FB2024_02 , released April 23, 2024
Gene: Dmel\Idgf6
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General Information
Symbol
Dmel\Idgf6
Species
D. melanogaster
Name
Imaginal disc growth factor 6
Annotation Symbol
CG5210
Feature Type
protein_coding_gene
FlyBase ID
FBgn0013763
Gene Model Status
Current
Stock Availability
7 publicly available
Gene Summary
Imaginal disc growth factor 6 (Idgf6) is one of six genes in the IDGF family, which evolved from chitinases that lost their enzymatic activity. Idgf6 encodes a secreted protein that is highly expressed in larval fat body and adult head. Idgf6 product is involved in molting and egg chamber tube morphogenesis. [Date last reviewed: 2018-09-13] (FlyBase Gene Snapshot)
All Summaries
Also Known As

DS47, Chit, Chitinase-like, DmDS47

Key Links
Genomic Location
Cytogenetic map
53D2-53D2
Sequence location
Recombination map
2-80
RefSeq locus
NT_033778 REGION:16691022..16693751
Sequence
Get Decorated FASTA
Genomic Maps
Other Genome Views
The following external sites may use different assemblies or annotations than FlyBase.
NCBI
UCSC
Ensembl
PopFly
Function
Gene Ontology (GO) Annotations (11 terms)
Molecular Function (3 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
enables chitin binding
inferred from direct assay
(Zhu et al., 2008)
NOT enables chitinase activity
inferred from direct assay
(Zhu et al., 2008)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
enables chitin binding
inferred from electronic annotation with InterPro:IPR011583
(InterPro Project Members, 2004-)
enables imaginal disc growth factor receptor binding
inferred from sequence or structural similarity with FLYBASE:Idgf4; FB:FBgn0026415
(Gene Ontology Curators, 2002-)
NOT enables chitinase activity
inferred from key residues
(Kirkpatrick et al., 1995)
Biological Process (6 terms)
Terms Based on Experimental Evidence (3 terms)
CV Term
Evidence
References
involved_in chitin-based cuticle development
inferred from mutant phenotype
(Pesch et al., 2016)
involved_in ecdysis, chitin-based cuticle
inferred from mutant phenotype
(Pesch et al., 2016)
involved_in wound healing
inferred from mutant phenotype
(Pesch et al., 2016)
Terms Based on Predictions or Assertions (3 terms)
CV Term
Evidence
References
involved_in carbohydrate metabolic process
inferred from electronic annotation with InterPro:IPR001223
(InterPro Project Members, 2004-)
involved_in chitin catabolic process
inferred from biological aspect of ancestor with PANTHER:PTN000126545
(GO Reference Genome Project, 2011-)
involved_in imaginal disc development
inferred from sequence or structural similarity with FLYBASE:Idgf4; FB:FBgn0026415
(Gene Ontology Curators, 2002-)
Cellular Component (2 terms)
Terms Based on Experimental Evidence (2 terms)
CV Term
Evidence
References
located_in extracellular region
inferred from high throughput direct assay
(Karlsson et al., 2004)
located_in extracellular space
inferred from direct assay
(Zhu et al., 2008)
Terms Based on Predictions or Assertions (1 term)
CV Term
Evidence
References
is_active_in extracellular region
inferred from biological aspect of ancestor with PANTHER:PTN000126545
(GO Reference Genome Project, 2011-)
Gene Group (FlyBase)
Protein Family (UniProt)
Belongs to the glycosyl hydrolase 18 family. IDGF subfamily. (Q23997)
Protein Signatures (InterPro)
Summaries
Gene Snapshot
Imaginal disc growth factor 6 (Idgf6) is one of six genes in the IDGF family, which evolved from chitinases that lost their enzymatic activity. Idgf6 encodes a secreted protein that is highly expressed in larval fat body and adult head. Idgf6 product is involved in molting and egg chamber tube morphogenesis. [Date last reviewed: 2018-09-13]
Gene Group (FlyBase)
IMAGINAL DISC GROWTH FACTORS -
The Imaginal Disc Growth Factors (IDGF) belong to the 18-glycosylhydrolase family. IDGFs possess a single glyco18 domain which is catalytically inactive and may act as a chitin binding module. (Adapted from FBrf0231276 and FBrf0230884).
Protein Function (UniProtKB)
Probably required to stimulate the proliferation, polarization and motility of imaginal disk cells. May act by stabilizing the binding of insulin-like peptides to its receptor through a simultaneous interaction with both molecules to form a multiprotein signaling complex (By similarity).
(UniProt, Q23997)
Gene Model and Products
Number of Transcripts
2
Number of Unique Polypeptides
1

