Data

Subunit Structure (UniProtKB)

Component of the CSN complex, probably composed of CSN1b, alien/CSN2, CSN3, CSN4, CSN5, CSN6, CSN7 and CSN8.

(UniProt, Q9VCY3)

Crossreferences

InterPro - A database of protein families, domains and functional sites

PDB - An information portal to biological macromolecular structures

4E0Q

Linkouts

Sequences Consistent with the Gene Model

Nucleotide / Polypeptide Records

UniProt

Q9VCY3

Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\CSN6 using the Feature Mapper tool.

External Data

Crossreferences

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CSN6_1

Linkouts

Expression Data

Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

2.64

Transcript Expression

in situ

Stage

Tissue/Position (including subcellular localization)

Reference

embryonic stage 1 -- 3

organism

Comment: maternally deposited

(Fisher et al., 2012)

embryonic stage 4 -- 6

organism | ubiquitous

(Fisher et al., 2012)

embryonic stage 7 -- 8

anterior endoderm anlage

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 9 -- 10

anterior endoderm

(Fisher et al., 2012)

head mesoderm

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

posterior endoderm

(Fisher et al., 2012)

trunk mesoderm

(Fisher et al., 2012)

embryonic stage 11 -- 12

anterior midgut primordium

(Fisher et al., 2012)

central brain primordium

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

ventral nerve cord primordium

(Fisher et al., 2012)

embryonic stage 13 -- 16

embryonic/larval midgut

(Fisher et al., 2012)

organism | faint | ubiquitous

(Fisher et al., 2012)

organism | ubiquitous

(Fisher et al., 2012)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Polypeptide Expression

mass spectroscopy

Stage

Tissue/Position (including subcellular localization)

Reference

adult stage

adult head

• membrane

(Aradska et al., 2015)

Additional Descriptive Data

Marker for

Subcellular Localization

CV Term

Evidence

References

Expression Deduced from Reporters

High-Throughput Expression Data

Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\CSN6 in JBrowse

RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region

View exonic expression by developmental stage for Dmel\CSN6

View exonic expression by tissue for Dmel\CSN6

Bulk Downloads

RNA-Seq RPKM values for all genes

Reference

See Gelbart and Emmert, 2013 for analysis details and data files for all genes.

Developmental Proteome: Life Cycle

Developmental Proteome: Embryogenesis

External Data and Images

Linkouts

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0028837

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42661/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0028837

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0028837

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0028837

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6932

Flygut - An atlas of the Drosophila adult midgut

FBgn0028837

Images

FlyExpress - Embryonic expression images (BDGP data)

Show all FlyExpress processed images for Dmel\CSN6

Stages(s) 1-3
Stages(s) 4-6
Stages(s) 7-8
Stages(s) 9-10
Stages(s) 11-12

FlyBase Wiki

Image Based Resources

Alleles, Insertions, Transgenic Constructs, and Aberrations

Classical and Insertion Alleles ( 2 )

For All Classical and Insertion Alleles Show

Other relevant insertions

Transgenic Constructs ( 11 )

For All Alleles Carried on Transgenic Constructs Show

Transgenic constructs containing/affecting coding region of CSN6

Transgenic constructs containing regulatory region of CSN6

Aberrations (Deficiencies and Duplications) ( 3 )

Inferred from experimentation ( 3 )

Gene disrupted in

Df(3R)Exel6273

(Ryder, 2004.4.26)

Df(3R)hh

(Gemmill et al., 2005)

Gene partially disrupted in

Df(3R)CRIMIC-CR71100

(Gene Disruption Project members, 2018-)

Inferred from location ( 0 )

Variants

Variant Molecular Consequences

Alleles Representing Disease-Implicated Variants

Phenotypes

For more details about a specific phenotype click on the relevant allele symbol.

