FlyBase Allele Report: Scer\GAL4[VGlut.PD]

ScerGAL4^VGlut.PD drives expression in the ellipsoid body rings in the innervation regions of R3 and R4d ring neurons and in a ring proximal to the R3 ring. In the fan-shaped body strong expression is detected in the central layers with weaker signal in the dorsal and ventral layers. Expression is also observed in the nodulus and in the protocerebral bridge (except for two segments on each lateral side). Co-localisation with mGluR protein is observed in the ellipsoid body rings R3 and R4d, in the fan-shaped body, nodulus and protocerebral bridge.

(Kahsai et al., 2012)

ScerGAL4^VGlut.PD is labels a subset of glutamatergic neurons in the medulla, lamina, lobula and lobula plate.

(Raghu and Borst, 2011)

Expression of ScerGAL4^VGlut.PD is seen in many, but not all, glutamatergic neurons of the larva, and a few apparently non-glutamatergic neurons. In the adult brain, expression of VGlut shows extensive expression in central neuropil compartments, but is predominantly absent from the mushroom body only being detectable as punctae in the base of the gamma-lobes, the tip but not the base of the alpha-lobe (in contrast to VGlut which is seen in the base), the spur, and faintly in the calyx. Expression of ScerGAL4^VGlut.PD does not perfectly reflect expression of VGlut. Expression in the adult brain is seen in a few motor neurons that innervate head muscles. Expression within the ellipsoid body is observed within its inner and outer layers, a pattern suggestive of R-cell innervation. The expression seen in the protocerebral bridge is extensive across all glomeruli, but is weaker in the most distal glomerulus - glomerulus number 8. Expression in the adult optic lobe is strongest in an outer medulla layer and the inner medulla.

(Daniels et al., 2008)

Marker for

Reflects expression of

VGlut

(Chen et al., 2012, Kahsai et al., 2012, Raghu and Borst, 2011, Wu et al., 2010, Graf et al., 2009)

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal locomotor behavior | adult stage, with VGlut^UAS.cDa

(Daniels et al., 2011)

abnormal locomotor behavior | larval stage, with brp^{C-tip.UAS.CFP,Tag:FLAG}

(Scholz et al., 2019)

abnormal locomotor behavior | third instar larval stage, with Hsap\TARDBP^UAS.cHa

(Deshpande et al., 2016)

abnormal locomotor behavior | third instar larval stage, with Rab11^N124I.UAS

(Deshpande et al., 2016)

abnormal locomotor behavior | wandering third instar larval stage, with Tmep^HMC04736

(Cho et al., 2022)

abnormal locomotor behavior | wandering third instar larval stage, with Tmep^KK108183

(Cho et al., 2022)

abnormal neuroanatomy, with VGlut^UAS.EGFP

(Daniels et al., 2011)

abnormal neuroanatomy | third instar larval stage, with Hsap\TARDBP^UAS.cHa

(Deshpande et al., 2016)

abnormal neuroanatomy | third instar larval stage, with Rab11^N124I.UAS

(Deshpande et al., 2016)

abnormal neurophysiology, with VGlut^UAS.cDa

(Daniels et al., 2011)

abnormal neurophysiology | third instar larval stage, with Tmep^HMC04736

(Cho et al., 2022)

abnormal neurophysiology | third instar larval stage, with Tmep^KK108183

(Cho et al., 2022)

abnormal oxidative stress response | adult stage, with ERR^JF02431

(Velo Escarcena et al., 2021)

female semi-sterile, with Bx^GD1385

(Kairamkonda and Nongthomba, 2014)

flightless, with VGlut^UAS.cDa

(Daniels et al., 2011)

lethal, with VGlut^UAS.cDa

(Daniels et al., 2011)

lethal, with VGlut^UAS.EGFP

(Daniels et al., 2011)

lethal - all die before end of larval stage, with Hsap\TARDBP^{M337V.UAS.cLa}

(Choksi et al., 2014)

lethal - all die before end of P-stage, with Hsap\TARDBP^{Q331K.UAS.cLa}

(Choksi et al., 2014)

lethal - all die before end of P-stage, with Hsap\TARDBP^UAS.cLa

(Choksi et al., 2014)

lethal - all die before end of pupal stage, with VGlut^UAS.EGFP

(Grygoruk et al., 2010)

some die during pupal stage, with VGlut^UAS.EGFP

(Grygoruk et al., 2010)

uncoordinated, with VGlut^UAS.cDa

(Daniels et al., 2011)

viable, with VGlut^B1.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B2.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B3.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B4.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B5.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B7.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B9.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B10.UAS

