FlyBase Allele Report: Dmel\RasGAP1[B2]

General Information

Symbol

Dmel\RasGAP1^B2

Species

D. melanogaster

Name

FlyBase ID

FBal0029795

Feature type

allele

Associated gene

Dmel\RasGAP1

Associated Insertion(s)

Carried in Construct

Also Known As

gap1^B2

Key Links

Allele class

amorphic allele - genetic evidence

Mutagen

ethyl methanesulfonate

Nature of the Allele

Allele class

amorphic allele - genetic evidence

(Powe et al., 1999, Hou et al., 1995, Gaul et al., 1992)

Mutagen

ethyl methanesulfonate

(Nakato et al., 1995, Gaul et al., 1992)

Progenitor genotype

Cytology

Description

Mutations Mapped to the Genome

Curation Data

Type

Location

Additional Notes

References

Variant Molecular Consequences

Associated Sequence Data

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

UniProtKB/Swiss-Prot

UniProtKB/TrEMBL

Expression Data

Reporter Expression

Additional Information

Statement

Reference

Marker for

Reflects expression of

Reporter construct used in assay

Human Disease Associations

Disease Ontology (DO) Annotations

Models Based on Experimental Evidence ( 0 )

Disease

Evidence

References

Modifiers Based on Experimental Evidence ( 0 )

Disease

Interaction

References

Comments on Models/Modifiers Based on Experimental Evidence ( 0 )

Disease-implicated variant(s)

Phenotypic Data

Phenotypic Class

lethal | maternal effect

(Chou et al., 1993)

visible | recessive

(Gaul et al., 1992)

Phenotype Manifest In

Detailed Description

Statement

Reference

Heterozygotes have normal wings.

(Friedman and Perrimon, 2006)

On the legs and wings of mutant adults mechanosensory bristles have two or more bracts.

(del Alamo et al., 2002)

Gap1^B2/+ heterozygotes show wild type wing veins.

(Bai et al., 2001)

Average number of R7 cells per ommatidium is 2.9.

(Powe et al., 1999)

Mosaics in the follicular epithelium cause localized dorsalization of the embryonic cuticle, concomitant with localized disruptions in the nuclear localization of dl gene product.

(Duffy et al., 1998)

Severe Gap1 allele.

(Nakato et al., 1995)

Mutation has no effect on rho^hs.sev rough eye phenotype.

(Freeman, 1994)

Homozygous females lay eggs with a weak dorsalized egg shell morphology. The embryos are also partially dorsalized.

(Chou et al., 1993)

Rough eye phenotype. Ommatidia are improperly oriented and occasionally are fused. Ommatidia contain supernumerary cells that are characteristic of R7 cells. Supernumerary cells are derived from a cone cell precursor, or a mystery cell, that adopts a neural fate in the disc. Wings show additional longitudinal veinlet branches of the posterior crossvein and delta-like structures. One or two extra sex combs form in ectopic positions and in both sexes duplications of epidermal structures associated with bristles of the distal leg.

(Gaul et al., 1992)

External Data

Linkouts

Interactions

Show genetic interaction network for Enhancers & Suppressors

Phenotypic Class

Enhancer of

Statement

Reference

Gap1[+]/RasGAP1^B2 is an enhancer of visible phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

RasGAP1^B2 is an enhancer of visible phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

RasGAP1^B2 is an enhancer of visible phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

RasGAP1^B2 is an enhancer of visible phenotype of Ret^GMR.PR

(Read et al., 2005)

Gap1[+]/RasGAP1^B2 is an enhancer of visible | dominant phenotype of Egfr^E3

(Bai et al., 2001)

Suppressor of

Statement

Reference

RasGAP1^B2 is a suppressor of visible phenotype of Ptpmeg^UAS.cLa, Scer\GAL4^en.PU

(Li et al., 2015)

Other

Statement

Reference

GckIII^UAS.Tag:HA, Gap1[+]/RasGAP1^B2, Scer\GAL4^Bx-MS1096 has visible phenotype

(Friedman and Perrimon, 2006)

RasGAP1^B2, ed[+]/ed^1X5 has visible phenotype

(Bai et al., 2001)

RasGAP1^B2, ed^1X5 has visible phenotype

(Bai et al., 2001)

Phenotype Manifest In

Enhancer of

Statement

Reference

RasGAP1^B2, Scer\GAL4^Tub.PU is an enhancer of wing vein phenotype of Scer\GAL4^Tub.PU, csw^Y279C.UASp

(Oishi et al., 2009)

Gap1[+]/RasGAP1^B2 is an enhancer of wing vein | ectopic phenotype of Scer\GAL4^Tub.PU, csw^N308D.UASp

(Oishi et al., 2006)

RasGAP1^B2 is an enhancer of eye phenotype of Ret^MEN2B.GMR

(Read et al., 2005)

RasGAP1^B2 is an enhancer of eye phenotype of Ret^MEN2A.GMR

(Read et al., 2005)

RasGAP1^B2 is an enhancer of eye phenotype of Ret^GMR.PR

(Read et al., 2005)

