FlyBase Allele Report: Dmel\Zip42C.2[GD1831]

General Information

Symbol

Dmel\Zip42C.2^GD1831

Species

D. melanogaster

Name

FlyBase ID

FBal0206225

Feature type

allele

Associated gene

Dmel\Zip42C.2

Associated Insertion(s)

Carried in Construct

P{GD1831}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD1831}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD1831

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal - all die during pupal stage, with Scer\GAL4^Tub.PU

(Lye et al., 2012)

partially lethal - majority die, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

some die during pupal stage, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

viable, with Dcr-2^UAS.cDa, Scer\GAL4^elav.PLu

(Neely et al., 2010)

viable, with Scer\GAL4^Mef2.PR

(Schnorrer et al., 2010)

viable, with Scer\GAL4^tin.CΔ4

(Neely et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

The mutant eye phenotype seen in flies co-expressing both ZnT63C^VDRC.cUa and Zip42C.1^{Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^GMR.PFa is suppressed if the flies are also co-expressing Zip42C.2^GD1831.

The thorax defects caused by co-expression of ZnT63C^VDRC.cUa and Zip42C.1^{Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^pnr-MD237 are enhanced if the flies are also co-expressing Zip42C.2^GD1831.

(Lye et al., 2013)

Expression of Zip42C.2^GD1831 under the control of Scer\GAL4^tub.PU results in early pupal lethality.

Expression of Zip42C.2^GD1831 under the control of Scer\GAL4^GMR.PFa does not result in a mutant phenotype.

Expression of Zip42C.2^GD1831 under the control of Scer\GAL4^pnr-MD237 does not result in a mutant phenotype.

(Lye et al., 2012)

Adults expressing Zip42C.2^GD1831 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 may result in semi-lethality, depending on the insertion line used.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1831

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Zip42C.2^GD1831/Scer\GAL4^GMR.long is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.cDa

(Dechen et al., 2015)

Zip42C.2^GD1831/Scer\GAL4^GMR.long is an enhancer of abnormal eye color phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.cDa

(Dechen et al., 2015)

Zip42C.2^GD1831/Scer\GAL4^GMR.long is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.long, Zip71B^UAS.Tag:FLAG

(Dechen et al., 2015)

Zip42C.2^GD1831/Scer\GAL4^GMR.long is an enhancer of abnormal eye color phenotype of Scer\GAL4^GMR.long, Zip71B^UAS.Tag:FLAG

(Dechen et al., 2015)

Zip42C.2^GD1831/Scer\GAL4^pnr-MD237 is an enhancer of visible phenotype of Scer\GAL4^pnr-MD237, Zip42C.1^UAS.EGFP, ZnT63C^VDRC.cUa

(Lye et al., 2013)

Suppressor of

Statement

Reference

Zip42C.2^GD1831/Scer\GAL4^GMR.PFa is a suppressor of visible phenotype of Scer\GAL4^GMR.PFa, Zip42C.1^UAS.EGFP, ZnT63C^VDRC.cUa

(Lye et al., 2013)

NOT Suppressor of

Statement

Reference

Zip42C.2^GD1831/Scer\GAL4^GMR.long is a non-suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.EGFP

(Dechen et al., 2015)

Zip42C.2^GD1831/Scer\GAL4^GMR.long is a non-suppressor of abnormal eye color phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.EGFP

(Dechen et al., 2015)

Zip42C.2^GD1831/Scer\GAL4^GMR.long is a non-suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.long, Zip71B^UAS.Tag:FLAG

(Dechen et al., 2015)

Phenotype Manifest In

Enhancer of

Statement

Reference

Zip42C.2^GD1831/Scer\GAL4^GMR.long is an enhancer of eye phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.cDa

(Dechen et al., 2015)

Zip42C.2^GD1831/Scer\GAL4^GMR.long is an enhancer of eye phenotype of Scer\GAL4^GMR.long, Zip71B^UAS.Tag:FLAG

(Dechen et al., 2015)

Zip42C.2^GD1831/Scer\GAL4^pnr-MD237 is an enhancer of adult thorax phenotype of Scer\GAL4^pnr-MD237, Zip42C.1^UAS.EGFP, ZnT63C^VDRC.cUa

(Lye et al., 2013)

Suppressor of

Statement

Reference

Zip42C.2^GD1831/Scer\GAL4^GMR.PFa is a suppressor of eye phenotype of Scer\GAL4^GMR.PFa, Zip42C.1^UAS.EGFP, ZnT63C^VDRC.cUa

(Lye et al., 2013)

NOT Suppressor of

Statement

Reference

Zip42C.2^GD1831/Scer\GAL4^GMR.long is a non-suppressor of eye phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.EGFP

(Dechen et al., 2015)

Zip42C.2^GD1831/Scer\GAL4^GMR.long is a non-suppressor of eye phenotype of Scer\GAL4^GMR.long, Zip71B^UAS.Tag:FLAG

(Dechen et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

The pigmentation defects in the adult eye seen upon expression of ZnT86D^Scer\UAS.cDa under the control of Scer\GAL4^GMR.long are strongly exacerbated by co-expression of Zip42C.2^GD1831 but the morphological defects remain unchanged.

The morphological and pigmentation defects in the adult eye seen upon expression of ZnT86D^{Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^GMR.long do not change upon co-expression of Zip42C.2^GD1831 RNAi.

The adult eye phenotype seen upon expression of Zip71B^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^GMR.long can be partially modified by co-expression of Zip42C.2^GD1831 RNAi: the morphological defects are unchanged but the pigmentation loss is mildly worsened.

(Dechen et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v7339

w¹¹¹⁸; P{GD1831}v7339/TM3

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 1 )

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

1831

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

CG9430^GD1831

Zip42C.2^GD1831

dZip42C.2^RNAi

(Dechen et al., 2015)

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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