UASt regulatory sequences drive expression of a mutant form of Rab3 in which amino acid residues 124-126 are mutated from WDN to AAA. This is predicted to disrupt interactions that involve the second complementarity-determining region (CDR).
Scer\GAL4VGlut.PD/Rab3WDN124-126AAA.UAS rescues Df(2R)ED2076/Rab3rup
Expression of Rab3WDN124-126AAA.Scer\UAS driven by Scer\GAL4VGlut.PD rescues active zone defects at the NMJ of Rab3rup/Df(2R)ED2076 third instar larvae.