FB2024_03 , released June 25, 2024
Allele: Dmel\FakY430F.UAS
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General Information
Symbol
Dmel\FakY430F.UAS
Species
D. melanogaster
Name
FlyBase ID
FBal0280193
Feature type
allele
Associated gene
Dmel\Fak
Associated Insertion(s)
Carried in Construct
P{UAS-Fak.Y430F}
Key Links
Transgenic product class
missense_variant
(Tsai et al., 2008)
Mutagen
Nature of the Allele
Transgenic product class
missense_variant
(Tsai et al., 2008)
Mutagen
in vitro construct
(Tsai et al., 2008)
Progenitor genotype
Carried in construct
P{UAS-Fak.Y430F}
Cytology
Description

UAS regulatory sequences drive expression of a mutated form of Fak which carries the amino acid replacement Y430F.

(Tsai et al., 2008)
Allele components
Component
Use(s)
Regulatory region(s)
UAS
Encoded product / tool
Fak
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      Additional Information
      Statement
      Reference
       
      Marker for
      Reflects expression of
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 1 )
      Disease
      Interaction
      References
      ameliorates  tauopathy
      modeled by Hsap\MAPT4xA.UAS.2N4R
      (Dourlen et al., 2017)
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference

      Significant overgrowth of the neuromuscular junction (NMJ) (increased bouton number per muscle area and increased NMJ length per muscle area) is seen in third instar larvae expressing FakY430F.Scer\UAS under the control of Scer\GAL4elav.PU.

      (Tsai et al., 2008)
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      NOT Enhancer of
      Statement
      Reference

      FakCG1, FakY430F.UAS, Scer\GAL4GMR.PU is a non-enhancer of visible phenotype of RetGMR.PR

      (Macagno et al., 2014)
      Suppressor of
      Statement
      Reference

      FakY430F.UAS/Scer\GAL4GMR.PU is a suppressor | partially of visible phenotype of RetMEN2A.GMR

      (Macagno et al., 2014)
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference

      Expression of FakY430F.Scer\UAS under the control of Scer\GAL4GMR.PU partially suppresses the small eye size induced by expression of one copy of RetMEN2A.GMR.

      Heterozygous FakCG1 enhances the ommatidial mis-patterning seen in eyes expressing RetGMR.PR. Homozygous FakCG1 causes a smaller eye due to a completely disrupted ommatidial pattern. This enhancement is reversed upon co-expression of either FakScer\UAS.T:Ivir\HA1 or FakY430F.Scer\UAS under the control of Scer\GAL4GMR.PU.

      (Macagno et al., 2014)
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Comments
      Images (0)
      Mutant
      Wild-type
      Stocks (0)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      FakY430F.Scer\UAS
      FakY430F.UAS
      Name Synonyms
      Secondary FlyBase IDs
        References (3)