General Information | |||
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Term | metallopeptidase activity | ID (Ontology) | GO:0008237 (Gene Ontology) |
Definition | Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. | ||
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QuickGO data AmiGO data | |||
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Records annotated with this term OR any of its CHILD TERMS | |||
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hydrolase activity_______________________ catalytic activity, acting on a protein__| peptidase activity |__metallopeptidase activity 150 rec. |__metal-dependent deNEDDylase activity 2 rec. |__metal-dependent deubiquitinase activity 7 rec. |__metalloendopeptidase activity 64 rec. | |__metalloendopeptidase activity involved in amyloid precursor protein catabolic process |__metalloexopeptidase activity 71 rec. |__metalloaminopeptidase activity 27 rec. |__metallocarboxypeptidase activity(+) 22 rec. |__metallodipeptidase activity 5 rec. |
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Is a | peptidase activity | ||
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Secondary IDs | |||
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Reactome:R-HSA-157629 "NOTCH2-ligand complex is cleaved to produce NEXT2" Reactome:R-HSA-157632 "Complex of NOTCH1 with its ligand is cleaved to produce NEXT1" Reactome:R-HSA-193679 "alpha-secretase cleaves the p75NTR extracellular domain" Reactome:R-HSA-2022368 "MME:Zn2+ hydrolyses AGT(34-42)" Reactome:R-HSA-2022393 "ANPEP hydrolyzes Angiotensin-(2-8) to Angiotensin-(3-8)" Reactome:R-HSA-2022396 "MME:Zn2+ hydrolyses AGT(34-43)" Reactome:R-HSA-2022399 "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8)" Reactome:R-HSA-2220944 "ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants" Reactome:R-HSA-2220976 "NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding" Reactome:R-HSA-2666278 "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1" Reactome:R-HSA-2730752 "NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding" Reactome:R-HSA-3928660 "ADAM10 cleaves EFNAs" Reactome:R-HSA-5211340 "Anthrax lef cleaves target cell MAP2K1 (MEK1)" Reactome:R-HSA-5211356 "Anthrax lef cleaves target cell MAP2K2 (MEK2)" Reactome:R-HSA-5211387 "Anthrax lef cleaves target cell MAP2K7 (MEK7)" Reactome:R-HSA-5211391 "Anthrax lef cleaves target cell MAP2K4 (MEK4)" Reactome:R-HSA-5211400 "Anthrax lef cleaves target cell MAP2K3 (MEK3)" Reactome:R-HSA-5211405 "Anthrax lef cleaves target cell MAP2K6 (MEK6)" Reactome:R-HSA-8986181 "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)" Reactome:R-HSA-9013284 "NOTCH3-ligand complex is cleaved to produce NEXT3" Reactome:R-HSA-9604264 "ADAM10 cleaves NOTCH4" Reactome:R-HSA-9662837 "p-S,T-ADAM17(215-827):Zn2+ cleaves CD163" Reactome:R-HSA-9759522 "Membrane-bound CDH11 is cleaved to produce secreted CDH11 isoform" |