FlyBase Allele Report: Dmel\Ret[GMR.PR]

General Information

Symbol

Dmel\Ret^GMR.PR

Species

D. melanogaster

Name

FlyBase ID

FBal0192090

Feature type

allele

Associated gene

Dmel\Ret

Associated Insertion(s)

Carried in Construct

P{GMR-Ret.WT}

Also Known As

GMR-dRet^WT

Key Links

Transgenic product class

cDNA

(Read et al., 2005)

wild_type

(Read et al., 2005)

Mutagen

in vitro construct

Nature of the Allele

Transgenic product class

cDNA

(Read et al., 2005)

wild_type

(Read et al., 2005)

Mutagen

in vitro construct

(Read et al., 2005)

Progenitor genotype

Carried in construct

P{GMR-Ret.WT}

Cytology

Description

GMR regulatory sequences drive expression of a full length, wild-type Ret cDNA.

(Read et al., 2005)

Allele components

Component

Use(s)

Regulatory region(s)

GMR

engineered transcription regulatory region

Encoded product / tool

Ret

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 1 )

Disease

Evidence

References

model of familial medullary thyroid carcinoma

CEA

(Vidal et al., 2005)

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

abnormal size | adult stage

(Vidal et al., 2005)

decreased cell death

(Macagno et al., 2014)

visible

(Macagno et al., 2014, Read et al., 2005, Vidal et al., 2005)

Phenotype Manifest In

eye

(Macagno et al., 2014, Read et al., 2005, Vidal et al., 2005)

interommatidial cell | increased number

(Macagno et al., 2014)

ommatidium

(Read et al., 2005)

Detailed Description

Statement

Reference

Expression of Ret^GMR.PR disturbs the normal array of ommatidia, creating a rough eye phenotype. The ommatidial remains normal, with four cone cells surrounded by two primary pigment cell, but supernumerary interommatidial cells are seen. In contrast to wild type, Ret^GMR.PR retinas contain virtually no apoptotic cells 28 hours after pupal formation.

(Macagno et al., 2014)

Flies carrying one copy of Ret^GMR.PR have either no mutant phenotype or a mild rough eye phenotype. Flies carrying two copies of Ret^GMR.PR show a severe eye phenotype in which the eye becomes an irregular mass that bulges from the side of the head.

(Read et al., 2005)

Expression of Ret^GMR.PR in the developing eye leads to overproliferation, alterations in cell fate differentiation, and ectopic cell death, giving rise to "rough" adult eyes consisting of fused, poorly patterned lenses and a reduction in the eyes' overall size.

(Vidal et al., 2005)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhanced by

Statement

Reference

Ret^GMR.PR has visible phenotype, enhanceable by Fak^CG1/Fak[+]

(Macagno et al., 2014)

Ret^GMR.PR has visible phenotype, enhanceable by Fak^CG1

(Macagno et al., 2014)

Ret^GMR.PR, hid^GMR.PG has visible phenotype, enhanceable by Fak^UAS.Tag:HA/Scer\GAL4^GMR.PU

(Macagno et al., 2014)

Ret^GMR.PR has visible phenotype, enhanceable by Csk^j1D8/Csk[+]

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by Df(1)lz-90b24/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by l(3)j2D5^j2D5/l(3)j2D5[+]

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by msn[+]/msn^j1E2

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by neur¹¹

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by tws^S049902/tws[+]

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by Df(1)sd72b/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by Df(2L)H20/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by Df(2L)TW137/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by Df(2L)TW50/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by Df(1)B25/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by Df(2L)cact-255rv64/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by Df(2R)vg-C/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by Df(3L)ZN47/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by Df(3R)M-Kx1/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by Df(3R)T-32/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by Df(3R)e-N19/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by Df(3R)e-R1/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by RasGAP1^B2

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by In(2LR)DTD16^LDTD42^R/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by Mi-2^S005504/Mi-2[+]

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by Df(1)C128/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by Mi-2^S047526/Mi-2[+]

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by Mi-2^S147412/Mi-2[+]

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by Pp1-87B¹

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by Sin3A[+]/Sin3A⁰⁸²⁶⁹

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by Sin3A^ex4

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by Sin3A^k08919

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by bon^S048706/bon[+]

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by crb⁰⁷²⁰⁷

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by crb^j1B5/crb[+]

