Ku70, YPF1, DmKu70, Ku, YPF1β
Please see the JBrowse view of Dmel\Irbp for information on other features
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AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Some regions with low pLDDT may be unstructured in isolation.
Gene model reviewed during 5.47
Low-frequency RNA-Seq exon junction(s) not annotated.
Multiphase exon postulated: exon reading frame differs in alternative transcripts.
None of the polypeptides share 100% sequence identity.
Heterodimer of a 70 kDa and a 80 kDa subunit.
Click to get a list of regulatory features (enhancers, TFBS, etc.) and gene disruptions (point mutations, indels, etc.) within or overlapping Dmel\Irbp using the Feature Mapper tool.
The testis specificity index was calculated from modENCODE tissue expression data by Vedelek et al., 2018 to indicate the degree of testis enrichment compared to other tissues. Scores range from -2.52 (underrepresented) to 5.2 (very high testis bias).
Comment: maternally deposited
JBrowse - Visual display of RNA-Seq signals
View Dmel\Irbp in JBrowsePlease Note FlyBase no longer curates genomic clone accessions so this list may not be complete
Please Note This section lists cDNAs and ESTs that fall within the genomic extent of the gene model, which may include cDNAs and ESTs of genes within introns, or of overlapping genes. Please see JBrowse for alignment of the cDNAs and ESTs to the gene model.
For each fully sequenced cDNA the DGRC maintains various forms of the cDNA (e.g tagged or untagged) in several different host vectors for subsequent cloning and expression in Drosophila and Drosophila cell lines.
monoclonal
polyclonal
Irbp has a role in length regulation of telomeres.
A decrease in Irbp gene dosage causes a sharp increase in the frequency of HeT-A and TART-element attachments to a broken chromosome end and strongly enhances terminal DNA elongation by gene conversion. However, reduction in Irbp function also reduces the stability of terminally deficient chromosomes.
Irbp gene product specifically interacts with the outer half of the 31bp terminal inverted repeats.
Isolated from an ovarian cDNA expression library.
DNase I footprinting has identified a protein from Kc cells that binds to the P-element 31bp inverted repeats. UV photochemical crosslinking and purification of protein identifies the DNA binding activity within a polypeptide of 66kD.
Source for merge of: Irbp Ypf1b
snoRNA:Irbp-a is encoded in an intron of Irbp.
It had previously been suggested that mus309 corresponds to Irbp (FBrf0086898). Detailed deletion mapping suggests that this was incorrect and mus309 actually corresponds to blm, which is supported by the identification of mutations in the blm coding sequence for two mus309 alleles.
Identity of "Irbp" to "Ypf1b" based on DNA sequence identity.
mus309 stated to correspond to Irbp. Subsequent information suggests that this is not the case (see Kusano et al., 2001, Science 291(5513): 2600--2602).