Lethality

Allele

lethal, with Scer\GAL4^insc-Mz1407

CSN6^GD12078

lethal - all die before end of pupal stage, with Scer\GAL4^dpp.PU

CSN6^GD12078

lethal - all die before end of pupal stage, with Scer\GAL4^sqh.PW

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

CSN6^GD12078

viable, with Scer\GAL4^Mef2.PR

CSN6^GD12078

viable, with Scer\GAL4^pnr-MD237

CSN6^GD12078

viable, with Scer\GAL4^tin.CΔ4

CSN6^GD12078

Other Phenotypes

Allele

abnormal locomotor behavior | adult stage, with Scer\GAL4^elav.PU

short lived, with Scer\GAL4^elav.PU

short lived, with Scer\GAL4^Mef2.PR

CSN6^GD12078

some die during pupal stage, with Scer\GAL4^dpp.PU

CSN6^GD12078

some die during pupal stage, with Scer\GAL4^sqh.PW

visible, with Scer\GAL4^dpp.PU

CSN6^KK100377

visible, with Scer\GAL4^pnr-MD237

CSN6^GD12078

Phenotype manifest in

Allele

chaeta | increased number, with Scer\GAL4^pnr-MD237

CSN6^GD12078

embryonic/larval brain | larval stage, with Scer\GAL4^insc-Mz1407

CSN6^GD12078

female germline stem cell | somatic clone, with Scer\GAL4^{VP16.nanos.-FRT}

CSN6^RNAi.UASp

mesothoracic tergum, with Scer\GAL4^pnr-MD237

CSN6^GD12078

scutellar bristle, with Scer\GAL4^dpp.PU

CSN6^KK100377

testis, with Scer\GAL4^A3.eya

CSN6^HMS02392

testis, with Scer\GAL4^c784

CSN6^HMS02392

testis, with Scer\GAL4^NP1624

CSN6^HMS02392

trichogen cell, with Scer\GAL4^dpp.PU

CSN6^KK100377

trichogen cell, with Scer\GAL4^pnr-MD237

CSN6^GD12078

trichogen cell | increased number, with Scer\GAL4^pnr-MD237

CSN6^GD12078

Orthologs

Downloads

Download All DIOPT Orthologs

Human Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Homo sapiens (Human) (11)

Hsap\COPS6

14 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Model Organism Orthologs (via DIOPT v9.1)

Species\Gene Symbol

Score

Best Score

Best Reverse Score

Source

Alignment

Complementation?

Transgene?

Rattus norvegicus (Norway rat) (11)

Rnor\Cops6

14 of 14

Yes

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Mus musculus (laboratory mouse) (11)

Mmus\Cops6

13 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Xenopus tropicalis (Western clawed frog) (7)

Xtro\cops6

11 of 13

Yes

1 of 13

1 of 13

1 of 13

1 of 13

Yes

Xtro\psmd7

1 of 13

Xtro\psmd14

1 of 13

Danio rerio (Zebrafish) (12)

Drer\cops6

2 of 14

Yes

Drer\eif3f

2 of 14

Yes

Drer\psmd14

2 of 14

Yes

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

1 of 14

Caenorhabditis elegans (Nematode, roundworm) (6)

Cele\csn-6

11 of 14

Yes

2 of 14

2 of 14

2 of 14

2 of 14

2 of 14

Anopheles gambiae (African malaria mosquito) (8)

Agam\AgaP_AGAP008156

12 of 12

Yes

2 of 12

2 of 12

2 of 12

2 of 12

1 of 12

1 of 12

1 of 12

Arabidopsis thaliana (thale-cress) (14)

Atha\CSN6A

13 of 13

Yes

Atha\CSN6B

13 of 13

Yes

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

1 of 13

Saccharomyces cerevisiae (Brewer's yeast) (3)

Scer\RPN8

3 of 13

Yes

Scer\RPN11

2 of 13

Scer\RRI1

1 of 13

Schizosaccharomyces pombe (Fission yeast) (5)

Spom\csn5

2 of 12

Yes

Spom\rpn8

2 of 12

Yes

Spom\rpn11

2 of 12

Yes

Spom\SPBC4C3.07

2 of 12

Yes

Spom\sst2

1 of 12

Escherichia coli (enterobacterium) (0)

Other Organism Orthologs (via OrthoDB)

Data provided directly from OrthoDB:CSN6. Refer to their site for version information.

