FB2024_03 , released June 25, 2024
Gene Group: RECEPTOR GUANYLATE CYCLASES
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General Information
Name
RECEPTOR GUANYLATE CYCLASES
Species
D. melanogaster
Symbol
RGC
FlyBase ID
FBgg0000224
Date last reviewed
2015-08-26
Number of members
8
Description
Description
Receptor guanylate cyclases are single-pass transmembrane receptors with an extracellular ligand-binding domain and intracellular guanylate cyclase and pseudokinase kinase domains. Ligand binding results in the activation of the intracellular guanylyl cyclase domain and the production of cyclic GMP from GTP. The kinase domain may have a regulatory role and may bind ATP. (Adapted from FBrf0228387).
Notes on Group

The Gyc76C and CG42637 transcription units are completely duplicated in the iso-1 reference strain genome. The duplication is a polymorphic variant that is present in the sequenced strain, but does not exist in other D.melanogaster strains (FBrf0211329).

Source Material
The RECEPTOR GUANYLATE CYCLASES Gene Group has been compiled using the following publication(s): Werner et al., 2024, Sopko et al., 2014, Vogel et al., 2013, Cooper et al., 2010, Anamika et al., 2009, Biswas et al., 2009, and Manning et al., 2002 .
Key Gene Ontology (GO) terms
Molecular Function
guanylate cyclase activity
Biological Process
Cellular Component
plasma membrane
Enzymatic activity
Enzyme name (EC)
guanylate cyclase (4.6.1.2)
Related Gene Groups
Parent group(s)
GUANYLATE CYCLASES
PSEUDOKINASES
TRANSMEMBRANE RECEPTORS
Members (8)
For all members:
GO ribbon stack
 molecular functionbiological processcellular component
Gene Symbol
Gene Name
Also Known As
Source Material for Membership
CG3216
(Werner et al., 2024, Sopko et al., 2014, Vogel et al., 2013, Anamika et al., 2009, Biswas et al., 2009, Manning et al., 2002)
CG10738
(Werner et al., 2024, Sopko et al., 2014, Vogel et al., 2013, Anamika et al., 2009, Biswas et al., 2009, Manning et al., 2002)
CG31183
(Werner et al., 2024, Sopko et al., 2014, Vogel et al., 2013, Anamika et al., 2009, Biswas et al., 2009, Manning et al., 2002)
CG33958
(Biswas et al., 2009)
CG42637
(Vogel et al., 2013, Cooper et al., 2010)
Gucy2d
Guanylate cyclase 2d
(Werner et al., 2024, Sopko et al., 2014, Vogel et al., 2013, Biswas et al., 2009, Manning et al., 2002)
Gyc32E
Guanylyl cyclase at 32E
GC, Guanyl cyclase at 32E
(Werner et al., 2024, Vogel et al., 2013, Anamika et al., 2009, Biswas et al., 2009, Manning et al., 2002)
Gyc76C
Guanylyl cyclase at 76C
l(3)76BDl, DrGC-1, drgc, gimli
(Werner et al., 2024, Vogel et al., 2013, Cooper et al., 2010, Biswas et al., 2009, Manning et al., 2002)
External Data
Equivalent Group(s)
Other resource(s)
Synonyms and Secondary IDs
Synonym(s)
RGC
RECEPTOR GUANYLATE CYCLASES
Receptor GC
Guanylyl cyclase-coupled receptors
Type 1 guanylyl cyclases
Secondary FlyBase ID(s)
References (8)