l(2)01738
homeodomain transcription factor - involved in the establishment of two gut structures: the proventriculus (a foregut structure) and the central midgut
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.39
Gene model reviewed during 5.51
5.0, 1.7 (northern blot)
4.9 (longest cDNA)
None of the polypeptides share 100% sequence identity.
1021, 245 (aa)
1019 (aa)
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\dve using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm anlage
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as procephalic ectoderm primordium
Comment: reported as dorsal/lateral sensory complexes
Comment: AMG
Comment: reference states 0-18 hr AEL
Expression pattern inferred from unspecified enhancer trap line.
Expression is observed in the anterior midline glial cells.
The 5.0 kb dve transcript is expressed at high levels in embryos. Starting in stage 9 embryos, dve transcript is detected in the anterior midgut primordium in a region that will give rise to the proventriculus endoderm. This expression persists and in later stages is confined to the outer endodermal wall of the developing proventriculus. At stage 12, expression is detected at the anterior tip of the posterior midgut primordium, in endodermal cells in the midgut/hindgut boundary, and in cells at the base of the pharynx. At stage 13, expression is detected in the anterior, central and posterior portions of the midgut. In stage 14 embryos, the central expression domain expands, and by stage 16 covers the second and third midgut lobes. Additional expression is detected in mesectodermal cells in stage 9, neural cells in the ventral nerve cord and in the brain lobes at stage 13, and the tip cells of the Malpighian tubules.
The 1.7 kb dve transcript is expressed at low levels in embryos. A probe that detects both the 1.7 and 5.0 kb dve transcripts, and a probe that detects only the 5.0 kb transcript give the same in situ hybridization pattern, indicating that the expression pattern of the 1.7 kb and 5.0 kb transcripts overlap.
Comment: endodermal cells
dve expression in wing discs is first seen in late second instar/early third instar as a small group of cells in the center of the rn domain. The dve domain starts earlier and is one or two cells broader than the nab domain but narrower than the rn domain in the presumptive wing. The dve and nab domains are nearly complementary to the zfh2 domain.
dve protein is expressed in the entodermal cells of the developing embryonic foregut. Expression stops sharply at the ectodermal/endodermal boundary.
Protein expression is first detected in the wing disc at the time that wg expression resolves into a peripheral ring and a stripe at the dorsal-ventral boundary. dve expression is observed in a disc-like domain within the ring of wg expression and is excluded from most of the dorsal-ventral boundary soon after expression is initiated.
In early to midthird instar larvae dve protein is detected in the developing wing pouch. Expression initially overlaps that of wg. In mid to late third instar larvae dve protein is excluded from the dorsal/ventral boundary and is expressed in a pattern complementary to wg protein. In late third instar larvae the distal expression of dve is decreased but the proximal expression remains.
dve protein is first detected in the invaginated stomodeum of stage 10 embryos. dve and wg protein expression in the stomodeum overlap at first, but subsequently separate into adjacent but non-overlapping regions. dve protein is expressed in the anterior-most region of the midgut, in the region that will become the outer layer of the proventriculus at stage 16. Starting at stage 13, dve protein is also detected in the central and posterior-most regions of the midgut; the central region, where the anterior and posterior midgut primordia are fused, will become the second and third gut lobes at stage 16. All four types of specialized embryonic/larval midgut cells including copper and interstitial cell precursors in this region express dve at stage 16; in larval stages, dve expression is repressed in copper cells.
JBrowse - Visual display of RNA-Seq signals
View Dmel\dve in JBrowse2-99
2-104.1
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Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
dve is required for male accessory gland development, both for binucleation of main cells and survival or secondary cells.
dve isoform-A is important for proventriculus morphogenesis and functional development.
dve is required at the foregut/midgut boundary for the formation of the proventriculus.
Identified during an enhancer trap screen for flies with an abnormal object fixation response.
Source for identity of: dve CG5799