Please see the JBrowse view of Dmel\Idgf6 for information on other features

To submit a correction to a gene model please use the Contact FlyBase form

Protein Domains (via Pfam)
Isoform displayed:
Pfam protein domains
InterPro name
classification
start
end
Protein Domains (via SMART)
Isoform displayed:
SMART protein domains
InterPro name
classification
start
end
Structure
Protein 3D structure   (Predicted by AlphaFold)   (AlphaFold entry Q23997)

If you don't see a structure in the viewer, refresh your browser.
Model Confidence:
  • Very high (pLDDT > 90)
  • Confident (90 > pLDDT > 70)
  • Low (70 > pLDDT > 50)
  • Very low (pLDDT < 50)

AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.

Experimentally Determined Structures
Crossreferences
Comments on Gene Model

Gene model reviewed during 5.50

Gene model reviewed during 5.56

Sequence Ontology: Class of Gene
gene_with_edited_transcript
(Rodriguez et al., 2012)
nuclear_gene
protein_coding_gene
Transcript Data
Annotated Transcripts
Name
FlyBase ID
RefSeq ID
Length (nt)
Assoc. CDS (aa)
Idgf6-RA
FBtr0087111
NM_057733
1541
452
Idgf6-RB
FBtr0340066
NM_001299570
1811
452
Additional Transcript Data and Comments
Reported size (kB)

1.6 (northern blot)

(Kirkpatrick et al., 1995)
Comments
External Data
Crossreferences
Polypeptide Data
Annotated Polypeptides
Name
FlyBase ID
Predicted MW (kDa)
Length (aa)
Theoretical pI
UniProt
RefSeq ID
GenBank
Idgf6-PA
FBpp0086257
50.4
452
8.06
Q23997
NP_477081
AAF57965
Idgf6-PB
FBpp0309072
50.4
452
8.06
Q23997
NP_001286499
AHN56295
Polypeptides with Identical Sequences

The group(s) of polypeptides indicated below share identical sequence to each other.

452 aa isoforms: Idgf6-PA, Idgf6-PB
Additional Polypeptide Data and Comments
Reported size (kDa)

452 (aa); 47 (kD observed)

(Kirkpatrick et al., 1995)
Comments
External Data
Post Translational Modification

Glycosylated.

(UniProt, Q23997)
Crossreferences
InterPro - A database of protein families, domains and functional sites
Linkouts
Sequences Consistent with the Gene Model
Nucleotide / Polypeptide Records
 
UniProt
Mapped Features

Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Idgf6 using the Feature Mapper tool.

External Data
Crossreferences
Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
Linkouts
Expression Data
Testis-specificity index

The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).

-0.73

Transcript Expression
in situ
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage 1 -- 3
organism

Comment: maternally deposited

(Fisher et al., 2012)
embryonic stage 4 -- 6
organism | ubiquitous

Comment: apically cleared

(Fisher et al., 2012)
yolk
(Fisher et al., 2012)
embryonic stage 7 -- 8
organism | ubiquitous
(Fisher et al., 2012)
embryonic stage 9 -- 10
amnioserosa
(Fisher et al., 2012)
anterior endoderm
(Fisher et al., 2012)
head mesoderm
(Fisher et al., 2012)
organism | ubiquitous
(Fisher et al., 2012)
posterior endoderm
(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
embryonic stage 11 -- 12
amnioserosa
(Fisher et al., 2012)
anterior midgut primordium
(Fisher et al., 2012)
posterior midgut primordium
(Fisher et al., 2012)
somatic muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
visceral muscle primordium