Gap1[+]/RasGAP1^B2 is an enhancer of eye phenotype of Scer\GAL4^GMR.PF, fred^RNAi.UAS

(Chandra et al., 2003)

Gap1[+]/RasGAP1^B2 is an enhancer of eye phenotype of Egfr^E3

(Bai et al., 2001)

Gap1[+]/RasGAP1^B2 is an enhancer of photoreceptor cell R7 | ectopic phenotype of sty²²⁶

(Kramer et al., 1999)

Suppressor of

Statement

Reference

RasGAP1^B2 is a suppressor of wing vein phenotype of Ptpmeg^UAS.cLa, Scer\GAL4^en.PU

(Li et al., 2015)

RasGAP1^B2 is a suppressor of phenotype of csw^lf

(Firth et al., 2000)

RasGAP1^B2 is a suppressor of photoreceptor cell R7 phenotype of boss¹

(Gaul et al., 1992)

RasGAP1^B2 is a suppressor of photoreceptor cell R7 phenotype of sev¹⁴

(Gaul et al., 1992)

Other

Statement

Reference

GckIII^UAS.Tag:HA, Gap1[+]/RasGAP1^B2, Scer\GAL4^Bx-MS1096 has wing vein | ectopic phenotype

(Friedman and Perrimon, 2006)

RasGAP1^B2, ed[+]/ed^1X5 has wing vein | increased number phenotype

(Bai et al., 2001)

RasGAP1^B2, ed^1X5 has wing vein | increased number phenotype

(Bai et al., 2001)

RasGAP1^B2, boss¹ has photoreceptor cell R7 | ectopic phenotype

(Gaul et al., 1992)

RasGAP1^B2, sev¹⁴ has photoreceptor cell R7 | ectopic phenotype

(Gaul et al., 1992)

RasGAP1^B2, sina² has photoreceptor cell R7 phenotype

(Gaul et al., 1992)

Additional Comments

Genetic Interactions

Statement

Reference

RasGAP1^B2 suppresses the wing vein loss seen when Ptpmeg^Scer\UAS.cLa is expressed under the control of Scer\GAL4^en.PU.

(Li et al., 2015)

The presence of a Gap1^B2 background significantly enhances ectopic wing vein formation found in csw^{Y279C.Scer\UAS} (Scer\GAL4^tub) mutants.

(Oishi et al., 2009)

Gap1^B2/+ flies expressing GckIII^{Scer\UAS.T:Ivir\HA1} under the control of Scer\GAL4^Bx-MS1096 have ectopic wing veins.

(Friedman and Perrimon, 2006)

The addition of heterozygous Gap1^B2 moderately enhances the rough eye phenotype seen in fred^{dsRNA.Scer\UAS}, Scer\GAL4^GMR.PF animals. However only 30% of animals exhibited increased roughness.

(Chandra et al., 2003)

Gap1^B2 pk^unspecified (sple) animals show extra bracts, all with the same polarity.

(del Alamo et al., 2002)

Heterozygotes for Gap1^B2 and ed^1X5 show extra wing veins.

(Bai et al., 2001)

Enhances the extra-R7 cell eye phenotype of sty²²⁶/+ heterozygotes.

(Kramer et al., 1999)

Heterozygous Gap1^B2/+ in combination with sl¹ show more than 80% of ommatidia with multiple R7 cells. Average number of R7 cells per ommatidium is 2.2.

(Powe et al., 1999)

Xenogenetic Interactions

Statement

Reference

Complementation and Rescue Data

Rescued by

RasGAP1^B2 is rescued by RasGAP1^sev.PP

(Powe et al., 1999)

Partially rescued by

RasGAP1^B2 is partially rescued by RasGAP1^ΔC2a.sev

(Powe et al., 1999)

RasGAP1^B2 is partially rescued by RasGAP1^ΔN.sev

(Powe et al., 1999)

RasGAP1^B2 is partially rescued by RasGAP1^R786C.sev

(Powe et al., 1999)

Not rescued by

RasGAP1^B2 is not rescued by RasGAP1^ΔC2b.sev

(Powe et al., 1999)

RasGAP1^B2 is not rescued by RasGAP1^M.sev

(Powe et al., 1999)

Comments

Images (0)

Mutant

Wild-type

Stocks (2)

Bloomington

5781

w^*; RasGAP1^B2/TM3, Sb¹

Kyoto

108423

w^*; RasGAP1^B2/TM3, Sb¹

Notes on Origin

Discoverer

External Crossreferences and Linkouts ( 0 )

Synonyms and Secondary IDs (7)

Reported As

Symbol Synonym

GAP1^B2

(Duffy et al., 1998)

Gap1^B2

(Tan et al., 2012, Oishi et al., 2009, Christensen et al., 2007.10.29, Christensen et al., 2007.10.29, Friedman and Perrimon, 2006, Oishi et al., 2006)

Gap1^r1533B2

(Hayashi et al., 1998)

RasGAP1^B2

RasGAP1B2

(Li et al., 2015)

gap1^B2

(del Alamo et al., 2002)

rI533^B2

(Gaul et al., 1992)

Name Synonyms

Secondary FlyBase IDs

References (25)

Report Sections

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