(Grygoruk et al., 2010)

viable, with VGlut^B11.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B13.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B15.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B16.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B18.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B19.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B20.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B21.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B22.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B23.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B24.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B25.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B26.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B27.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B28.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B29.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B30.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B31.UAS

(Grygoruk et al., 2010)

viable, with VGlut^B32.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B33.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B34.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B35.UAS

(Grygoruk et al., 2010)

viable, with VGlut^B38.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B39.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B40.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B41.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B42.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B43.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B44.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B45.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B46.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B47.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B48.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B49.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B50.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^B52.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^RD7.UAS.EGFP

(Grygoruk et al., 2010)

viable, with VGlut^{RD16.UAS.EGFP}

(Grygoruk et al., 2010)

Phenotype Manifest In

Detailed Description

Statement

Reference

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Suppressed by

Statement

Reference

Scer\GAL4^VGlut.PD, Tmep^KK108183 has abnormal locomotor behavior | wandering third instar larval stage phenotype, suppressible by Itpr^HMC03351, Scer\GAL4^VGlut.PD

(Cho et al., 2022)

Scer\GAL4^VGlut.PD, Tmep^KK108183 has abnormal locomotor behavior | wandering third instar larval stage phenotype, suppressible by RyR^HM05130, Scer\GAL4^VGlut.PD

(Cho et al., 2022)

Scer\GAL4^VGlut.PD, Tmep^KK108183 has abnormal locomotor behavior | wandering third instar larval stage phenotype, suppressible by Nmnat^UAS.cZa, Scer\GAL4^VGlut.PD

(Cho et al., 2022)

Hsap\TARDBP^UAS.cHa, Scer\GAL4^VGlut.PD has abnormal neuroanatomy | third instar larval stage phenotype, suppressible | partially by Dad^j1E4/Dad^j1E4

(Deshpande et al., 2016)

Hsap\TARDBP^UAS.cHa, Scer\GAL4^VGlut.PD has abnormal neuroanatomy | third instar larval stage phenotype, suppressible | partially by Dad^j1E4/Dad[+]

(Deshpande et al., 2016)

Hsap\TARDBP^UAS.cHa, Scer\GAL4^VGlut.PD has abnormal neuroanatomy | third instar larval stage phenotype, suppressible | partially by Rab11^N124I.UAS, Scer\GAL4^VGlut.PD

(Deshpande et al., 2016)

Hsap\TARDBP^UAS.cHa, Scer\GAL4^VGlut.PD has abnormal locomotor behavior | third instar larval stage phenotype, suppressible | partially by Rab11^N124I.UAS, Scer\GAL4^VGlut.PD

(Deshpande et al., 2016)

NOT suppressed by

Statement

Reference

Hsap\TARDBP^UAS.cHa, Scer\GAL4^VGlut.PD has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by Rab5^S43N.UAS, Scer\GAL4^VGlut.PD

(Deshpande et al., 2016)

Hsap\TARDBP^UAS.cHa, Scer\GAL4^VGlut.PD has abnormal locomotor behavior | third instar larval stage phenotype, non-suppressible by Snx16^3A.UAS.GFP/tkv^{Q199D.UAS.Tag:HA}, Scer\GAL4^VGlut.PD

(Deshpande et al., 2016)

Hsap\TARDBP^UAS.cHa, Scer\GAL4^VGlut.PD has abnormal neuroanatomy | third instar larval stage phenotype, non-suppressible by Snx16^3A.UAS.GFP/tkv^{Q199D.UAS.Tag:HA}, Scer\GAL4^VGlut.PD

(Deshpande et al., 2016)

Suppressor of

Statement

Reference

Itpr^HMC03351, Scer\GAL4^VGlut.PD is a suppressor of abnormal locomotor behavior | wandering third instar larval stage phenotype of Scer\GAL4^VGlut.PD, Tmep^KK108183

(Cho et al., 2022)

RyR^HM05130, Scer\GAL4^VGlut.PD is a suppressor of abnormal locomotor behavior | wandering third instar larval stage phenotype of Scer\GAL4^VGlut.PD, Tmep^KK108183

(Cho et al., 2022)

Nmnat^UAS.cZa, Scer\GAL4^VGlut.PD is a suppressor of abnormal locomotor behavior | wandering third instar larval stage phenotype of Scer\GAL4^VGlut.PD, Tmep^KK108183

(Cho et al., 2022)

Rab11^N124I.UAS, Scer\GAL4^VGlut.PD is a suppressor | partially of abnormal neuroanatomy | third instar larval stage phenotype of Hsap\TARDBP^UAS.cHa, Scer\GAL4^VGlut.PD

