FlyBase Allele Report: Dmel\ERR[JF02431]

General Information

Symbol

Dmel\ERR^JF02431

Species

D. melanogaster

Name

FlyBase ID

FBal0220775

Feature type

allele

Associated gene

Dmel\ERR

Associated Insertion(s)

Carried in Construct

P{TRiP.JF02431}

Key Links

Genomic Maps

JBrowse

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.3.31)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

RNAi_reagent

(Perkins et al., 2009.3.31)

Mutagen

in vitro construct

(Perkins et al., 2009.3.31)

Progenitor genotype

Carried in construct

P{TRiP.JF02431}

Cytology

Description

UAS regulatory sequences drive expression of an inverted repeat.

(Perkins et al., 2009.3.31)

Allele components

Component

Use(s)

Regulatory region(s)

UAS

binary expression system - regulatory region

Encoded product / tool

dsRNA-JF02431

Also carries

loxP

recombinase target site

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 1 )

Disease

Interaction

References

ameliorates frontotemporal dementia and/or amyotrophic lateral sclerosis 1

modeled by Zzzz\GGGGCC^30.UAS.EGFP

(Pun et al., 2022)

ameliorates high grade glioma

modeled by Hsap\FGFR3::Hsap\TACC3^UAS.cFa

(Frattini et al., 2018)

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal oxidative stress response | adult stage, with Scer\GAL4^Appl.G1a

(Velo Escarcena et al., 2021)

abnormal oxidative stress response | adult stage, with Scer\GAL4^Eaat2.PB

(Velo Escarcena et al., 2021)

abnormal oxidative stress response | adult stage, with Scer\GAL4^Rdl.PS

(Velo Escarcena et al., 2021)

abnormal oxidative stress response | adult stage, with Scer\GAL4^VGlut.PD

(Velo Escarcena et al., 2021)

male semi-sterile, with Scer\GAL4^{CG13917-BG01278}

(Misra et al., 2017)

Phenotype Manifest In

axoneme, with Scer\GAL4^{CG13917-BG01278}

(Misra et al., 2017)

mitochondrial derivative, with Scer\GAL4^{CG13917-BG01278}

(Misra et al., 2017)

seminal vesicle, with Scer\GAL4^{CG13917-BG01278}

(Misra et al., 2017)

spermatocyte fusome, with Scer\GAL4^{CG13917-BG01278}

(Misra et al., 2017)

spermatozoon, with Scer\GAL4^{CG13917-BG01278}

(Misra et al., 2017)

sperm flagellum, with Scer\GAL4^{CG13917-BG01278}

(Misra et al., 2017)

Detailed Description

Statement

Reference

Expression of ERR^JF02431 under the control of Scer\GAL4^{CG13917-BG01278} strongly decreases male fertility (number of progeny produced by wild-type females mated to the knock-down males) as the males show severely underdeveloped testicular lobes (deformed globular testes) and seminal vesicles as well as fusome morphological defects (reduced fusome branching). The males also show several ultrastructural abnormalities: disorganization of the sperm bundles, decreased size of the mitochondrial derivatives as well as disruption of the axoneme structure in the sperm flagella. The number of mature sperm stored in the seminal vesicles of the knock-down males is significantly reduced and mature sperm is dispersed throughout the deformed testes, females mated to the ERR^JF02431-expressing males have either no or less sperm in their sperm storage organs.

(Misra et al., 2017)

Expression of ERR^JF02431 under the control of Scer\GAL4^bbg-C96 does not result in any obvious wing phenotype.

(Ellis et al., 2015)

Expression of ERR^JF02431 in the fat body under the control of Scer\GAL4^DcG results in significant hyperglycaemia.

Expression of ERR^JF02431 in muscle under the control of Scer\GAL4^Mef2.PU results in significant hyperglycaemia.

(Ugrankar et al., 2015)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

ERR^JF02431, Scer\GAL4^bbg-C96 is an enhancer of visible phenotype of Scer\GAL4^bbg-C96, dom^RNAi.Sym.UAS

(Ellis et al., 2015)

Phenotype Manifest In

Enhancer of

Statement

Reference

ERR^JF02431, Scer\GAL4^bbg-C96 is an enhancer of wing phenotype of Scer\GAL4^bbg-C96, dom^RNAi.Sym.UAS

(Ellis et al., 2015)

Additional Comments

Genetic Interactions

Statement

Reference

Co-expression of ERR^JF02431 enhances the wing nicking phenotype of flies expressing dom^{dsRNA.Sym.Scer\UAS} under the control of Scer\GAL4^bbg-C96.

(Ellis et al., 2015)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (1)

Bloomington

27085

y¹ v¹; P{TRiP.JF02431}attP2

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

ERR^JF02431

Name Synonyms

Secondary FlyBase IDs

References (10)

Report Sections

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