Comment: reported as muscle system primordium

(Fisher et al., 2012)
trunk mesoderm
(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
embryonic stage 13 -- 16
embryonic/larval lymph gland
(Fisher et al., 2012)
embryonic/larval plasmatocyte
(Fisher et al., 2012)
yolk nucleus
(Fisher et al., 2012)
northern blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage & larval stage
(Kirkpatrick et al., 1995)
larval stage
embryonic/larval fat body
(Kirkpatrick et al., 1995)
hemolymph
(Kirkpatrick et al., 1995)
adult stage | female
(Kirkpatrick et al., 1995)
adult stage | male
(Kirkpatrick et al., 1995)
Additional Descriptive Data

Idgf6 transcripts are detected at all developmental stages examined (all but pupae) and in S2 cells on northern blots. Transcripts are detected by in situ hybridization in extracellular spaces occupied by hemolymph. Blots on RNA from dissected tissues shows that a major site of expression is the larval fat body.

(Kirkpatrick et al., 1995)
Marker for
 
Subcellular Localization
CV Term
Polypeptide Expression
mass spectroscopy
Stage
Tissue/Position (including subcellular localization)
Reference
adult stage
adult head
(Aradska et al., 2015)
day 7 of adulthood -- day 49 of adulthood
adult heart
(Cammarato et al., 2011)
western blot
Stage
Tissue/Position (including subcellular localization)
Reference
embryonic stage -- adult stage
(Kirkpatrick et al., 1995)
larval stage
hemolymph
(Kirkpatrick et al., 1995)
embryonic/larval fat body
(Kirkpatrick et al., 1995)
Additional Descriptive Data

Idgf6 protein is detected throughout development on Western blots. In larval dissected tissues it is most abundant in the hemolymph. A small amount is found associated with fat body.

(Kirkpatrick et al., 1995)
Marker for
 
Subcellular Localization
CV Term
Evidence
References
located_in extracellular region
inferred from high throughput direct assay
(Karlsson et al., 2004)
located_in extracellular space
inferred from direct assay
(Zhu et al., 2008)
Expression Deduced from Reporters
High-Throughput Expression Data
Associated Tools

JBrowse - Visual display of RNA-Seq signals

View Dmel\Idgf6 in JBrowse
RNA-Seq by Region - Search RNA-Seq expression levels by exon or genomic region
Bulk Downloads
RNA-Seq RPKM values for all genes
Reference
See Gelbart and Emmert, 2013 for analysis details and data files for all genes.
Developmental Proteome: Life Cycle
Developmental Proteome: Embryogenesis
External Data and Images
Linkouts
BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
Flygut - An atlas of the Drosophila adult midgut
Images
FlyExpress - Embryonic expression images (BDGP data)
  • Stages(s) 4-6
  • Stages(s) 7-8
  • Stages(s) 9-10
  • Stages(s) 11-12
  • Stages(s) 13-16
FlyBase Wiki
Image Based Resources
Alleles, Insertions, Transgenic Constructs, and Aberrations
Classical and Insertion Alleles ( 2 )
For All Classical and Insertion Alleles Show
 