Paralogs

Downloads

Download All DIOPT Paralogs

Paralogs (via DIOPT v9.1)

Gene Symbol

Score

Source

Alignment

Drosophila melanogaster (Fruit fly) (8)

4 of 13

4 of 13

4 of 13

2 of 13

2 of 13

1 of 13

1 of 13

1 of 13

Human Disease Associations

FlyBase Human Disease Model Reports

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Allele

Disease

Evidence

References

Potential Models Based on Orthology ( 0 )

Human Ortholog

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Allele

Disease

Interaction

References

Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)

Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.

Homo sapiens (Human)

Gene name

Score

OMIM

OMIM Phenotype

DO term

Complementation?

Transgene?

COPS6; COP9 signalosome subunit 6

14 of 14

614729

Functional Complementation Data

Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.

Interactions

Summary of Physical Interactions

esyN Network Diagram

Show neighbor-neighbor interactions:

Off

Show/hide secondary interactors
(data from AllianceMine provided by esyN)

Select Layout:

Force Directed

Circle

Concentric

Legend:

Protein

RNA

Selected Interactor(s)

Interactions Browser

View in Interactions Browser

Please see the Physical Interaction reports below for full details

MIST Molecular Interaction Search Tool

View in MIST tool (external link)

Please see the Physical Interaction reports below for full details

protein-protein

Physical Interaction

Assay

References

CSN6 - CSN4

experimental knowledge based, anti tag coimmunoprecipitation, anti tag western blot

(Pan et al., 2014, Guruharsha et al., 2011)

CSN6 - CSN5

anti tag coimmunoprecipitation, anti tag western blot

(Pan et al., 2014)

CSN6 - CSN7

anti tag coimmunoprecipitation, anti tag western blot, experimental knowledge based

(Pan et al., 2014, Guruharsha et al., 2011)

CSN6 - alien

experimental knowledge based

(Guruharsha et al., 2011)

Summary of Genetic Interactions

esyN Network Diagram

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

Starting gene(s)

Interaction type

Interacting gene(s)

Reference

External Data

Subunit Structure (UniProtKB)

Component of the CSN complex, probably composed of CSN1b, alien/CSN2, CSN3, CSN4, CSN5, CSN6, CSN7 and CSN8.

(UniProt, Q9VCY3 )

Linkouts

BioGRID - A database of protein and genetic interactions.

67615

DroID - A comprehensive database of gene and protein interactions.

FBgn0028837

MIST (protein-protein) - An integrated Molecular Interaction Database

42661

Pathways

Signaling Pathways (FlyBase)

Metabolic Pathways

External Data

Linkouts

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

Genomic Location and Detailed Mapping Data

Chromosome (arm)

Recombination map

3-75

Cytogenetic map

94B5-94B5

Sequence location

3R:22,580,773..22,582,033 [+]

FlyBase Computed Cytological Location

Cytogenetic map

Evidence for location

94B5-94B5

Limits computationally determined from genome sequence between P{PZ}l(3)rQ178^rQ178 and P{lacW}Dph5^L4910

Experimentally Determined Cytological Location

Cytogenetic map

Notes

References

Experimentally Determined Recombination Data

Location

3-75

(FlyBase, 2016)

3-77.8

(Comeron et al., 2012)

Left of (cM)

Right of (cM)

Notes

Stocks and Reagents

Stocks (9)

Aberrations including deletions of this gene Aberrations including duplications of this gene

