FB2024_03 , released June 25, 2024
Allele: Scer\GAL4lab.PH
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General Information
Symbol
Scer\GAL4lab.PH
Species
S. cerevisiae
Name
labial promoter construct of Hirth
FlyBase ID
FBal0130637
Feature type
allele
Associated gene
Scer\GAL4
Associated Insertion(s)
Carried in Construct
P{lab-GAL4.H}
Also Known As
Labial-GAL4, Lab-GAL4
Transgenic product class
Mutagen
Nature of the Allele
Transgenic product class
Mutagen
in vitro construct
(Hirth et al., 2001)
Progenitor genotype
Carried in construct
P{lab-GAL4.H}
Cytology
Description

A 3.6kb genomic fragment extending from the HindIII site 3.6kb upstream of the lab transcriptional start site to the BssHII site at +10bp regulates expression of a GAL4 driver.

(Hirth et al., 2001)
Allele components
Component
Use(s)
Regulatory region(s)
lab
Encoded product / tool
GAL4
Mutations Mapped to the Genome
Curation Data
Type
Location
Additional Notes
References
Variant Molecular Consequences
Associated Sequence Data
DDBJ / EMBL / GenBank
DNA sequence
Protein sequence
 
UniProtKB/Swiss-Prot
    UniProtKB/TrEMBL
      Expression Data
      Reporter Expression
      distribution deduced from reporter (Gal4 UAS)
      Stage
      Tissue/Position (including subcellular localization)
      Reference
      embryonic stage
      procephalic segment
      (Bloomington Drosophila Stock Center, 2017)
      embryonic tritocerebrum
      (Bloomington Drosophila Stock Center, 2017)
      embryonic stage 10 -- 15
      larval tritocerebrum
      (Hirth et al., 2001)
      embryonic procephalic segment
      (Hirth et al., 2001)
      embryonic stage 15
      embryonic/larval tritocerebral commissure
      (Hirth et al., 2001)
      larval stage
      embryonic/larval copper cell
      (Redhai et al., 2020)
      third instar larval stage
      embryonic/larval copper cell
      (Veenstra, 2009)
      embryonic/larval midgut interstitial cell
      (Veenstra, 2009)
      larval enteroendocrine cell
      (Veenstra, 2009)
      adult stage
      adult copper cell
      (Iatsenko et al., 2018)
      Additional Information
      Statement
      Reference

      ScerGAL4lab.PH drives expression in embryos in the procephalon and the tritocerebral neuromere; procephalic expression is delayed by 2.5 hours relative to endogenous lab.

      (Bloomington Drosophila Stock Center, 2017)

      Reporter expression is observed in the copper cells and in smaller cells in this region as well as in cells of the anterior-middle midgut junction.

      (Veenstra, 2009)

      ScerGAL4lab.PH drives expression in the embryonic brain in a pattern that recapitulates that of endogenous lab. Expression is observed in the procephalic segment and in the tirocerebrum starting at embryonic stage 10.

      (Hirth et al., 2001)
       
      Marker for
      Reflects expression of
      lab
      (Bloomington Drosophila Stock Center, 2017, Veenstra, 2009, Hirth et al., 2001)
      Reporter construct used in assay
      Human Disease Associations
      Disease Ontology (DO) Annotations
      Models Based on Experimental Evidence ( 0 )
      Disease
      Evidence
      References
      Modifiers Based on Experimental Evidence ( 0 )
      Disease
      Interaction
      References
      Comments on Models/Modifiers Based on Experimental Evidence ( 0 )
       
      Disease-implicated variant(s)
       
      Phenotypic Data
      Phenotypic Class
      Phenotype Manifest In
      Detailed Description
      Statement
      Reference
      External Data
      Interactions
      Show genetic interaction network for Enhancers & Suppressors
      Phenotypic Class
      Phenotype Manifest In
      Additional Comments
      Genetic Interactions
      Statement
      Reference
      Xenogenetic Interactions
      Statement
      Reference
      Complementation and Rescue Data
      Images (0)
      Mutant
      Wild-type
      Stocks (1)
      Notes on Origin
      Discoverer
      External Crossreferences and Linkouts ( 0 )
      Synonyms and Secondary IDs (2)
      Reported As
      Symbol Synonym
      Scer\GAL4lab.PH
      Name Synonyms
      labial promoter construct of Hirth
      (Hirth et al., 2001)
      Secondary FlyBase IDs
        References (9)