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by hh[+]/hh^rJ413

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by Df(1)KA14/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by l(3)S000718[+]/l(3)S000718^S000718

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by l(3)S001405^S001405/l(3)S001405[+]

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by l(3)S012805^S012805/l(3)S012805[+]

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by l(3)S016805[+]/l(3)S016805^S016805

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by l(3)S023549^S090101/l(3)S023549[+]

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by l(3)S023901[+]/l(3)S023901^S023901

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by l(3)S024329^S024329/l(3)S024329[+]

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by l(3)S026238^S026238/l(3)S026238[+]

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by l(3)S026421^S026421/l(3)S026421[+]

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by l(3)S046604^S046604/l(3)S046604[+]

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by Df(1)RA2/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by l(3)S056113[+]/l(3)S056113^S056113

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by l(3)S057101[+]/l(3)S057101^S057101

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by l(3)S066607[+]/l(3)S066607^S066607

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by l(3)S068808^S068808/l(3)S068808[+]

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by l(3)S081003^S145911/l(3)S081003[+]

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by l(3)S090114[+]/l(3)S090114^S090114

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by l(3)S092708[+]/l(3)S092708^S092708

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by l(3)S133117[+]/l(3)S133117^S133117

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by l(3)S135703^S135703/l(3)S135703[+]

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, enhanceable by l(3)S142909^S142909/l(3)S142909[+]

(Read et al., 2005)

NOT Enhanced by

Statement

Reference

Ret^GMR.PR has visible phenotype, non-enhanceable by Fak^CG1/Fak^UAS.Tag:HA/Scer\GAL4^GMR.PU

(Macagno et al., 2014)

Ret^GMR.PR has visible phenotype, non-enhanceable by Fak^CG1/Fak^Y430F.UAS/Scer\GAL4^GMR.PU

(Macagno et al., 2014)

Ret^GMR.PR has visible phenotype, non-enhanceable by +/Df(3R)Delta-BX12

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, non-enhanceable by S[+]/S^k09538a

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, non-enhanceable by drk^k02401

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, non-enhanceable by dsh⁶

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, non-enhanceable by kis[+]/kis^k10237

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, non-enhanceable by kis^k13416

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, non-enhanceable by ksr^S-627

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, non-enhanceable by l(3)S023708[+]/l(3)S023708^S023708

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, non-enhanceable by neur³

(Read et al., 2005)

Suppressed by

Statement

Reference

Ret^GMR.PR has visible phenotype, suppressible by Fak^UAS.Tag:HA/Scer\GAL4^GMR.PU

(Macagno et al., 2014)

Ret^GMR.PR has decreased cell death phenotype, suppressible by Fak^UAS.Tag:HA/Scer\GAL4^GMR.PU

(Macagno et al., 2014)

Ret^GMR.PR has visible phenotype, suppressible by Df(2L)TW161/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, suppressible by Df(2L)al/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, suppressible by Df(2L)net-PMF/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, suppressible by +/Df(2R)59AD

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, suppressible by Df(2R)AA21/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, suppressible by Df(2R)CX1/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, suppressible by Df(2R)P34/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, suppressible by Df(2R)Pu-D17/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, suppressible by Df(2R)ST1/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, suppressible by Df(2R)X58-12/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, suppressible by Df(3L)Pc-2q/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, suppressible by Df(3R)Antp17/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, suppressible by Df(3R)Cha7/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, suppressible by Df(3R)DG2/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, suppressible by Df(3R)Hu/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, suppressible by Df(3R)ME15/+

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, suppressible by Jra^IA109

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, suppressible by drk¹⁰⁶²⁶

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, suppressible by drk^k13809

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, suppressible by ebi[+]/ebi^k16213

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, suppressible by ksr^j5E2

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, suppressible by l(3)S009515[+]/l(3)S009515^S009515

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, suppressible by px[+]/px^k08316

(Read et al., 2005)

NOT suppressed by

Statement

Reference

Ret^GMR.PR has visible phenotype, non-suppressible by +/Df(3R)Delta-BX12

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, non-suppressible by S[+]/S^k09538a

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, non-suppressible by dsh⁶

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, non-suppressible by kis[+]/kis^k10237

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, non-suppressible by kis^k13416

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, non-suppressible by ksr^S-627

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, non-suppressible by l(3)S023708[+]/l(3)S023708^S023708