Other relevant insertions
Transgenic Constructs ( 6 )
For All Alleles Carried on Transgenic Constructs Show
Transgenic constructs containing/affecting coding region of Idgf6
Transgenic constructs containing regulatory region of Idgf6
Aberrations (Deficiencies and Duplications) ( 1 )
Inferred from experimentation ( 1 )
Gene disrupted in
Df(2R)Exel6064
(Sustar et al., 2023, Ryder, 2004.4.26)
Inferred from location ( 0 )
Variants
Variant Molecular Consequences
Alleles Representing Disease-Implicated Variants
Phenotypes
Orthologs
Downloads
Download All DIOPT Orthologs
Human Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Homo sapiens (Human) (7)
Hsap\CHI3L1
5 of 14
Yes
No
Hsap\CHIT1
5 of 14
Yes
No
Hsap\OVGP1
5 of 14
Yes
No
Hsap\CHI3L2
4 of 14
No
No
Hsap\CHIA
4 of 14
No
No
1  
Hsap\CTBS
1 of 14
No
No
Hsap\USP49
1 of 14
No
No
Model Organism Orthologs (via DIOPT v9.1)
Species\Gene Symbol
Score
Best Score
Best Reverse Score
Source
Compara
Domainoid
eggNOG
Hieranoid
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Complementation?
Transgene?
Rattus norvegicus (Norway rat) (7)
Rnor\Chi3l1
4 of 14
Yes
No
Rnor\Chit1
4 of 14
Yes
No
Rnor\RGD1309110
4 of 14
Yes
No
Rnor\Chi3l3
3 of 14
No
No
Rnor\Chia
3 of 14
No
No
Rnor\Ctbs
1 of 14
No
No
Rnor\Usp49
1 of 14
No
No
Mus musculus (laboratory mouse) (10)
Mmus\Chil1
5 of 14
Yes
No
Mmus\Chit1
5 of 14
Yes
No
Mmus\Ovgp1
5 of 14
Yes
No
Mmus\Chia1
4 of 14
No
No
Mmus\Chil3
4 of 14
No
No
Mmus\Chil4
4 of 14
No
No
Mmus\Chil6
4 of 14
No
No
Mmus\Chil5
3 of 14
No
No
Mmus\Ctbs
1 of 14
No
No
Mmus\Usp49
1 of 14
No
No
Xenopus tropicalis (Western clawed frog) (6)
Xtro\chit1
3 of 13
Yes
No
Xtro\XB5763442
2 of 13
No
No
Xtro\arsj
1 of 13
No
No
Xtro\ctbs
1 of 13
No
No
Xtro\usp49
1 of 13
No
No
Xtro\wdr73
1 of 13
No
Yes
Danio rerio (Zebrafish) (9)
Drer\chia.3
5 of 14
Yes
No
Drer\chia.6
5 of 14
Yes
No
Drer\chia.1
4 of 14
No
No
Drer\chia.2
4 of 14
No
No
Drer\chia.4
4 of 14
No
No
Drer\ovgp1
3 of 14
No
No
Drer\chia.5
2 of 14
No
No
Drer\si:ch211-226m16.2
1 of 14
No
No
Drer\usp49
1 of 14
No
No
Caenorhabditis elegans (Nematode, roundworm) (39)
Cele\chil-7
4 of 14
Yes
No
Cele\chil-15
4 of 14
Yes
No
Cele\chil-16
4 of 14
Yes
No
Cele\chil-17
4 of 14
Yes
No
Cele\chil-18
4 of 14
Yes
No
Cele\chil-2
3 of 14
No
No
Cele\chil-3
3 of 14
No
No
Cele\chil-4
3 of 14
No
No
Cele\chil-5
3 of 14
No
No
Cele\chil-6
3 of 14
No
No
Cele\chil-8
3 of 14
No
No
Cele\chil-9
3 of 14
No
No
Cele\chil-11
3 of 14
No
No
Cele\chil-12
3 of 14
No
No
Cele\chil-13
3 of 14
No
No
Cele\chil-19
3 of 14
No
No
Cele\chil-21
3 of 14
No
No
Cele\chil-22
3 of 14
No
No
Cele\chil-24
3 of 14
No
No
Cele\chil-25
3 of 14
No
No
Cele\cht-1
3 of 14
No
No
Cele\cht-2
3 of 14
No
No
Cele\lmd-4
3 of 14
No
No
Cele\lmd-5
3 of 14
No
No
Cele\R09D1.14
3 of 14
No
No
Cele\T19H5.6
3 of 14
No
No
Cele\chil-1
2 of 14
No
No
Cele\chil-20
2 of 14
No
No
Cele\chil-23
2 of 14
No
No
Cele\chil-26
2 of 14
No
No
Cele\chil-27
2 of 14
No
No
Cele\cht-3
2 of 14
No
Yes
Cele\cht-4
2 of 14
No
No
Cele\T01C4.8
2 of 14
No
No
Cele\btb-16
1 of 14
No
Yes
Cele\btb-17
1 of 14
No
Yes
Cele\btb-18
1 of 14
No
Yes
Cele\C45E5.3
1 of 14
No
Yes
Cele\K08F9.3
1 of 14
No
No
Anopheles gambiae (African malaria mosquito) (29)
Agam\AgaP_AGAP008060
12 of 12
Yes
Yes