Bloomington

41991

y¹ v¹; P{TRiP.HMS02392}attP40

92156

w¹¹¹⁸; PBac{WH}CSN6^f03517/TM6B, Tb¹

36073

y¹ sc^* v¹ sev²¹; P{TRiP.GL00492}attP2

602331

y¹ w^*; Df(3R)CRIMIC-CR71100 TI{KozakGAL4}CSN6^{CR71100-KO-kG4}/TM3, Sb¹ Ser¹

FlyORF

F001380

M{UAS-CSN6.ORF}ZH-86Fb

F001041

M{UAS-CSN6.ORF.3xHA}ZH-86Fb

NIG-Fly

HMJ21516

y¹ v¹; P{TRiP.HMJ21516}attP40/CyO

VDRC

v105385

P{KK100377}VIE-260B

v22308

w¹¹¹⁸; P{GD12078}v22308

Genomic Clones (21)

Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete

cDNA Clones (111)

Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

cDNA clones, fully sequenced

BDGP DGC clones

RE71054

Other clones

Drosophila Genomics Resource Center cDNA clones

For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

FBgn0028837

cDNA Clones, End Sequenced (ESTs)

BDGP DGC clones

Other clones

RNAi and Array Information

Linkouts

DRSC - Results frm RNAi screens

FBgn0028837

Antibody Information

Laboratory Generated Antibodies

Commercially Available Antibodies

Cell Line Information

Publicly Available Cell Lines

Other Stable Cell Lines

Other Comments

Identification: On the basis of sequence similarity to COP9 signalosome units.

(Freilich et al., 1999)

COP9 signalosome is essential for development.

(Freilich et al., 1999)

Relationship to Other Genes

Source for database merge of

Additional comments

Nomenclature History

Source for database identify of

Nomenclature comments

Etymology

Synonyms and Secondary IDs (10)

Reported As

Symbol Synonym

CG6932

(National Institute of Genetics Fly Stocks, 2023-, Páhi et al., 2022, Hosono et al., 2015, Schertel et al., 2013, Tsou et al., 2012, Zhang et al., 2012, Ni et al., 2011.7.19, Ni et al., 2010.12.1, Keleman et al., 2009.8.5, Gandhi et al., 2007)

CH6

Csn6

(Minervini et al., 2022, Lee et al., 2010, Oron et al., 2007)

Dch6

(Wei and Deng, 2003, Freilich et al., 1999)

Q9VCY3

(Clague et al., 2013)

csn6

(Lu et al., 2015)

Name Synonyms

COP9 complex homolog subunit 6

(Freilich et al., 1999)

COP9 signalosome subunit 6

Drosophila COP9 signalosome homolog 6

(Freilich et al., 1999)

Secondary FlyBase IDs

Datasets (0)

Study focus (0)

Experimental Role

Project

Project Type

Title

Study result (0)

Result

Result Type

Title

External Crossreferences and Linkouts ( 40 )

Sequence Crossreferences

NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.

42661

GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.

GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.

RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.

UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.

Q9VCY3

UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information

Q9VCY3

Other crossreferences

AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.

Q9VCY3

BDGP expression data - Patterns of gene expression in Drosophila embryogenesis

FBgn0028837

DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species

42661/tissue=All

EMBL-EBI Single Cell Expression Atlas - Single cell expression across species

FBgn0028837

FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data

FBgn0028837

FlyMine - An integrated database for Drosophila genomics

FBgn0028837

InterPro - A database of protein families, domains and functional sites

KEGG Genes - Molecular building blocks of life in the genomic space.

dme:Dmel_CG6932

MARRVEL_MODEL - MARRVEL (model organism gene)

42661

PDB - An information portal to biological macromolecular structures

4E0Q

Linkouts

BioGRID - A database of protein and genetic interactions.

67615

Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones

FBgn0028837

DroID - A comprehensive database of gene and protein interactions.

FBgn0028837

DRSC - Results frm RNAi screens

FBgn0028837

Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.

CSN6_1

FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array

FBgn0028837

FlyCyc Genes - Genes from a BioCyc PGDB for Dmel

FBGN0028837

Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns

CG6932

Flygut - An atlas of the Drosophila adult midgut

FBgn0028837

FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.

FBgn0028837

iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)

TC002246

MIST (protein-protein) - An integrated Molecular Interaction Database

42661

Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.

References (75)

The following external sites may use different assemblies or annotations than FlyBase.

2.64

Report Sections