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, non-suppressible by neur³

(Read et al., 2005)

Ret^GMR.PR has visible phenotype, non-suppressible by drk^k02401

(Read et al., 2005)

Suppressor of

Statement

Reference

Ret^GMR.PR is a suppressor of visible phenotype of hid^GMR.PG

(Macagno et al., 2014)

Phenotype Manifest In

Enhanced by

Statement

Reference

Ret^GMR.PR has eye phenotype, enhanceable by Fak^CG1/Fak[+]

(Macagno et al., 2014)

Ret^GMR.PR has eye phenotype, enhanceable by Fak^CG1

(Macagno et al., 2014)

Ret^GMR.PR has eye phenotype, enhanceable by Fak^CG1/Fak^UAS.Tag:HA/Scer\GAL4^GMR.PU

(Macagno et al., 2014)

Ret^GMR.PR, hid^GMR.PG has eye phenotype, enhanceable by Fak^UAS.Tag:HA/Scer\GAL4^GMR.PU

(Macagno et al., 2014)

Ret^GMR.PR has eye phenotype, enhanceable by Csk^j1D8/Csk[+]

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by l(3)j2D5^j2D5/l(3)j2D5[+]

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by msn[+]/msn^j1E2

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by neur¹¹

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by tws^S049902/tws[+]

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by Df(1)lz-90b24/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by Df(1)sd72b/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by Df(2L)H20/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by Df(2L)TW137/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by Df(2L)TW50/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by Df(2L)cact-255rv64/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by Df(2R)vg-C/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by Df(3L)ZN47/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by Df(3R)M-Kx1/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by Df(3R)T-32/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by Df(1)B25/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by Df(3R)e-N19/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by Df(3R)e-R1/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by RasGAP1^B2

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by In(2LR)DTD16^LDTD42^R/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by Mi-2^S005504/Mi-2[+]

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by Mi-2^S047526/Mi-2[+]

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by Mi-2^S147412/Mi-2[+]

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by Pp1-87B¹

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by Sin3A[+]/Sin3A⁰⁸²⁶⁹

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by Sin3A^ex4

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by Df(1)C128/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by Sin3A^k08919

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by bon^S048706/bon[+]

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by crb⁰⁷²⁰⁷

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by crb^j1B5/crb[+]

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by hh[+]/hh^rJ413

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by l(3)S000718[+]/l(3)S000718^S000718

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by l(3)S001405^S001405/l(3)S001405[+]

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by l(3)S012805^S012805/l(3)S012805[+]

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by l(3)S016805[+]/l(3)S016805^S016805

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by l(3)S023549^S090101/l(3)S023549[+]

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by Df(1)KA14/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by l(3)S023901[+]/l(3)S023901^S023901

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by l(3)S024329^S024329/l(3)S024329[+]

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by l(3)S026238^S026238/l(3)S026238[+]

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by l(3)S026421^S026421/l(3)S026421[+]

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by l(3)S046604^S046604/l(3)S046604[+]

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by l(3)S056113[+]/l(3)S056113^S056113

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by l(3)S057101[+]/l(3)S057101^S057101

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by l(3)S066607[+]/l(3)S066607^S066607

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by l(3)S068808^S068808/l(3)S068808[+]

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by l(3)S081003^S145911/l(3)S081003[+]

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by Df(1)RA2/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by l(3)S090114[+]/l(3)S090114^S090114

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by l(3)S092708[+]/l(3)S092708^S092708

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by l(3)S133117[+]/l(3)S133117^S133117

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by l(3)S135703^S135703/l(3)S135703[+]

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, enhanceable by l(3)S142909^S142909/l(3)S142909[+]

(Read et al., 2005)

NOT Enhanced by

Statement

Reference

Ret^GMR.PR has eye phenotype, non-enhanceable by +/Df(3R)Delta-BX12

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, non-enhanceable by S[+]/S^k09538a

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, non-enhanceable by drk^k02401

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, non-enhanceable by dsh⁶

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, non-enhanceable by kis[+]/kis^k10237

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, non-enhanceable by kis^k13416

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, non-enhanceable by ksr^S-627

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, non-enhanceable by l(3)S023708[+]/l(3)S023708^S023708

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, non-enhanceable by neur³

(Read et al., 2005)

