l(3)87Ca, Vacuolar H+-ATPase 55kD B subunit, l(3)j2E9, V-ATPase, l(3)SzA
Please see the JBrowse view of Dmel\Vha55 for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.50
Low-frequency RNA-Seq exon junction(s) not annotated.
2.8, 2.6, 2.5, 2.0, 1.8 (longest cDNA)
490 (aa); 55 (kD)
V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits VhaAC45 and ATP6AP2 (By similarity).
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Vha55 using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
Comment: enriched in acidic region
JBrowse - Visual display of RNA-Seq signals
View Dmel\Vha55 in JBrowse
Please Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
polyclonal
Most extreme hemizygous phenotype is embryonic lethality, even though homozygous Df(3R)kar3J, which lacks the locus entirely, dies during the first larval instar (Ish-Horowicz, Holden and Gehring, 1977). First instar larvae have transparent Malpighian tubules; autonomous in transplants. Two alleles isolated on the basis of their dominant suppression of ectopic sex-comb teeth in Pc4/+ males (Kennison and Tamkun, 1988).
