FlyBase Allele Report: Dmel\foi[GD2367]

General Information

Symbol

Dmel\foi^GD2367

Species

D. melanogaster

Name

FlyBase ID

FBal0209581

Feature type

allele

Associated gene

Dmel\foi

Associated Insertion(s)

Carried in Construct

P{GD2367}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Dickson et al., 2007.7.18)

Mutagen

in vitro construct

(Dickson et al., 2007.7.18)

Progenitor genotype

Carried in construct

P{GD2367}

Cytology

Description

UASt regulatory sequences drive expression of an inverted repeat.

(Dickson et al., 2007.7.18)

Allele components

Component

Use(s)

Regulatory region(s)

UASt

binary expression system - regulatory region

Encoded product / tool

dsRNA-GD2367

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

Phenotype Manifest In

ganglion mother cell | larval stage, with Scer\GAL4^insc-Mz1407

(Neumüller et al., 2011)

larval neuroblast | larval stage, with Scer\GAL4^insc-Mz1407

(Neumüller et al., 2011)

mesothoracic tergum, with Scer\GAL4^pnr-MD237

(Mummery-Widmer et al., 2009)

Detailed Description

Statement

Reference

Expression of foi^GD2367 under the control of Scer\GAL4^GMR.PFa does not result in a mutant phenotype.

Expression of foi^GD2367 under the control of Scer\GAL4^pnr-MD237 does not result in a mutant phenotype.

Expression of foi^GD2367 under the control of Scer\GAL4^tub.PU results in early larval lethality.

(Lye et al., 2012)

Expression under the control of Scer\GAL4¹⁴⁰⁷ results in shorter neuroblast lineages (less daughter cells per neuroblast) in the larval brain compared to controls.

Expression under the control of Scer\GAL4¹⁴⁰⁷ results in mild defects in the shape of ganglion mother cells in the larval brain.

Expression under the control of Scer\GAL4¹⁴⁰⁷ results in mild defects in the shape of neuroblasts in the larval brain.

(Neumüller et al., 2011)

Adults expressing foi^GD2367 under the control of Scer\GAL4^elav.PLu (in the presence of Dcr-2^Scer\UAS.cDa to increase the efficiency of RNAi) do not show a significant defect in avoidance of noxious temperature (46[o]C) compared to control flies.

(Neely et al., 2010)

Expression under the control of Scer\GAL4^Mef2.PR results in early pupal lethality.

(Schnorrer et al., 2010)

Expression under the control of Scer\GAL4^pnr-MD237 results in loss of bristles on the notum in 30-40% of the Scer\GAL4^pnr-MD237 expression domain.

Expression under the control of Scer\GAL4^pnr-MD237 results in mild thorax closure defects.

Expression under the control of Scer\GAL4^pnr-MD237 results in an enlarged notum.

(Mummery-Widmer et al., 2009)

External Data

Linkouts

Bristle Screen Database (Knoblich Lab) - A database for RNAi phenotypes in bristle and notum development

2367

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

foi^GD2367/Scer\GAL4^GMR.long is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.cDa

(Dechen et al., 2015)

foi^GD2367/Scer\GAL4^GMR.long is an enhancer of abnormal eye color phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.cDa

(Dechen et al., 2015)

foi^GD2367/Scer\GAL4^GMR.long is an enhancer of visible | adult stage phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.EGFP

(Dechen et al., 2015)

foi^GD2367/Scer\GAL4^GMR.long is an enhancer of abnormal eye color phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.EGFP

(Dechen et al., 2015)

NOT Enhancer of

Statement

Reference

foi^GD2367/Scer\GAL4^GMR.PFa is a non-enhancer of visible phenotype of Scer\GAL4^GMR.PFa, Zip42C.1^UAS.EGFP, ZnT63C^VDRC.cUa

(Lye et al., 2013)

foi^GD2367/Scer\GAL4^pnr-MD237 is a non-enhancer of visible phenotype of Scer\GAL4^pnr-MD237, Zip42C.1^UAS.EGFP, ZnT63C^VDRC.cUa

(Lye et al., 2013)

Suppressor of

Statement

Reference

foi^GD2367/Scer\GAL4^GMR.long is a suppressor | partially of visible | adult stage phenotype of Scer\GAL4^GMR.long, Zip71B^UAS.Tag:FLAG

(Dechen et al., 2015)

foi^GD2367/Scer\GAL4^GMR.long is a suppressor | partially of abnormal eye color phenotype of Scer\GAL4^GMR.long, Zip71B^UAS.Tag:FLAG

(Dechen et al., 2015)