(Deshpande et al., 2016)

Rab11^N124I.UAS, Scer\GAL4^VGlut.PD is a suppressor | partially of abnormal locomotor behavior | third instar larval stage phenotype of Hsap\TARDBP^UAS.cHa, Scer\GAL4^VGlut.PD

(Deshpande et al., 2016)

Rab11^N124I.UAS/Scer\GAL4^VGlut.PD is a suppressor | partially of abnormal locomotor behavior | third instar larval stage phenotype of Df(2R)BSC610/TBPH^Δ23

(Deshpande et al., 2016)

NOT Suppressor of

Statement

Reference

Scer\GAL4^VGlut.PD/Rab3^UAS.cCa is a non-suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Rab3-GEF^SC225

(Bae et al., 2016)

Rab3^Q80L.UAS/Scer\GAL4^VGlut.PD is a non-suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Rab3-GEF^SC225

(Bae et al., 2016)

Snx16^3A.UAS.GFP/tkv^{Q199D.UAS.Tag:HA}, Scer\GAL4^VGlut.PD is a non-suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Hsap\TARDBP^UAS.cHa, Scer\GAL4^VGlut.PD

(Deshpande et al., 2016)

Rab5^S43N.UAS, Scer\GAL4^VGlut.PD is a non-suppressor of abnormal neuroanatomy | third instar larval stage phenotype of Hsap\TARDBP^UAS.cHa, Scer\GAL4^VGlut.PD

(Deshpande et al., 2016)

Snx16^3A.UAS.GFP/tkv^{Q199D.UAS.Tag:HA}, Scer\GAL4^VGlut.PD is a non-suppressor of abnormal locomotor behavior | third instar larval stage phenotype of Hsap\TARDBP^UAS.cHa, Scer\GAL4^VGlut.PD

(Deshpande et al., 2016)

Phenotype Manifest In

Suppressed by

Statement

Reference

Hsap\TARDBP^UAS.cHa, Scer\GAL4^VGlut.PD has embryonic/larval neuromuscular junction | third instar larval stage phenotype, suppressible | partially by Dad^j1E4/Dad^j1E4

(Deshpande et al., 2016)

Hsap\TARDBP^UAS.cHa, Scer\GAL4^VGlut.PD has NMJ bouton | third instar larval stage phenotype, suppressible | partially by Dad^j1E4/Dad^j1E4

(Deshpande et al., 2016)

Hsap\TARDBP^UAS.cHa, Scer\GAL4^VGlut.PD has NMJ bouton | third instar larval stage phenotype, suppressible | partially by Dad^j1E4/Dad[+]

(Deshpande et al., 2016)

Hsap\TARDBP^UAS.cHa, Scer\GAL4^VGlut.PD has embryonic/larval neuromuscular junction | third instar larval stage phenotype, suppressible | partially by Rab11^N124I.UAS, Scer\GAL4^VGlut.PD

(Deshpande et al., 2016)

Hsap\TARDBP^UAS.cHa, Scer\GAL4^VGlut.PD has NMJ bouton | third instar larval stage phenotype, suppressible | partially by Rab11^N124I.UAS, Scer\GAL4^VGlut.PD

(Deshpande et al., 2016)

NOT suppressed by

Statement

Reference

Hsap\TARDBP^UAS.cHa, Scer\GAL4^VGlut.PD has embryonic/larval neuromuscular junction | third instar larval stage phenotype, non-suppressible by Dad^j1E4/Dad[+]

(Deshpande et al., 2016)

Hsap\TARDBP^UAS.cHa, Scer\GAL4^VGlut.PD has NMJ bouton | third instar larval stage phenotype, non-suppressible by Snx16^3A.UAS.GFP/tkv^{Q199D.UAS.Tag:HA}, Scer\GAL4^VGlut.PD

(Deshpande et al., 2016)

Hsap\TARDBP^UAS.cHa, Scer\GAL4^VGlut.PD has NMJ bouton | third instar larval stage phenotype, non-suppressible by Rab5^S43N.UAS, Scer\GAL4^VGlut.PD

(Deshpande et al., 2016)

Suppressor of

Statement

Reference

Rab11^N124I.UAS, Scer\GAL4^VGlut.PD is a suppressor | partially of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Hsap\TARDBP^UAS.cHa, Scer\GAL4^VGlut.PD

(Deshpande et al., 2016)

Rab11^N124I.UAS, Scer\GAL4^VGlut.PD is a suppressor | partially of NMJ bouton | third instar larval stage phenotype of Hsap\TARDBP^UAS.cHa, Scer\GAL4^VGlut.PD

(Deshpande et al., 2016)

