FlyBase Aberration Report: Dmel\Df(3R)M-Kx1

General Information

Symbol

Df(3R)M-Kx1

Species

D. melanogaster

Name

FlyBase ID

FBab0002601

Feature type

chromosomal_deletion

Also Known As

Df(3R)Kx1, Df(3R)Kx-1, Df(3R)MKX1, Df(3R)M-Kxl

Computed Breakpoints include

86C1;87B5

Features within 86C1--87B5

Genomic Maps

JBrowse

Sequence coordinates

3R:10,873,773..10,878,131 (Df(3R)M-Kx1:bk1)

(Yamamoto et al., 2009.2.25)

3R:12,324,838..12,350,415 (Df(3R)M-Kx1:bk2)

(Yamamoto et al., 2009.2.25)

Member of large scale dataset(s)

Nature of Aberration

Cytological Order

Progenitor

Mutagen

Class of aberration (relative to wild type)

chromosomal_deletion

(FlyBase, 2007)

Class of aberration (relative to progenitor)

chromosomal_deletion

(Price et al., 1997, Bhadra and Birchler, 1996, Duffy et al., 1996, Harbecke and Lengyel, 1995, Pauli et al., 1995, Landecker et al., 1994, Smith et al., 1993, Reuter et al., 1987)

Breakpoints

86C1;87B1-87B5

(Bhadra and Birchler, 1996, Duffy et al., 1996, Pauli et al., 1995, Smith et al., 1993, Reuter et al., 1987)

86C1;87B5

(Price et al., 1997, Landecker et al., 1994)

86C1;85B1-85B5

(Harbecke and Lengyel, 1995)

Causes alleles

Carries alleles

Transposon Insertions

Formalized genetic data

hth << bk1 << TfIIFβ << svp << bk2 << Pp1-87B

Genetic mapping information

Comments

Comments on Cytology

The left Df(3R)M-Kx1 breakpoint lies in CG4596 or Sodh-2 or in the region between them, and lies in the range 3R:6699495..6703853 (R5) (predicted cytology: 86C7).

(Yamamoto et al., 2009.2.25)

The right breakpoint of Df(3R)M-Kx1 lies within CG10013 or CG10038 or in the region between them, and lies in the range 3R:8150560..8176137 (R5) (predicted cytology: 87B6-7).

(Yamamoto et al., 2009.2.25)

Limits of break 1 from polytene analysis (FBrf0047003) Left limit of break 2 from polytene analysis (FBrf0076124) Right limit of break 2 from polytene analysis (FBrf0047003)

Sequence Crossreferences

DDBJ / EMBL / GenBank

DNA sequence

Protein sequence

Gene Deletion and Duplication Data

Genes Deleted / Disrupted

Complementation Data

Completely deleted / disrupted

Blm

(Szabad, 1998.4.8)

COX5A

(Szeged Stock Center, 1998-)

Csk

(Stewart et al., 2003, Stewart, 2000.3.3, Spradling et al., 1999, Szeged Stock Center, 1998-, BDGP Project Members, 1994-1999)

l(3)86Fg

(Szeged Stock Center, 1998-)

l(3)87Ae

(Szabad, 1998.4.8)

l(3)04629

(Spradling et al., 1999, Szeged Stock Center, 1998-, BDGP Project Members, 1994-1999)

l(3)09656

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

l(3)10621

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

l(3)neo38

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

l(3)S005302b

(Szeged Stock Center, 1998-)

l(3)S005818

(Szeged Stock Center, 1998-)

l(3)S050407a

(Szeged Stock Center, 1998-)

l(3)S094310

(Szeged Stock Center, 1998-)

l(3)S101902

(Szeged Stock Center, 1998-)

l(3)S113208a

(Szeged Stock Center, 1998-)

ninaG

(Sarfare et al., 2005)

pros

(Balakireva et al., 2000, Spradling et al., 1999, Szeged Stock Center, 1998-, BDGP Project Members, 1994-1999, Vaessin et al., 1991)

sals

(Bai et al., 2007)

sd-4

(Babcock et al., 2003)

Su(var)3-13

(Reuter et al., 1987)

Su(var)3-14

(Reuter et al., 1987)

svp

(Babcock et al., 2003, Spradling et al., 1999, Szeged Stock Center, 1998-, BDGP Project Members, 1994-1999)