Agam\AgaP_AGAP008061
11 of 12
No
Yes
Agam\AgaP_AGAP002457
3 of 12
No
No
Agam\AgaP_AGAP004876
3 of 12
No
No
Agam\AgaP_AGAP005337
3 of 12
No
No
Agam\AgaP_AGAP005339
3 of 12
No
No
Agam\AgaP_AGAP005634
3 of 12
No
No
Agam\AgaP_AGAP006086
3 of 12
No
No
Agam\AgaP_AGAP006191
3 of 12
No
No
Agam\AgaP_AGAP006414
3 of 12
No
No
Agam\AgaP_AGAP006898
3 of 12
No
No
Agam\AgaP_AGAP009049
3 of 12
No
No
Agam\AgaP_AGAP011033
3 of 12
No
No
Agam\AgaP_AGAP013260
3 of 12
No
No
Agam\AgaP_AGAP000198
2 of 12
No
No
Agam\AgaP_AGAP000436
2 of 12
No
No
Agam\AgaP_AGAP004831
2 of 12
No
Yes
Agam\AgaP_AGAP007182
2 of 12
No
No
Agam\AgaP_AGAP008561
2 of 12
No
No
Agam\AgaP_AGAP008562
2 of 12
No
No
Agam\AgaP_AGAP008566
2 of 12
No
No
Agam\AgaP_AGAP009022
2 of 12
No
No
Agam\AgaP_AGAP010371
2 of 12
No
No
Agam\AgaP_AGAP013120
2 of 12
No
No
Agam\AgaP_AGAP013166
2 of 12
No
No
Agam\AgaP_AGAP013496
2 of 12
No
No
Agam\AgaP_AGAP001863
1 of 12
No
No
Agam\AgaP_AGAP004367
1 of 12
No
No
Agam\AgaP_AGAP005975
1 of 12
No
No
Arabidopsis thaliana (thale-cress) (9)
Atha\AT4G19720
4 of 13
Yes
No
Atha\AT4G19730
4 of 13
Yes
No
Atha\AT4G19750
4 of 13
Yes
No
Atha\AT4G19760
4 of 13
Yes
No
Atha\AT4G19800
4 of 13
Yes
No
Atha\AT4G19820
4 of 13
Yes
No
Atha\ChiC
4 of 13
Yes
No
Atha\AT4G19770
3 of 13
No
No
Atha\AT4G19740
2 of 13
No
No
Saccharomyces cerevisiae (Brewer's yeast) (1)
Scer\CTS2
4 of 13
Yes
No
Schizosaccharomyces pombe (Fission yeast) (0)
Escherichia coli (enterobacterium) (0)
Other Organism Orthologs (via OrthoDB)
Data provided directly from OrthoDB:Idgf6. Refer to their site for version information.
Paralogs
Downloads
Download All DIOPT Paralogs
Paralogs (via DIOPT v9.1)
Gene Symbol
Score
Source
Compara
Domainoid
eggNOG
Homologene
Inparanoid
OMA
OrthoDB
OrthoFinder
OrthoInspector
orthoMCL
Panther
Phylome
SonicParanoid
Alignment
Drosophila melanogaster (Fruit fly) (20)
Idgf4
11 of 13
Cht4
6 of 13
Cht8
6 of 13
Cht9
6 of 13
Cht12
6 of 13
Idgf1
6 of 13
Idgf2
6 of 13
Idgf3
6 of 13
Idgf5
6 of 13
Cht2
5 of 13
Cht5
5 of 13
Cht7
5 of 13
Cht10
4 of 13
Cht6
3 of 13
Cht11
3 of 13
Cda4
1 of 13
Cda5
1 of 13
CG8460
1 of 13
Muc26B
1 of 13
Muc96D
1 of 13
Human Disease Associations
FlyBase Human Disease Model Reports
    Disease Ontology (DO) Annotations
    Models Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Evidence
    References
    Potential Models Based on Orthology ( 1 )
    Human Ortholog
    Disease
    Evidence
    References
    CHI3L1; chitinase 3 like 1
    model of  schizophrenia
    IEA
    (FlyBase, 2019-)
    Modifiers Based on Experimental Evidence ( 0 )
    Allele
    Disease
    Interaction
    References
    Disease Associations of Human Orthologs (via DIOPT v9.1 and OMIM)
    Note that ortholog calls supported by only 1 or 2 algorithms (DIOPT score < 3) are not shown.
    Homo sapiens (Human)
    Gene name
    Score
    OMIM
    OMIM Phenotype
    DO term
    Complementation?
    Transgene?
    CHI3L1; chitinase 3 like 1
    5 of 14
    601525
    CHIT1; chitinase 1
    5 of 14
    600031
      OVGP1; oviductal glycoprotein 1
      5 of 14
      603578
          CHI3L2; chitinase 3 like 2
          4 of 14
          601526
              CHIA; chitinase acidic
              4 of 14
              606080
                   
