ept, erupted, vps23, dTsg101, ESCRT-I
an ESCRT-I complex component that acts as an adapter for membrane rearrangements operated by ESCRT-III - binds monoubiquitinated substrates predicted to be ubiquitinated cytoplasmic tails of membrane bound proteins; this interaction delivers cargos to the lysosome via multivesicular bodies.
Please see the JBrowse view of Dmel\TSG101 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Low-frequency RNA-Seq exon junction(s) not annotated.
Gene model reviewed during 5.46
There is only one protein coding transcript and one polypeptide associated with this gene
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\TSG101 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
JBrowse - Visual display of RNA-Seq signals
View Dmel\TSG101 in JBrowse3-45
3-39.5
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
TSG101 is required cell autonomously for dendrite pruning in sensory neurons.
TSG101 is involved in ubiquitin-dependent regulation of proteins.
TSG101 mutant cells in the eye-antennal disc survive poorly. The eyes and heads of flies that contain TSG101 mutant cells are dramatically overgrown, yet are composed of mostly wild type cells. TSG101 mutant cells hyperactivate N signaling and overproduce the secreted growth factor os. TSG101 mutant cells provoke local tissue hyperplasia and ectopic S phase entry in surrounding wild type cells; the resulting overgrowth is dependent upon signaling through the os-responsive JAK/STAT pathway.
Source for merge of: TSG101 ept
Source for identity of: TSG101 CG9712
Named 'Tumor susceptibility gene 101' after the symbol of the human ortholog.