FB2024_03 , released April 23, 2024
Aberration: Dmel\Df(2R)X58-12
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General Information
Symbol
Df(2R)X58-12
Species
D. melanogaster
Name
FlyBase ID
FBab0022257
Feature type
chromosomal_deletion
Computed Breakpoints include

58D1-58D2;59A1

Features within 58D1--59A1
Genomic Maps
Sequence coordinates
2R:22,193,486..22,329,416 (Df(2R)X58-12:bk1)
(Cook, 2016.2.8)
2R:22,692,524..22,799,099 (Df(2R)X58-12:bk2)
(Cook, 2016.2.8)
Member of large scale dataset(s)
Nature of Aberration
Cytological Order
Progenitor
P{wAR}58D
(Kerrebrock et al., 1995)
Mutagen
X ray
(Kerrebrock et al., 1995)
Class of aberration (relative to wild type)
chromosomal_deletion
(FlyBase, 2007)
Class of aberration (relative to progenitor)
chromosomal_deletion
(Tear, 1997.6.13, Kerrebrock et al., 1995, Orr-Weaver, 1994.11.24)
Breakpoints

58D1-58D2;59A

(Tear, 1997.6.13, Kerrebrock et al., 1995, Orr-Weaver, 1994.11.24)
Causes alleles
Carries alleles
Transposon Insertions
Formalized genetic data

mei-S332 << bk1 << robo << l(2)59ABc << bk2 << blw

Genetic mapping information
Comments

The 2R:22193486..22329416 release 6 coordinates of the left breakpoint are estimates. The left extent corresponds to the estimated position of the right end of 58C7, because the published cytology indicates the breakpoint lies within the 58D1,2 doublet band. The right extent corresponds to the right end of Gp150, which published results say is deleted.

(Cook, 2016.2.8)

The 2R:22692524..22799099 release 6 coordinates of the right breakpoint are estimates. The left extent corresponds to the left end of robo1, which published results say is deleted. The right extent corresponds to the left end of blw, which published results say is not deleted.

(Cook, 2016.2.8)

This deletion removes multiple ribosomal protein-coding genes (in addition to other genes).

(Marygold et al., 2007)
Comments on Cytology

Limits of break 1 from polytene analysis (FBrf0075399) Left limit of break 2 from polytene analysis (FBrf0075399) Right limit of break 2 from non-inclusion of blw (FBrf0104928)

Sequence Crossreferences
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
Gene Deletion and Duplication Data
Genes Deleted / Disrupted
Genes NOT Deleted / Disrupted
Genes Duplicated
Complementation Data
Completely duplicated
Partially duplicated
Molecular Data
Completely duplicated
Partially duplicated
Genes NOT Duplicated
Complementation Data
 
Molecular Data
 
Affected Genes Inferred by Location
Phenotypic Data
In combination with other aberrations

Lethal in combination with Df(2R)BSC787.

(Kahsai et al., 2016)

Inferred to overlap with: Df(2R)X58-5.

(Moore, 1997)
NOT in combination with other aberrations

Flies heterozygous for the deletion show a Minute bristle phenotype.

(Marygold et al., 2007)

The Df(2R)X58-12 chromosome acts as a dominant moderate suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{wvar}KR3-2", a stable "brown-red" variant of the P{3'WP-2,wvar}2Lt insertion).

(Mason et al., 2004)
Stocks (3)
Notes on Origin
Discoverer
 
Balancer / Genotype Variants of the Aberration
 
Separable Components
 
Other Comments
 
Synonyms and Secondary IDs (1)
References (32)