                  Functional Complementation Data
                  Functional complementation data is computed by FlyBase using a combination of the orthology data obtained from DIOPT and OrthoDB and the allele-level genetic interaction data curated from the literature.
                  Interactions
                  Summary of Physical Interactions
                  esyN Network Diagram
                  Show neighbor-neighbor interactions:
                  Show/hide secondary interactors 
                  (data from AllianceMine provided by esyN)
                  Select Layout:
                  Legend:
                  Protein
                  RNA
                  Selected Interactor(s)
                  Other Interaction Browsers
                  View in FlyBase Interactions Browser   View in MIST tool (external link)
                  Please see the Physical Interaction reports below for full details
                  protein-protein
                  Physical Interaction
                  Assay
                  References
                  Idgf6 - Pdi
                  experimental knowledge based
                  (Guruharsha et al., 2011)
                  Idgf6 - Recs1
                  two hybrid
                  (Hu et al., 2017.6.13)
                  RNA-RNA
                  Physical Interaction
                  Assay
                  References
                  Idgf6 - mir-8
                  quantitative reverse transcription pcr
                  (Lee et al., 2015)
                  Summary of Genetic Interactions
                  esyN Network Diagram
                  Other Interaction Browsers
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  Starting gene(s)
                  Interaction type
                  Interacting gene(s)
                  Reference
                  External Data
                  Linkouts
                  DroID - A comprehensive database of gene and protein interactions.
                  MIST (protein-protein) - An integrated Molecular Interaction Database
                  Pathways
                  Signaling Pathways (FlyBase)
                  Metabolic Pathways
                  External Data
                  Linkouts
                  Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                  Genomic Location and Detailed Mapping Data
                  Chromosome (arm)
                  2R
                  Recombination map
                  2-80
                  Cytogenetic map
                  53D2-53D2
                  Sequence location
                  FlyBase Computed Cytological Location
                  Cytogenetic map
                  Evidence for location
                  53D2-53D2
                  Limits computationally determined from genome sequence between P{PZ}Sema-2a03021&P{PZ}Cdk405428 and P{EP}BEST:SD02913EP2148&P{lacW}Dekk09907
                  Experimentally Determined Cytological Location
                  Cytogenetic map
                  Notes
                  References
                  53D-53D
                  (determined by in situ hybridisation)
                  (Kirkpatrick et al., 1995)
                  Experimentally Determined Recombination Data
                  Location

