FB2024_03 , released June 25, 2024
Allele: Dmel\Zip71BUAS.Tag:FLAG
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General Information
Symbol
Dmel\Zip71BUAS.Tag:FLAG
Species
D. melanogaster
Name
FlyBase ID
FBal0319541
Feature type
allele
Associated gene
Associated Insertion(s)
Carried in Construct
Key Links
Transgenic product class
Nature of the Allele
Transgenic product class
Progenitor genotype
Carried in construct
Cytology
Description

UASt regulatory sequences drive expression of the full-length Zip71B open reading frame, that is tagged at the C-terminal end with Tag:FLAG.

Allele components
Component
Use(s)
Encoded product / tool
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DNA sequence
Protein sequence
 
Expression Data
Reporter Expression
Additional Information
Statement
Reference
 
Marker for
Reflects expression of
Reporter construct used in assay
Human Disease Associations
Disease Ontology (DO) Annotations
Models Based on Experimental Evidence ( 0 )
Disease
Evidence
References
Modifiers Based on Experimental Evidence ( 0 )
Disease
Interaction
References
Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
 
Disease-implicated variant(s)
 
Phenotypic Data
Phenotypic Class
Phenotype Manifest In
Detailed Description
Statement
Reference

Ectopic expression of Zip71BScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4GMR.long results in flatter adult eyes of normal size and patchy loss of pigmentation in the anterior half, when two copies of the Zip71BScer\UAS.T:Zzzz\FLAG are used the eye size is strongly reduced, with central loss of pigmentation and interommatidial bristles and shiny, glazed appearance.

External Data
Interactions
Show genetic interaction network for Enhancers & Suppressors
Phenotypic Class
Enhanced by
Statement
Reference
Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference
Enhancer of
Suppressor of
Other
Phenotype Manifest In
Enhanced by
Statement
Reference
Suppressed by
Statement
Reference
NOT suppressed by
Statement
Reference
Enhancer of
Suppressor of
Additional Comments
Genetic Interactions
Statement
Reference

The morphological defects in the adult eye seen upon expression of Zip71BScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4GMR.long are exacerbated to a varying degree by co-expression of any of the following: Zip42C.1Scer\UAS.T:Zzzz\FLAG, Zip42C.2Scer\UAS.T:Zzzz\FLAG, Zip48CScer\UAS.T:Zzzz\FLAG, Zip88EScer\UAS.T:Zzzz\FLAG, Zip89BScer\UAS.T:Zzzz\FLAG, Zip99CScer\UAS.T:Zzzz\FLAG, Zip102BScer\UAS.T:Zzzz\FLAG, foiScer\UAS.T:Zzzz\FLAG, CatsupScer\UAS.cLa.T:Zzzz\FLAG, ZnT33DKK100432, ZnT41FScer\UAS.T:Zzzz\FLAG, ZnT63CKK102261, ZnT77CScer\UAS.T:Zzzz\FLAG, ZnT86DScer\UAS.T:Zzzz\FLAG.

The pigmentation defects in the adult eye seen upon expression of Zip71BScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4GMR.long are exacerbated to a varying degree by co-expression of any of the following: Zip42C.1Scer\UAS.T:Zzzz\FLAG, Zip42C.2Scer\UAS.T:Zzzz\FLAG, Zip42C.2GD1831, Zip89BScer\UAS.T:Zzzz\FLAG, Zip99CScer\UAS.T:Zzzz\FLAG, Zip102BScer\UAS.T:Zzzz\FLAG, CatsupScer\UAS.cLa.T:Zzzz\FLAG, ZnT33DKK100432, ZnT35CScer\UAS.T:Zzzz\FLAG, ZnT86DScer\UAS.T:Zzzz\FLAG.

The morphological defects in the adult eye seen upon expression of Zip71BScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4GMR.long are ameliorated to a varying degree by co-expression of any of the following: Zip48CKK101374, Zip88EKK110168, Zip99CGD370, CatsupKK103630, ZnT33DScer\UAS.PB.T:Zzzz\FLAG, ZnT35CScer\UAS.T:Zzzz\FLAG, ZnT35CKK112697, ZnT63CScer\UAS.T:Zzzz\FLAG.

The pigmentation defects in the adult eye seen upon expression of Zip71BScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4GMR.long are ameliorated to a varying degree by co-expression of any of the following: Zip48CKK101374, Zip88EKK110168, Zip99CGD370, Zip102BGD3683, foiGD2367, CatsupKK103630, ZnT33DScer\UAS.PB.T:Zzzz\FLAG, ZnT35CKK112697, ZnT63CScer\UAS.T:Zzzz\FLAG, ZnT77CGD2749.

The morphological and pigmentation defects in the adult eye seen upon expression of Zip71BScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4GMR.long are not changed by co-expression of any of the following: Zip42C.1GD1830, Zip89BGD3013, ZnT41FGD4522, ZnT49BGD1962, ZnT86DKK101698.

The morphological defects in the adult eye seen upon expression of Zip71BScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4GMR.long are not changed (unlike the loss of pigmentation phenotype, which is modified) by co-expression of any of the following: Zip42C.2GD1831, Zip102BGD3683, foiGD2367, ZnT77CGD2749.

The loss of pigmentation defect in the adult eye seen upon expression of Zip71BScer\UAS.T:Zzzz\FLAG under the control of Scer\GAL4GMR.long is not changed (unlike the morphological phenotype, which is modified) by co-expression of any of the following: Zip48CScer\UAS.T:Zzzz\FLAG, Zip88EScer\UAS.T:Zzzz\FLAG, foiScer\UAS.T:Zzzz\FLAG, ZnT41FScer\UAS.T:Zzzz\FLAG, ZnT77CScer\UAS.T:Zzzz\FLAG.

The morphological and pigmentation defects in the adult eye seen upon expression of ZnT86DScer\UAS.cDa under the control of Scer\GAL4GMR.long are severely exacerbated by co-expression of Zip71BScer\UAS.T:Zzzz\FLAG which also leads to partial lethality.

The morphological and pigmentation defects in the adult eye seen upon expression of ZnT86DScer\UAS.T:Avic\GFP-EGFP under the control of Scer\GAL4GMR.long are ameliorated by co-expression of Zip71BScer\UAS.T:Zzzz\FLAG.

Xenogenetic Interactions
Statement
Reference
Complementation and Rescue Data
Comments

Expression of Zip71BGD2461 under the control of Scer\GAL4GMR.long rescues the flat eye shape and loss of pigmentation induced by Zip71BScer\UAS.T:Zzzz\FLAG expression.

Images (0)
Mutant
Wild-type
Stocks (0)
Notes on Origin
Discoverer
External Crossreferences and Linkouts ( 0 )
Synonyms and Secondary IDs (2)
Reported As
Symbol Synonym
Zip71BScer\UAS.T:Zzzz\FLAG
Zip71BUAS.Tag:FLAG
Name Synonyms
Secondary FlyBase IDs
    References (1)