Suppressed by

Statement

Reference

Ret^GMR.PR has eye phenotype, suppressible by Fak^UAS.Tag:HA/Scer\GAL4^GMR.PU

(Macagno et al., 2014)

Ret^GMR.PR has eye phenotype, suppressible by Df(2L)TW161/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, suppressible by Df(2L)al/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, suppressible by Df(2L)net-PMF/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, suppressible by +/Df(2R)59AD

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, suppressible by Df(2R)AA21/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, suppressible by Df(2R)CX1/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, suppressible by Df(2R)P34/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, suppressible by Df(2R)Pu-D17/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, suppressible by Df(2R)ST1/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, suppressible by Df(2R)X58-12/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, suppressible by Df(3L)Pc-2q/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, suppressible by Df(3R)Antp17/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, suppressible by Df(3R)Cha7/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, suppressible by Df(3R)DG2/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, suppressible by Df(3R)Hu/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, suppressible by Df(3R)ME15/+

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, suppressible by Jra^IA109

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, suppressible by drk¹⁰⁶²⁶

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, suppressible by drk^k13809

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, suppressible by ebi[+]/ebi^k16213

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, suppressible by ksr^j5E2

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, suppressible by l(3)S009515[+]/l(3)S009515^S009515

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, suppressible by px[+]/px^k08316

(Read et al., 2005)

NOT suppressed by

Statement

Reference

Ret^GMR.PR has eye phenotype, non-suppressible by S[+]/S^k09538a

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, non-suppressible by drk^k02401

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, non-suppressible by dsh⁶

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, non-suppressible by kis[+]/kis^k10237

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, non-suppressible by kis^k13416

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, non-suppressible by ksr^S-627

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, non-suppressible by l(3)S023708[+]/l(3)S023708^S023708

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, non-suppressible by neur³

(Read et al., 2005)

Ret^GMR.PR has eye phenotype, non-suppressible by +/Df(3R)Delta-BX12

(Read et al., 2005)

Suppressor of

Statement

Reference

Ret^GMR.PR is a suppressor of eye phenotype of hid^GMR.PG

(Macagno et al., 2014)

Other

Statement

Reference

Fak^CG1, Ret^GMR.PR has ommatidium phenotype

(Macagno et al., 2014)

Fak^CG1, Ret^GMR.PR has eye disc phenotype

(Macagno et al., 2014)

Fak^CG1, Ret^GMR.PR has retina phenotype

(Macagno et al., 2014)

Fak^CG1, Ret^GMR.PR has interommatidial cell phenotype

(Macagno et al., 2014)

Fak^CG1, Ret^GMR.PR has cone cell | increased number | pupal stage phenotype

(Macagno et al., 2014)

Additional Comments

Genetic Interactions

Statement

Reference

Heterozygous Fak^CG1 enhances the ommatidial mis-patterning seen in eyes expressing Ret^GMR.PR. Homozygous Fak^CG1 causes a smaller eye due to a completely disrupted ommatidial pattern. This enhancement is reversed upon co-expression of either Fak^{Scer\UAS.T:Ivir\HA1} or Fak^{Y430F.Scer\UAS} under the control of Scer\GAL4^GMR.PU.

The retinas of pupae (42 hours after pupal formation) expressing Ret^GMR.PR in a homozygous Fak^CG1 mutant background lack the hexagonal array and identifiable ommatidial units. Numerous ct-positive cone cells are seen. Some bristle cells and a few cells recognisable as primary pigment cells remain, but there are no detectable cells with the appearance of normal interommatidial cells. Ommatidial units with extranumerary cone cells are also seen at early stages of development (4 hours after pupal development). Eye discs contain normal number of photoreceptors, albeit some clusters have rotation defects.

Expression of Fak^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^GMR.PU suppresses the rough eye phenotype seen upon expression of Ret^GMR.PR. The reduction in retinal apoptosis is also rescued.

Expression of Ret^GMR.PR partially suppresses the reduction in eye size seen in flies expressing hid^GMR.PG. This suppression is partially reversed when Fak^{Scer\UAS.T:Ivir\HA1} is expressed under the control of Scer\GAL4^GMR.PU.

(Macagno et al., 2014)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Comments

Images (0)

Mutant

Wild-type

Stocks (0)

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (1)

Reported As

Symbol Synonym

Ret^GMR.PR

Name Synonyms

Secondary FlyBase IDs

References (3)

Report Sections

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