NOT Suppressor of

Statement

Reference

foi^GD2367/Scer\GAL4^GMR.long is a non-suppressor of visible | adult stage phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.cDa

(Dechen et al., 2015)

foi^GD2367/Scer\GAL4^GMR.long is a non-suppressor | partially of visible | adult stage phenotype of Scer\GAL4^GMR.long, Zip71B^UAS.Tag:FLAG

(Dechen et al., 2015)

foi^GD2367/Scer\GAL4^GMR.PFa is a non-suppressor of visible phenotype of Scer\GAL4^GMR.PFa, Zip42C.1^UAS.EGFP, ZnT63C^VDRC.cUa

(Lye et al., 2013)

foi^GD2367/Scer\GAL4^pnr-MD237 is a non-suppressor of visible phenotype of Scer\GAL4^pnr-MD237, Zip42C.1^UAS.EGFP, ZnT63C^VDRC.cUa

(Lye et al., 2013)

Other

Statement

Reference

Scer\GAL4^GMR.long, ZnT86D^UAS.EGFP, foi^GD2367 has partially lethal phenotype

(Dechen et al., 2015)

Phenotype Manifest In

Enhancer of

Statement

Reference

foi^GD2367/Scer\GAL4^GMR.long is an enhancer of eye phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.cDa

(Dechen et al., 2015)

foi^GD2367/Scer\GAL4^GMR.long is an enhancer of eye phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.EGFP

(Dechen et al., 2015)

NOT Enhancer of

Statement

Reference

foi^GD2367/Scer\GAL4^GMR.PFa is a non-enhancer of eye phenotype of Scer\GAL4^GMR.PFa, Zip42C.1^UAS.EGFP, ZnT63C^VDRC.cUa

(Lye et al., 2013)

foi^GD2367/Scer\GAL4^pnr-MD237 is a non-enhancer of adult thorax phenotype of Scer\GAL4^pnr-MD237, Zip42C.1^UAS.EGFP, ZnT63C^VDRC.cUa

(Lye et al., 2013)

Suppressor of

Statement

Reference

foi^GD2367/Scer\GAL4^GMR.long is a suppressor | partially of eye phenotype of Scer\GAL4^GMR.long, Zip71B^UAS.Tag:FLAG

(Dechen et al., 2015)

NOT Suppressor of

Statement

Reference

foi^GD2367/Scer\GAL4^GMR.long is a non-suppressor of eye phenotype of Scer\GAL4^GMR.long, ZnT86D^UAS.cDa

(Dechen et al., 2015)

foi^GD2367/Scer\GAL4^GMR.long is a non-suppressor | partially of eye phenotype of Scer\GAL4^GMR.long, Zip71B^UAS.Tag:FLAG

(Dechen et al., 2015)

foi^GD2367/Scer\GAL4^GMR.PFa is a non-suppressor of eye phenotype of Scer\GAL4^GMR.PFa, Zip42C.1^UAS.EGFP, ZnT63C^VDRC.cUa

(Lye et al., 2013)

foi^GD2367/Scer\GAL4^pnr-MD237 is a non-suppressor of adult thorax phenotype of Scer\GAL4^pnr-MD237, Zip42C.1^UAS.EGFP, ZnT63C^VDRC.cUa

(Lye et al., 2013)

Additional Comments

Genetic Interactions

Statement

Reference

The adult eye phenotype seen upon expression of ZnT86D^Scer\UAS.cDa under the control of Scer\GAL4^GMR.long can be partially modified by co-expression of foi^GD2367 : the morphological defects are unchanged but the pigmentation loss is mildly worsened.

The morphological and pigmentation defects in the adult eye seen upon expression of ZnT86D^{Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^GMR.long are severely exacerbated by co-expression of foi^GD2367 RNAi, which also leads to partial lethality.

The adult eye phenotype seen upon expression of Zip71B^{Scer\UAS.T:Zzzz\FLAG} under the control of Scer\GAL4^GMR.long can be partially modified by co-expression of foi^GD2367 : the morphological defects are unchanged but the pigmentation loss is mildly ameliorated.

(Dechen et al., 2015)

Co-expression of foi^GD2367 has no effect on the mutant eye phenotype seen in flies co-expressing both ZnT63C^VDRC.cUa and Zip42C.1^{Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^GMR.PFa.

Co-expression of foi^GD2367 has no effect on the mutant thorax phenotype seen in flies co-expressing both ZnT63C^VDRC.cUa and Zip42C.1^{Scer\UAS.T:Avic\GFP-EGFP} under the control of Scer\GAL4^pnr-MD237.

(Lye et al., 2013)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

VDRC

v10102