NOT Suppressor of

Statement

Reference

Scer\GAL4^VGlut.PD/Rab3^UAS.cCa is a non-suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Rab3-GEF^SC225

(Bae et al., 2016)

Rab3^Q80L.UAS/Scer\GAL4^VGlut.PD is a non-suppressor of embryonic/larval neuromuscular junction | third instar larval stage phenotype of Rab3-GEF^SC225

(Bae et al., 2016)

Snx16^3A.UAS.GFP/tkv^{Q199D.UAS.Tag:HA}, Scer\GAL4^VGlut.PD is a non-suppressor of NMJ bouton | third instar larval stage phenotype of Hsap\TARDBP^UAS.cHa, Scer\GAL4^VGlut.PD

(Deshpande et al., 2016)

Rab5^S43N.UAS, Scer\GAL4^VGlut.PD is a non-suppressor of NMJ bouton | third instar larval stage phenotype of Hsap\TARDBP^UAS.cHa, Scer\GAL4^VGlut.PD

(Deshpande et al., 2016)

Additional Comments

Genetic Interactions

Statement

Reference

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescues

Rab3-GEF^UAS.cBa/Scer\GAL4^VGlut.PD rescues Rab3-GEF^SC225/Df(1)ED7289

(Bae et al., 2016)

Scer\GAL4^VGlut.PD/Rab3^UAS.cCa rescues Df(2R)ED2076/Rab3^rup

(Chen et al., 2015)

Rab3^Q80L.UAS/Scer\GAL4^VGlut.PD rescues Df(2R)ED2076/Rab3^rup

(Chen et al., 2015)

Scer\GAL4^VGlut.PD/Rab3^F58S.UAS rescues Df(2R)ED2076/Rab3^rup

(Chen et al., 2015)

Scer\GAL4^VGlut.PD/Rab3^V51A.UAS rescues Df(2R)ED2076/Rab3^rup

(Chen et al., 2015)

Scer\GAL4^VGlut.PD/Rab3^S52A.UAS rescues Df(2R)ED2076/Rab3^rup

(Chen et al., 2015)

Rab3^{FDY18-20AAA.UAS}/Scer\GAL4^VGlut.PD rescues Df(2R)ED2076/Rab3^rup

(Chen et al., 2015)

Scer\GAL4^VGlut.PD/Rab3^{WDN124-126AAA.UAS} rescues Df(2R)ED2076/Rab3^rup

(Chen et al., 2015)

Scer\GAL4^VGlut.PD/Rab3^{KM185-186AA.UAS} rescues Df(2R)ED2076/Rab3^rup

(Chen et al., 2015)

Rab3^{L189-190AA.UAS}/Scer\GAL4^VGlut.PD rescues Df(2R)ED2076/Rab3^rup

(Chen et al., 2015)

Rab3^UAS.cGa/Scer\GAL4^VGlut.PD rescues Df(2R)ED2076/Rab3^rup

(Graf et al., 2009)

Partially rescues

Scer\GAL4^VGlut.PD/Rab3^F50A.UAS partially rescues Df(2R)ED2076/Rab3^rup

(Chen et al., 2015)

Scer\GAL4^VGlut.PD/Rab3^T53A.UAS partially rescues Df(2R)ED2076/Rab3^rup

(Chen et al., 2015)

Rab3^R82A.UAS/Scer\GAL4^VGlut.PD partially rescues Df(2R)ED2076/Rab3^rup

(Chen et al., 2015)

Scer\GAL4^VGlut.PD/Rab3^Y83A.UAS partially rescues Df(2R)ED2076/Rab3^rup

(Chen et al., 2015)

Scer\GAL4^VGlut.PD/Rim^UAS.cGa partially rescues Rim^UAS.cGa

(Graf et al., 2012)

Fails to rescue

Scer\GAL4^VGlut.PD/Rab3^{N134I.UAS.cCa} fails to rescue Df(2R)ED2076/Rab3^rup

(Chen et al., 2015)

Rab3^T35N.UAS/Scer\GAL4^VGlut.PD fails to rescue Df(2R)ED2076/Rab3^rup

(Chen et al., 2015)

Scer\GAL4^VGlut.PD/Rab3^ΔC.UAS fails to rescue Df(2R)ED2076/Rab3^rup

(Chen et al., 2015)

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

24635

P{VGlut-GAL4.D}1, w^*

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (3)

Reported As

Symbol Synonym

Scer\GAL4^VGlut.PD

Scer\GAL4^VGlut

Name Synonyms

Vesicular glutamate transporter promoter construct of Daniels

Secondary FlyBase IDs

References (49)

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