                  2-80

                  (FlyBase, 2016)

                  2-83.9

                  (Comeron et al., 2012)

                  2-

                  Left of (cM)
                  Right of (cM)
                  Notes
                  Stocks and Reagents
                  Stocks (7)
                  Genomic Clones (24)
                  cDNA Clones (294)
                   

                  Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.

                  cDNA clones, fully sequenced
                  BDGP DGC clones
                  Other clones
                  Drosophila Genomics Resource Center cDNA clones

                  For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.

                  cDNA Clones, End Sequenced (ESTs)
                  BDGP DGC clones
                  Other clones
                  RNAi and Array Information
                  Linkouts
                  DRSC - Results frm RNAi screens
                  Antibody Information
                  Laboratory Generated Antibodies
                   

                  polyclonal

                  (Kirkpatrick et al., 1995)
                  Commercially Available Antibodies
                   
                  Cell Line Information
                  Publicly Available Cell Lines
                   
                    Other Stable Cell Lines
                     
                      Other Comments

                      CG5210 is missing a critical glutamate residue within the conserved region II of family 18 chitinases and also lacks the C-terminal chitin binding domain. The protein has no chitinase activity in vitro, but it binds chitin tightly.

                      (Zhu et al., 2008)

                      Chit encodes an abundantly secreted 47kD glycoprotein. cDNA from a Schneider S2 library predicts a protein of 467 amino acids. mRNA and protein are present throughout the entire life cycle. Chit is related to mammalian glycoproteins expressed during immune activation.

                      (Kirkpatrick et al., 1995)
                      Relationship to Other Genes
                      Source for database merge of
                      Additional comments
                      Nomenclature History
                      Source for database identify of

                      Source for identity of: Idgf6 CG5210

                      (Zhang et al., 2011)
                      Nomenclature comments
                      Etymology
                      Synonyms and Secondary IDs (14)
                      Datasets (0)
                      Study focus (0)
                      Experimental Role
                      Project
                      Project Type
                      Title
                      Study result (0)
                      Result
                      Result Type
                      Title
                      External Crossreferences and Linkouts ( 45 )
                      Sequence Crossreferences
                      NCBI Gene - Gene integrates information from a wide range of species. A record may include nomenclature, Reference Sequences (RefSeqs), maps, pathways, variations, phenotypes, and links to genome-, phenotype-, and locus-specific resources worldwide.
                      GenBank Nucleotide - A collection of sequences from several sources, including GenBank, RefSeq, TPA, and PDB.
                      GenBank Protein - A collection of sequences from several sources, including translations from annotated coding regions in GenBank, RefSeq and TPA, as well as records from SwissProt, PIR, PRF, and PDB.
                      RefSeq - A comprehensive, integrated, non-redundant, well-annotated set of reference sequences including genomic, transcript, and protein.
                      UniProt/GCRP - The gene-centric reference proteome (GCRP) provides a 1:1 mapping between genes and UniProt accessions in which a single 'canonical' isoform represents the product(s) of each protein-coding gene.
                      UniProt/Swiss-Prot - Manually annotated and reviewed records of protein sequence and functional information
                      UniProt/TrEMBL - Automatically annotated and unreviewed records of protein sequence and functional information
                      Other crossreferences
                      AlphaFold DB - AlphaFold provides open access to protein structure predictions for the human proteome and other key proteins of interest, to accelerate scientific research.
                      BDGP expression data - Patterns of gene expression in Drosophila embryogenesis
                      DRscDB - A single-cell RNA-seq resource for data mining and data comparison across species
                      EMBL-EBI Single Cell Expression Atlas - Single cell expression across species
                      FlyAtlas2 - A Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data
                      FlyMine - An integrated database for Drosophila genomics
                      InterPro - A database of protein families, domains and functional sites
                      KEGG Genes - Molecular building blocks of life in the genomic space.
                      MARRVEL_MODEL - MARRVEL (model organism gene)
                      Linkouts
                      Drosophila Genomics Resource Center - Drosophila Genomics Resource Center (DGRC) cDNA clones
                      DroID - A comprehensive database of gene and protein interactions.
                      DRSC - Results frm RNAi screens
                      Eukaryotic Promoter Database - A collection of databases of experimentally validated promoters for selected model organisms.
                      FlyAtlas - Adult expression by tissue, using Affymetrix Dros2 array
                      FlyCyc Genes - Genes from a BioCyc PGDB for Dmel
                      Fly-FISH - A database of Drosophila embryo and larvae mRNA localization patterns
                      Flygut - An atlas of the Drosophila adult midgut
                      FlyMet - A comprehensive tissue-specific metabolomics resource for Drosophila.
                      iBeetle-Base - RNAi phenotypes in the red flour beetle (Tribolium castaneum)
                      MIST (protein-protein) - An integrated Molecular Interaction Database
                      Reactome - An open-source, open access, manually curated and peer-reviewed pathway database.
                      References (81)