Tctp

(Hsu et al., 2007)

tho

(Spradling et al., 1999, BDGP Project Members, 1994-1999)

Partially deleted / disrupted

Molecular Data

Completely deleted

Partially deleted

Genes NOT Deleted / Disrupted

Complementation Data

Molecular Data

Genes Duplicated

Complementation Data

Completely duplicated

Partially duplicated

Molecular Data

Completely duplicated

Partially duplicated

Genes NOT Duplicated

Complementation Data

Molecular Data

Affected Genes Inferred by Location

Related Comments

Phenotypic Data

In combination with other aberrations

Inferred to overlap with: Df(3R)Exel8154.

(Cook, 2009.5.2)

Dominant suppressor of In(1)w^m4h variegation.

NOT in combination with other aberrations

The size of the tracheal lumen is different to wild type in Df(3R)M-Kx1 embryos.

(Myat et al., 2005)

The Df(3R)M-Kx1 chromosome does not act as a dominant suppressor of telomeric silencing (assayed using the effect of the chromosome on the eye colour phenotype of flies carrying "P{w^var}KR3-2", a stable "brown-red" variant of the P{3'WP-2,w^var}2Lt insertion).

(Mason et al., 2004)

Heterozygosity for Df(3R)M-Kx1 results in 2.3% X chromosome nondisjunction and 0.0% fourth chromosome nondisjunction in In(1)FM7/X ; sv^spa-pol females.

(Harris et al., 2003)

Shows dominant enhancement of dominant haltere phenotype caused by Ubx¹⁹⁵ and Ubx^9.22.

(Burnette et al., 1999)

Heterozygous males differ significantly from control males in their homo- and heterosexual courtship. These males do not discriminate between male and female target flies.

(Balakireva et al., 1998)

Dominantly suppresses the Kr^If-1/+ eye phenotype.

(Carrera et al., 1998)

Does not cause unconditional lethality in hybrid females when heterozygous with D.simulans chromosome.

(Coyne et al., 1998)

No second site non-complementing phenotype with zip^Ebr and zip^mhc-c6.1.

(Halsell and Kiehart, 1998)

Shows no maternal enhancement of dpp^hr4.

(Nicholls and Gelbart, 1998)

Acts as a dosage sensitive maternal modifier of run : causes tergite defects in greater than 50% of run³ heterozygotes.

(Duffy et al., 1996)

Deficient embryos show an uninterpretable mutant midgut phenotype.

(Bilder and Scott, 1995)

Homozygous embryos have holes in the epidermis and dorsal closure is abnormal. Midgut constrictions are variable and the hindgut is contorted and bloated.

(Harbecke and Lengyel, 1995)

Heterozygosity for this deletion has no effect on the mutant ovarian phenotype of ovo^D2.

(Pauli et al., 1995)

Stocks (2)

Bloomington

3128

Df(3R)M-Kx1/TM3, Sb¹

Kyoto

106867

Df(3R)M-Kx1/TM3, Sb¹ Ser¹

Notes on Origin

Discoverer

Vassin.

Balancer / Genotype Variants of the Aberration

Separable Components

Other Comments

Synonyms and Secondary IDs (9)

Reported As

Symbol Synonym

Df(3R)Kx-1

(Balakireva et al., 1998, Reuter et al., 1987)

Df(3R)Kx1

(Balakireva et al., 2000, Gildea et al., 2000, Landecker et al., 1994)

Df(3R)M-Kx

(Mackay et al., 2005)

Df(3R)M-Kx1

(Galindo et al., 2014, Fernandes and Rao, 2011, Cook, 2009.5.2, Yamamoto et al., 2009.2.25, Bejarano et al., 2008, Casso et al., 2008, Bai et al., 2007, Hsu et al., 2007, Weiler, 2007, Sarfare et al., 2005)

Df(3R)M-Kxl

(Goodliffe et al., 2007, Neuburger et al., 2006)

Df(3R)MKX1

(Schottenfeld-Roames and Ghabrial, 2012, Vaessin et al., 1991)

Df(3R)Mk-x1

(Coyne et al., 1999)

DfKu70¹

(Melnikova et al., 2005)

M-Kx1

(Hirose et al., 2001)

Name Synonyms

Secondary FlyBase IDs

References (66)

Report Sections

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